Matthew J Wolf


Primary Appointment

Associate Professor, Medicine- Cardiovascular Medicine


  • Fellowship, Cardiology, Duke University School of Medicine, Durham, NC
  • Residency, Internal Medicine, Duke University School of Medicine, Durham, NC
  • MD, Washington University School of Medicine
  • PhD, Biochemistry, Washington University School of Medicine

Research Disciplines

Cardiovascular Biology, Genetics, Physiology

Research Interests

Identification of genes and pathways that cause or modify cardiac hypertrophy and heart failure.

Research Description

Our mission is to understand how signaling molecules mediate cardiomyocyte growth, hypertrophy, and heart failure. We use novel approaches based on fruit fly genetics to identify genes that cause or modify cardiomyopathies and translate these findings using mammalian cell-based systems and transgenic mice. Our multidisciplinary approach employs state-of-the-art Optical Coherence Tomography, confocal microscopy, molecular and cell biology, proteomics, and physiology to understand cardiovascular disease.


  • Basic Cardiovascular Research Training Grant

Selected Publications

Wolf MJ, Noeth D, Rammohan C, Shah SH, Complexities of Genetic Testing in Familial Dilated Cardiomyopathy., 2016; Circulation. Cardiovascular genetics. 9(1) 95-9. PMID: 26884609

Yu L, Daniels JP, Wu H, Wolf MJ, Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription., 2015; Science signaling. 8(362) ra13. PMID: 25650441

Hardy CM, Birse RT, Wolf MJ, Yu L, Bodmer R, Gibbs AG, Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster., 2015; American journal of physiology. Regulatory, integrative and comparative physiology. 309(6) R658-67. PMID: 26136533 | PMCID: PMC4591367

Gao QQ, Wyatt E, Goldstein JA, LoPresti P, Castillo LM, Gazda A, Petrossian N, Earley JU, Hadhazy M, Barefield DY, Demonbreun AR, Bönnemann C, Wolf M, McNally EM, Reengineering a transmembrane protein to treat muscular dystrophy using exon skipping., 2015; The Journal of clinical investigation. 125(11) 4186-95. PMID: 26457733 | PMCID: PMC4639981

Lee TE, Yu L, Wolf MJ, Rockman HA, Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila., 2014; Genetics. 198(2) 591-603. PMID: 25081566 | PMCID: PMC4196615

Wolf MJ, Towards understanding the impact of sarcomeric gene mutations., 2014; JACC. Heart failure. 1(6) 467-8. PMID: 24621998

Yu L, Daniels J, Glaser AE, Wolf MJ, Raf-mediated cardiac hypertrophy in adult Drosophila., 2013; Disease models & mechanisms. 6(4) 964-76. PMID: 23580199 | PMCID: PMC3701216

Abraham DM, Wolf MJ, Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction., 2013; PloS one. 8(10) e77785. PMID: 24098595 | PMCID: PMC3789689

Wooten EC, Hebl VB, Wolf MJ, Greytak SR, Orr NM, Draper I, Calvino JE, Kapur NK, Maron MS, Kullo IJ, Ommen SR, Bos JM, Ackerman MJ, Huggins GS, Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy., 2012; Circulation. Cardiovascular genetics. 6(1) 10-8. PMID: 23255317 | PMCID: PMC3578062

Casad ME, Yu L, Daniels JP, Wolf MJ, Rockman HA, Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy., 2012; Molecular genetics and genomics : MGG. 287(4) 351-60. PMID: 22398840 | PMCID: PMC3701947

Wolf MJ, Modeling dilated cardiomyopathies in Drosophila., 2012; Trends in cardiovascular medicine. 22(3) 55-61. PMID: 22863366 | PMCID: PMC3728662

Lin N, Badie N, Yu L, Abraham D, Cheng H, Bursac N, Rockman HA, Wolf MJ, A method to measure myocardial calcium handling in adult Drosophila., 2011; Circulation research. 108(11) 1306-15. PMID: 21493892 | PMCID: PMC3128985

Casad ME, Abraham D, Kim IM, Frangakis S, Dong B, Lin N, Wolf MJ, Rockman HA, Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster., 2011; Genetics. 189(3) 861-70. PMID: 21890737 | PMCID: PMC3213377

Wolf MJ, Rockman HA, Drosophila, genetic screens, and cardiac function., 2011; Circulation research. 109(7) 794-806. PMID: 21921272 | PMCID: PMC3678974

Kim IM, Wolf MJ, Rockman HA, Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand., 2010; Circulation research. 106(7) 1233-43. PMID: 20203305 | PMCID: PMC2860286

Yu L, Lee T, Lin N, Wolf MJ, Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila., 2010; PLoS genetics. 6(5) e1000969. PMID: 20523889 | PMCID: PMC2877733

Goldstein JA, Kelly SM, LoPresti PP, Heydemann A, Earley JU, Ferguson EL, Wolf MJ, McNally EM, SMAD signaling drives heart and muscle dysfunction in a Drosophila model of muscular dystrophy., 2010; Human molecular genetics. 20(5) 894-904. PMID: 21138941 | PMCID: PMC3033181

Kim IM, Wolf MJ, Serial examination of an inducible and reversible dilated cardiomyopathy in individual adult Drosophila., 2009; PloS one. 4(9) e7132. PMID: 19771157 | PMCID: PMC2740824

Yoo B, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA, Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction., 2009; American journal of physiology. Heart and circulatory physiology. 297(4) H1377-86. PMID: 19633206 | PMCID: PMC2770777

Wolf MJ, Rockman HA, Drosophila melanogaster as a model system for genetics of postnatal cardiac function., 2009; Drug discovery today. Disease models. 5(3) 117-123. PMID: 19802348 | PMCID: PMC2753975

Allikian MJ, Bhabha G, Dospoy P, Heydemann A, Ryder P, Earley JU, Wolf MJ, Rockman HA, McNally EM, Reduced life span with heart and muscle dysfunction in Drosophila sarcoglycan mutants., 2007; Human molecular genetics. 16(23) 2933-43. PMID: 17855453

Wolf MJ, Amrein H, Izatt JA, Choma MA, Reedy MC, Rockman HA, Drosophila as a model for the identification of genes causing adult human heart disease., 2006; Proceedings of the National Academy of Sciences of the United States of America. 103(5) 1394-9. PMID: 16432241 | PMCID: PMC1360529

Volovyk ZM, Wolf MJ, Prasad SV, Rockman HA, Agonist-stimulated beta-adrenergic receptor internalization requires dynamic cytoskeletal actin turnover., 2006; The Journal of biological chemistry. 281(14) 9773-80. PMID: 16461348

Curcio A, Noma T, Naga Prasad SV, Wolf MJ, Lemaire A, Perrino C, Mao L, Rockman HA, Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling., 2006; American journal of physiology. Heart and circulatory physiology. 291(4) H1754-60. PMID: 16699071

Wolf MJ, Tachibana H, Rockman HA, Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts., 2005; Methods in molecular medicine. 112() 353-62. PMID: 16010029

Perrino C, Naga Prasad SV, Patel M, Wolf MJ, Rockman HA, Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression., 2005; Journal of the American College of Cardiology. 45(11) 1862-70. PMID: 15936620

Wheeler FC, Fernandez L, Carlson KM, Wolf MJ, Rockman HA, Marchuk DA, QTL mapping in a mouse model of cardiomyopathy reveals an ancestral modifier allele affecting heart function and survival., 2005; Mammalian genome : official journal of the International Mammalian Genome Society. 16(6) 414-23. PMID: 16075368

Jenkins CM, Wolf MJ, Mancuso DJ, Gross RW, Identification of the calmodulin-binding domain of recombinant calcium-independent phospholipase A2beta. implications for structure and function., 2000; The Journal of biological chemistry. 276(10) 7129-35. PMID: 11118454

Ramanadham S, Wolf MJ, Li B, Bohrer A, Turk J, Glucose-responsitivity and expression of an ATP-stimulatable, Ca(2+)-independent phospholipase A2 enzyme in clonal insulinoma cell lines., 1997; Biochimica et biophysica acta. 1344(2) 153-64. PMID: 9030192

Wolf MJ, Wang J, Turk J, Gross RW, Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization., 1997; The Journal of biological chemistry. 272(3) 1522-6. PMID: 8999823

Ramanadham S, Wolf MJ, Ma Z, Li B, Wang J, Gross RW, Turk J, Evidence for association of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from pancreatic islets and HIT insulinoma cells with a phosphofructokinase-like protein., 1996; Biochemistry. 35(17) 5464-71. PMID: 8611537

Wolf MJ, Gross RW, The calcium-dependent association and functional coupling of calmodulin with myocardial phospholipase A2. Implications for cardiac cycle-dependent alterations in phospholipolysis., 1996; The Journal of biological chemistry. 271(35) 20989-92. PMID: 8702861

Wolf MJ, Gross RW, Expression, purification, and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2., 1996; The Journal of biological chemistry. 271(48) 30879-85. PMID: 8940072

Gross RW, Rudolph AE, Wang J, Sommers CD, Wolf MJ, Nitric oxide activates the glucose-dependent mobilization of arachidonic acid in a macrophage-like cell line (RAW 264.7) that is largely mediated by calcium-independent phospholipase A2., 1995; The Journal of biological chemistry. 270(25) 14855-8. PMID: 7797462

Wolf MJ, Izumi Y, Zorumski CF, Gross RW, Long-term potentiation requires activation of calcium-independent phospholipase A2., 1995; FEBS letters. 377(3) 358-62. PMID: 8549755

Ramanadham S, Wolf MJ, Jett PA, Gross RW, Turk J, Characterization of an ATP-stimulatable Ca(2+)-independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the beta-cell fuel sensor., 1994; Biochemistry. 33(23) 7442-52. PMID: 8003509

Hazen SL, Wolf MJ, Ford DA, Gross RW, The rapid and reversible association of phosphofructokinase with myocardial membranes during myocardial ischemia., 1994; FEBS letters. 339(3) 213-6. PMID: 8112458

Sun Zhongjie, Molecular Cardiology, ; Humana Press. () 353-362. PMID:

Ardehali Hossein, Bolli Roberto, Losordo DouglasW, REsearch Techiques in Cardiovascular Medicine, ; Wiley Blackwell. () 432-439. PMID: