Functional interactions between von Willebrand factor and lipoproteins: Implications for microvascular function and atherosclerosis In this lecture, I will describe the biochemistry and physics of VWF self-association, a process that produces strands and fibers with high adhesive capacity for platelets. … Read More
Role of Endothelial Dysfunction in the Pathogenesis of Pulmonary Arterial Hypertension. The endothelial cell-specific role in PAH is multi-faceted and impacts upon numerous pathophysiological processes including vasoconstriction, inflammation, metabolism, and oxidative/nitrative stress, as well as cell viability, growth.I will describe … Read More
ElectroCalcium Coupling and Alzheimer’s Disease This talk will focus on the neurovascular coupling mechanisms involved in the control of blood flow in the brain. The talk will also describe how neurovascular coupling mechanisms get altered in a mouse model of … Read More
TAKING THE RISK: Stem cell-based functional genomics to uncover cardiovascular risk The Lo Sardo laboratory combines pluripotent stem cell potential and functional genomics to understand how common genetic variants among individuals, including those in non-coding portions of the genome, contribute … Read More
Immunoengineering Next-Generation Cancer Therapies with Focused Ultrasound Despite the remarkable promise of cancer immunotherapy, a significant fraction of patients with solid tumors are yet unable to realize its unparalleled benefits. In this talk, I will introduce focused ultrasound (FUS) - … Read More
Rerouting Smooth Muscle Glycolysis Rescues Atherosclerosis-associated Mortality in Mice Heart attacks or strokes stemming from rupture or erosion of unstable atherosclerotic plaques lead to over half a million deaths annually. Postmortem studies of human coronary arteries correlated stable atherosclerotic lesions … Read More
Immune checkpoint inhibitor (ICI)-Myocarditis: Insights into cardiac-immune regulation Cardio-oncology (the cardiovascular care of cancer patients) has developed as a new translational and clinical field based on the expanding repertoire of mechanism-based cancer therapies. Cardio-oncology can also serve as a novel … Read More
Identifying and characterizing causal coronary artery disease-associated variants regulating gene expression in vascular smooth muscle cells Coronary artery disease (CAD) is a complex disorder with genetic and environmental influences. Genome-wide association studies (GWAS) have identified >300 loci associated with disease … Read More
MMP-2-Targeted Nanofibers as a Potential Diagnostic and Therapeutic Delivery Vehicle for Abdominal Aortic Aneurysms Abdominal aortic aneurysm (AAA) is the most common aortic pathology, and accounts for ~10,000 deaths/year in the United States. While many preclinical therapeutics have shown promise, … Read More
Sex specific effects of endothelial Pannexin1 in cerebral vascular function and ischemic stroke Our work examines the mechanisms regulating cerebral artery function in health and disease. We examine the role of endothelial Pannexin1, a critical regulator of purinergic signaling, in … Read More
A Call to Action to Control Hypertension: What will it take to improve health outcomes in medically underserved communities? The research seeks to gain an understanding of the gaps and barriers in medically underserved communities and the effect of their … Read More
Cardiac Fibroblast Phenotypes: Investigation of the Role of Mitochondrial Structure and Function More than 6 million Americans suffer from heart failure secondary to acute and chronic disease states that induce cardiac fibrosis. Fibrosis is the deposition of extracellular matrix that … Read More
