Rerouting Smooth Muscle Glycolysis Rescues Atherosclerosis-associated Mortality in Mice Heart attacks or strokes stemming from rupture or erosion of unstable atherosclerotic plaques lead to over half a million deaths annually. Postmortem studies of human coronary arteries correlated stable atherosclerotic lesions … Read More
Immune checkpoint inhibitor (ICI)-Myocarditis: Insights into cardiac-immune regulation Cardio-oncology (the cardiovascular care of cancer patients) has developed as a new translational and clinical field based on the expanding repertoire of mechanism-based cancer therapies. Cardio-oncology can also serve as a novel … Read More
Identifying and characterizing causal coronary artery disease-associated variants regulating gene expression in vascular smooth muscle cells Coronary artery disease (CAD) is a complex disorder with genetic and environmental influences. Genome-wide association studies (GWAS) have identified >300 loci associated with disease … Read More
MMP-2-Targeted Nanofibers as a Potential Diagnostic and Therapeutic Delivery Vehicle for Abdominal Aortic Aneurysms Abdominal aortic aneurysm (AAA) is the most common aortic pathology, and accounts for ~10,000 deaths/year in the United States. While many preclinical therapeutics have shown promise, … Read More
Sex specific effects of endothelial Pannexin1 in cerebral vascular function and ischemic stroke Our work examines the mechanisms regulating cerebral artery function in health and disease. We examine the role of endothelial Pannexin1, a critical regulator of purinergic signaling, in … Read More
A Call to Action to Control Hypertension: What will it take to improve health outcomes in medically underserved communities? The research seeks to gain an understanding of the gaps and barriers in medically underserved communities and the effect of their … Read More
Cardiac Fibroblast Phenotypes: Investigation of the Role of Mitochondrial Structure and Function More than 6 million Americans suffer from heart failure secondary to acute and chronic disease states that induce cardiac fibrosis. Fibrosis is the deposition of extracellular matrix that … Read More
Dynamic nitrosation - palmitoylation of endothelial CD36 regulates serum lipids My talk will focus specifically on a new post-translational modification of a fatty acid translocase CD36 and how this regulates lipid uptake into endothelium. PhD Candidate Physiology, Isakson Lab, University of … Read More
Cell Signaling And Immune Cell Involvement In Neointima Formation Connexin (Cx) proteins form gap junctions, allowing for communication between cells. Alterations in gap junctions have been associated with pathological proliferation in disease since their discovery in the 1950s. Our studies … Read More
Toward a Therapy for Atherosclerosis - Discuss growth and composition of the arterial plaque, with possible targets of therapy - Discuss feasibility and drivers of atherosclerosis regression VP/Chair, Scientific Council, Global Clinical Development, Regeneron
Novel transgenic/chemogenetic models of oxidative stress in the cardiovascular system Dr. Michel’s seminar will discuss the development and application of chemogenetic approaches to dynamically modulate tissue-specific oxidative stress. These studies have yielded new models of heart failure, neurodegeneration, and aortic … Read More
Extracellular vesicle-mediated communication in cardiovascular disease Extracellular vesicles (EVs) are produced by cells in the cardiovascular system, and they can be taken up by recipient cells to alter function. The contents and functions of EVs change during disease, and they … Read More
