Aging, Cellular Senescence, Senolytic Agents: The Path to Translation • Define cellular senescence • Recognize senolytics • Construct the route to eventual clinical application of senolytics for cardiovascular diseases Affiliation: Consultant, Division of General Internal Medicine, Department of Internal Medicine, Director, … Read More

Role of Epicardium-derived Cells in Myocardial Healing I will report on recent scRNAseq and secretom data , show that A2B signaling controls normoxic HIF1α formation and IL-6 production, provide first evidence for In vivo imaging of cardiac stromal cells by … Read More

Systems biology to predict drivers of cardiac differentiation and fibrosis The heart's form changes substantially through development and disease, yet how this is controlled by molecular networks is unclear. In this talk, I will present our computational and experimental systems … Read More

Divergent Roles of Integrated Stress Responses in Vascular Smooth Muscle Cells: Therapeutic Implications in Peripheral Vascular Diseases The diseased phenotypic switching of vascular smooth muscle cells (VSMC) critically contributes to the pathogenesis of peripheral vascular diseases. Integrated stress response (ISR) … Read More

Hosted by: Swapnil Sonkusare, PhD The two faces of HIPPO: targeting the HIPPO pathway in pulmonary arterial hypertension Growth suppressor HIPPO plays a central role in regulating cell fate and proliferation and controlling organ growth and regeneration.  Recent studies from … Read More

Endothelial Cell Cycle Control in Vascular Malformations: Therapeutics Implications in Hereditary Hemorrhagic Telangiectasia The hypothesis of our work is that improper cell cycle control in endothelial cells is a key factor leading to vascular malformations and that drugs regulating cell … Read More

Hosted by: Swapnil Sonkusare, PhD and Brant Isakson, PhD The Space Between: How Lymphatic Endothelial Junction Proteins Control Development Lymphatic vessels form specialized structures to enable the absorption and transport of interstitial fluid. Two of these structures are discontinuous button-like … Read More

Hosted by: Mete Civelek, PhD Sex-biased genetic factors influence obesity, lipid absorption, and statin adverse effects We are investigating sex differences in cardiometabolism to identify genetic factors that influence adiposity and lipid metabolism. We have identified histone demethylase enzymes that … Read More

Hosted by: Bowen Wang, PhD Reconstructing Organotypic Vasculature in a Dish: Towards Therapeutic Discovery and Precision Medicine Capillary endothelial cells are highly specialized in different organ systems at both molecular and functional levels.  However, the factors driving endothelial cell fate … Read More