William H. Guilford
- Phone: 434-243-2740
- Website: http://faculty.virginia.edu/guilford/index.html
Primary Appointment
Associate Professor, Biomedical Engineering
Education
- BS, Biology/Chemistry, Saint Francis College
- PhD, Physiology, University of Arizona
- Postdoc, Biophysics, University of Vermont
Research Disciplines
Biochemistry, Biomedical Engineering, Biophysics, Biotechnology, Cardiovascular Biology, Cell and Developmental Biology, Infectious Diseases/Biodefense, Physiology
Research Interests
Molecular Mechanics of Muscle Contraction and Cell Movement
Research Description
Training
- Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Sciences
Selected Publications
Clobes AM, Guilford WH, Loop 2 of myosin is a force-dependent inhibitor of the rigor bond., 2014; Journal of muscle research and cell motility. 35(2) 143-52. PMID: 24500136 | PMCID: PMC4096411
Guilford WH, Bloodgood RA, Laser trap measurements of flagellar membrane motility., 2013; Methods in enzymology. 525() 85-107. PMID: 23522466
Judge JM, Stukenborg GJ, Johnston WF, Guilford WH, Slingluff CL, Hallowell PT, Design, Development, and Evaluation of a Novel Retraction Device for Gallbladder Extraction During Laparoscopic Cholecystectomy., 2013; Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. () . PMID: 23897085
Reed ZH, Guilford W, Park JW, Thermal denaturation of tilapia myosin and its subunits as affected by constantly increasing temperature., 2012; Journal of food science. 76(7) C1018-24. PMID: 22417538
Rao VS, Clobes AM, Guilford WH, Force spectroscopy reveals multiple "closed states" of the muscle thin filament., 2011; The Journal of biological chemistry. 286(27) 24135-41. PMID: 21597115 | PMCID: PMC3129194
Snook JH, Guilford WH, The Effects of Load on E-Selectin Bond Rupture and Bond Formation., 2010; Cellular and molecular bioengineering. 3(2) 128-138. PMID: 20526425 | PMCID: PMC2880517
Python JL, Wilson KO, Snook JH, Guo B, Guilford WH, The viscoelastic properties of microvilli are dependent upon the cell-surface molecule., 2010; Biochemical and biophysical research communications. 397(3) 621-5. PMID: 20570653 | PMCID: PMC2907673
Evangelista AM, Rao VS, Filo AR, Marozkina NV, Doctor A, Jones DR, Gaston B, Guilford WH, Direct regulation of striated muscle myosins by nitric oxide and endogenous nitrosothiols., 2010; PloS one. 5(6) e11209. PMID: 20585450 | PMCID: PMC2887846
Laib JA, Marin JA, Bloodgood RA, Guilford WH, The reciprocal coordination and mechanics of molecular motors in living cells., 2009; Proceedings of the National Academy of Sciences of the United States of America. 106(9) 3190-5. PMID: 19221028 | PMCID: PMC2651315
Guilford WH, Experimental case studies to engage higher cognitive skills., 2009; Advances in physiology education. 33(4) 358-9. PMID: 19948689 | PMCID: PMC3776424
Rao VS, Marongelli EN, Guilford WH, Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unit., 2008; Cell motility and the cytoskeleton. 66(1) 10-23. PMID: 18985725 | PMCID: PMC2770177
Guilford WH, Downs KE, Royce TJ, Knowledge of prenatal health care among Costa Rican and Panamanian women., 2008; Revista panamericana de salud pública = Pan American journal of public health. 23(6) 369-76. PMID: 18644204
Rao VS, La Bonte LR, Xu Y, Yang Z, French BA, Guilford WH, Alterations to myofibrillar protein function in nonischemic regions of the heart early after myocardial infarction., 2007; American journal of physiology. Heart and circulatory physiology. 293(1) H654-9. PMID: 17400716
Paschall CD, Guilford WH, Lawrence MB, Enhancement of L-selectin, but not P-selectin, bond formation frequency by convective flow., 2007; Biophysical journal. 94(3) 1034-45. PMID: 17890384 | PMCID: PMC2186251
Snook JH, Li J, Helmke BP, Guilford WH, Peroxynitrite inhibits myofibrillar protein function in an in vitro assay of motility., 2007; Free radical biology & medicine. 44(1) 14-23. PMID: 18045543 | PMCID: PMC2180163
Guo B, Guilford WH, Mechanics of actomyosin bonds in different nucleotide states are tuned to muscle contraction., 2006; Proceedings of the National Academy of Sciences of the United States of America. 103(26) 9844-9. PMID: 16785439 | PMCID: PMC1502541
Guilford WH, "Shrink wrapping" lectures: teaching cell and molecular biology within the context of human pathologies., 2005; Cell biology education. 4(2) 138-42. PMID: 15917872 | PMCID: PMC1103715
Guilford WH, Tournas JA, Dascalu D, Watson DS, Creating multiple time-shared laser traps with simultaneous displacement detection using digital signal processing hardware., 2004; Analytical biochemistry. 326(2) 153-66. PMID: 15003556
Guo B, Guilford WH, The tail of myosin reduces actin filament velocity in the in vitro motility assay., 2004; Cell motility and the cytoskeleton. 59(4) 264-72. PMID: 15505809
Rinko LJ, Lawrence MB, Guilford WH, The molecular mechanics of P- and L-selectin lectin domains binding to PSGL-1., 2003; Biophysical journal. 86(1) 544-54. PMID: 14695299 | PMCID: PMC1303823
Guilford WH, Teaching peer review and the process of scientific writing., 2002; Advances in physiology education. 25(1) 167-75. PMID: 11824193
Cheezum MK, Walker WF, Guilford WH, Quantitative comparison of algorithms for tracking single fluorescent particles., 2001; Biophysical journal. 81(4) 2378-88. PMID: 11566807 | PMCID: PMC1301708
Guilford WH, Warshaw DM, The molecular mechanics of smooth muscle myosin., 1998; Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 119(3) 451-8. PMID: 9734329
Dupuis DE, Guilford WH, Wu J, Warshaw DM, Actin filament mechanics in the laser trap., 1997; Journal of muscle research and cell motility. 18(1) 17-30. PMID: 9147990
Guilford WH, Dupuis DE, Kennedy G, Wu J, Patlak JB, Warshaw DM, Smooth muscle and skeletal muscle myosins produce similar unitary forces and displacements in the laser trap., 1997; Biophysical journal. 72(3) 1006-21. PMID: 9138552 | PMCID: PMC1184489