Epigenetic Control of Smooth Muscle Differentiation: Insights from Smooth Muscle Dysfunction Syndrome Heterozygous ACTA2 p.R179 pathogenic variants cause Smooth Muscle Dysfunction Syndrome. ACTA2 encodes smooth muscle α-actin (SMA), and the p.R179 variant disrupts nuclear localization of SMA, leading to incomplete differentiation of smooth muscle … Read More
LVAD-Induced Bleeding & Acquired Von Willebrand Disease (aVWD) A translational journey on how to explain and reconcile the clinical signs of LVAD-related bleeding and laboratory findings associated with acquired Von Willebrand Disease Associate Professor of Medicine, University of Texas at … Read More
Nutrition, Obesity, and Metabolism in Heart Failure: Mechanistic Insights and Translational Opportunities The presentation will discuss the metabolic and physiological effects of diet and obesity on cardiometabolic health, with a focus on heart failure. The talk will bridge basic and … Read More
Low-grade inflammation memory and rejuvenation during atherosclerosis pathogenesis and treatment The Li laboratory studies the novel dynamics of innate immune memory that can “memorize” the relative strength and duration of danger/damage signals, with memory states ranging from low-grade inflammation to exhaustion of … Read More
Discovery of heart-derived myokines that shape responses to cardio-metabolic stress in the heart This seminar will highlight how molecular metabolism and proteomics reveal new pathways in heart–metabolic tissue communication. Dr. Khetarpal will discuss recent work linking the transcriptional coactivator PGC-1α … Read More
Altered Endothelial Metabolism: An Unrecognized Driver of, and Therapeutic Target for, Peripheral Artery Disease Angiogenesis is the growth and proliferation of blood vessels from existing vascular structures. Angiogenesis occurs in a host of situations ranging from physiologic conditions (i.e. exercise) … Read More
Iron regulation of endothelial function Iron deficiency is a severely understudied health disparity and a major contributor to the global burden of disease. Furthermore, iron deficiency is associated with poor prognosis in chronic diseases with its incidence being reported as … Read More
The role of the NO/sGC pathway in erythropoiesis This talk will examine the role of the NO/sGC pathway in maturation erythroid cells and its potential pharmacological and clinical relevance.
Identification of Functional Renin in the Brain The existence of renin in the central nervous system has been a topic of debate for over 5 decades. Using state-of-the-art approaches, we have demonstrated that renin is not only expressed but is … Read More
Microglial cyclooxygenase-1 modulates cerebral basal capillary tone in vivo Microglia and border associated macrophages have been implicated in hypercapnia, but it is unknown which myeloid cell modulates which vessel type. Previously, we documented in mice myeloid cell association with the brain … Read More
The New Modern Medicine In this talk, Jonathan Fuller will share research from his book The New Modern Medicine about how epidemiology transformed scientific medicine during the previous century, including in areas such as cardiovascular and cancer care, right down to its … Read More
Vascular inflammation in obesity and lung injury Endothelial signaling microdomains precisely regulate vascular homeostasis. However, the mechanism by which the abnormalities at these microdomains increase vascular tone and permeability is poorly understood. My work has defined a novel paracrine signaling … Read More
