Karen Kemper Hirschi

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Primary Appointment

Professor, Cell Biology

Education

  • PhD, Nutritional Biochemistry, University of Arizona

Research Disciplines

Cell and Developmental Biology, Development, Stem Cells & Regeneration

Research Interests

Understanding Cellular and Molecular Mechanisms Leading to Blood Vessel Formation

Research Description

Our laboratory is specifically interested in the regulation of vascular cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. We also aim to understand how some vascular cells acquire specialized functions, such as the generation and/or maintenance of multi-lineage stem/progenitor cells.

Personal Statement

Our laboratory is specifically interested in the regulation of vascular cell commitment, differentiation and cell cycle progression, and defining signaling pathways that modulate these processes. We also aim to understand how some vascular cells acquire specialized functions, such as the generation and/or maintenance of multi-lineage stem/progenitor cells.

Training

  • Basic Cardiovascular Research Training Grant
  • Biotechnology Training Grant

Selected Publications

Hirschi KK, Dejana E, Resident Endothelial Progenitors Make Themselves at Home., 2018; Cell stem cell. 23(2) 153-155. PMID: 30075124

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK, Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification., 2018; Nature communications. 9(1) 720. PMID: 29445140 | PMCID: PMC5813030

Genet N, Bhatt N, Bourdieu A, Hirschi KK, Multifaceted Roles of Connexin 43 in Stem Cell Niches., 2018; Current stem cell reports. 4(1) 1-12. PMID: 29600160 | PMCID: PMC5866259

Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS, A non-canonical Notch complex regulates adherens junctions and vascular barrier function., 2017; Nature. 552(7684) 258-262. PMID: 29160307 | PMCID: PMC5730479

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK, Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification., 2017; Nature communications. 8(1) 2149. PMID: 29247167 | PMCID: PMC5732288

Hirschi KK, Nicoli S, Walsh K, Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow., 2017; Developmental cell. 41(1) 7-9. PMID: 28399402 | PMCID: PMC6183053

Dejana E, Hirschi KK, Simons M, The molecular basis of endothelial cell plasticity., 2017; Nature communications. 8() 14361. PMID: 28181491 | PMCID: PMC5309780

Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE, Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells., 2017; Cell transplantation. 26(8) 1365-1379. PMID: 28901188 | PMCID: PMC5680973

Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A, PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia., 2016; Nature communications. 7() 13650. PMID: 27897192 | PMCID: PMC5141347

Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M, Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development., 2016; Development (Cambridge, England). 143(23) 4441-4451. PMID: 27789626 | PMCID: PMC5201046

Fang JS, Gritz EC, Marcelo KL, Hirschi KK, Isolation of Murine Embryonic Hemogenic Endothelial Cells., 2016; Journal of visualized experiments : JoVE. (112) . PMID: 27341393 | PMCID: PMC4927799

Gritz E, Hirschi KK, Specification and function of hemogenic endothelium during embryogenesis., 2016; Cellular and molecular life sciences : CMLS. 73(8) 1547-67. PMID: 26849156 | PMCID: PMC4805691

Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA, Corrigendum: Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers., 2015; Frontiers in oncology. 5() 255. PMID: 26636037 | PMCID: PMC4658418

Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA, Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers., 2015; Frontiers in oncology. 5() 231. PMID: 26528440 | PMCID: PMC4604322

Cuchiara ML, CoÅkun S, Banda OA, Horter KL, Hirschi KK, West JL, Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture., 2015; Biotechnology and bioengineering. 113(4) 870-81. PMID: 26497172