Chronic viral infection drives three gene expression states in cardiomyocytes Several viruses can infect the human heart and persist long term, leading to heart failure. This project identifies undiagnosed viral heart infections using large RNA-seq datasets collected from patient hearts. … Read More
Connexin-43 hemichannels as mediators of cardiac stress-induced arrhythmias and myocardial infarction Connexin 43 (Cx43) is the most abundant gap junction channel-forming isoform in cardiac ventricles. In multiple cardiac pathologies, Cx43 is found to be remodeled to the lateralized side of … Read More
Hosted by: Melissa Luse Interorgan transport of mitochondria from energetically stressed adipocytes Adipocytes that undergo mitochondrial stress, as in obesity, release damaged mitochondria in extracellular vesicles (mitoEVs). These mitoEVs enter circulation and can be taken up by multiple organs. This … Read More
Pioneering MRI-guided Focused Ultrasound for the Treatment of Cerebral Cavernous Malformations Cerebral cavernous malformations (CCMs) are hemorrhage-prone vascular lesions that form in the central nervous system. To date, the only available treatment option for CCMs is surgical resection of the lesion--a treatment option that is … Read More
Optical Dissection of Brain Capillary Function My lab uses in vivo multi-photon imaging and a combination of optical and genetic approaches to study how brain capillaries are perfused. Our goal is to define cellular and molecular targets to improve cerebral … Read More
Targeting the epigenome to increase cardiomyocyte proliferation and cardiac regeneration Epigenomic remodelling during cardiomyocyte maturation serves to suppress fetally expressed genes and promote the expression of genes necessary for adult function. Genes involved in cell cycle activity that are expressed … Read More
RNA binding proteins: Wizards of gene regulation in the heart Mutations in RNA binding proteins are associated with adult and congenital heart diseases. It is unclear how these RNA binding proteins alter gene expression in the heart and cause heart … Read More
Mechanisms of Endothelial Cell Fate Determination – Applications to Cardiac Tissue Regeneration Endothelial cell specification into arterial and venous phenotypes is critical for the development of a circulatory network, and requires coordination between extrinsic and intrinsic signaling. These maturation events … Read More
The Dark That Matters: Essential Role of the Long Non-coding RNA CARMN in Regulating Smooth Muscle Phenotype Professor, Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA
Redox Modulation and Targeted Drug Delivery for Cardiovascular Disease and Beyond Redox dysfunction is causally associated with a wide array of human pathologies. Particularly, redox dysfunction promotes the development of cardiovascular disease. However, clinical translation of antioxidant-therapy has yielded underwhelming … Read More
Functional interactions between von Willebrand factor and lipoproteins: Implications for microvascular function and atherosclerosis In this lecture, I will describe the biochemistry and physics of VWF self-association, a process that produces strands and fibers with high adhesive capacity for platelets. … Read More
Role of Endothelial Dysfunction in the Pathogenesis of Pulmonary Arterial Hypertension. The endothelial cell-specific role in PAH is multi-faceted and impacts upon numerous pathophysiological processes including vasoconstriction, inflammation, metabolism, and oxidative/nitrative stress, as well as cell viability, growth.I will describe … Read More
