Iris Jaffe, M.D., PhD
March 12 @ 11:00 am – 12:00 pm
Endothelial Inflammation as a Mechanism of Plaque Rupture and Cardiovascular Ischemic Events: Explaining Clinical Observations
The Jaffe lab brings clinical observations to the bench to explore mechanisms with the goal of enhancing understanding and ultimately improving treatment of human vascular diseases. This presentation summarizes two seemingly unrelated observations leading to unifying mechanisms; the hormone aldosterone and some Abl tyrosine kinase inhibitors associate with very high clinical risk of heart attack and stroke. Advances in understanding of the molecular mechanism by which these two different stimuli drive endothelial inflammation, plaque inflammation, and plaque rupture will be presented.
Executive Director, Tufts University–Tufts Medicine Research Enterprise, Tufts University and Tufts Medicine Health System, Boston MA