Brant Isakson, PhD, a professor of Molecular Physiology and Biological Physics and member of the Robert M. Berne Cardiovascular Research Center, has received the 2024 Robert M. Berne Distinguished Lectureship of the American Physiological Society
Dr. Isakson’s laboratory made the seminal discovery that hemoglobin alpha, a potent nitric oxide scavenger, is concentrated in myoendothelial gap junctions and regulates nitric oxide signaling. As a consequence, Hb alpha plays a previously unrecognized role in blood pressure regulation. He has established an important role for globins in cardiovascular physiology. Dr. Isakson’s research has also demonstrated the importance of pannexin-based purinergic signaling in the vasculature, showing their regulation of vasoconstriction, cellular proliferation, intercellular communication and signaling and their contribution to vascular health and disease.