Lawrence W. Gimple

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Primary Appointment

Professor, Medicine- Cardiovascular Medicine

Research Interests

Thrombosis, myocardial infarction, restenosis

Research Description

Interventional cardiology. Mechanisms of restenosis following vascular interventions. New educational teaching tools using multimedia and digital techniques.

Personal Statement

Dr. Gimple is involved in clinical research trials related to acute myocardial infarction, lipid management in patients with acute coronary syndromes, trials of antithrombotic therapy for patients undergoing coronary stenting for acute coronary syndromes, and research in stroke prevention in patients with a patent foramen ovale. Patients with acute coronary syndromes are often treated in the cardiac catheterization laboratory and these trials address opportunities to optimize the use of stents and anti-thrombotic agents. Young patients with strokes often have a patient foramen ovale, and this research addresses whether these patients are optimally treated by closing the intra-cardiac communication or by treating with medications alone.

Selected Publications

Keeley EC, Moorman JR, Liu L, Gimple LW, Lipson LC, Ragosta M, Taylor AM, Lake DE, Burdick MD, Mehrad B, Strieter RM, Plasma chemokine levels are associated with the presence and extent of angiographic coronary collaterals in chronic ischemic heart disease., 2011; PloS one. 6(6) e21174. PMID: 21731663 | PMCID: PMC3120847

Enkiri SA, Taylor AM, Keeley EC, Lipson LC, Gimple LW, Ragosta M, Coronary angiography is a better predictor of mortality than noninvasive testing in patients evaluated for renal transplantation., 2010; Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 76(6) 795-801. PMID: 20518007 | PMCID: PMC2991378

Jones DG, Taylor AM, Enkiri SA, Lobo P, Brayman KL, Keeley EC, Lipson LC, Gimple LW, Ragosta M, Extent and severity of coronary disease and mortality in patients with end-stage renal failure evaluated for renal transplantation., 2009; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 9(8) 1846-52. PMID: 19538490 | PMCID: PMC2850065

Ragosta M, Bishop AH, Lipson LC, Watson DD, Gimple LW, Sarembock IJ, Powers ER, Comparison between angiography and fractional flow reserve versus single-photon emission computed tomographic myocardial perfusion imaging for determining lesion significance in patients with multivessel coronary disease., 2007; The American journal of cardiology. 99(7) 896-902. PMID: 17398179

Chhatriwalla AK, Ragosta M, Powers ER, Sarembock IJ, Gimple LW, Fischer JJ, Barringhaus KG, Kramer CM, Samady H, High left ventricular mass index does not limit the utility of fractional flow reserve for the physiologic assessment of lesion severity., 2006; The Journal of invasive cardiology. 18(11) 544-9. PMID: 17090819

Fischer JJ, Wang XQ, Samady H, Sarembock IJ, Powers ER, Gimple LW, Ragosta M, Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment., 2006; Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 68(4) 544-8. PMID: 16969847

Ragosta M, Dee S, Sarembock IJ, Lipson LC, Gimple LW, Powers ER, Prevalence of unfavorable angiographic characteristics for percutaneous intervention in patients with unprotected left main coronary artery disease., 2006; Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 68(3) 357-62. PMID: 16892431