RNA binding proteins: Wizards of gene regulation in the heart Mutations in RNA binding proteins are associated with adult and congenital heart diseases. It is unclear how these RNA binding proteins alter gene expression in the heart and cause heart … Read More

Mechanisms of Endothelial Cell Fate Determination – Applications to Cardiac Tissue Regeneration Endothelial cell specification into arterial and venous phenotypes is critical for the development of a circulatory network, and requires coordination between extrinsic and intrinsic signaling. These maturation events … Read More

The Dark That Matters: Essential Role of the Long Non-coding RNA CARMN in Regulating Smooth Muscle Phenotype Professor, Department of Pharmacology & Toxicology, Medical College of Georgia, Augusta University, Augusta, GA

Redox Modulation and Targeted Drug Delivery for Cardiovascular Disease and Beyond Redox dysfunction is causally associated with a wide array of human pathologies. Particularly, redox dysfunction promotes the development of cardiovascular disease. However, clinical translation of antioxidant-therapy has yielded underwhelming … Read More

Functional interactions between von Willebrand factor and lipoproteins: Implications for microvascular function and atherosclerosis In this lecture, I will describe the biochemistry and physics of VWF self-association, a process that produces strands and fibers with high adhesive capacity for platelets. … Read More

Role of Endothelial Dysfunction in the Pathogenesis of Pulmonary Arterial Hypertension. The endothelial cell-specific role in PAH is multi-faceted and impacts upon numerous pathophysiological processes including vasoconstriction, inflammation, metabolism, and oxidative/nitrative stress, as well as cell viability, growth.I will describe … Read More

ElectroCalcium Coupling and Alzheimer’s Disease This talk will focus on the neurovascular coupling mechanisms involved in the control of blood flow in the brain. The talk will also describe how neurovascular coupling mechanisms get altered in a mouse model of … Read More

TAKING THE RISK: Stem cell-based functional genomics to uncover cardiovascular risk The Lo Sardo laboratory combines pluripotent stem cell potential and functional genomics to understand how common genetic variants among individuals, including those in non-coding portions of the genome, contribute … Read More