Richard J. Price

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Primary Appointment

Professor, Biomedical Engineering

Education

  • BS, Mechanical Engineering, Rochester Institute of Technology
  • BS, Mechanical Engineering, Rochester Institute of Technology
  • MS, Biomedical Engineering, University of Virginia
  • MS, Biomedical Engineering, University of Virginia
  • PhD, Biomedical Engineering, University of Virginia
  • PhD, Biomedical Engineering, University of Virginia
  • Postdoc, Biomedical Engineering, University of Virginia

Research Disciplines

Cancer Biology, Cardiovascular Biology, Neuroscience, Physiology

Research Interests

Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

Research Description

The Price Laboratory in the Department of Biomedical Engineering at the University of Virginia has two major areas of research interest. The first centers on the use of image-guided focused ultrasound for targeted drug and gene delivery. Specific projects entail using MRI-guided focused ultrasound to deliver gene- and drug-bearing nanoparticles across the blood-brain barrier to both treat brain tumors and reverse neurodegeneration in Parkinsonâs disease. In a similar vein, we are also actively investigating how the thermal and mechanical effects created by certain regimes of focused ultrasound can be used to elicit anti-tumor immune responses against breast cancer and melanoma. The second major area of research in the lab is vascular biomechanics. Here, our emphasis is on identifying the mechanisms through which epigenetic factors regulate collateral blood vessel growth and then using this information to develop new gene therapy approaches for treating peripheral arterial disease. Our research is highly collaborative. We work closely with UVa investigators in Radiology, the Human Immunotherapy Center, Neuro-oncology, and Cardiovascular Medicine, and we have a long-standing collaboration with investigators in the Johns Hopkins Center for Nanomedicine

Training

  • Basic Cardiovascular Research Training Grant
  • Cancer Research Training in Molecular Biology
  • Predoctoral Training in Neuroscience

Selected Publications

2024

Fisher, D. G., Sharifi, K. A., Shah, I. M., Gorick, C. M., Breza, V. R., Debski, A. C., . . . Price, R. J. (2024). Focused Ultrasound Blood-Brain Barrier Opening Arrests the Growth and Formation of Cerebral Cavernous Malformations.. bioRxiv. doi:10.1101/2024.01.31.577810

Thim, E. A., Kitelinger, L. E., Rivera-Escalera, F., Mathew, A. S., Elliott, M. R., Bullock, T. N. J., & Price, R. J. (2024). Focused ultrasound ablation of melanoma with boiling histotripsy yields abscopal tumor control and antigen-dependent dendritic cell activation.. bioRxiv. doi:10.1101/2023.09.02.552844

2023

Sharifi, K. A., Farzad, F., Soldozy, S., Price, R. J., Kalani, M. Y. S., & Tvrdik, P. (2023). Dynamics of Adult Axin2 Cell Lineage Integration in Granule Neurons of the Dentate Gyrus.. bioRxiv. doi:10.1101/2023.12.09.570930

Thim, E. A., Fox, T., Deering, T., Vass, L. R., Sheybani, N. D., Kester, M., & Price, R. J. (2023). Solid Tumor Treatment via Augmentation of Bioactive C6 Ceramide Levels with Thermally Ablative Focused Ultrasound.. bioRxiv. doi:10.1101/2023.03.23.532394

Thim, E. A., Fox, T., Deering, T., Vass, L. R., Sheybani, N. D., Kester, M., & Price, R. J. (2023). Solid tumor treatment via augmentation of bioactive C6 ceramide levels with thermally ablative focused ultrasound. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 13(12), 3145-3153. doi:10.1007/s13346-023-01377-w

Fisher, D. G., Sharifi, K. A., Ulutas, E. Z., Kumar, J. S., Kalani, M. Y. S., Miller, G. W., . . . Tvrdik, P. (2023). Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43(6), 958-970. doi:10.1161/ATVBAHA.122.318938

Mathew, A. S., Gorick, C. M., & Price, R. J. (2023). Single-cell mapping of focused ultrasound-transfected brain. GENE THERAPY, 30(3-4), 255-263. doi:10.1038/s41434-021-00226-0

2022

Gorick, C. M., Breza, V. R., Nowak, K. M., Cheng, V. W. T., Fisher, D. G., Debski, A. C., . . . Price, R. J. (2022). Applications of focused ultrasound-mediated blood-brain barrier opening. ADVANCED DRUG DELIVERY REVIEWS, 191. doi:10.1016/j.addr.2022.114583

Price, R. J., Bullock, T. N. J., & Sheybani, N. D. (2022). Letter to the editor regarding "Translation of focused ultrasound for blood-brain barrier opening in glioma". JOURNAL OF CONTROLLED RELEASE, 349, 16-17. doi:10.1016/j.jconrel.2022.06.041

Nowak, K. M. M., Schwartz, M. R. R., Breza, V. R. R., & Price, R. J. J. (2022). Sonodynamic therapy: Rapid progress and new opportunities for non-invasive tumor cell killing with sound. CANCER LETTERS, 532. doi:10.1016/j.canlet.2022.215592

Gorick, C. M., Saucerman, J. J., & Price, R. J. (2022). Computational model of brain endothelial cell signaling pathways predicts therapeutic targets for cerebral pathologies. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 164, 17-28. doi:10.1016/j.yjmcc.2021.11.005

Sheybani, N. D., Witter, A. R., Garrison, W. J., Miller, G. W., Price, R. J., & Bullock, T. N. J. (2022). Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound. JOURNAL OF NEURO-ONCOLOGY, 156(1), 109-122. doi:10.1007/s11060-021-03887-4

2021

Norat, P., Soldozy, S., Sokolowski, J. D., Gorick, C. M., Kumar, J. S., Chae, Y., . . . Kalani, M. Y. S. (2021). Author Correction: Mitochondrial dysfunction in neurological disorders: exploring mitochondrial transplantation.. NPJ Regenerative medicine, 6(1), 13. doi:10.1038/s41536-021-00125-3

Mathew, A. S., Gorick, C. M., & Price, R. J. (2021). Multiple regression analysis of a comprehensive transcriptomic data assembly elucidates mechanically- and biochemically-driven responses to focused ultrasound blood-brain barrier disruption. THERANOSTICS, 11(20), 9847-9858. doi:10.7150/thno.65064

Schwartz, M. R., Debski, A. C., & Price, R. J. (2021). Ultrasound-targeted nucleic acid delivery for solid tumor therapy. JOURNAL OF CONTROLLED RELEASE, 339, 531-546. doi:10.1016/j.jconrel.2021.10.010

Clark, R. A., Garman, Z. G., Price, R. J., & Sheybani, N. D. (2021). Functional intersections between extracellular vesicles and oncolytic therapies. TRENDS IN PHARMACOLOGICAL SCIENCES, 42(11), 883-896. doi:10.1016/j.tips.2021.09.001

Sheybani, N. D., Breza, V. R., Paul, S., McCauley, K. S., Berr, S. S., Miller, G. W., . . . Price, R. J. (2021). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. JOURNAL OF CONTROLLED RELEASE, 331, 19-29. doi:10.1016/j.jconrel.2021.01.023

2020

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2021). Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia. BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(2). doi:10.1002/btm2.10198

Norat, P., Soldozy, S., Sokolowski, J. D., Gorick, C. M., Kumar, J. S., Chae, Y., . . . Kalani, M. Y. S. (2020). Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation. NPJ REGENERATIVE MEDICINE, 5(1). doi:10.1038/s41536-020-00107-x

Curley, C. T., Mead, B. P., Negron, K., Kim, N., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. SCIENCE ADVANCES, 6(18). doi:10.1126/sciadv.aay1344

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2020). Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia. doi:10.1101/2020.07.24.211136

Sheybani, N., Paul, S., McCauley, K., Breza, V., Berr, S., Miller, W., . . . Price, R. (2020). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. doi:10.1101/2020.07.27.223206

Sheybani, N. D., Witter, A. R., Thim, E. A., Yagita, H., Bullock, T. N. J., & Price, R. J. (2020). Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8(2). doi:10.1136/jitc-2020-001008

Curley, C. T., Stevens, A. D., Mathew, A. S., Stasiak, K., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound. THERANOSTICS, 10(19), 8821-8833. doi:10.7150/thno.47983

Sheybani, N. D., Batts, A. J., Mathew, A. S., Thim, E. A., & Price, R. J. (2020). Focused Ultrasound Hyperthermia Augments Release of Glioma-derived Extracellular Vesicles with Differential Immunomodulatory Capacity. THERANOSTICS, 10(16), 7436-7447. doi:10.7150/thno.46534

Gorick, C. M., Mathew, A. S., Garrison, W. J., Thim, E. A., Fisher, D. G., Copeland, C. A., . . . Price, R. J. (2020). Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(11), 5644-5654. doi:10.1073/pnas.1914595117

2019

Mead, B. P., Curley, C. T., Kim, N., Negron, K., Garrison, W. J., Song, J., . . . Price, R. J. (2019). Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System. SMALL, 15(49). doi:10.1002/smll.201903460

Fisher, D. G., & Price, R. J. (2019). Recent Advances in the Use of Focused Ultrasound for Magnetic Resonance Image-Guided Therapeutic Nanoparticle Delivery to the Central Nervous System. FRONTIERS IN PHARMACOLOGY, 10. doi:10.3389/fphar.2019.01348

Sheybani, N. D., & Price, R. J. (2019). Perspectives on Recent Progress in Focused Ultrasound Immunotherapy. THERANOSTICS, 9(25), 7749-7758. doi:10.7150/thno.37131

Gorick, C. M., Chappell, J. C., & Price, R. J. (2019). Applications of Ultrasound to Stimulate Therapeutic Revascularization. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(12). doi:10.3390/ijms20123081

Price, R. J., Fisher, D. G., Suk, J. S., Hanes, J., Ko, H. S., & Kordower, J. H. (2019). Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?. MOVEMENT DISORDERS, 34(9), 1279-1282. doi:10.1002/mds.27675

Heuslein, J. L., Gorick, C. M., & Price, R. J. (2019). Epigenetic regulators of the revascularization response to chronic arterial occlusion. CARDIOVASCULAR RESEARCH, 115(4), 701-712. doi:10.1093/cvr/cvz001

2018

Heuslein, J. L., Gorick, C. M., McDonnell, S. P., Song, J., Annex, B. H., & Price, R. J. (2018). Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a-5p as a Potent Regulator of Arteriogenesis. MOLECULAR THERAPY-NUCLEIC ACIDS, 12, 829-844. doi:10.1016/j.omtn.2018.08.001

Gorick, C. M., Sheybani, N. D., Curley, C. T., & Price, R. J. (2018). Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound. THERANOSTICS, 8(11), 2988-2991. doi:10.7150/thno.26025

Heuslein, J. L., McDonnell, S. P., Song, J., Annex, B. H., & Price, R. J. (2018). MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 6. doi:10.3389/fbioe.2018.00001

2017

Mead, B., Kim, N., Negron, K., Miller, W., Mastorakos, P., Suk, J. S., . . . Price, R. J. (2017). Intersections of neuromodulation, focused ultrasound, and gene delivery with brain-penetrating nanoparticles. The Journal of the Acoustical Society of America, 142(4_Supplement), 2669. doi:10.1121/1.5014725

Mead, B. P., Kim, N., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., . . . Price, R. J. (2017). Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. NANO LETTERS, 17(6), 3533-3542. doi:10.1021/acs.nanolett.7b00616

Dallapiazza, R. F., Timbie, K. F., Holmberg, S., Gatesman, J., Lopes, M. B., Price, R. J., . . . Elias, W. J. (2018). Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. JOURNAL OF NEUROSURGERY, 128(3), 875-884. doi:10.3171/2016.11.JNS16976

Timbie, K. F., Afzal, U., Date, A., Zhang, C., Song, J., Miller, G. W., . . . Price, R. J. (2017). MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 263, 120-131. doi:10.1016/j.jconrel.2017.03.017

Heuslein, J. L., Gorick, C. M., Song, J., & Price, R. J. (2017). DNA Methyltransferase 1-Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(12). doi:10.1161/JAHA.117.007673

Curley, C. T., Sheybani, N. D., Bullock, T. N., & Price, R. J. (2017). Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities. THERANOSTICS, 7(15), 3608-3623. doi:10.7150/thno.21225

2016

Heuslein, J. L., Murrell, K. P., Leiphart, R. J., Llewellyn, R. A., Meisner, J. K., & Price, R. J. (2016). Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion. SCIENTIFIC REPORTS, 6. doi:10.1038/srep27029

2015

Mead, B. P., Mastorakos, P., Suk, J. S., Klibanov, A. L., Hanes, J., & Price, R. J. (2016). Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 223, 109-117. doi:10.1016/j.jconrel.2015.12.034

Ando, Y., Timbie, K., Song, J., Larner, J., Price, R., & Andarawewa, K. (2015). Inhibition of melanoma growth in a subcutaneous model using ultrasound with low duty cycle. Journal of Therapeutic Ultrasound, 3(S1). doi:10.1186/2050-5736-3-s1-p55

Moyer, L., Timbie, K., Sheeran, P., Price, R., Miller, W., & Dayton, P. (2015). Direct nanodroplet and microbubble comparison for high intensity focused ultrasound ablation enhancement and safety. Journal of Therapeutic Ultrasound, 3(S1). doi:10.1186/2050-5736-3-s1-o67

Timbie, K. F., Mead, B. P., & Price, R. J. (2015). Drug and gene delivery across the blood-brain barrier with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 219, 61-75. doi:10.1016/j.jconrel.2015.08.059

Hsiang, Y. -H., Song, J., & Price, R. J. (2015). The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure. JOURNAL OF NANOPARTICLE RESEARCH, 17(8). doi:10.1007/s11051-015-3153-8

Heuslein, J. L., Li, X., Murrell, K. P., Annex, B. H., Peirce, S. M., & Price, R. J. (2015). Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease. MICROCIRCULATION, 22(5), 360-369. doi:10.1111/micc.12203

Heuslein, J. L., Meisner, J. K., Li, X., Song, J., Vincentelli, H., Leiphart, R. J., . . . Price, R. J. (2015). Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(11), 2354-2365. doi:10.1161/ATVBAHA.115.305775

Moyer, L. C., Timbie, K. F., Sheeran, P. S., Price, R. J., Miller, G. W., & Dayton, P. A. (2015). High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. JOURNAL OF THERAPEUTIC ULTRASOUND, 3. doi:10.1186/s40349-015-0029-4

Meisner, J. K., Annex, B. H., & Price, R. J. (2015). Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice. JOURNAL OF VASCULAR SURGERY, 61(6), 1583-+. doi:10.1016/j.jvs.2014.01.038

2014

Nance, E., Timbie, K., Miller, G. W., Song, J., Louttit, C., Klibanov, A. L., . . . Price, R. J. (2014). Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood - brain barrier using MRI-guided focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 189, 123-132. doi:10.1016/j.jconrel.2014.06.031

Burke, C. W., Alexander, E., Timbie, K., Kilbanov, A. L., & Price, R. J. (2014). Ultrasound-activated Agents Comprised of 5FU-bearing Nanoparticles Bonded to Microbubbles Inhibit Solid Tumor Growth and Improve Survival. MOLECULAR THERAPY, 22(2), 321-328. doi:10.1038/mt.2013.259

Bruce, A. C., Kelly-Goss, M. R., Heuslein, J. L., Meisner, J. K., Price, R. J., & Peirce, S. M. (2014). Monocytes Are Recruited From Venules During Arteriogenesis in the Murine Spinotrapezius Ligation Model. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(9), 2012-2022. doi:10.1161/ATVBAHA.114.303399

2013

Meisner, J. K., Niu, J., Sumer, S., & Price, R. J. (2013). Trans-illuminated laser speckle imaging of collateral artery blood flow in ischemic mouse hindlimb. JOURNAL OF BIOMEDICAL OPTICS, 18(9). doi:10.1117/1.JBO.18.9.096011

Meisner, J. K., Song, J., Annex, B. H., & Price, R. J. (2013). Myoglobin Overexpression Inhibits Reperfusion in the Ischemic Mouse Hindlimb through Impaired Angiogenesis but Not Arteriogenesis. AMERICAN JOURNAL OF PATHOLOGY, 183(6), 1710-1718. doi:10.1016/j.ajpath.2013.08.005

Bruce, A., Meisner, J. K., Price, R. J., & Peirce, S. M. (2013). Monocyte Recruitment during Microvascular Arteriogenesis is Induced by Altered Flow and Influenced by Proximity of Venules to Collateral Arterioles. FASEB JOURNAL, 27.

2012

Meisner, J. K., Sumer, S., Murrell, K. P., Higgins, T. J., & Price, R. J. (2012). Laser Speckle Flowmetry Method for Measuring Spatial and Temporal Hemodynamic Alterations Throughout Large Microvascular Networks. MICROCIRCULATION, 19(7), 619-631. doi:10.1111/j.1549-8719.2012.00197.x

Burke, C. W., Suk, J. S., Kim, A. J., Hsiang, Y. -H. J., Klibanov, A. L., Hanes, J., & Price, R. J. (2012). Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles. JOURNAL OF CONTROLLED RELEASE, 162(2), 414-421. doi:10.1016/j.jconrel.2012.07.005

Meisner, J. K., Song, J., & Price, R. J. (2012). Arteriolar and Venular Remodeling Are Differentially Regulated by Bone Marrow-Derived Cell-Specific CX3CR1 and CCR2 Expression. PLOS ONE, 7(9). doi:10.1371/journal.pone.0046312

2011

Burke, C. W., Hsiang, Y. -H. J., Alexander, E., Kilbanov, A. L., & Price, R. J. (2011). Covalently Linking Poly(lactic-co-glycolic acid) Nanoparticles to Microbubbles Before Intravenous Injection Improves their Ultrasound-Targeted Delivery to Skeletal Muscle. SMALL, 7(9), 1227-1235. doi:10.1002/smll.201001934

Burke, C. W., Klibanov, A. L., Sheehan, J. P., & Price, R. J. (2011). Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating. JOURNAL OF NEUROSURGERY, 114(6), 1654-1661. doi:10.3171/2010.11.JNS101201

2010

Burke, C. W., & Price, R. J. (2010). Contrast ultrasound targeted treatment of gliomas in mice via drug-bearing nanoparticle delivery and microvascular ablation.. Journal of visualized experiments : JoVE, (46), 2145. doi:10.3791/2145

Meisner, J. K., & Price, R. J. (2010). Spatial and Temporal Coordination of Bone Marrow-Derived Cell Activity during Arteriogenesis: Regulation of the Endogenous Response and Therapeutic Implications. MICROCIRCULATION, 17(8), 583-599. doi:10.1111/j.1549-8719.2010.00051.x