Dr. Matt Wolf Featured in UVA Today Article, Mending the Heart: UVA Discovery Could Lead to Better Heart Attack Outcomes

University of Virginia School of Medicine scientists have identified a potential way to improve heart function after heart attacks – and it could involve a drug extracted from plants commonly used as folk medicine.

The researchers, led by Dr. Matthew J. Wolf, found that blocking a particular enzyme after heart attacks helped repair damage to the organ in lab mice. The research team did this by using a drug called harmine, which is found in certain plants, including Syrian rue, which has long been used for medicinal and ritual purposes.

“Our findings show that investigating the signals controlling normal heart growth can lead to new therapeutic targets to unlock cardiac regeneration,” said Wolf, the co-director of UVA Health’s cardiovascular genetics program. “We hope our research can identify new adjuvant medications that can be added to standard care when someone has a heart attack. Our goals are to help improve heart function and reduce the chances of developing heart failure.”

View the full article at UVA news website