Rerouting Smooth Muscle Glycolysis Rescues Atherosclerosis-associated Mortality in Mice Heart attacks or strokes stemming from rupture or erosion of unstable atherosclerotic plaques lead to over half a million deaths annually. Postmortem studies of human coronary arteries correlated stable atherosclerotic lesions … Read More
Immune checkpoint inhibitor (ICI)-Myocarditis: Insights into cardiac-immune regulation Cardio-oncology (the cardiovascular care of cancer patients) has developed as a new translational and clinical field based on the expanding repertoire of mechanism-based cancer therapies. Cardio-oncology can also serve as a novel … Read More
Noah Perry - 5th Year PhD Candidate Biomedical Engineering, Civelek Lab Ian Liyayi - 5th Year PhD Candidate MIC, Criss Lab Deborah Powers - 5th Year PhD Candidate Biochemistry and Molecular Genetics, Papin Lab Mike Lemke - 4th Year PhD … Read More
Kaitlyn - Systems-enabled drug repurposing for cardiomyocyte proliferation Wyatt - Novel roles for hydrogen peroxide in vascular function and immunology Skylar - Anti-Inflammatory Therapeutic Loading of Atherosclerotic Plaque-Targeted Nanofibers
Endothelium at the Interface of Lipid Metabolism, Vascular Function and Disease The endothelium is the key cell type at the interface of circulating lipids and the vessels wall. New insights into how lipids and inflammatory signaling impacts endothelial cell functions … Read More
Nicholas Chavkin, PhD - Postdoctoral Researcher University of Virginia Matthew DeWitt, PhD - Senior Scientist University of Virginia
Dr. Matteo Ottolini, PharmD, PhD - Medical Science Liaison (Bayer) Dr. Alyssa Brunal, PhD - Research Development and Communications Advisor (BEAM diagnostics)
Identifying and characterizing causal coronary artery disease-associated variants regulating gene expression in vascular smooth muscle cells Coronary artery disease (CAD) is a complex disorder with genetic and environmental influences. Genome-wide association studies (GWAS) have identified >300 loci associated with disease … Read More
Dr. Gloria Shenynkman, PhD - Assistant Professor Molecular Physiology and Biological Physics Jane Jackson - Software Developer | Welld Health
MMP-2-Targeted Nanofibers as a Potential Diagnostic and Therapeutic Delivery Vehicle for Abdominal Aortic Aneurysms Abdominal aortic aneurysm (AAA) is the most common aortic pathology, and accounts for ~10,000 deaths/year in the United States. While many preclinical therapeutics have shown promise, … Read More
Uncovering metabolic drivers of aging and geroprotection Metabolic dysregulation is a defining characteristic of aging. Nevertheless, transcriptomics atlases of aging tissues such as the Tabula Muris Senis and the C. elegans Aging Atlas, and histochemical and biochemical studies have shown … Read More
Sex specific effects of endothelial Pannexin1 in cerebral vascular function and ischemic stroke Our work examines the mechanisms regulating cerebral artery function in health and disease. We examine the role of endothelial Pannexin1, a critical regulator of purinergic signaling, in … Read More
