Michael Ragosta


Primary Appointment

Albert M., Kate L., and Peter R. Kaplan Professor of Cardiology, Medicine- Cardiovascular Medicine


  • Fellowship, Cardiology, University of Virginia
  • Fellowship, Interventional Cardiology, University of Virginia
  • MD, Medicine, Brown University
  • Residency, Internal Medicine, Yale New Haven Hospitals

Research Interests

Coronary flow reserve, Coronary artery disease, Myocardial viability, Restenosis, Hemodynamics, Ischemic heart disease, Myocardial infarction and atherosclerosis

Research Description

Dr. Ragosta is the principal or co-principal investigator on numerous multi-center clinical trials, including the EXCEL trial (left main PCI VS CAB6) and both the PARTNER trail (trans-catheter aortic valve replacement) and the REALISM trial (mitral EVALVE). He is actively involved in several UVa based trials and research projects involving novel biomarkers for atherosclerosis, outcomes in patients undergoing evaluation for liver and renal transplantation, and coronary physiology.

Personal Statement

Michael Ragosta, M.D., is board certified in internal medicine, cardiovascular diseases and interventional cardiology. He specializes in interventional cardiology, heart valve disease, general cardiology and peripheral arterial disease.
Dr. Ragosta has been principal investigator or co-principal investigator on 10 clinical trials involving myocardial viability, coronary collateral circulation, coronary flow reserve, fractional flow reserve and myocardial contrast echocardiography. He has shared his research and experience through more than 40 invited lectures or visiting professorships and by authoring or co-authoring more than 120 peer-reviewed journal publications, book chapters and scientific abstracts. Dr. Ragosta is Medical Director for Interventional Cardiology at UVA.

Selected Publications

Taylor AM, Ragosta M, Understanding Left Main Disease: Will the Right SYNTAX Help Us EXCEL in (PRE)COMBAT?, 2015; Journal of cardiovascular translational research. 8(4) 209-10. PMID: 26031243

Saji M, Rossi AM, Ailawadi G, Dent J, Ragosta M, Scott Lim D, Adjunctive intracardiac echocardiography imaging from the left ventricle to guide percutaneous mitral valve repair with the mitraclip in patients with failed prior surgical rings., 2015; Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. () . PMID: 26105191

Saji M, Ragosta M, Dent J, Lim DS, Use of intracardiac echocardiography to guide percutaneous transluminal mitral commissurotomy: A 20-patient case series., 2015; Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. () . PMID: 25946719

De Marchena E, Mesa J, Pomenti S, Marin Y Kall C, Marincic X, Yahagi K, Ladich E, Kutz R, Aga Y, Ragosta M, Chawla A, Ring ME, Virmani R, Thrombus formation following transcatheter aortic valve replacement., 2015; JACC. Cardiovascular interventions. 8(5) 728-39. PMID: 25946447

Ragosta M, What to do about ischemic mitral regurgitation?, 2015; JACC. Cardiovascular interventions. 8(2) 364-6. PMID: 25700759

Salerno M, Taylor A, Yang Y, Kuruvilla S, Ragosta M, Meyer CH, Kramer CM, Adenosine stress cardiovascular magnetic resonance with variable-density spiral pulse sequences accurately detects coronary artery disease: initial clinical evaluation., 2014; Circulation. Cardiovascular imaging. 7(4) 639-46. PMID: 24759900 | PMCID: PMC4102611

Manichaikul A, Rich SS, Perry H, Yeboah J, Law M, Davis M, Parker M, Ragosta M, Connelly JJ, McNamara CA, Taylor AM, A functionally significant polymorphism in ID3 is associated with human coronary pathology., 2014; PloS one. 9(3) e90222. PMID: 24603695 | PMCID: PMC3946163

Bhamidipati CM, Scott Lim D, Ragosta M, Ailawadi G, Percutaneous transjugular implantation of MELODY® valve into tricuspid bioprosthesis., 2013; Journal of cardiac surgery. 28(4) 391-3. PMID: 23772880 | PMCID: PMC3723778

Ragosta M, Multi-modality imaging of the aortic valve in the era of transcatheter aortic valve replacement: a guide for patient selection, valve selection, and valve delivery., 2013; Journal of cardiovascular translational research. 6(5) 665-74. PMID: 23943424

Ragosta M, Rust in the pipes: the importance of oxidative stress in the pathophysiology of coronary artery disease and the valuable contribution of translational research., 2011; Atherosclerosis. 219(1) 26-7. PMID: 21880314