Aging, Cellular Senescence, Senolytic Agents: The Path to Translation • Define cellular senescence • Recognize senolytics • Construct the route to eventual clinical application of senolytics for cardiovascular diseases Affiliation: Consultant, Division of General Internal Medicine, Department of Internal Medicine, Director, … Read More
Leveraging Nature’s Success: Lessons from Modifiers of Marfan Syndrome and Related Aneurysm Conditions Dysregulation of TGFβ signaling has been implicated in many disease states including Marfan syndrome (MFS), a condition caused by deficiency of the extracellular matrix protein fibrillin-1. Many … Read More
Role of Epicardium-derived Cells in Myocardial Healing I will report on recent scRNAseq and secretom data , show that A2B signaling controls normoxic HIF1α formation and IL-6 production, provide first evidence for In vivo imaging of cardiac stromal cells by … Read More
TBD
TBD
Systems biology to predict drivers of cardiac differentiation and fibrosis The heart's form changes substantially through development and disease, yet how this is controlled by molecular networks is unclear. In this talk, I will present our computational and experimental systems … Read More
Divergent Roles of Integrated Stress Responses in Vascular Smooth Muscle Cells: Therapeutic Implications in Peripheral Vascular Diseases The diseased phenotypic switching of vascular smooth muscle cells (VSMC) critically contributes to the pathogenesis of peripheral vascular diseases. Integrated stress response (ISR) … Read More
Shelby Cain - Endothelial Cell Cycle Control to Normalize Tumor Vasculature Morgan Coburn- Microglia and High Fat Diet David Csordas - Leveraging idiopathic pulmonary fibrosis samples to investigate microvascular remodeling
Cassidy - Endothelial cell-derived inhibitor of differentiation 3 (Id3) and atherosclerosis Victoria - Selective Inhibition of IL-6 trans signaling to promote atheroprotective effects Matt - Quantitative MRI for the Characterization of Blood Brain Barrier Disruption with Focuses Ultrasound
Dr. Megan McGroddy & Ms. Margaret “Jane” Jackson Senior Scientist, Science Systems and Applications Inc, Lanham MD Software Developer, Welldhealth, Charlottesville VA
Hosted by: Swapnil Sonkusare, PhD The two faces of HIPPO: targeting the HIPPO pathway in pulmonary arterial hypertension Growth suppressor HIPPO plays a central role in regulating cell fate and proliferation and controlling organ growth and regeneration. Recent studies from … Read More
Taylor - Expansion of a Network Model with Protein Interaction Databases Identifies Antihypertrophic Drugs Catherine - The Role of Extended Pulse Lengths on Sonoselective Transfection of Cerebral Vasculature
