Frederick H. Epstein

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Primary Appointment

Professor, Biomedical Engineering

Education

  • BS, Physics, University of Rochester
  • PhD, Biomedical Engineering, University of Virginia

Research Disciplines

Biomedical Engineering, Cardiovascular Biology

Research Interests

Cardiovascular Magnetic Resonance Imaging; Coronary Heart Disease; Myocardial Function; Myocardial Perfusion

Research Description

The general goal of my lab is to develop MRI techniques for assessing the structure, function, and perfusion of the cardiovascular system, particularly in the setting of heart disease. Recent projects have included developing MRI methods for imaging myocardial perfusion and developing displacement-encoded MRI for high-resolution measurements of intramyocardial motion. We have access to state-of-the-art whole body 3T scanners for human imaging studies and to a high-field 7T MRI scanner for imaging small animals, particularly mice. Through collaborations with cardiologists and molecular biologists, our novel MRI methods are applied to studies involving both clinical cardiology and basic cardiovascular science.Current Projects:
Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes) MRI, including pulse sequence development and improving image analysis methods.
MRI in mouse models of cardiovascular disease.  Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress. 
MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models.
Current Projects:
Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes)MRI, including pulse sequence development and improving image analysis methods.
MRI in mouse models of cardiovascular disease. Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress.
MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models.
UNLEASH:
Undergraduates seeking work in this lab need to have coursework/experience in programming, linear algebra, and signal analysis.

Personal Statement

The general goal of my lab is to develop MRI techniques for assessing the structure, function, and perfusion of the cardiovascular system, particularly in the setting of heart disease. Recent projects have included developing MRI methods for imaging myocardial perfusion and developing displacement-encoded MRI for high-resolution measurements of intramyocardial motion. We have access to state-of-the-art whole body 3T scanners for human imaging studies and to a high-field 7T MRI scanner for imaging small animals, particularly mice. Through collaborations with cardiologists and molecular biologists, our novel MRI methods are applied to studies involving both clinical cardiology and basic cardiovascular science.Current Projects:
Imaging myocardial mechanics with Cine DENSE (Displacement Encoding with Stimulated Echoes) MRI, including pulse sequence development and improving image analysis methods.
MRI in mouse models of cardiovascular disease.  Some projects include 3D Cine DENSE in mice, MRI of macrophage infiltration in myocardial infarction, using arterial spin labeling and first-pass MRI to quantify myocardial perfusion, T2-weighted imaging of myocardial edema, and 3D phase contrast MRI of aortic blood flow and wall shear stress. 
MRI of pancreatic beta cells using manganese and other targeted contrast agents as well as quantitation through MR relaxometry and multi-compartment models.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

2024

Subramaniam, S., Akay, M., Anastasio, M. A., Bailey, V., Boas, D., Bonato, P., . . . Miller, M. I. (2024). Grand Challenges at the Interface of Engineering and Medicine. IEEE OPEN JOURNAL OF ENGINEERING IN MEDICINE AND BIOLOGY, 5, 1-13. doi:10.1109/OJEMB.2024.3351717

2023

Wang, Y., Sun, C., Ghadimi, S., Auger, D. C., Croisille, P., Viallon, M., . . . Epstein, F. H. (2023). StrainNet: Improved Myocardial Strain Analysis of Cine MRI by Deep Learning from DENSE. RADIOLOGY-CARDIOTHORACIC IMAGING, 5(3). doi:10.1148/ryct.220196

Li, J., Minczuk, K., Huang, Q., Kemp, B. A., Howell, N. L., Chordia, M. D., . . . Keller, S. R. (2023). Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 12(10). doi:10.1161/JAHA.122.026950

2022

Shah, S. A., Echols, J. T., Sun, C., Wolf, M. J., & Epstein, F. H. (2022). Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity-induced coronary microvascular disease. MAGNETIC RESONANCE IN MEDICINE, 88(4), 1734-1747. doi:10.1002/mrm.29348

Sun, C., Robinson, A., Wang, Y., Bilchick, K. C., Kramer, C. M., Weller, D., . . . Epstein, F. H. (2022). A Slice-Low-Rank Plus Sparse (slice-L plus S) Reconstruction Method for k-t Undersampled Multiband First-Pass Myocardial Perfusion MRI. MAGNETIC RESONANCE IN MEDICINE, 88(3), 1140-1155. doi:10.1002/mrm.29281

Auger, D. A., Ghadimi, S., Cai, X., Reagan, C. E., Sun, C., Abdi, M., . . . Epstein, F. H. (2022). Reproducibility of global and segmental myocardial strain using cine DENSE at 3 T: a multicenter cardiovascular magnetic resonance study in healthy subjects and patients with heart disease. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 24(1). doi:10.1186/s12968-022-00851-7

2021

Weiner, D. K., Holloway, K., Levin, E., Keyserling, H., Epstein, F., Monaco, E., . . . Perera, S. (2021). Identifying biopsychosocial factors that impact decompressive laminectomy outcomes in veterans with lumbar spinal stenosis: a prospective cohort study.. Pain, 162(3), 835-845. doi:10.1097/j.pain.0000000000002072

Gao, X., Abdi, M., Auger, D. A., Sun, C., Hanson, C. A., Robinson, A. A., . . . Bilchick, K. C. (2021). Cardiac Magnetic Resonance Assessment of Response to Cardiac Resynchronization Therapy and Programming Strategies. JACC-CARDIOVASCULAR IMAGING, 14(12), 2369-2383. doi:10.1016/j.jcmg.2021.06.015

Wang, V. Y., Tartibi, M., Zhang, Y., Selvaganesan, K., Haraldsson, H., Auger, D. A., . . . Ratcliffe, M. B. (2021). A kineniatic model-based analysis framework for 3D Cine-DENSE validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction. MAGNETIC RESONANCE IN MEDICINE, 86(4), 2105-2121. doi:10.1002/mrtu.28775

Abdi, M., Feng, X., Sun, C., Bilchick, K. C., Meyer, C. H., & Epstein, F. H. (2021). Suppression of artifact-generating echoes in cine DENSE using deep learning. MAGNETIC RESONANCE IN MEDICINE, 86(4), 2095-2104. doi:10.1002/mrm.28832

Wang, J., Yang, Y., Weller, D. S., Zhou, R., Van Houten, M., Sun, C., . . . Salerno, M. (2021). High spatial resolution spiral first-pass myocardial perfusion imaging with whole-heart coverage at 3 T. MAGNETIC RESONANCE IN MEDICINE, 86(2), 648-662. doi:10.1002/mrm.28701

Shah, S. A., Reagan, C. E., French, B. A., & Epstein, F. H. (2021). Molecular Mechanisms of Adenosine Stress T1 Mapping. CIRCULATION-CARDIOVASCULAR IMAGING, 14(3), 210-220. doi:10.1161/CIRCIMAGING.120.011774

Ghadimi, S., Auger, D. A., Feng, X., Sun, C., Meyer, C. H., Bilchick, K. C., . . . Epstein, F. H. (2021). Fully-automated global and segmental strain analysis of DENSE cardiovascular magnetic resonance using deep learning for segmentation and phase unwrapping. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 23(1). doi:10.1186/s12968-021-00712-9

2020

Mangion, K., Loughrey, C. M., Auger, D. A., McComb, C., Lee, M. M., Corcoran, D., . . . Berry, C. (2020). Displacement Encoding With Stimulated Echoes Enables the Identification of Infarct Transmurality Early Postmyocardial Infarction. JOURNAL OF MAGNETIC RESONANCE IMAGING, 52(6), 1722-1731. doi:10.1002/jmri.27295

Shah, S. A., Cui, S. X., Waters, C. D., Sano, S., Wang, Y., Doviak, H., . . . Epstein, F. H. (2020). Nitroxide-enhanced MRI of cardiovascular oxidative stress. NMR IN BIOMEDICINE, 33(9). doi:10.1002/nbm.4359

Naresh, N. K., Misener, S., Zhang, Z., Yang, C., Ruh, A., Bertolino, N., . . . Allen, B. A. (2020). Cardiac MRI Myocardial Functional and Tissue Characterization Detects Early Cardiac Dysfunction in a Mouse Model of Chemotherapy-Induced Cardiotoxicity. NMR IN BIOMEDICINE, 33(9). doi:10.1002/nbm.4327

Li, J., Minczuk, K., Massey, J. C., Howell, N. L., Roy, R. J., Paul, S., . . . Kundu, B. K. (2020). Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(7). doi:10.1161/JAHA.119.015154

Bilchick, K. C., Auger, D. A., Abdishektaei, M., Mathew, R., Sohn, M. -W., Cai, X., . . . Epstein, F. H. (2020). CMR DENSE and the Seattle Heart Failure Model Inform Survival and Arrhythmia Risk After CRT. JACC-CARDIOVASCULAR IMAGING, 13(4), 924-936. doi:10.1016/j.jcmg.2019.10.017

Sun, C., Yang, Y., Cai, X., Salerno, M., Meyer, C. H., Weller, D., & Epstein, F. H. (2020). Non-Cartesian slice-GRAPPA and slice-SPIRiT reconstruction methods for multiband spiral cardiac MRI. MAGNETIC RESONANCE IN MEDICINE, 83(4), 1235-1249. doi:10.1002/mrm.28002

2019

Loffler, A. I., Pan, J. A., Balfour, P. C., Shaw, P. W., Yang, Y., Nasir, M., . . . Salerno, M. (2019). Frequency of Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis (Measured by Cardiovascular Magnetic Resonance) in Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction. AMERICAN JOURNAL OF CARDIOLOGY, 124(10), 1584-1589. doi:10.1016/j.amjcard.2019.08.011

Mangion, K., Carrick, D., Clerfond, G., Rush, C., McComb, C., Oldroyd, K. G., . . . Berry, C. (2019). Predictors of segmental myocardial functional recovery in patients after an acute ST-Elevation myocardial infarction. EUROPEAN JOURNAL OF RADIOLOGY, 112, 121-129. doi:10.1016/j.ejrad.2019.01.010

Li, J., Kemp, B. A., Howell, N. L., Massey, J., Minczuk, K., Huang, Q., . . . Kundu, B. K. (2019). Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 8(4). doi:10.1161/JAHA.118.010926

Tayal, U., Wage, R., Ferreira, P. F., Nielles-Vallespin, S., Epstein, F. H., Auger, D., . . . Prasad, S. K. (2019). The feasibility of a novel limited field of view spiral cine DENSE sequence to assess myocardial strain in dilated cardiomyopathy. MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 32(3), 317-329. doi:10.1007/s10334-019-00735-5

Mansion, K., Carrick, D., Carberry, J., Mahrous, A., McComb, C., Oldroyd, K. G., . . . Berry, C. (2019). Circumferential Strain Predicts Major Adverse Cardiovascular Events Following an Acute ST-Segment-Elevation Myocardial Infarction. RADIOLOGY, 290(2), 329-337. doi:10.1148/radiol.2018181253

2018

Kingsmore, K. M., Vaccari, A., Abler, D., Cui, S. X., Epstein, F. H., Rockne, R. C., . . . Munson, J. M. (2018). MRI analysis to map interstitial flow in the brain tumor microenvironment. APL BIOENGINEERING, 2(3). doi:10.1063/1.5023503

Nagalakshmi, V. K., Li, M., Shah, S., Gigliotti, J. C., Klibanov, A. L., Epstein, F. H., . . . Sequeira-Lopez, M. L. S. (2018). Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction. CLINICAL SCIENCE, 132(23), 2519-2545. doi:10.1042/CS20180623

Cai, X., & Epstein, F. H. (2018). Free-breathing cine DENSE MRI using phase cycling with matchmaking and stimulated-echo image-based navigators. MAGNETIC RESONANCE IN MEDICINE, 80(5), 1907-1921. doi:10.1002/mrm.27199

Zorach, B., Shaw, P. W., Bourque, J., Kuruvilla, S., Balfour, P. C., Yang, Y., . . . Salerno, M. (2018). Quantitative cardiovascular magnetic resonance perfusion imaging identifies reduced flow reserve in microvascular coronary artery disease. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 20. doi:10.1186/s12968-018-0435-1

Cui, S. X., & Epstein, F. H. (2018). MRI assessment of coronary microvascular endothelial nitric oxide synthase function using myocardial T1 mapping. MAGNETIC RESONANCE IN MEDICINE, 79(4), 2246-2253. doi:10.1002/mrm.26870

Yang, Y., Zhao, L., Chen, X., Shaw, P. W., Gonzalez, J. A., Epstein, F. H., . . . Salerno, M. (2018). Reduced field of view single-shot spiral perfusion imaging. MAGNETIC RESONANCE IN MEDICINE, 79(1), 208-216. doi:10.1002/mrm.26664

2017

Gutknecht, M. F., Seaman, M. E., Ning, B., Cornejo, D. A., Mugler, E., Antkowiak, P. F., . . . Kelly, K. A. (2017). Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity. NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-00488-6

Mangion, K., McComb, C., Auger, D. A., Epstein, F. H., & Berry, C. (2017). Magnetic Resonance Imaging of Myocardial Strain After Acute ST-Segment-Elevation Myocardial Infarction A Systematic Review. CIRCULATION-CARDIOVASCULAR IMAGING, 10(8). doi:10.1161/CIRCIMAGING.117.006498

Auger, D. A., Bilchick, K. C., Gonzalez, J. A., Cui, S. X., Holmes, J. W., Kramer, C. M., . . . Epstein, F. H. (2017). Imaging Left-Ventricular Mechanical Activation in Heart Failure Patients Using Cine DENSE MRI: Validation and Implications for Cardiac Resynchronization Therapy. JOURNAL OF MAGNETIC RESONANCE IMAGING, 46(3), 887-896. doi:10.1002/jmri.25613

2016

Chen, X., Yang, Y., Cai, X., Auger, D. A., Meyer, C. H., Salerno, M., & Epstein, F. H. (2016). Accelerated two-dimensional cine DENSE cardiovascular magnetic resonance using compressed sensing and parallel imaging. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 18. doi:10.1186/s12968-016-0253-2

Jing, L., Binkley, C. M., Suever, J. D., Umasankar, N., Haggerty, C. M., Rich, J., . . . Fornwalt, B. K. (2016). Cardiac remodeling and dysfunction in childhood obesity: a cardiovascular magnetic resonance study. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 18. doi:10.1186/s12968-016-0247-0

Kain, D., Amit, U., Yagil, C., Landa, N., Naftali-Shani, N., Molotski, N., . . . Leor, J. (2016). Macrophages dictate the progression and manifestation of hypertensive heart disease. INTERNATIONAL JOURNAL OF CARDIOLOGY, 203, 381-395. doi:10.1016/j.ijcard.2015.10.126

Naresh, N. K., Chen, X., Moran, E., Tian, Y., French, B. A., & Epstein, F. H. (2016). Repeatability and Variability of Myocardial Perfusion Imaging Techniques in Mice: Comparison of Arterial Spin Labeling and First-Pass Contrast-Enhanced MRI. MAGNETIC RESONANCE IN MEDICINE, 75(6), 2394-2405. doi:10.1002/mrm.25769

2015

Mehta, B. B., Auger, D. A., Gonzalez, J. A., Workman, V., Chen, X., Chow, K., . . . Bilchick, K. C. (2015). Detection of elevated right ventricular extracellular volume in pulmonary hypertension using Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGIE) cardiovascular magnetic resonance. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 17. doi:10.1186/s12968-015-0209-y

Haggerty, C. M., Mattingly, A. C., Kramer, S. P., Binkley, C. M., Jing, L., Suever, J. D., . . . Fornwalt, B. K. (2015). Left ventricular mechanical dysfunction in diet-induced obese mice is exacerbated during inotropic stress: a cine DENSE cardiovascular magnetic resonance study. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 17. doi:10.1186/s12968-015-0180-7

Nayak, K. S., Nielsen, J. -F., Bernstein, M. A., Markl, M., Gatehouse, P. D., Botnar, R. M., . . . Raman, S. V. (2015). Cardiovascular magnetic resonance phase contrast imaging. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 17. doi:10.1186/s12968-015-0172-7

Wehner, G. J., Suever, J. D., Haggerty, C. M., Jing, L., Powell, D. K., Hamlet, S. M., . . . Fornwalt, B. K. (2015). Validation of in vivo 2D displacements from spiral cine DENSE at 3T. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 17. doi:10.1186/s12968-015-0119-z

Lopez, D., Pollak, A. W., Meyer, C. H., Epstein, F. H., Zhao, L., Pesch, A. J., . . . Kramer, C. M. (2015). Arterial spin labeling perfusion cardiovascular magnetic resonance of the calf in peripheral arterial disease: cuff occlusion hyperemia vs exercise. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 17. doi:10.1186/s12968-015-0128-y

O'Connor, D. M., Naresh, N. K., Piras, B. A., Xu, Y., Smith, R. S., Epstein, F. H., . . . French, B. A. (2015). A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction. PHYSIOLOGICAL REPORTS, 3(3). doi:10.14814/phy2.12351

Kuruvilla, S., Janardhanan, R., Antkowiak, P., Keeley, E. C., Adenaw, N., Brooks, J., . . . Salerno, M. (2015). Increased Extracellular Volume and Altered Mechanics Are Associated With LVH in Hypertensive Heart Disease, Not Hypertension Alone. JACC-CARDIOVASCULAR IMAGING, 8(2), 172-180. doi:10.1016/j.jcmg.2014.09.020

Ramachandran, R., Chen, X., Kramer, C. M., Epstein, F. H., & Bilchick, K. C. (2015). Singular Value Decomposition Applied to Cardiac Strain from MR Imaging for Selection of Optimal Cardiac Resynchronization Therapy Candidates. RADIOLOGY, 275(2), 413-420. doi:10.1148/radiol.14141578

Mehta, B. B., Chen, X., Bilchick, K. C., Salerno, M., & Epstein, F. H. (2015). Accelerated and Navigator-Gated Look-Locker Imaging for Cardiac T1 Estimation (ANGIE): Development and Application to T1 Mapping of the Right Ventricle. MAGNETIC RESONANCE IN MEDICINE, 73(1), 150-160. doi:10.1002/mrm.25100

Naresh, N. K., Chen, X., Roy, R. J., Antkowiak, P. F., Annex, B. H., & Epstein, F. H. (2015). Accelerated Dual-Contrast First-Pass Perfusion MRI of the Mouse Heart: Development and Application to Diet-Induced Obese Mice. MAGNETIC RESONANCE IN MEDICINE, 73(3), 1237-1245. doi:10.1002/mrm.25238

2014

Kuruvilla, S., Janardhanan, R., Keeley, E., Epstein, F. H., Kramer, C. M., & Salerno, M. (2014). Elevated extracellular volume and arterial stiffness are associated with left ventricular hypertrophy in hypertensive heart disease. Journal of the American Society of Hypertension, 8(4), e95. doi:10.1016/j.jash.2014.03.218

Suever, J. D., Wehner, G. J., Jing, L., Powell, D., Haggerty, C. M., Zhong, X., . . . Fornwalt, B. K. (2014). Quantification of right ventricular function from short-axis displacement-encoded images. Journal of Cardiovascular Magnetic Resonance, 16, P52. doi:10.1186/1532-429x-16-s1-p52

Suever, J. D., Wehner, G. J., Haggerty, C. M., Jing, L., Hamlet, S. M., Binkley, C. M., . . . Fornwalt, B. K. (2014). Simplified post processing of cine DENSE cardiovascular magnetic resonance for quantification of cardiac mechanics. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 16. doi:10.1186/s12968-014-0094-9

Chen, X., Salerno, M., Yang, Y., & Epstein, F. H. (2014). Motion-Compensated Compressed Sensing for Dynamic Contrast-Enhanced MRI Using Regional Spatiotemporal Sparsity and Region Tracking: Block LOw-rank Sparsity with Motion-guidance (BLOSM). MAGNETIC RESONANCE IN MEDICINE, 72(4), 1028-1038. doi:10.1002/mrm.25018

Haraldsson, H., Hope, M., Acevedo-Bolton, G., Tseng, E., Zhong, X., Epstein, F. H., . . . Saloner, D. (2014). Feasibility of asymmetric stretch assessment in the ascending aortic wall with DENSE cardiovascular magnetic resonance. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 16. doi:10.1186/1532-429X-16-6

Auger, D. A., Zhong, X., Epstein, F. H., Meintjes, E. M., & Spottiswoode, B. S. (2014). Semi-automated left ventricular segmentation based on a guide point model approach for 3D cine DENSE cardiovascular magnetic resonance. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 16. doi:10.1186/1532-429X-16-8

Rinkevich-Shop, S., Landa-Rouben, N., Epstein, F. H., Holbova, R., Feinberg, M. S., Goitein, O., . . . Leor, J. (2014). Injectable Collagen Implant Improves Survival, Cardiac Remodeling, and Function in the Early Period After Myocarditis in Rats. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 19(5), 470-480. doi:10.1177/1074248414522347

Bilchick, K. C., Kuruvilla, S., Hamirani, Y. S., Ramachandran, R., Clarke, S. A., Parker, K. M., . . . Epstein, F. H. (2014). Impact of Mechanical Activation, Scar, and Electrical Timing on Cardiac Resynchronization Therapy Response and Clinical Outcomes. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(16), 1657-1666. doi:10.1016/j.jacc.2014.02.533

Haggerty, C. M., Kramer, S. P., Skrinjar, O., Binkley, C. M., Powell, D. K., Mattingly, A. C., . . . Fornwalt, B. K. (2014). Quantification of Left Ventricular Volumes, Mass, and Ejection Fraction Using Cine Displacement Encoding With Stimulated Echoes (DENSE) MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 40(2), 398-406. doi:10.1002/jmri.24350

2013

Mina, Y., Rinkevich-Shop, S., Konen, E., Goitein, O., Kushnir, T., Epstein, F. H., . . . Landa-Rouben, N. (2013). Mast Cell Inhibition Attenuates Myocardial Damage, Adverse Remodeling, and Dysfunction During Fulminant Myocarditis in the Rat. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 18(2), 152-161. doi:10.1177/1074248412458975

Salerno, M., Janardhanan, R., Jiji, R. S., Brooks, J., Adenaw, N., Mehta, B., . . . Epstein, F. H. (2013). Comparison of methods for determining the partition coefficient of gadolinium in the myocardium using T1 mapping. JOURNAL OF MAGNETIC RESONANCE IMAGING, 38(1), 217-224. doi:10.1002/jmri.23875

Jiji, R. S., Pollak, A. W., Epstein, F. H., Antkowiak, P. F., Meyer, C. H., Weltman, A. L., . . . Kramer, C. M. (2013). Reproducibility of rest and exercise stress contrast-enhanced calf perfusion magnetic resonance imaging in peripheral arterial disease. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 15. doi:10.1186/1532-429X-15-14

Rinkevich-Shop, S., Konen, E., Kushnir, T., Epstein, F. H., Landa-Rouben, N., Goitein, O., . . . Leor, J. (2013). Non-invasive assessment of experimental autoimmune myocarditis in rats using a 3 T clinical MRI scanner. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 14(11), 1069-1079. doi:10.1093/ehjci/jet044

Ben-Mordechai, T., Holbova, R., Landa-Rouben, N., Harel-Adar, T., Feinberg, M. S., Abd Elrahman, I., . . . Leor, J. (2013). Macrophage Subpopulations Are Essential for Infarct Repair With and Without Stem Cell Therapy. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 62(20), 1890-1901. doi:10.1016/j.jacc.2013.07.057

Haggerty, C. M., Kramer, S. P., Binkley, C. M., Powell, D. K., Mattingly, A. C., Charnigo, R., . . . Fornwalt, B. K. (2013). Reproducibility of cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance for measuring left ventricular strains, torsion, and synchrony in mice. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 15. doi:10.1186/1532-429X-15-71

Kramer, S. P., Powell, D. K., Haggerty, C. M., Binkley, C. M., Mattingly, A. C., Cassis, L. A., . . . Fornwalt, B. K. (2013). Obesity reduces left ventricular strains, torsion, and synchrony in mouse models: a cine displacement encoding with stimulated echoes (DENSE) cardiovascular magnetic resonance study. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 15. doi:10.1186/1532-429X-15-109

Antkowiak, P. F., Stevens, B. K., Nunemaker, C. S., McDuffle, M., & Epstein, F. H. (2013). Manganese-Enhanced Magnetic Resonance Imaging Detects Declining Pancreatic β-Cell Mass in a Cyclophosphamide-Accelerated Mouse Model of Type 1 Diabetes. DIABETES, 62(1), 44-48. doi:10.2337/db12-0153

2012

Beyers, R. J., Smith, R. S., Xu, Y., Piras, B. A., Salerno, M., Berr, S. S., . . . Epstein, F. H. (2012). T2âweighted MRI of postâinfarct myocardial edema in mice. Magnetic Resonance in Medicine, 67(1). doi:10.1002/mrm.24160

Beyers, R. J., Smith, R. S., Xu, Y., Piras, B. A., Salerno, M., Berr, S. S., . . . Epstein, F. H. (2012). T2-weighted MRI of post-infarct myocardial edema in mice. MAGNETIC RESONANCE IN MEDICINE, 67(1), 201-209. doi:10.1002/mrm.22975

Vandsburger, M. H., French, B. A., Kramer, C. M., Zhong, X., & Epstein, F. H. (2012). Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 302(2), H412-H419. doi:10.1152/ajpheart.00705.2011

Antkowiak, P. F., Vandsburger, M. H., & Epstein, F. H. (2012). Quantitative pancreatic β cell MRI using manganese-enhanced Look-Locker imaging and two-site water exchange analysis. MAGNETIC RESONANCE IN MEDICINE, 67(6), 1730-1739. doi:10.1002/mrm.23139

Auger, D. A., Zhong, X., Epstein, F. H., & Spottiswoode, B. S. (2012). Mapping right ventricular myocardial mechanics using 3D cine DENSE cardiovascular magnetic resonance. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 14. doi:10.1186/1532-429X-14-4

Fiorentino, N. M., Epstein, F. H., & Blemker, S. S. (2012). Activation and aponeurosis morphology affect in vivo muscle tissue strains near the myotendinous junction. JOURNAL OF BIOMECHANICS, 45(4), 647-652. doi:10.1016/j.jbiomech.2011.12.015

West, A. M., Anderson, J. D., Epstein, F. H., Meyer, C. H., Hagspiel, K. D., Berr, S. S., . . . Kramer, C. M. (2012). Percutaneous intervention in peripheral artery disease improves calf muscle phosphocreatine recovery kinetics: A pilot study. VASCULAR MEDICINE, 17(1), 3-9. doi:10.1177/1358863X11431837

Gilliam, A. D., & Epstein, F. H. (2012). Automated Motion Estimation for 2-D Cine DENSE MRI. IEEE TRANSACTIONS ON MEDICAL IMAGING, 31(9), 1669-1681. doi:10.1109/TMI.2012.2195194

Naresh, N. K., Xu, Y., Klibanov, A. L., Vandsburger, M. H., Meyer, C. H., Leor, J., . . . Epstein, F. H. (2012). Monocyte and/or Macrophage Infiltration of Heart after Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes. RADIOLOGY, 264(2), 428-435. doi:10.1148/radiol.12111863

Tarroni, G., Corsi, C., Antkowiak, P. F., Veronesi, F., Kramer, C. M., Epstein, F. H., . . . Patel, A. R. (2012). Myocardial Perfusion: Near-automated Evaluation from Contrast-enhanced MR Images Obtained at Rest and during Vasodilator Stress. RADIOLOGY, 265(2), 576-583. doi:10.1148/radiol.12112475

Budge, L. P., Helms, A. S., Salerno, M., Kramer, C. M., Epstein, F. H., & Bilchick, K. C. (2012). MR Cine DENSE Dyssynchrony Parameters for the Evaluation of Heart Failure Comparison With Myocardial Tissue Tagging. JACC-CARDIOVASCULAR IMAGING, 5(8), 789-797. doi:10.1016/j.jcmg.2011.12.024

Konkalmatt, P. R., Wang, F., Piras, B. A., Xu, Y., O'Connor, D. M., Beyers, R. J., . . . French, B. A. (2012). Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling. JOURNAL OF GENE MEDICINE, 14(9-10), 609-620. doi:10.1002/jgm.2673

Pollak, A. W., Meyer, C. H., Epstein, F. H., Jiji, R. S., Hunter, J. R., DiMaria, J. M., . . . Kramer, C. M. (2012). Arterial Spin Labeling MR Imaging Reproducibly Measures Peak-Exercise Calf Muscle Perfusion A Study in Patients With Peripheral Arterial Disease and Healthy Volunteers. JACC-CARDIOVASCULAR IMAGING, 5(12), 1224-1230. doi:10.1016/j.jcmg.2012.03.022

Jehle, A. B., Xu, Y., DiMaria, J. M., French, B. A., Epstein, F. H., Berr, S. S., . . . Kramer, C. M. (2012). A Nonpeptide Angiotensin II Type 2 Receptor Agonist Does Not Attenuate Postmyocardial Infarction Left Ventricular Remodeling in Mice. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 59(4), 363-368. doi:10.1097/FJC.0b013e3182444110

2011

Jiji, R. S., West, A. M., Epstein, F. H., Antkowiak, P. F., Meyer, C. H., Weltman, A., . . . Kramer, C. M. (2011). Reproducibility of Contrast-Enhanced Calf Perfusion MRI Measures in Peripheral Arterial Disease. CIRCULATION, 124(21).

Vandsburger, M. H., & Epstein, F. H. (2011). Emerging MRI Methods in Translational Cardiovascular Research. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 4(4), 477-492. doi:10.1007/s12265-011-9275-1

West, A. M., Anderson, J. D., Meyer, C. H., Epstein, F. H., Wang, H., Hagspiel, K. D., . . . Kramer, C. M. (2011). The effect of ezetimibe on peripheral arterial atherosclerosis depends upon statin use at baseline. ATHEROSCLEROSIS, 218(1), 156-162. doi:10.1016/j.atherosclerosis.2011.04.005

Janiczek, R. L., Blackman, B. R., Roy, R. J., Meyer, C. H., Acton, S. T., & Epstein, F. H. (2011). Three-Dimensional Phase Contrast Angiography of the Mouse Aortic Arch Using Spiral MRI. MAGNETIC RESONANCE IN MEDICINE, 66(5), 1382-1390. doi:10.1002/mrm.22937

West, A. M., Anderson, J. D., Epstein, F. H., Meyer, C. H., Wang, H., Hagspiel, K. D., . . . Kramer, C. M. (2011). Low-Density Lipoprotein Lowering Does Not Improve Calf Muscle Perfusion, Energetics, or Exercise Performance in Peripheral Arterial Disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 58(10), 1068-1076. doi:10.1016/j.jacc.2011.04.034

Naresh, N. K., Ben-Mordechai, T., Leor, J., & Epstein, F. H. (2011). Molecular Imaging of Healing After Myocardial Infarction. CURRENT CARDIOVASCULAR IMAGING REPORTS, 4(1). doi:10.1007/s12410-010-9058-0

Epstein, F. H., & Meyer, C. H. (2011). Myocardial Perfusion Using Arterial Spin Labeling CMR Promise and Challenges. JACC-CARDIOVASCULAR IMAGING, 4(12), 1262-1264. doi:10.1016/j.jcmg.2011.08.015

Zhong, X., Gibberman, L. B., Spottiswoode, B. S., Gilliam, A. D., Meyer, C. H., French, B. A., & Epstein, F. H. (2011). Comprehensive Cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 13. doi:10.1186/1532-429X-13-83

2010

Vandsburger, M. H., French, B. A., Kramer, C. M., & Epstein, F. H. (2010). Cine DENSE and Manganese-enhanced MRI Demonstrate that nNOS, and not eNOS, Plays a Dominant Role in Modulating EC-coupling in the Mouse Heart.. CIRCULATION, 122(21).

Vandsburger, M. H., Janiczek, R. L., Xu, Y., French, B. A., Meyer, C. H., Kramer, C. M., & Epstein, F. H. (2010). Improved Arterial Spin Labeling After Myocardial Infarction in Mice Using Cardiac and Respiratory Gated Look-Locker Imaging With Fuzzy C-Means Clustering. MAGNETIC RESONANCE IN MEDICINE, 63(3), 648-657. doi:10.1002/mrm.22280

de Kemp, R. A., Epstein, F. H., Catana, C., Tsui, B. M. W., & Ritman, E. L. (2010). Small-Animal Molecular Imaging Methods. JOURNAL OF NUCLEAR MEDICINE, 51, 18S-32S. doi:10.2967/jnumed.109.068148

Zhong, X., Spottiswoode, B. S., Meyer, C. H., Kramer, C. M., & Epstein, F. H. (2010). Imaging Three-Dimensional Myocardial Mechanics Using Navigator-Gated Volumetric Spiral Cine DENSE MRI. MAGNETIC RESONANCE IN MEDICINE, 64(4), 1089-1097. doi:10.1002/mrm.22503

Patel, A. R., Antkowiak, P. F., Nandalur, K. R., West, A. M., Salerno, M., Arora, V., . . . Kramer, C. M. (2010). Assessment of Advanced Coronary Artery Disease Advantages of Quantitative Cardiac Magnetic Resonance Perfusion Analysis. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 56(7), 561-569. doi:10.1016/j.jacc.2010.02.061