CVTG- RIP Journal Club
MR6 Room 2502Presenters: Chase Binion, Austin Hogwood, Randall Schirra, Skylar Rodgers https://www.nature.com/articles/s41586-023-06311-1
Presenters: Chase Binion, Austin Hogwood, Randall Schirra, Skylar Rodgers https://www.nature.com/articles/s41586-023-06311-1
All Trainees Trainees should prepare a 3-4 minute introduction about themselves and their project—no slides! Audience will be quiet diverse from 2nd year graduate students just getting into labs to faculty and also from very different areas. These short “elevator … Read More
All Trainees These sessions are initiated by having Dr. Isakson randomly selecting a trainee (by pulling a name from a jar) to give a 5-6 minute summary of their research project without slides indicating why their project is important, what … Read More
GPR126 is a mechanoreceptor by which the endocardium senses cardiac load We have combined the use of genetic and physiologic approaches in mice to define how the adhesion GPCR GPR126 functions in vivo. Our findings reveal that GPR126 is activated by … Read More
Epigenetic Control of Smooth Muscle Differentiation: Insights from Smooth Muscle Dysfunction Syndrome Heterozygous ACTA2 p.R179 pathogenic variants cause Smooth Muscle Dysfunction Syndrome. ACTA2 encodes smooth muscle α-actin (SMA), and the p.R179 variant disrupts nuclear localization of SMA, leading to incomplete differentiation of smooth muscle … Read More
Maddie - Connexin 37 and cell cycle regulation of lymphatic valve morphogenesis Randall - Caveolin without borders: ancient proteins in prokaryotes and bacteria
LVAD-Induced Bleeding & Acquired Von Willebrand Disease (aVWD) A translational journey on how to explain and reconcile the clinical signs of LVAD-related bleeding and laboratory findings associated with acquired Von Willebrand Disease Associate Professor of Medicine, University of Texas at … Read More
Nutrition, Obesity, and Metabolism in Heart Failure: Mechanistic Insights and Translational Opportunities The presentation will discuss the metabolic and physiological effects of diet and obesity on cardiometabolic health, with a focus on heart failure. The talk will bridge basic and … Read More
Low-grade inflammation memory and rejuvenation during atherosclerosis pathogenesis and treatment The Li laboratory studies the novel dynamics of innate immune memory that can “memorize” the relative strength and duration of danger/damage signals, with memory states ranging from low-grade inflammation to exhaustion of … Read More
Gabrielle - MEK signaling as a therapeutic vulnerability of KRAS-driven somatic brain arteriovenous malformations Katie - Autoimmune Mechanism of Peripartum Cardiomyopathy in a Novel Murine Model Aqiyl - Role of H3K20 Methylation Writers and Changes of Epigenetic Memory Markers in Neointimal Hyperplasia
Discovery of heart-derived myokines that shape responses to cardio-metabolic stress in the heart This seminar will highlight how molecular metabolism and proteomics reveal new pathways in heart–metabolic tissue communication. Dr. Khetarpal will discuss recent work linking the transcriptional coactivator PGC-1α … Read More
Altered Endothelial Metabolism: An Unrecognized Driver of, and Therapeutic Target for, Peripheral Artery Disease Angiogenesis is the growth and proliferation of blood vessels from existing vascular structures. Angiogenesis occurs in a host of situations ranging from physiologic conditions (i.e. exercise) … Read More