Zhiyu Dai, PhD, FAHA

Role of Endothelial Dysfunction in the Pathogenesis of Pulmonary Arterial Hypertension.

The endothelial cell-specific role in PAH is multi-faceted and impacts upon numerous pathophysiological processes including vasoconstriction, inflammation, metabolism, and oxidative/nitrative stress, as well as cell viability, growth.I will describe how EC dysfunction and cell signaling regulate the pathogenesis of PAH.

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Director, Translational Endothelial Research, Department of Internal Medicine,

Assistant Professor (Tenure Track) of Medicine, Department of Internal Medicine, Member of Translational Cardiovascular Research Center, Member of BIO5 Institute, Member of Sarver Heart Center, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA