Role of Epicardium-derived Cells in Myocardial Healing I will report on recent scRNAseq and secretom data , show that A2B signaling controls normoxic HIF1α formation and IL-6 production, provide first evidence for In vivo imaging of cardiac stromal cells by … Read More
TBD
TBD
Systems biology to predict drivers of cardiac differentiation and fibrosis The heart's form changes substantially through development and disease, yet how this is controlled by molecular networks is unclear. In this talk, I will present our computational and experimental systems … Read More
Divergent Roles of Integrated Stress Responses in Vascular Smooth Muscle Cells: Therapeutic Implications in Peripheral Vascular Diseases The diseased phenotypic switching of vascular smooth muscle cells (VSMC) critically contributes to the pathogenesis of peripheral vascular diseases. Integrated stress response (ISR) … Read More
Hosted by: Swapnil Sonkusare, PhD The two faces of HIPPO: targeting the HIPPO pathway in pulmonary arterial hypertension Growth suppressor HIPPO plays a central role in regulating cell fate and proliferation and controlling organ growth and regeneration. Recent studies from … Read More
Endothelial Cell Cycle Control in Vascular Malformations: Therapeutics Implications in Hereditary Hemorrhagic Telangiectasia The hypothesis of our work is that improper cell cycle control in endothelial cells is a key factor leading to vascular malformations and that drugs regulating cell … Read More
Hosted by: Swapnil Sonkusare, PhD and Brant Isakson, PhD The Space Between: How Lymphatic Endothelial Junction Proteins Control Development Lymphatic vessels form specialized structures to enable the absorption and transport of interstitial fluid. Two of these structures are discontinuous button-like … Read More
Hosted by: Mete Civelek, PhD Sex-biased genetic factors influence obesity, lipid absorption, and statin adverse effects We are investigating sex differences in cardiometabolism to identify genetic factors that influence adiposity and lipid metabolism. We have identified histone demethylase enzymes that … Read More
Hosted by: Bowen Wang, PhD Reconstructing Organotypic Vasculature in a Dish: Towards Therapeutic Discovery and Precision Medicine Capillary endothelial cells are highly specialized in different organ systems at both molecular and functional levels. However, the factors driving endothelial cell fate … Read More
Chronic viral infection drives three gene expression states in cardiomyocytes Several viruses can infect the human heart and persist long term, leading to heart failure. This project identifies undiagnosed viral heart infections using large RNA-seq datasets collected from patient hearts. … Read More
Connexin-43 hemichannels as mediators of cardiac stress-induced arrhythmias and myocardial infarction Connexin 43 (Cx43) is the most abundant gap junction channel-forming isoform in cardiac ventricles. In multiple cardiac pathologies, Cx43 is found to be remodeled to the lateralized side of … Read More
