Altering Cardiac Cell Fate for Heart Repair We will discuss how insights from developmental biology and stem cell concepts—particularly in cell identity, fate determination, and epigenetics—have been leveraged to uncover the molecular mechanisms underlying direct cardiac reprogramming, concomitantly enhancing reprogramming … Read More

Targeting the microtubule network to treat hypertension This talk will focus on the role of the microtubule network in vascular smooth muscle andhow it can regulate vascular tone. This work has revealed how targeting the microtubulenetwork may represent a potential … Read More

The forkhead transcription FoxO1 signaling in health and disease. The topic will cover the complex regulatory mechanisms of Foxo1 by multiple hormones, such as insulin, estrogen, and glucagon, which reveals the mechanism of insulin resistance for type 2 diabetes and … Read More

LINCing the Nucleus to Endothelial Cell Function in Blood Vessels Blood flow-generated shear forces regulate vascular endothelial cell status and signaling, and disrupted responses are linked to cardiovascular disease. We investigate how nuclear membrane proteins integrate forces and communicate to cell-cell … Read More

Sex-dependent cAMP Pools in Vascular Smooth Muscle: Role of Sex Hormones  This talk focuses on the sex-dependent regulation of subcellular cAMP compartments in vascular smooth muscle. Our research revealed a sex-specific distribution of cAMP pools that contribute to sex-dependent regulation … Read More