Patrice G. Guyenet

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Primary Appointment

Professor Emeritus, Pharmacology

Education

  • BS, Physiology & Biochemistry, Ecole Normale Superieure
  • PhD, Neurochemistry, University of Paris
  • Postdoc, Neuropharmacology, Yale University

Research Disciplines

Cardiovascular Biology, Molecular Pharmacology, Neuroscience

Personal Statement

My research is a branch of Integrative Neuroscience, a discipline that seeks to understand how the brain processes specific types of information. The laboratory studies how the mammalian brain regulates respiration and blood pressure, two physiological processes that are dysfunctional in very common diseases (hypertension, obesity, apneic syndromes, heart failure, etc.). The work consists of identifying relevant neuronal networks in rodents using electrophysiologic and neuroanatomic methods. The main focus is on a region of the brainstem that provides the chemical drive to breathe and contains the neurons that maintain blood pressure.

Selected Publications

Bochorishvili G, Nguyen T, Coates MB, Viar KE, Stornetta RL, Guyenet PG, The orexinergic neurons receive synaptic input from C1 cells in rats., 2014; The Journal of comparative neurology. 522(17) 3834-46. PMID: 24984694 | PMCID: PMC4167913

Abbott SB, DePuy SD, Nguyen T, Coates MB, Stornetta RL, Guyenet PG, Selective optogenetic activation of rostral ventrolateral medullary catecholaminergic neurons produces cardiorespiratory stimulation in conscious mice., 2013; The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(7) 3164-77. PMID: 23407970 | PMCID: PMC3596815

Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J, Wild-type microglia arrest pathology in a mouse model of Rett syndrome., 2012; Nature. 484(7392) 105-9. PMID: 22425995 | PMCID: PMC3321067

Guyenet PG, Loss of brainstem serotonergic neurons impairs autoresuscitation in neonate rats: is this relevant to the sudden infant death syndrome?, 2011; The Journal of physiology. 589(0) 5343-4. PMID: 22086249 | PMCID: PMC3240874

Guyenet PG, Stornetta RL, Bayliss DA, Central respiratory chemoreception., 2010; The Journal of comparative neurology. 518(19) 3883-906. PMID: 20737591 | PMCID: PMC2929977

Guyenet PG, Bayliss DA, Stornetta RL, Fortuna MG, Abbott SB, DePuy SD, Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity., 2009; Respiratory physiology & neurobiology. 168(1) 59-68. PMID: 19712903 | PMCID: PMC2734912

Takakura AC, Moreira TS, Stornetta RL, West GH, Gwilt JM, Guyenet PG, Selective lesion of retrotrapezoid Phox2b-expressing neurons raises the apnoeic threshold in rats., 2008; The Journal of physiology. 586(0) 2975-91. PMID: 18440993 | PMCID: PMC2517201

Mulkey DK, Talley EM, Stornetta RL, Siegel AR, West GH, Chen X, Sen N, Mistry AM, Guyenet PG, Bayliss DA, TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity., 2007; The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(51) 14049-58. PMID: 18094244

Mulkey DK, Rosin DL, West G, Takakura AC, Moreira TS, Bayliss DA, Guyenet PG, Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism., 2007; The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(51) 14128-38. PMID: 18094252

Mulkey DK, Mistry AM, Guyenet PG, Bayliss DA, Purinergic P2 receptors modulate excitability but do not mediate pH sensitivity of RTN respiratory chemoreceptors., 2006; The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(27) 7230-3. PMID: 16822980

Stornetta RL, Moreira TS, Takakura AC, Kang BJ, Chang DA, West GH, Brunet JF, Mulkey DK, Bayliss DA, Guyenet PG, Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat., 2006; The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(40) 10305-14. PMID: 17021186

Guyenet PG, The sympathetic control of blood pressure., 2006; Nature reviews. Neuroscience. 7(5) 335-46. PMID: 16760914

Guyenet PG, Mulkey DK, Stornetta RL, Bayliss DA, Regulation of ventral surface chemoreceptors by the central respiratory pattern generator., 2005; The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(39) 8938-47. PMID: 16192384

Mulkey DK, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA, Guyenet PG, Respiratory control by ventral surface chemoreceptor neurons in rats., 2004; Nature neuroscience. 7(12) 1360-9. PMID: 15558061