A team led by Swapnil K. Sonkusare, PhD, of UVA’s Department of Molecular Physiology and Biological Physics, identified a cascade of cellular changes that take place within the lung that ultimately result in what is known as “ischemia-reperfusion injury,” a major cause or organ rejection and death after transplant.
Doctors may be able to prevent ischemia reperfusion injury by targeting the underlying biological processes Sonkusare and his team have identified, the researchers say.
“Our collaborative studies with Dr. Victor Laubach from [UVA’s Department of] Surgery show a new mechanism for lung ischemia-reperfusion injury,” said Sonkusare, of UVA’s Robert M. Berne Cardiovascular Research Center. “This mechanism could be targeted to improve the clinical success of lung transplantation.” Read more about research in the Kron/Laubach lab here.
View the full article at the SOM Medicine in Motion News Section