Microglial cyclooxygenase-1 modulates cerebral basal capillary tone in vivo Microglia and border associated macrophages have been implicated in hypercapnia, but it is unknown which myeloid cell modulates which vessel type. Previously, we documented in mice myeloid cell association with the brain … Read More
The New Modern Medicine In this talk, Jonathan Fuller will share research from his book The New Modern Medicine about how epidemiology transformed scientific medicine during the previous century, including in areas such as cardiovascular and cancer care, right down to its … Read More
Vascular inflammation in obesity and lung injury Endothelial signaling microdomains precisely regulate vascular homeostasis. However, the mechanism by which the abnormalities at these microdomains increase vascular tone and permeability is poorly understood. My work has defined a novel paracrine signaling … Read More
Intersecting pathways: Immune mechanisms linking cardiovascular disease and cancer Cardiovascular disease and cancer, while distinct, exhibit cross-disease communication that exacerbates morbidity. Cancer patients are at significantly increased risk for CVD and ischemic cardiovascular events can in turn accelerate tumor growth. Immune … Read More
Beyond Neurons: Vascular Pathways in Autism Dr. Lacoste and his team have established a unique research niche bridging basic and translational neurovascular biology. The Lacoste Lab, established in 2016, has discovered novel mechanisms regulating cerebrovascular maturation1, and the vascular contributions … Read More
Mechanisms of Reduced Exercise Capacity: Insights from Novel MRI Methods Reduced exercise capacity (reduced VO2max, oxygen consumption) is a hallmark feature of heart failure, affecting quality of life and reflecting disease severity and outcomes. Survivors of breast cancer therapy are at increased … Read More
Endothelial Inflammation as a Mechanism of Plaque Rupture and Cardiovascular Ischemic Events: Explaining Clinical Observations The Jaffe lab brings clinical observations to the bench to explore mechanisms with the goal of enhancing understanding and ultimately improving treatment of human vascular … Read More
Deciphering the role of nucleoporin93 (Nup93) in endothelial and vascular function The vascular network is uniquely subject to mechanical changes and hence capable of perceiving various biophysical forces. While emerging studies identify nucleoskeletal elements (i.e. nuclear lamina) and linker of … Read More
Pulmonary vascular dynamics: rise and fall of SMC clones The presentation will discuss vascular remodeling in the context of pulmonary hypertension. It will focus on cellular and molecular mechanisms that regulate expansion of smooth muscle cells down the pulmonary arteriole … Read More
Translational Tales of the Human Microvasculature This presentation will provide an overview of the translational projects beingconducted in the Freed laboratory with particular focus on the importance of studyingthe microvasculature, mechanisms of human microvascular dysfunction, andstrategies in which to increase … Read More
TGF-beta signaling cascades in cardiac repair and fibrosis Myocardial fibrosis is a common pathophysiological feature of most cardiac diseases and may be either reparative or maladaptive. This presentation will address: (a) the cellular mediators of cardiac fibrosis; (b) the molecular … Read More
Hypertension Compromises Tissue-Resident Endothelial Progenitor Cells, Driving Impaired Vascular Regeneration and Highlighting Partial Reprogramming as a Therapeutic Strategy I will present some preliminary data demonstrating a reduction in tissue-resident endothelial progenitor cells (EPCs) in hypertensive animals. I will show that … Read More
