Wolf Lab

Welcome to the Wolf Lab

Mission Statement

Our mission is to understand how signaling molecules mediate cardiomyocyte growth, hypertrophy, and heart failure. We use novel approaches based on fruit fly genetics to identify genes that cause or modify cardiomyopathies and translate these findings using mammalian cell-based systems and transgenic mice. Our multidisciplinary approach employs state-of-the-art Optical Coherence Tomography, confocal microscopy, molecular and cell biology, proteomics, and physiology to understand cardiovascular disease.


Collaborations

Howard Rockman Lab, Duke University Medical Center
Don Fox Lab, Department of Pharmacology and Cancer Biology: http://www.foxlabduke.com/

Associated Sites at UVa

Robert M. Berne Cardiovascular Research Center (aka CVRC)
Department of Cardiovascular Medicine
Cardiovascular Training Grant (CVTG and Facebook)

Selected Publications

1. Yu, L., Daniels, J., Wu, H. and Wolf, M.J. (2015) Cardiac hypertrophy induced by active Raf depends on Yorkie-mediated transcription. Science Signaling 8 (362): ra13

2. Yu, L., Daniels, J., Glaser, A. and Wolf M.J. (2013) Raf-mediated Cardiac Hypertrophy in Adult Drosophila. Disease Models and Mechanisms. 6(4):964-76.

3. Wolf, M.J. (2012) Modeling Cardiomyopathies in Drosophila. Trends in Cardiovascular Medicine 22(3):55-61.

4. Lin, N., Badie, N., Yu, L., Abraham, D., Cheng, H., Bursac, N., Rockman, H.A., and Wolf, M.J. (2011) A Method to Measure Myocardial Calcium Handling in Adult Drosophila. Circ. Res. May 27;108(11):1306-15

5. Yu L, Lee T, Lin N, Wolf MJ. (2010) Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet. 6(5):e1000969

6. Wolf, M.J., Amerin, H., Izatt, J.A., Choma, M.A., Reedy, M.C., and Rockman, H.A. (2006) Drosophila as a Model for the Identification of Genes Causing Adult Human Heart Disease. Proc. Natl. Acad. Sci. U.S.A. 103: 1394-9