Identifying and characterizing causal coronary artery disease-associated variants regulating gene expression in vascular smooth muscle cells Coronary artery disease (CAD) is a complex disorder with genetic and environmental influences. Genome-wide association studies (GWAS) have identified >300 loci associated with disease … Read More

MMP-2-Targeted Nanofibers as a Potential Diagnostic and Therapeutic Delivery Vehicle for Abdominal Aortic Aneurysms Abdominal aortic aneurysm (AAA) is the most common aortic pathology, and accounts for ~10,000 deaths/year in the United States. While many preclinical therapeutics have shown promise, … Read More

Sex specific effects of endothelial Pannexin1 in cerebral vascular function and ischemic stroke Our work examines the mechanisms regulating cerebral artery function in health and disease. We examine the role of endothelial Pannexin1, a critical regulator of purinergic signaling, in … Read More