Cell Signaling And Immune Cell Involvement In Neointima Formation Connexin (Cx) proteins form gap junctions, allowing for communication between cells. Alterations in gap junctions have been associated with pathological proliferation in disease since their discovery in the 1950s. Our studies … Read More
Toward a Therapy for Atherosclerosis - Discuss growth and composition of the arterial plaque, with possible targets of therapy - Discuss feasibility and drivers of atherosclerosis regression VP/Chair, Scientific Council, Global Clinical Development, Regeneron
Novel transgenic/chemogenetic models of oxidative stress in the cardiovascular system Dr. Michel’s seminar will discuss the development and application of chemogenetic approaches to dynamically modulate tissue-specific oxidative stress. These studies have yielded new models of heart failure, neurodegeneration, and aortic … Read More
Extracellular vesicle-mediated communication in cardiovascular disease Extracellular vesicles (EVs) are produced by cells in the cardiovascular system, and they can be taken up by recipient cells to alter function. The contents and functions of EVs change during disease, and they … Read More
Transgenic Rabbits for Cardiovascular Research and Drug Development Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality worldwide. Genome-wide association studies are powerful epidemiological tools to find genes and variants associated with CVD while follow-up biological studies allow … Read More
Cavitation Facilitated AAV Transduction This presentation will focus on multidisciplinary collaborative studies between CVRC and BME that investigating how ultrasound cavitation of microbubble contrast agents can produce site-targeted augmentation of AAV to the heart. These studies are intended to optimize … Read More
Follistatin mediates MASLD and MASH during hepatic insulin resistance on a high fructose diet MASLD (metabolic dysfunction-associated steatotic liver disease) and its progression to steatohepatitis (MASH) correlates with IR (insulin resistance). However, mice with complete hepatic IR owing to hepatic … Read More
From Data to Discovery: The Role of AI in Transforming Healthcare Research This talk will focus on the current and future role of AI tools in medical research, highlighting the subtleties of leveraging this powerful tool to increase efficiency and … Read More
Cell-specific LRP1 signaling in acute myocardial infarction Improving the treatment of acute myocardial infarction (AMI) to prevent heart failure (HF) and death remains an urgent unmet medical need. The AHA estimates that every 42 seconds an American will have an … Read More
RMB CVRC & School of Medicine MPBP Seminar Role of extracellular myeloperoxidase in atherosclerosis development and late-stage pathogenesis Atherosclerosis is a chronic inflammatory disease whose clinical complications, including major adverse cardiovascular events (MACE) such as myocardial infarction (MI) and stroke, … Read More
Immune Metabolism of Human Salt Sensitive Hypertension Salt sensitive hypertension is an independent risk factor for cardiovascular disease. This talk will highlight novel mechanisms in immune metabolism contributing to salt-sensitivity of blood pressure. Associate Professor of Medicine, Clinical Pharmacology; Associate … Read More
The Nitrate-Nitrite-Nitric Oxide Pathway: Ergogenic or Therapeutic - Who is it Good For Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which in relatively low … Read More
