Nikolaos Frangogiannis, MD

TGF-beta signaling cascades in cardiac repair and fibrosis

Myocardial fibrosis is a common pathophysiological feature of most cardiac diseases and may be either reparative or maladaptive. This presentation will address: (a) the cellular mediators of cardiac fibrosis; (b) the molecular mechanisms driving fibroblast activation, with particular emphasis on the TGF-β superfamily; and (c) the challenges and opportunities associated with therapeutic strategies in heart failure patients with predominant fibrosis.

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Professor of Medicine, Professor of Microbiology and Immunology, The Edmond J Safra/Republic National Bank of New York Professor of Cardiovascular Medicine, Albert Einstein College of Medicine.