Connexin-43 hemichannels as mediators of cardiac stress-induced arrhythmias and myocardial infarction Connexin 43 (Cx43) is the most abundant gap junction channel-forming isoform in cardiac ventricles. In multiple cardiac pathologies, Cx43 is found to be remodeled to the lateralized side of … Read More
Dr. Qianyi Yang Senior Scientist at Vertex
Yonathan - Predicting mechanisms of action at genetic loci associated with discordant effects on type 2 diabetes and abdominal fat accumulation Kelsey - : Impact of sodium-glucose cotransporter 2 inhibitors on systemic inflammation in women with coronary microvascular disease Luke - … Read More
Hosted by: Melissa Luse Interorgan transport of mitochondria from energetically stressed adipocytes Adipocytes that undergo mitochondrial stress, as in obesity, release damaged mitochondria in extracellular vesicles (mitoEVs). These mitoEVs enter circulation and can be taken up by multiple organs. This … Read More
Pioneering MRI-guided Focused Ultrasound for the Treatment of Cerebral Cavernous Malformations Cerebral cavernous malformations (CCMs) are hemorrhage-prone vascular lesions that form in the central nervous system. To date, the only available treatment option for CCMs is surgical resection of the lesion--a treatment option that is … Read More
Who: All Trainees Selected Group: Taylor Eggertsen Yonathan Aberra Catherine Gorick Matt Hoch Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells https://www.nature.com/articles/s41467-023-37256-8
Optical Dissection of Brain Capillary Function My lab uses in vivo multi-photon imaging and a combination of optical and genetic approaches to study how brain capillaries are perfused. Our goal is to define cellular and molecular targets to improve cerebral … Read More
Targeting the epigenome to increase cardiomyocyte proliferation and cardiac regeneration Epigenomic remodelling during cardiomyocyte maturation serves to suppress fetally expressed genes and promote the expression of genes necessary for adult function. Genes involved in cell cycle activity that are expressed … Read More
Trainees should prepare a 3-4 minute introduction about themselves and their project—no slides! Also, remember that the audience will be quiet diverse from 2nd year graduate students just getting into labs to faculty and also from very different areas. These … Read More
All Trainees Randomly selected a trainees will give a 5-6 minute summary of their research project without slides indicating why their project is important, what has been done so far, what needs to be done, the project hypothesis, and experimental … Read More
RNA binding proteins: Wizards of gene regulation in the heart Mutations in RNA binding proteins are associated with adult and congenital heart diseases. It is unclear how these RNA binding proteins alter gene expression in the heart and cause heart … Read More
Mechanisms of Endothelial Cell Fate Determination – Applications to Cardiac Tissue Regeneration Endothelial cell specification into arterial and venous phenotypes is critical for the development of a circulatory network, and requires coordination between extrinsic and intrinsic signaling. These maturation events … Read More
