GPR126 is a mechanoreceptor by which the endocardium senses cardiac load We have combined the use of genetic and physiologic approaches in mice to define how the adhesion GPCR GPR126 functions in vivo. Our findings reveal that GPR126 is activated by … Read More

Epigenetic Control of Smooth Muscle Differentiation: Insights from Smooth Muscle Dysfunction Syndrome Heterozygous ACTA2 p.R179 pathogenic variants cause Smooth Muscle Dysfunction Syndrome. ACTA2 encodes smooth muscle α-actin (SMA), and the p.R179 variant disrupts nuclear localization of SMA, leading to incomplete differentiation of smooth muscle … Read More

LVAD-Induced Bleeding & Acquired Von Willebrand Disease (aVWD) A translational journey on how to explain and reconcile the clinical signs of LVAD-related bleeding and laboratory findings associated with acquired Von Willebrand Disease Associate Professor of Medicine, University of Texas at … Read More