Endothelial Cell Cycle Control in Vascular Malformations: Therapeutics Implications in Hereditary Hemorrhagic Telangiectasia The hypothesis of our work is that improper cell cycle control in endothelial cells is a key factor leading to vascular malformations and that drugs regulating cell … Read More

Hosted by: Swapnil Sonkusare, PhD and Brant Isakson, PhD The Space Between: How Lymphatic Endothelial Junction Proteins Control Development Lymphatic vessels form specialized structures to enable the absorption and transport of interstitial fluid. Two of these structures are discontinuous button-like … Read More

Hosted by: Mete Civelek, PhD Sex-biased genetic factors influence obesity, lipid absorption, and statin adverse effects We are investigating sex differences in cardiometabolism to identify genetic factors that influence adiposity and lipid metabolism. We have identified histone demethylase enzymes that … Read More

Hosted by: Bowen Wang, PhD Reconstructing Organotypic Vasculature in a Dish: Towards Therapeutic Discovery and Precision Medicine Capillary endothelial cells are highly specialized in different organ systems at both molecular and functional levels.  However, the factors driving endothelial cell fate … Read More

Chronic viral infection drives three gene expression states in cardiomyocytes Several viruses can infect the human heart and persist long term, leading to heart failure. This project identifies undiagnosed viral heart infections using large RNA-seq datasets collected from patient hearts. … Read More