Patrice G. Guyenet
- Phone: 434-924-9974
- Fax: 434-982-3878
Primary Appointment
Professor Emeritus, Pharmacology
Education
- BS, Physiology & Biochemistry, Ecole Normale Superieure
- PhD, Neurochemistry, University of Paris
- Postdoc, Neuropharmacology, Yale University
Research Disciplines
Cardiovascular Biology, Molecular Pharmacology, Neuroscience
Personal Statement
Selected Publications
2021
Simonson, T. S., Baker, T. L., Banzett, R. B., Bishop, T., Dempsey, J. A., Feldman, J. L., . . . Malhotra, A. (2021). Silent hypoxaemia in COVID-19 patients.. The Journal of physiology, 599(4), 1057-1065. doi:10.1113/jp280769
Shi, Y., Stornetta, D. S., Reklow, R. J., Sahu, A., Wabara, Y., Nguyen, A., . . . Bayliss, D. A. (2021). A brainstem peptide system activated at birth protects postnatal breathing. NATURE, 589(7842), 426-+. doi:10.1038/s41586-020-2991-4
2020
Souza, G. M. P. R., Stornetta, R. L., Stornetta, D. S., Abbott, S. B. G., & Guyenet, P. G. (2020). Differential Contribution of the Retrotrapezoid Nucleus and C1 Neurons to Active Expiration and Arousal in Rats. JOURNAL OF NEUROSCIENCE, 40(45), 8683-8697. doi:10.1523/JNEUROSCI.1006-20.2020
Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., & Brooks, V. L. (2020). Neuronal Networks in Hypertension Recent Advances. HYPERTENSION, 76(2), 300-311. doi:10.1161/HYPERTENSIONAHA.120.14521
2019
Souza, G. M. P. R., Stornetta, R. L., Stornetta, D. S., Abbott, S. B. G., & Guyenet, P. G. (2019). Contribution of the Retrotrapezoid Nucleus and Carotid Bodies to Hypercapnia- and Hypoxia-induced Arousal from Sleep. JOURNAL OF NEUROSCIENCE, 39(49), 9725-9737. doi:10.1523/JNEUROSCI.1268-19.2019
Guyenet, P. G., Stornetta, R. L., Souza, G. M. P. R., Abbott, S. B. G., Shi, Y., & Bayliss, D. A. (2019). The Retrotrapezoid Nucleus: Central Chemoreceptor and Regulator of Breathing Automaticity. TRENDS IN NEUROSCIENCES, 42(11), 807-824. doi:10.1016/j.tins.2019.09.002
Guyenet, P. G. (2019). Sodium Is Detected by the OVLT to Regulate Sympathetic Tone. NEURON, 101(1), 3-5. doi:10.1016/j.neuron.2018.12.015
2018
Guyenet, P. G., Stornetta, R. L., Holloway, B. B., Souza, G. M. P. R., & Abbott, S. B. G. (2018). Rostral Ventrolateral Medulla and Hypertension. HYPERTENSION, 72(3), 559-566. doi:10.1161/HYPERTENSIONAHA.118.10921
Souza, G. M. P. R., Kanbar, R., Stornetta, D. S., Abbott, S. B. G., Stornetta, R. L., & Guyenet, P. G. (2018). Breathing regulation and blood gas homeostasis after near complete lesions of the retrotrapezoid nucleus in adult rats. JOURNAL OF PHYSIOLOGY-LONDON, 596(13), 2521-2545. doi:10.1113/JP275866
Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Kanbar, R., Shi, Y., Holloway, B. B., . . . Wenker, I. C. (2018). Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 596(15), 3029-3042. doi:10.1113/JP274357
Stornetta, R. L., & Guyenet, P. G. (2018). C1 neurons: a nodal point for stress?. EXPERIMENTAL PHYSIOLOGY, 103(3), 332-336. doi:10.1113/EP086435
2017
Valentino, R. J., Guyenet, P., Hou, X. H., & Herman, M. (2017). Central Network Dynamics Regulating Visceral and Humoral Functions. JOURNAL OF NEUROSCIENCE, 37(45), 10848-10854. doi:10.1523/JNEUROSCI.1833-17.2017
Shi, Y., Stornetta, R. L., Stornetta, D. S., Onengut-Gumuscu, S., Farber, E. A., Turner, S. D., . . . Bayliss, D. A. (2017). Neuromedin B Expression Defines the Mouse Retrotrapezoid Nucleus. JOURNAL OF NEUROSCIENCE, 37(48), 11744-11757. doi:10.1523/JNEUROSCI.2055-17.2017
Wenker, I. C., Abe, C., Viar, K. E., Stornetta, D. S., Stornetta, R. L., & Guyenet, P. G. (2017). Blood Pressure Regulation by the Rostral Ventrolateral Medulla in Conscious Rats: Effects of Hypoxia, Hypercapnia, Baroreceptor Denervation, and Anesthesia. JOURNAL OF NEUROSCIENCE, 37(17), 4565-4583. doi:10.1523/JNEUROSCI.3922-16.2017
Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. NATURE NEUROSCIENCE, 20(5), 700-+. doi:10.1038/nn.4526
Guyenet, P. G. (2017). Putative Mechanism of Salt-Dependent Neurogenic Hypertension: Cell-Autonomous Activation of Organum Vasculosum Laminae Terminalis Neurons by Hypernatremia. HYPERTENSION, 69(1), 20-22. doi:10.1161/HYPERTENSIONAHA.116.08470
2016
Kanbar, R., Stornetta, R. L., & Guyenet, P. G. (2016). Sciatic nerve stimulation activates the retrotrapezoid nucleus in anesthetized rats. JOURNAL OF NEUROPHYSIOLOGY, 116(5), 2081-2092. doi:10.1152/jn.00543.2016
Shi, Y., Abe, C., Holloway, B. B., Shu, S., Kumar, N. N., Weaver, J. L., . . . Bayliss, D. A. (2016). Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing. JOURNAL OF NEUROSCIENCE, 36(31), 8174-8187. doi:10.1523/JNEUROSCI.1096-16.2016
Inoue, T., Abe, C., Sung, S. -S. J., Moscalu, S., Jankowski, J., Huang, L., . . . Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR<SUP>+</SUP> splenocytes. JOURNAL OF CLINICAL INVESTIGATION, 126(5), 1939-1952. doi:10.1172/JCI83658
Basting, T. M., Abe, C., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2016). Is plasticity within the retrotrapezoid nucleus responsible for the recovery of the PCO2 set-point after carotid body denervation in rats?. JOURNAL OF PHYSIOLOGY-LONDON, 594(12), 3371-3390. doi:10.1113/JP272046
Guyenet, P. G., Bayliss, D. A., Stornetta, R. L., Ludwig, M. -G., Kumar, N. N., Shi, Y., . . . Wenker, I. C. (2016). Proton detection and breathing regulation by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 594(6), 1529-1551. doi:10.1113/JP271480
Stornetta, R. L., Inglis, M. A., Viar, K. E., & Guyenet, P. G. (2016). Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice. BRAIN STRUCTURE & FUNCTION, 221(8), 4027-4044. doi:10.1007/s00429-015-1143-3
2015
Guyenet, P. G., & Bayliss, D. A. (2015). Neural Control of Breathing and CO<sub>2</sub> Homeostasis. NEURON, 87(5), 946-961. doi:10.1016/j.neuron.2015.08.001
Burke, P. G. R., Kanbar, R., Basting, T. M., Hodges, W. M., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). State-dependent control of breathing by the retrotrapezoid nucleus. JOURNAL OF PHYSIOLOGY-LONDON, 593(13), 2909-2926. doi:10.1113/JP270053
Holloway, B. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). The retrotrapezoid nucleus stimulates breathing by releasing glutamate in adult conscious mice. EUROPEAN JOURNAL OF NEUROSCIENCE, 42(6), 2271-2282. doi:10.1111/ejn.12996
Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Bayliss, D. A. (2015). Regulation of breathing by CO<sub>2</sub> requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. SCIENCE, 348(6240), 1255-1260. doi:10.1126/science.aaa0922
Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. JOURNAL OF APPLIED PHYSIOLOGY, 118(12), 1491-1501. doi:10.1152/japplphysiol.00164.2015
Basting, T. M., Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, D. S., Stornetta, R. L., & Guyenet, P. G. (2015). Hypoxia Silences Retrotrapezoid Nucleus Respiratory Chemoreceptors via Alkalosis. JOURNAL OF NEUROSCIENCE, 35(2), 527-543. doi:10.1523/JNEUROSCI.2923-14.2015
Bayliss, D. A., Barhanin, J., Gestreau, C., & Guyenet, P. G. (2015). The role of pH-sensitive TASK channels in central respiratory chemoreception. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 467(5), 917-929. doi:10.1007/s00424-014-1633-9
2014
Bochorishvili, G., Nguyen, T., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). The Orexinergic Neurons Receive Synaptic Input From C1 Cells in Rats. JOURNAL OF COMPARATIVE NEUROLOGY, 522(17), 3834-3846. doi:10.1002/cne.23643
Bochorishvili, G., Thanh, N., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). The Orexinergic Neurons Receive Synaptic Input From C1 Cells in Rats. JOURNAL OF COMPARATIVE NEUROLOGY, 522(17), 3834-3846. doi:10.1002/cne.23643
Burke, P., Kanbar, R., Hodges, W., Viar, K., Coates, M., Stornetta, R., & Guyenet, P. (2014). State-dependent regulation of breathing by the retrotrapezoid nucleus. FASEB JOURNAL, 28(1). Retrieved from https://www.webofscience.com/
Guyenet, P. G. (2014). Regulation of Breathing and Autonomic Outflows by Chemoreceptors. COMPREHENSIVE PHYSIOLOGY, 4(4), 1511-1562. doi:10.1002/cphy.c140004
Abbott, S. B. G., Holloway, B. B., Viar, K. E., & Guyenet, P. G. (2014). Vesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice <i>in vivo</i>. EUROPEAN JOURNAL OF NEUROSCIENCE, 39(1), 98-106. doi:10.1111/ejn.12421
Burke, P. G. R., Abbott, S. B. G., Coates, M. B., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2014). Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State-Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190(11), 1301-1310. doi:10.1164/rccm.201407-1262OC
2013
Stornetta, R. L., Macon, C. J., Nguyen, T. M., Coates, M. B., & Guyenet, P. G. (2013). Cholinergic neurons in the mouse rostral ventrolateral medulla target sensory afferent areas. BRAIN STRUCTURE & FUNCTION, 218(2), 455-475. doi:10.1007/s00429-012-0408-3
Guyenet, P. G., Abbott, S. B. G., & Stornetta, R. L. (2013). The respiratory chemoreception conundrum: Light at the end of the tunnel?. BRAIN RESEARCH, 1511, 126-137. doi:10.1016/j.brainres.2012.10.028
Depuy, S. D., Stornetta, R. L., Bochorishvili, G., Deisseroth, K., Witten, I., Coates, M., & Guyenet, P. G. (2013). Glutamatergic Neurotransmission between the C1 Neurons and the Parasympathetic Preganglionic Neurons of the Dorsal Motor Nucleus of the Vagus. JOURNAL OF NEUROSCIENCE, 33(4), 1486-1497. doi:10.1523/JNEUROSCI.4269-12.2013
Abbott, S. B. G., Depuy, S. D., Thanh, N., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2013). Selective Optogenetic Activation of Rostral Ventrolateral Medullary Catecholaminergic Neurons Produces Cardiorespiratory Stimulation in Conscious Mice. JOURNAL OF NEUROSCIENCE, 33(7), 3164-3177. doi:10.1523/JNEUROSCI.1046-12.2013
Abbott, S. B. G., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2013). Optogenetic Stimulation of C1 and Retrotrapezoid Nucleus Neurons Causes Sleep State-Dependent Cardiorespiratory Stimulation and Arousal in Rats. HYPERTENSION, 61(4), 835-+. doi:10.1161/HYPERTENSIONAHA.111.00860
Guyenet, P. G., & Abbott, S. B. G. (2013). Chemoreception and asphyxia-induced arousal. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 188(3), 333-343. doi:10.1016/j.resp.2013.04.011
Guyenet, P. G., Stornetta, R. L., Bochorishvili, G., DePuy, S. D., Burke, P. G. R., & Abbott, S. B. G. (2013). C1 neurons: the body's EMTs. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 305(3), R187-R204. doi:10.1152/ajpregu.00054.2013
Holloway, B. B., Stornetta, R. L., Bochorishvili, G., Erisir, A., Viar, K. E., & Guyenet, P. G. (2013). Monosynaptic Glutamatergic Activation of Locus Coeruleus and Other Lower Brainstem Noradrenergic Neurons by the C1 Cells in Mice. JOURNAL OF NEUROSCIENCE, 33(48), 18792-18805. doi:10.1523/JNEUROSCI.2916-13.2013
Wang, S., Shi, Y., Shu, S., Guyenet, P. G., & Bayliss, D. A. (2013). Phox2b-Expressing Retrotrapezoid Neurons Are Intrinsically Responsive to H<SUP>+</SUP> and CO<sub>2</sub>. JOURNAL OF NEUROSCIENCE, 33(18), 7756-7761. doi:10.1523/JNEUROSCI.5550-12.2013
Wang, S., Benamer, N., Zanella, S., Kumar, N. N., Shi, Y., Bevengut, M., . . . Bayliss, D. A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons. JOURNAL OF NEUROSCIENCE, 33(41), 16033-16044. doi:10.1523/JNEUROSCI.2451-13.2013
2012
Bochorishvili, G., Stornetta, R. L., Coates, M. B., & Guyenet, P. G. (2012). Pre-Botzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons. JOURNAL OF COMPARATIVE NEUROLOGY, 520(5), 1047-1061. doi:10.1002/cne.22769
Abbott, S. B., Kanbar, R., Bochorishvili, G., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2012). C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. JOURNAL OF PHYSIOLOGY-LONDON, 590(12), 2897-2915. doi:10.1113/jphysiol.2012.232157
Guyenet, P. G., Stornetta, R. L., Abbott, S. B. G., Depuy, S. D., & Kanbar, R. (2012). The Retrotrapezoid Nucleus and Breathing. ARTERIAL CHEMORECEPTION: FROM MOLECULES TO SYSTEMS, 758, 115-122. doi:10.1007/978-94-007-4584-1_16
Derecki, N. C., Cronk, J. C., Lu, Z., Xu, E., Abbott, S. B. G., Guyenet, P. G., & Kipnis, J. (2012). Wild-type microglia arrest pathology in a mouse model of Rett syndrome. NATURE, 484(7392), 105-+. doi:10.1038/nature10907
2011
Kanbar, R., Depuy, S. D., West, G. H., Stornetta, R. L., & Guyenet, P. G. (2011). Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents. JOURNAL OF PHYSIOLOGY-LONDON, 589(4), 903-917. doi:10.1113/jphysiol.2010.198374
DePuy, S. D., Kanbar, R., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2011). Control of Breathing by Raphe Obscurus Serotonergic Neurons in Mice. JOURNAL OF NEUROSCIENCE, 31(6), 1981-1990. doi:10.1523/JNEUROSCI.4639-10.2011
Abbott, S. B. G., Stornetta, R. L., Coates, M. B., & Guyenet, P. G. (2011). Phox2b-Expressing Neurons of the Parafacial Region Regulate Breathing Rate, Inspiration, and Expiration in Conscious Rats. JOURNAL OF NEUROSCIENCE, 31(45), 16410-16422. doi:10.1523/JNEUROSCI.3280-11.2011
Guyenet, P. G. (2011). Loss of brainstem serotonergic neurons impairs autoresuscitation in neonate rats: is this relevant to the sudden infant death syndrome?. JOURNAL OF PHYSIOLOGY-LONDON, 589(22), 5343-5344. doi:10.1113/jphysiol.2011.221143
Lazarenko, R. M., Stornetta, R. L., Bayliss, D. A., & Guyenet, P. G. (2011). Orexin A activates retrotrapezoid neurons in mice. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 175(2), 283-287. doi:10.1016/j.resp.2010.12.003
2010
Abbott, S. B. G., Stornetta, R. L., West, G. H., & Guyenet, P. G. (2010). PHOTOSTIMULATION OF CHANNELRHODOPSIN2-TRANSFECTED C1 NEURONS ACTIVATES PERIPHERAL SYMPATHETIC VASOMOTOR AFFERENTS AND NEURONS IN THE LOCUS COERULEUS AND A5 REGION IN SPRAGUE DAWLEY RATS. HYPERTENSION, 55(6), 1493. Retrieved from https://www.webofscience.com/
Guyenet, P. G., Stornetta, R. L., Abbott, S. B. G., Depuy, S. D., Fortuna, M. G., & Kanbar, R. (2010). Central CO<sub>2</sub> chemoreception and integrated neural mechanisms of cardiovascular and respiratory control. JOURNAL OF APPLIED PHYSIOLOGY, 108(4), 995-1002. doi:10.1152/japplphysiol.00712.2009
Guyenet, P. G., & Mulkey, D. K. (2010). Retrotrapezoid nucleus and parafacial respiratory group. RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 173(3), 244-255. doi:10.1016/j.resp.2010.02.005
Kanbar, R., Stornetta, R. L., Cash, D. R., Lewis, S. J., & Guyenet, P. G. (2010). Photostimulation of Phox2b Medullary Neurons Activates Cardiorespiratory Function in Conscious Rats. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 182(9), 1184-1194. doi:10.1164/rccm.201001-0047OC
Lazarenko, R. M., Fortuna, M. G., Shi, Y., Mulkey, D. K., Takakura, A. C., Moreira, T. S., . . . Bayliss, D. A. (2010). Anesthetic Activation of Central Respiratory Chemoreceptor Neurons Involves Inhibition of a THIK-1-Like Background K<SUP>+</SUP> Current. JOURNAL OF NEUROSCIENCE, 30(27), 9324-9334. doi:10.1523/JNEUROSCI.1956-10.2010
Guyenet, P. G., Stornetta, R. L., & Bayliss, D. A. (2010). Central Respiratory Chemoreception. JOURNAL OF COMPARATIVE NEUROLOGY, 518(19), 3883-3906. doi:10.1002/cne.22435