From Data to Discovery: The Role of AI in Transforming Healthcare Research This talk will focus on the current and future role of AI tools in medical research, highlighting the subtleties of leveraging this powerful tool to increase efficiency and … Read More
Cell-specific LRP1 signaling in acute myocardial infarction Improving the treatment of acute myocardial infarction (AMI) to prevent heart failure (HF) and death remains an urgent unmet medical need. The AHA estimates that every 42 seconds an American will have an … Read More
RMB CVRC & School of Medicine MPBP Seminar Role of extracellular myeloperoxidase in atherosclerosis development and late-stage pathogenesis Atherosclerosis is a chronic inflammatory disease whose clinical complications, including major adverse cardiovascular events (MACE) such as myocardial infarction (MI) and stroke, … Read More
Immune Metabolism of Human Salt Sensitive Hypertension Salt sensitive hypertension is an independent risk factor for cardiovascular disease. This talk will highlight novel mechanisms in immune metabolism contributing to salt-sensitivity of blood pressure. Associate Professor of Medicine, Clinical Pharmacology; Associate … Read More
The Nitrate-Nitrite-Nitric Oxide Pathway: Ergogenic or Therapeutic - Who is it Good For Oral consumption of inorganic nitrate, which is abundant in green leafy vegetables and roots, has been shown to increase circulating plasma nitrite concentration, which in relatively low … Read More
Lupus Associated Cardiovascular Disease: Pathological Role of Endothelial Autoantibodies Systemic Lupus erythematosus (SLE) is a chronic autoimmune disease that is 3x more likely to affect minority women compared to white women. SLE has been demonstrated to affect the heart, kidney, … Read More
Sex differences in hypertension, inflammation and diabetes, and the impact of menopause on disease progression Premenopausal females are known to be protected against developing hypertension. However, after going through menopause, a woman’s risk of developing hypertension and other cardiovascular complications … Read More
Altering Cardiac Cell Fate for Heart Repair We will discuss how insights from developmental biology and stem cell concepts—particularly in cell identity, fate determination, and epigenetics—have been leveraged to uncover the molecular mechanisms underlying direct cardiac reprogramming, concomitantly enhancing reprogramming … Read More
Targeting the microtubule network to treat hypertension This talk will focus on the role of the microtubule network in vascular smooth muscle andhow it can regulate vascular tone. This work has revealed how targeting the microtubulenetwork may represent a potential … Read More
The forkhead transcription FoxO1 signaling in health and disease. The topic will cover the complex regulatory mechanisms of Foxo1 by multiple hormones, such as insulin, estrogen, and glucagon, which reveals the mechanism of insulin resistance for type 2 diabetes and … Read More
LINCing the Nucleus to Endothelial Cell Function in Blood Vessels Blood flow-generated shear forces regulate vascular endothelial cell status and signaling, and disrupted responses are linked to cardiovascular disease. We investigate how nuclear membrane proteins integrate forces and communicate to cell-cell … Read More
Sex-dependent cAMP Pools in Vascular Smooth Muscle: Role of Sex Hormones This talk focuses on the sex-dependent regulation of subcellular cAMP compartments in vascular smooth muscle. Our research revealed a sex-specific distribution of cAMP pools that contribute to sex-dependent regulation … Read More
