Richard J. Price
- Email: rjp2z@virginia.edu
- Website: http://price-lab.org/
Primary Appointment
Professor, Biomedical Engineering
Education
- BS, Mechanical Engineering, Rochester Institute of Technology
- BS, Mechanical Engineering, Rochester Institute of Technology
- MS, Biomedical Engineering, University of Virginia
- MS, Biomedical Engineering, University of Virginia
- PhD, Biomedical Engineering, University of Virginia
- PhD, Biomedical Engineering, University of Virginia
- Postdoc, Biomedical Engineering, University of Virginia
Research Disciplines
Cancer Biology, Cardiovascular Biology, Neuroscience, Physiology
Research Interests
Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis
Research Description
Training
- Basic Cardiovascular Research Training Grant
- Cancer Research Training in Molecular Biology
- Predoctoral Training in Neuroscience
Selected Publications
2024
Fisher, D. G., Sharifi, K. A., Shah, I. M., Gorick, C. M., Breza, V. R., Debski, A. C., . . . Price, R. J. (2024). Focused Ultrasound Blood-Brain Barrier Opening Arrests the Growth and Formation of Cerebral Cavernous Malformations.. bioRxiv. doi:10.1101/2024.01.31.577810
Thim, E. A., Kitelinger, L. E., Rivera-Escalera, F., Mathew, A. S., Elliott, M. R., Bullock, T. N. J., & Price, R. J. (2024). Focused ultrasound ablation of melanoma with boiling histotripsy yields abscopal tumor control and antigen-dependent dendritic cell activation.. bioRxiv. doi:10.1101/2023.09.02.552844
2023
Sharifi, K. A., Farzad, F., Soldozy, S., Price, R. J., Kalani, M. Y. S., & Tvrdik, P. (2023). Dynamics of Adult Axin2 Cell Lineage Integration in Granule Neurons of the Dentate Gyrus.. bioRxiv. doi:10.1101/2023.12.09.570930
Thim, E. A., Fox, T., Deering, T., Vass, L. R., Sheybani, N. D., Kester, M., & Price, R. J. (2023). Solid Tumor Treatment via Augmentation of Bioactive C6 Ceramide Levels with Thermally Ablative Focused Ultrasound.. bioRxiv. doi:10.1101/2023.03.23.532394
Thim, E. A., Fox, T., Deering, T., Vass, L. R., Sheybani, N. D., Kester, M., & Price, R. J. (2023). Solid tumor treatment via augmentation of bioactive C6 ceramide levels with thermally ablative focused ultrasound. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 13(12), 3145-3153. doi:10.1007/s13346-023-01377-w
Fisher, D. G., Sharifi, K. A., Ulutas, E. Z., Kumar, J. S., Kalani, M. Y. S., Miller, G. W., . . . Tvrdik, P. (2023). Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43(6), 958-970. doi:10.1161/ATVBAHA.122.318938
Mathew, A. S., Gorick, C. M., & Price, R. J. (2023). Single-cell mapping of focused ultrasound-transfected brain. GENE THERAPY, 30(3-4), 255-263. doi:10.1038/s41434-021-00226-0
2022
Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., . . . Price, R. J. (2022). Applications of focused ultrasound-mediated blood-brain barrier opening. ADVANCED DRUG DELIVERY REVIEWS, 191. doi:10.1016/j.addr.2022.114583
Price, R. J., Bullock, T. N. J., & Sheybani, N. D. (2022). Letter to the editor regarding "Translation of focused ultrasound for blood-brain barrier opening in glioma". JOURNAL OF CONTROLLED RELEASE, 349, 16-17. doi:10.1016/j.jconrel.2022.06.041
Nowak, K. M. M., Schwartz, M. R. R., Breza, V. R. R., & Price, R. J. J. (2022). Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound. CANCER LETTERS, 532. doi:10.1016/j.canlet.2022.215592
Gorick, C. M., Saucerman, J. J., & Price, R. J. (2022). Computational model of brain endothelial cell signaling pathways predicts therapeutic targets for cerebral pathologies. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 164, 17-28. doi:10.1016/j.yjmcc.2021.11.005
Sheybani, N. D., Witter, A. R., Garrison, W. J., Miller, G. W., Price, R. J., & Bullock, T. N. J. (2022). Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound. JOURNAL OF NEURO-ONCOLOGY, 156(1), 109-122. doi:10.1007/s11060-021-03887-4
2021
Norat, P., Soldozy, S., Sokolowski, J. D., Gorick, C. M., Kumar, J. S., Chae, Y., . . . Kalani, M. Y. S. (2021). Author Correction: Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation.. NPJ Regenerative medicine, 6(1), 13. doi:10.1038/s41536-021-00125-3
Mathew, A. S., Gorick, C. M., & Price, R. J. (2021). Multiple regression analysis of a comprehensive transcriptomic data assembly elucidates mechanically- and biochemically-driven responses to focused ultrasound blood-brain barrier disruption. THERANOSTICS, 11(20), 9847-9858. doi:10.7150/thno.65064
Schwartz, M. R., Debski, A. C., & Price, R. J. (2021). Ultrasound-targeted nucleic acid delivery for solid tumor therapy. JOURNAL OF CONTROLLED RELEASE, 339, 531-546. doi:10.1016/j.jconrel.2021.10.010
Clark, R. A., Garman, Z. G., Price, R. J., & Sheybani, N. D. (2021). Functional intersections between extracellular vesicles and oncolytic therapies. TRENDS IN PHARMACOLOGICAL SCIENCES, 42(11), 883-896. doi:10.1016/j.tips.2021.09.001
Sheybani, N. D., Breza, V. R., Paul, S., McCauley, K. S., Berr, S. S., Miller, G. W., . . . Price, R. J. (2021). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. JOURNAL OF CONTROLLED RELEASE, 331, 19-29. doi:10.1016/j.jconrel.2021.01.023
2020
Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2021). Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia. BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(2). doi:10.1002/btm2.10198
Norat, P., Soldozy, S., Sokolowski, J. D., Gorick, C. M., Kumar, J. S., Chae, Y., . . . Kalani, M. Y. S. (2020). Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation. NPJ REGENERATIVE MEDICINE, 5(1). doi:10.1038/s41536-020-00107-x
Curley, C. T., Mead, B. P., Negron, K., Kim, N., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. SCIENCE ADVANCES, 6(18). doi:10.1126/sciadv.aay1344
Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2020). Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia. doi:10.1101/2020.07.24.211136
Sheybani, N., Paul, S., McCauley, K., Breza, V., Berr, S., Miller, W., . . . Price, R. (2020). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. doi:10.1101/2020.07.27.223206
Sheybani, N. D., Witter, A. R., Thim, E. A., Yagita, H., Bullock, T. N. J., & Price, R. J. (2020). Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8(2). doi:10.1136/jitc-2020-001008
Curley, C. T., Stevens, A. D., Mathew, A. S., Stasiak, K., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound. THERANOSTICS, 10(19), 8821-8833. doi:10.7150/thno.47983
Sheybani, N. D., Batts, A. J., Mathew, A. S., Thim, E. A., & Price, R. J. (2020). Focused Ultrasound Hyperthermia Augments Release of Glioma-derived Extracellular Vesicles with Differential Immunomodulatory Capacity. THERANOSTICS, 10(16), 7436-7447. doi:10.7150/thno.46534
Gorick, C. M., Mathew, A. S., Garrison, W. J., Thim, E. A., Fisher, D. G., Copeland, C. A., . . . Price, R. J. (2020). Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(11), 5644-5654. doi:10.1073/pnas.1914595117
2019
Fisher, D. G., & Price, R. J. (2019). Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System. FRONTIERS IN PHARMACOLOGY, 10. doi:10.3389/fphar.2019.01348
Sheybani, N. D., & Price, R. J. (2019). Perspectives on Recent Progress in Focused Ultrasound Immunotherapy. THERANOSTICS, 9(25), 7749-7758. doi:10.7150/thno.37131
Mead, B. P., Curley, C. T., Kim, N., Negron, K., Garrison, W. J., Song, J., . . . Price, R. J. (2019). Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System. SMALL, 15(49). doi:10.1002/smll.201903460
Gorick, C. M., Chappell, J. C., & Price, R. J. (2019). Applications of Ultrasound to Stimulate Therapeutic Revascularization. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(12). doi:10.3390/ijms20123081
Price, R. J., Fisher, D. G., Suk, J. S., Hanes, J., Ko, H. S., & Kordower, J. H. (2019). Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?. MOVEMENT DISORDERS, 34(9), 1279-1282. doi:10.1002/mds.27675
Heuslein, J. L., Gorick, C. M., & Price, R. J. (2019). Epigenetic regulators of the revascularization response to chronic arterial occlusion. CARDIOVASCULAR RESEARCH, 115(4), 701-712. doi:10.1093/cvr/cvz001
2018
Heuslein, J. L., Gorick, C. M., McDonnell, S. P., Song, J., Annex, B. H., & Price, R. J. (2018). Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a-5p as a Potent Regulator of Arteriogenesis. MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 829-844. doi:10.1016/j.omtn.2018.08.001
Gorick, C. M., Sheybani, N. D., Curley, C. T., & Price, R. J. (2018). Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound. THERANOSTICS, 8(11), 2988-2991. doi:10.7150/thno.26025
Heuslein, J. L., McDonnell, S. P., Song, J., Annex, B. H., & Price, R. J. (2018). MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 6. doi:10.3389/fbioe.2018.00001
2017
Mead, B., Kim, N., Negron, K., Miller, W., Mastorakos, P., Suk, J. S., . . . Price, R. J. (2017). Intersections of neuromodulation, focused ultrasound, and gene delivery with brain-penetrating nanoparticles. The Journal of the Acoustical Society of America, 142(4_Supplement), 2669. doi:10.1121/1.5014725
Mead, B. P., Kim, N., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., . . . Price, R. J. (2017). Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. NANO LETTERS, 17(6), 3533-3542. doi:10.1021/acs.nanolett.7b00616
Dallapiazza, R. F., Timbie, K. F., Holmberg, S., Gatesman, J., Lopes, M. B., Price, R. J., . . . Elias, W. J. (2018). Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. JOURNAL OF NEUROSURGERY, 128(3), 875-884. doi:10.3171/2016.11.JNS16976
Timbie, K. F., Afzal, U., Date, A., Zhang, C., Song, J., Miller, G. W., . . . Price, R. J. (2017). MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 263, 120-131. doi:10.1016/j.jconrel.2017.03.017
Heuslein, J. L., Gorick, C. M., Song, J., & Price, R. J. (2017). DNA Methyltransferase 1-Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(12). doi:10.1161/JAHA.117.007673
Curley, C. T., Sheybani, N. D., Bullock, T. N., & Price, R. J. (2017). Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities. THERANOSTICS, 7(15), 3608-3623. doi:10.7150/thno.21225
2016
Heuslein, J. L., Murrell, K. P., Leiphart, R. J., Llewellyn, R. A., Meisner, J. K., & Price, R. J. (2016). Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27029
2015
Mead, B. P., Mastorakos, P., Suk, J. S., Klibanov, A. L., Hanes, J., & Price, R. J. (2016). Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 223, 109-117. doi:10.1016/j.jconrel.2015.12.034
Ando, Y., Timbie, K., Song, J., Larner, J., Price, R., & Andarawewa, K. (2015). Inhibition of melanoma growth in a subcutaneous model using ultrasound with low duty cycle. Journal of Therapeutic Ultrasound, 3(S1). doi:10.1186/2050-5736-3-s1-p55
Moyer, L., Timbie, K., Sheeran, P., Price, R., Miller, W., & Dayton, P. (2015). Direct nanodroplet and microbubble comparison for high intensity focused ultrasound ablation enhancement and safety. Journal of Therapeutic Ultrasound, 3(S1). doi:10.1186/2050-5736-3-s1-o67
Timbie, K. F., Mead, B. P., & Price, R. J. (2015). Drug and gene delivery across the blood-brain barrier with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 219, 61-75. doi:10.1016/j.jconrel.2015.08.059
Hsiang, Y. -H., Song, J., & Price, R. J. (2015). The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure. JOURNAL OF NANOPARTICLE RESEARCH, 17(8). doi:10.1007/s11051-015-3153-8
Heuslein, J. L., Li, X., Murrell, K. P., Annex, B. H., Peirce, S. M., & Price, R. J. (2015). Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease. MICROCIRCULATION, 22(5), 360-369. doi:10.1111/micc.12203
Heuslein, J. L., Meisner, J. K., Li, X., Song, J., Vincentelli, H., Leiphart, R. J., . . . Price, R. J. (2015). Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(11), 2354-2365. doi:10.1161/ATVBAHA.115.305775
Moyer, L. C., Timbie, K. F., Sheeran, P. S., Price, R. J., Miller, G. W., & Dayton, P. A. (2015). High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. JOURNAL OF THERAPEUTIC ULTRASOUND, 3. doi:10.1186/s40349-015-0029-4
Meisner, J. K., Annex, B. H., & Price, R. J. (2015). Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice. JOURNAL OF VASCULAR SURGERY, 61(6), 1583-+. doi:10.1016/j.jvs.2014.01.038
2014
Nance, E., Timbie, K., Miller, G. W., Song, J., Louttit, C., Klibanov, A. L., . . . Price, R. J. (2014). Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood - brain barrier using MRI-guided focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 189, 123-132. doi:10.1016/j.jconrel.2014.06.031
Burke, C. W., Alexander, E., Timbie, K., Kilbanov, A. L., & Price, R. J. (2014). Ultrasound-activated Agents Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor Growth and Improve Survival. MOLECULAR THERAPY, 22(2), 321-328. doi:10.1038/mt.2013.259
Bruce, A. C., Kelly-Goss, M. R., Heuslein, J. L., Meisner, J. K., Price, R. J., & Peirce, S. M. (2014). Monocytes Are Recruited From Venules During Arteriogenesis in the Murine Spinotrapezius Ligation Model. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(9), 2012-2022. doi:10.1161/ATVBAHA.114.303399
2013
Meisner, J. K., Niu, J., Sumer, S., & Price, R. J. (2013). Trans-illuminated laser speckle imaging of collateral artery blood flow in ischemic mouse hindlimb. JOURNAL OF BIOMEDICAL OPTICS, 18(9). doi:10.1117/1.JBO.18.9.096011
Meisner, J. K., Song, J., Annex, B. H., & Price, R. J. (2013). Myoglobin Overexpression Inhibits Reperfusion in the Ischemic Mouse Hindlimb through Impaired Angiogenesis but Not Arteriogenesis. AMERICAN JOURNAL OF PATHOLOGY, 183(6), 1710-1718. doi:10.1016/j.ajpath.2013.08.005
Bruce, A., Meisner, J. K., Price, R. J., & Peirce, S. M. (2013). Monocyte Recruitment during Microvascular Arteriogenesis is Induced by Altered Flow and Influenced by Proximity of Venules to Collateral Arterioles. FASEB JOURNAL, 27.
2012
Meisner, J. K., Sumer, S., Murrell, K. P., Higgins, T. J., & Price, R. J. (2012). Laser Speckle Flowmetry Method for Measuring Spatial and Temporal Hemodynamic Alterations Throughout Large Microvascular Networks. MICROCIRCULATION, 19(7), 619-631. doi:10.1111/j.1549-8719.2012.00197.x
Burke, C. W., Suk, J. S., Kim, A. J., Hsiang, Y. -H. J., Klibanov, A. L., Hanes, J., & Price, R. J. (2012). Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. JOURNAL OF CONTROLLED RELEASE, 162(2), 414-421. doi:10.1016/j.jconrel.2012.07.005
Meisner, J. K., Song, J., & Price, R. J. (2012). Arteriolar and Venular Remodeling Are Differentially Regulated by Bone Marrow-Derived Cell-Specific CX3CR1 and CCR2 Expression. PLOS ONE, 7(9). doi:10.1371/journal.pone.0046312
2011
Burke, C. W., Hsiang, Y. -H. J., Alexander, E., Kilbanov, A. L., & Price, R. J. (2011). Covalently Linking Poly(lactic-co-glycolic acid) Nanoparticles to Microbubbles Before Intravenous Injection Improves their Ultrasound-Targeted Delivery to Skeletal Muscle. SMALL, 7(9), 1227-1235. doi:10.1002/smll.201001934
Burke, C. W., Klibanov, A. L., Sheehan, J. P., & Price, R. J. (2011). Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating. JOURNAL OF NEUROSURGERY, 114(6), 1654-1661. doi:10.3171/2010.11.JNS101201
2010
Burke, C. W., & Price, R. J. (2010). Contrast ultrasound targeted treatment of gliomas in mice via drug-bearing nanoparticle delivery and microvascular ablation.. Journal of visualized experiments : JoVE, (46), 2145. doi:10.3791/2145
Meisner, J. K., & Price, R. J. (2010). Spatial and Temporal Coordination of Bone Marrow-Derived Cell Activity during Arteriogenesis: Regulation of the Endogenous Response and Therapeutic Implications. MICROCIRCULATION, 17(8), 583-599. doi:10.1111/j.1549-8719.2010.00051.x