Robin A. Felder

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Primary Appointment

Professor, Pathology

Education

  • PhD, Georgetown University

Research Disciplines

Biochemistry, Bioinformatics and Genomics, Cardiovascular Biology, Computational Biology, Epigenetics, Experimental Pathology, Genetics, Molecular Biology, Molecular Pharmacology, Structural Biology, Translational Science

Research Interests

Clinical Chemistry and Toxicology. Medical Automation Research. Neurotransmitters, cell surface receptors and intracellular second messengers.

Research Description

They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly) endpoints will affect over 50% of the adult population. We have discovered a key regulatory pathway that controls sodium handling by epithelial cells, induces high blood pressure in mice, and is recapitulated in human test subjects. We have three laboratories (including support core facilities) focused on studying various aspects of the molecular basis of sodium excretion and blood pressure control. We employ genetic screening, cell based assays, clinical trial protocols, and behavioral surveys in order to fully understand the etiology of disease. Our automated drug discovery laboratory will also train students in modern techniques of setting up and running laboratory automation. In addition, we have a translational component of our research that has resulted in 8 "spin-out" companies, which have provided private sector opportunities for students post graduation.

Personal Statement

They have no symptoms, but subjects with untreated hypertension and salt sensitivity will have major health challenges such as blindness, stroke, kidney failure, and heart attacks. These devastating (and costly) endpoints will affect over 50% of the adult population. We have discovered key regulatory pathways that controls sodium handling by epithelial cells, induces high blood pressure in mice, and is recapitulated in human test subjects. We have three laboratories (including support core facilities) focused on studying various aspects of the molecular basis of sodium excretion and blood pressure control. We employ genetic screening, cell based assays, clinical trial protocols, and behavioral surveys in order to fully understand the etiology of disease. Our automated drug discovery laboratory will also train students in modern techniques of setting up and running laboratory automation. In addition, we have a translational component of our research that has resulted in 8 "spin-out" companies, which have provided private sector opportunities for students post graduation.

Selected Publications

2023

Amatya, B., Yang, S., Yu, P., de Castro, P. A. S. V., Armando, I., Zeng, C., . . . Lee, H. (2023). Peroxiredoxin-4 and Dopamine D5 Receptor Interact to Reduce Oxidative Stress and Inflammation in the Kidney. ANTIOXIDANTS & REDOX SIGNALING, 38(16), 1150-1166. doi:10.1089/ars.2022.0034

Twum, S., Fosu, K., Felder, R. A., & Sarpong, K. A. N. (2023). Bridging the gaps in newborn screening programmes: Challenges and opportunities to detect in Africa. AFRICAN JOURNAL OF LABORATORY MEDICINE, 12(1). doi:10.4102/ajlm.v12i1.2225

Xiao, L., Matharoo, J., Chi, J., Ma, J., Chen, M., Manley, B., . . . Li, X. (2023). Transient depletion of macrophages alters local inflammatory response at the site of disc herniation in a transgenic mouse model. OSTEOARTHRITIS AND CARTILAGE, 31(7), 894-907. doi:10.1016/j.joca.2023.01.574

2022

Gildea, J. J., Xu, P., Schiermeyer, K. A., Yue, W., Carey, R. M., Jose, P. A., & Felder, R. A. (2022). Inverse Salt Sensitivity of Blood Pressure Is Associated with an Increased Renin-Angiotensin System Activity. BIOMEDICINES, 10(11). doi:10.3390/biomedicines10112811

Felder, R. A., Gildea, J. J., Xu, P., Yue, W., Armando, I., Carey, R. M., & Jose, P. A. (2022). Inverse Salt Sensitivity of Blood Pressure: Mechanisms and Potential Relevance for Prevention of Cardiovascular Disease. CURRENT HYPERTENSION REPORTS, 24(9), 361-374. doi:10.1007/s11906-022-01201-9

Xu, P., Sudarikova, A. V., Ilatovskaya, D. V., Gildea, J. J., Akhter, M., Carey, R. M., . . . Felder, R. A. (2022). Epithelial Sodium Channel Alpha Subunit (αENaC) Is Associated with Inverse Salt Sensitivity of Blood Pressure. BIOMEDICINES, 10(5). doi:10.3390/biomedicines10050981

Xiao, L., Huang, R., Sulimai, N., Yao, R., Manley, B., Xu, P., . . . Li, X. (2022). Amine Functionalized Trimetallic Nitride Endohedral Fullerenes: A Class of Nanoparticle to Tackle Low Back/Leg Pain. ACS APPLIED BIO MATERIALS, 5(6), 2943-2955. doi:10.1021/acsabm.2c00269

2021

Kaczmarczyk, J. A., Roberts, R. R., Luke, B. T., Chan, K. C., Van Wagoner, C. M., Felder, R. A., . . . Blonder, J. (2021). Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells.. Oncotarget, 12(20), 2022-2038. doi:10.18632/oncotarget.28072

Amatya, B., Lee, H., Asico, L. D., Konkalmatt, P., Armando, I., Felder, R. A., & Jose, P. A. (2021). SNX-PXA-RGS-PXC Subfamily of SNXs in the Regulation of Receptor-Mediated Signaling and Membrane Trafficking. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(5). doi:10.3390/ijms22052319

Yue, W., Tran, H. T., Wang, J. -P., Schiermeyer, K., Gildea, J. J., Xu, P., & Felder, R. A. (2021). The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.. Breast cancer : basic and clinical research, 15, 11782234211015753. doi:10.1177/11782234211015753

Lee, H., Jiang, X., Perwaiz, I., Yu, P., Wang, J., Wang, Y., . . . Jose, P. A. (2021). Dopamine D5 receptor-mediated decreases in mitochondrial reactive oxygen species production are cAMP and autophagy dependent. HYPERTENSION RESEARCH, 44(6), 628-641. doi:10.1038/s41440-021-00646-w

2020

Tiu, A. C., Yang, J., Asico, L. D., Konkalmatt, P., Zheng, X., Cuevas, S., . . . Villar, V. A. M. (2020). Lipid rafts are required for effective renal D1 dopamine receptor function. FASEB JOURNAL, 34(5), 6999-7017. doi:10.1096/fj.201902710RR

Chin, A. C., Gao, Z., Riley, A. M., Furkert, D., Wittwer, C., Dutta, A., . . . Fu, C. (2020). The inositol pyrophosphate 5-InsP7 drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α. SCIENCE ADVANCES, 6(44). doi:10.1126/sciadv.abb8542

Yang, J., Asico, L. D., Beitelshees, A. L., Feranil, J. B., Wang, X., Jones, J. E., . . . Villar, V. A. M. (2020). Sorting nexin 1 loss results in increased oxidative stress and hypertension. FASEB JOURNAL, 34(6), 7941-7957. doi:10.1096/fj.201902448R

Xu, P., Gildea, J. J., Zhang, C., Konkalmatt, P., Santiago, S., Wang, D. B., . . . Felder, R. A. (2020). Stomach gastrin is regulated by sodium via PPAR-α and dopamine D1 receptor. JOURNAL OF MOLECULAR ENDOCRINOLOGY, 64(2), 53-65. doi:10.1530/JME-19-0053

2019

Han, F., Konkalmatt, P., Mokashi, C., Kumar, M., Zhang, Y., Ko, A., . . . Armando, I. (2019). Dopamine D2 receptor modulates Wnt expression and control of cell proliferation. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-52528-4

Gildea, J. J., Xu, P., Kemp, B. A., Carey, R. M., Jose, P. A., & Felder, R. A. (2019). The Dopamine D1 Receptor and Angiotensin II Type-2 Receptor are Required for Inhibition of Sodium Transport Through a Protein Phosphatase 2A Pathway. HYPERTENSION, 73(6), 1258-1265. doi:10.1161/HYPERTENSIONAHA.119.12705

2018

Gildea, J. J., Xu, P., Kemp, B. A., Carlson, J. M., Tran, H. T., Wang, D. B., . . . Felder, R. A. (2018). Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells. PLOS ONE, 13(4). doi:10.1371/journal.pone.0189464

Li, F., Yang, J., Villar, V. A. M., Asico, L. D., Ma, X., Armando, I., . . . Wang, X. (2018). Loss of renal SNX5 results in impaired IDE activity and insulin resistance in mice. DIABETOLOGIA, 61(3), 727-737. doi:10.1007/s00125-017-4482-1

Genzen, J. R., Burnham, C. -A. D., Felder, R. A., Hawker, C. D., Lippi, G., & Palmer, O. M. P. (2018). Challenges and Opportunities in Implementing Total Laboratory Automation. CLINICAL CHEMISTRY, 64(2), 259-264. doi:10.1373/clinchem.2017.274068

2017

Yatabe, M. S., Iwahori, T., Watanabe, A., Takano, K., Sanada, H., Watanabe, T., . . . Yatabe, J. (2017). Urinary Sodium-to-Potassium Ratio Tracks the Changes in Salt Intake during an Experimental Feeding Study Using Standardized Low-Salt and High-Salt Meals among Healthy Japanese Volunteers. NUTRIENTS, 9(9). doi:10.3390/nu9090951

Gildea, J. J., Van Sciver, R. E., McGrath, H. E., Kemp, B. A., Jose, P. A., Carey, R. M., & Felder, R. A. (2017). Dopaminergic Immunofluorescence Studies in Kidney Tissue. HYPERTENSION: METHODS AND PROTOCOLS, 1527, 151-161. doi:10.1007/978-1-4939-6625-7_12

Jiang, X., Zhang, Y., Yang, Y., Yang, J., Asico, L. D., Chen, W., . . . Yang, Z. (2017). Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of L-DOPA. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 312(1), E1-E10. doi:10.1152/ajpendo.00116.2016

2016

Felder, R. A., Jose, P. A., Xu, P., & Gildea, J. J. (2016). The Renal Sodium Bicarbonate Cotransporter NBCe2: Is It a Major Contributor to Sodium and pH Homeostasis?. CURRENT HYPERTENSION REPORTS, 18(9). doi:10.1007/s11906-016-0679-9

Villar, V. A. M., Zheng, C., Konkalmatt, P., Wang, X., Asico, L. D., Felder, R. A., . . . Jose, P. A. (2016). Differential HDAC class 1 isoenzyme regulation of blood pressure. Journal of the American Society of Hypertension, 10(4), e54. doi:10.1016/j.jash.2016.03.132

Jose, P. A., Felder, R. A., Yang, Z., Zeng, C., & Eisner, G. M. (2016). Gastrorenal Axis. HYPERTENSION, 67(6), 1056-1063. doi:10.1161/HYPERTENSIONAHA.115.06424

Jose, P. A., Yang, Z., Zeng, C., & Felder, R. A. (2016). The importance of the gastrorenal axis in the control of body sodium homeostasis. EXPERIMENTAL PHYSIOLOGY, 101(4), 465-470. doi:10.1113/EP085286

Jiang, X., Chen, W., Liu, X., Wang, Z., Liu, Y., Felder, R. A., . . . Yang, Z. (2016). The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146641

Wang, Z., Zeng, C., Villar, V. A. M., Chen, S. -Y., Konkalmatt, P., Wang, X., . . . Jose, P. A. (2016). Human GRK4γ142V Variant Promotes Angiotensin II Type I Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition. HYPERTENSION, 67(2), 325-334. doi:10.1161/HYPERTENSIONAHA.115.05962

2015

Villar, V. A. M., Yang, J., Asico, L. D., Feranil, J. B., Wang, X., Jones, J. E., . . . Jose, P. A. (2015). Increased oxidative stress and hypertension in Snx1 knockout mice. Journal of the American Society of Hypertension, 9(4), e83. doi:10.1016/j.jash.2015.03.198

Sanada, H., Yoneda, M., Yatabe, J., Williams, S. M., Bartlett, J., White, M. J., . . . Jose, P. A. (2016). Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade. PHARMACOGENOMICS JOURNAL, 16(1), 3-9. doi:10.1038/tpj.2015.6

Gildea, J. J., Xu, P., Carlson, J. M., Gaglione, R. T., Wang, D. B., Kemp, B. A., . . . Felder, R. A. (2015). The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309(11), R1447-R1459. doi:10.1152/ajpregu.00150.2015

Li, F., Yang, J., Jones, J. E., Villar, V. A. M., Yu, P., Armando, I., . . . Jose, P. A. (2015). Sorting Nexin 5 and Dopamine D1 Receptor Regulate the Expression of the Insulin Receptor in Human Renal Proximal Tubule Cells. ENDOCRINOLOGY, 156(6), 2211-2221. doi:10.1210/en.2014-1638

Han, F., Konkalmatt, P., Chen, J., Gildea, J., Felder, R. A., Jose, P. A., & Armando, I. (2015). miR-217 Mediates the Protective Effects of the Dopamine D2 Receptor on Fibrosis in Human Renal Proximal Tubule Cells. HYPERTENSION, 65(5), 1118-U856. doi:10.1161/HYPERTENSIONAHA.114.05096

2014

Armando, I., Konkalmatt, P., Felder, R. A., & Jose, P. A. (2015). The renal dopaminergic system: novel diagnostic Cross Mark and therapeutic approaches in hypertension and kidney disease. TRANSLATIONAL RESEARCH, 165(4), 505-511. doi:10.1016/j.trsl.2014.07.006

Yu, P., Sun, M., Villar, V. A. M., Zhang, Y., Weinman, E. J., Felder, R. A., & Jose, P. A. (2014). Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. CELLULAR SIGNALLING, 26(11), 2521-2529. doi:10.1016/j.cellsig.2014.07.003

Gildea, J. J., Seaton, J. E., Victor, K. G., Reyes, C. M., Wang, D. B., Pettigrew, A. C., . . . Felder, R. A. (2014). Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells. CLINICAL BIOCHEMISTRY, 47(15), 89-94. doi:10.1016/j.clinbiochem.2014.06.018

Han, F., Konkalmatt, P., Gildea, J., Jones, J. E., Felder, R. A., Jose, P. A., & Armando, I. (2014). Single nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. Journal of the American Society of Hypertension, 8(4), e3. doi:10.1016/j.jash.2014.03.010

Sanada, H., Yokokawa, H., Yatabe, J., Williams, S. M., Felder, R. A., Jose, P. A., & Takenosita, S. (2014). Association between lifestyle-related disorders and visceral fat mass in Japanese males: a hospital based cross-sectional study. ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 19(6), 429-435. doi:10.1007/s12199-014-0411-9

Jiang, X., Konkalmatt, P., Yang, Y., Gildea, J., Jones, J. E., Cuevas, S., . . . Armando, I. (2014). Single-Nucleotide Polymorphisms of the Dopamine D2 Receptor Increase Inflammation and Fibrosis in Human Renal Proximal Tubule Cells. HYPERTENSION, 63(3), E74-E80. doi:10.1161/HYPERTENSIONAHA.113.02569

Felder, R. A. (2014). Automated Specimen Inspection, Quality Analysis, and Its Impact on Patient Safety: Beyond the Bar Code. CLINICAL CHEMISTRY, 60(3), 433-434. doi:10.1373/clinchem.2013.219352

Lee, H., Abe, Y., Lee, I., Shrivastav, S., Crusan, A. P., Huettemann, M., . . . Kopp, J. B. (2014). Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats. KIDNEY INTERNATIONAL, 85(3), 561-569. doi:10.1038/ki.2013.397

Felder, R. A., Jackson, K. D., & Walter, A. M. (2014). Process Evaluation of an Open Architecture Real-Time Molecular Laboratory Platform. JALA, 19(5), 468-473. doi:10.1177/2211068214533195

Yu, P., Han, W., Villar, V. A. M., Yang, Y., Lu, Q., Lee, H., . . . Jose, P. A. (2014). Unique role of NADPH oxidase 5 in oxidative stress in human renal proximal tubule cells. REDOX BIOLOGY, 2, 570-579. doi:10.1016/j.redox.2014.01.020

Kitada, K., Nakano, D., Ohsaki, H., Hitomi, H., Minamino, T., Yatabe, J., . . . Nishiyama, A. (2014). Hyperglycemia causes cellular senescence via a SGLT2-and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 28(5), 604-611. doi:10.1016/j.jdiacomp.2014.05.010

Yokokawa, H., Goto, A., Sanada, H., Watanabe, T., Felder, R. A., Jose, P. A., & Yasumura, S. (2014). Association between control to target blood pressures and healthy lifestyle factors among Japanese hypertensive patients: Longitudinal data analysis from Fukushima Research of Hypertension (FRESH). OBESITY RESEARCH & CLINICAL PRACTICE, 8(4), E364-E373. doi:10.1016/j.orcp.2013.08.004

Gildea, J. J., Shah, I. T., Van Sciver, R. E., Israel, J. A., Enzensperger, C., McGrath, H. E., . . . Felder, R. A. (2014). The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. KIDNEY INTERNATIONAL, 86(1), 118-126. doi:10.1038/ki.2014.5

Armando, I., Villar, V. A. M., Jones, J. E., Lee, H., Wang, X., Asico, L. D., . . . Jose, P. A. (2014). Dopamine D3 receptor inhibits the ubiquitin-specific peptidase 48 to promote NHE3 degradation. FASEB JOURNAL, 28(3), 1422-1434. doi:10.1096/fj.13-243840

2013

Gildea, J. J., Lahiff, D. T., Van Sciver, R. E., Weiss, R. S., Shah, N., McGrath, H. E., . . . Felder, R. A. (2013). A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: The virtual renal biopsy. CLINICA CHIMICA ACTA, 421, 236-242. doi:10.1016/j.cca.2013.02.021

Gildea, J. J., Wang, X., Shah, N., Tran, H., Spinosa, M., Van Sciver, R., . . . Felder, R. A. (2013). Dopamine and Angiotensin Type 2 Receptors Cooperatively Inhibit Sodium Transport in Human Renal Proximal Tubule Cells (vol 60, pg 396, 2012). HYPERTENSION, 61(1), E7. doi:10.1161/HYP.0b013e31827a7c3b

Villar, V. A. M., Jones, J. E., Armando, I., Asico, L. D., Escano, C. S. J., Lee, H., . . . Jose, P. A. (2013). Sorting Nexin 1 Loss Results in D5 Dopamine Receptor Dysfunction in Human Renal Proximal Tubule Cells and Hypertension in Mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(1), 152-163. doi:10.1074/jbc.M112.428458

Gildea, J. J., McGrath, H. E., Van Sciver, R. E., Wang, D. B., & Felder, R. A. (2013). Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods.. Methods in molecular biology (Clifton, N.J.), 945, 329-345. doi:10.1007/978-1-62703-125-7_20

Felder, R. A., White, M. J., Williams, S. M., & Jose, P. A. (2013). Diagnostic tools for hypertension and salt sensitivity testing. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 22(1), 65-76. doi:10.1097/MNH.0b013e32835b3693

Gildea, J. J., Tran, H. T., Van Sciver, R. E., Wang, D. B., Carlson, J. M., & Felder, R. A. (2013). A Novel Role for c-Myc in G Protein-Coupled Receptor Kinase 4 (GRK4) Transcriptional Regulation in Human Kidney Proximal Tubule Cells. HYPERTENSION, 61(5), 1021-+. doi:10.1161/HYPERTENSIONAHA.111.00321

Gildea, J. J., Carlson, J. M., Schoeffel, C. D., Carey, R. M., & Felder, R. A. (2013). Urinary exosome miRNome analysis and its applications to salt sensitivity of blood pressure. CLINICAL BIOCHEMISTRY, 46(12), 1131-1134. doi:10.1016/j.clinbiochem.2013.05.052

2012

Carey, R. M., Schoeffel, C. D., Gildea, J. J., Jones, J. E., McGrath, H. E., Gordon, L. N., . . . Felder, R. A. (2012). Salt Sensitivity of Blood Pressure Is Associated With Polymorphisms in the Sodium-Bicarbonate Cotransporter. HYPERTENSION, 60(5), 1359-+. doi:10.1161/HYPERTENSIONAHA.112.196071

Yokokawa, H., Goto, A., Sanada, H., Watanabe, T., Felder, R. A., Jose, P. A., & Yasumura, S. (2012). 192 ACHIEVEMENT STATUS TOWARD GOAL BLOOD PRESSURE LEVELS AND HEALTHY LIFESTYLES AMONG JAPANESE HYPERTENSIVE PATIENTS; LONGITUDINAL DATA ANALYSIS FROM FUKUSHIMA RESEARCH OF HYPERTENSION (FRESH). Journal of Hypertension, 30(Supplement 1), e57. doi:10.1097/01.hjh.0000420016.07716.f2

Yang, Y., Zhang, Y., Cuevas, S., Villar, V. A., Escano, C., Asico, L. D., . . . Jose, P. A. (2012). Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase. FREE RADICAL BIOLOGY AND MEDICINE, 53(3), 437-446. doi:10.1016/j.freeradbiomed.2012.05.015

Yatabe, J., Yatabe, M. S., Yoneda, M., Felder, R. A., Jose, P. A., & Sanada, H. (2012). Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults. INTERNATIONAL JOURNAL OF HYPERTENSION, 2012. doi:10.1155/2012/806810

Sanada, H., Yokokawa, H., Yoneda, M., Yatabe, J., Yatabe, M. S., Williams, S. M., . . . Jose, P. A. (2012). High Body Mass Index is an Important Risk Factor for the Development of Type 2 Diabetes. INTERNAL MEDICINE, 51(14), 1821-1826. doi:10.2169/internalmedicine.51.7410

Gildea, J. J., Wang, X., Shah, N., Tran, H., Spinosa, M., Van Sciver, R., . . . Felder, R. A. (2012). Dopamine and Angiotensin Type 2 Receptors Cooperatively Inhibit Sodium Transport in Human Renal Proximal Tubule Cells. HYPERTENSION, 60(2), 396-+. doi:10.1161/HYPERTENSIONAHA.112.194175

2011

Yu, P., Han, W., Zhang, Y., Villar, V. A. M., Li, H., Felder, R. E. A., . . . Yu, P. (2011). NADPH Oxidase 5 May Play a Role in Human Essential Hypertension. Free Radical Biology and Medicine, 51, S53. doi:10.1016/j.freeradbiomed.2011.10.136

Yatabe, J., Yoneda, M., Yatabe, M. S., Watanabe, T., Felder, R. A., Jose, P. A., & Sanada, H. (2011). Angiotensin III Stimulates Aldosterone Secretion from Adrenal Gland Partially via Angiotensin II Type 2 Receptor But Not Angiotensin II Type 1 Receptor. ENDOCRINOLOGY, 152(4), 1582-1588. doi:10.1210/en.2010-1070

Yokokawa, H., Goto, A., Sanada, H., Watanabe, T., Felder, R. A., Jose, P. A., & Yasumura, S. (2011). Achievement Status toward Goal Blood Pressure Levels and Healthy Lifestyles among Japanese Hypertensive Patients; Cross-sectional Survey Results from Fukushima Research of Hypertension (FRESH). INTERNAL MEDICINE, 50(11), 1149-1156. doi:10.2169/internalmedicine.50.4969

Felder, R. A. (2011). Preanalytical Errors Introduced by Sample-Transportation Systems: A Means to Assess Them. CLINICAL CHEMISTRY, 57(10), 1349-1350. doi:10.1373/clinchem.2011.172452

Fan, Y. -Y., Kohno, M., Hitomi, H., Kitada, K., Fujisawa, Y., Yatabe, J., . . . Nakano, D. (2011). Aldosterone/Mineralocorticoid Receptor Stimulation Induces Cellular Senescence in the Kidney. ENDOCRINOLOGY, 152(2), 680-688. doi:10.1210/en.2010-0829

Gildea, J. J., Kemp, B. A., Howell, N. L., Van Sciver, R. E., Carey, R. M., & Felder, R. A. (2011). Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 300(4), F914-F920. doi:10.1152/ajprenal.00380.2010

2010

Yu, P., Han, W., Villar, V. A. M., Li, H., Arnaldo, F. B., Concepcion, G. P., . . . Jose, P. A. (2011). Dopamine D1 receptor-mediated inhibition of NADPH oxidase activity in human kidney cells occurs via protein kinase A-protein kinase C cross talk. FREE RADICAL BIOLOGY AND MEDICINE, 50(7), 832-840. doi:10.1016/j.freeradbiomed.2010.12.027

Li, H., Yu, P., Sun, Y., Felder, R. A., Periasamy, A., & Jose, P. A. (2010). Actin cytoskeleton-dependent Rab GTPase-regulated angiotensin type I receptor lysosomal degradation studied by fluorescence lifetime imaging microscopy. JOURNAL OF BIOMEDICAL OPTICS, 15(5). doi:10.1117/1.3484751

Jose, P. A., Soares-da-Silva, P., Eisner, G. M., & Felder, R. A. (2010). Dopamine and G protein-coupled receptor kinase 4 in the kidney: Role in blood pressure regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1802(12), 1259-1267. doi:10.1016/j.bbadis.2010.02.004

Yokokawa, H., Sanada, H., Goto, A., Watanabe, T., Felder, R. A., Jose, P. A., . . . Yasumura, S. (2010). Characteristics of Antihypertensive Medication and Change of Prescription Over 1 Year of Follow-Up in Japan: Fukushima Research of Hypertension (FRESH). AMERICAN JOURNAL OF HYPERTENSION, 23(12), 1299-1305. doi:10.1038/ajh.2010.175

Gildea, J. J., Shah, I., Weiss, R., Casscells, N. D., McGrath, H. E., Zhang, J., & Felder, R. A. (2010). HK-2 Human Renal Proximal Tubule Cells as a Model for G Protein-Coupled Receptor Kinase Type 4-Mediated Dopamine 1 Receptor Uncoupling. HYPERTENSION, 56(3), 505-511. doi:10.1161/HYPERTENSIONAHA.110.152256

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