The forkhead transcription FoxO1 signaling in health and disease. The topic will cover the complex regulatory mechanisms of Foxo1 by multiple hormones, such as insulin, estrogen, and glucagon, which reveals the mechanism of insulin resistance for type 2 diabetes and … Read More

LINCing the Nucleus to Endothelial Cell Function in Blood Vessels Blood flow-generated shear forces regulate vascular endothelial cell status and signaling, and disrupted responses are linked to cardiovascular disease. We investigate how nuclear membrane proteins integrate forces and communicate to cell-cell … Read More

Sex-dependent cAMP Pools in Vascular Smooth Muscle: Role of Sex Hormones  This talk focuses on the sex-dependent regulation of subcellular cAMP compartments in vascular smooth muscle. Our research revealed a sex-specific distribution of cAMP pools that contribute to sex-dependent regulation … Read More

Brains, Blood Vessels, & Hearts: Investigating Cardio-Cerebral Crosstalk using Pig Models of Heart Failure The primary focus of my research is to investigate mechanisms involved in the development of heart disease and associated cognitive impairment, with the goal of discovering … Read More

Age-related clonal hematopoiesis: A Novel Driver of Hypertension? The rising prevalence of hypertension with age poses a major public health challenge due to its role as a critical risk factor for cardiovascular disease. Parallel to this trend, older individuals frequently … Read More