Richard J. Price

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Primary Appointment

Professor, Biomedical Engineering

Education

  • BS, Mechanical Engineering, Rochester Institute of Technology
  • BS, Mechanical Engineering, Rochester Institute of Technology
  • MS, Biomedical Engineering, University of Virginia
  • MS, Biomedical Engineering, University of Virginia
  • PhD, Biomedical Engineering, University of Virginia
  • PhD, Biomedical Engineering, University of Virginia
  • Postdoc, Biomedical Engineering, University of Virginia

Research Disciplines

Cancer Biology, Cardiovascular Biology, Neuroscience, Physiology

Research Interests

Image Guided Drug and Gene Delivery for Neurodegeneration and Cancer; Focused Ultrasound and Immunotherapy; Arteriogenesis and Angiogenesis

Research Description

The Price Laboratory in the Department of Biomedical Engineering at the University of Virginia has two major areas of research interest. The first centers on the use of image-guided focused ultrasound for targeted drug and gene delivery. Specific projects entail using MRI-guided focused ultrasound to deliver gene- and drug-bearing nanoparticles across the blood-brain barrier to both treat brain tumors and reverse neurodegeneration in Parkinsonâs disease. In a similar vein, we are also actively investigating how the thermal and mechanical effects created by certain regimes of focused ultrasound can be used to elicit anti-tumor immune responses against breast cancer and melanoma. The second major area of research in the lab is vascular biomechanics. Here, our emphasis is on identifying the mechanisms through which epigenetic factors regulate collateral blood vessel growth and then using this information to develop new gene therapy approaches for treating peripheral arterial disease. Our research is highly collaborative. We work closely with UVa investigators in Radiology, the Human Immunotherapy Center, Neuro-oncology, and Cardiovascular Medicine, and we have a long-standing collaboration with investigators in the Johns Hopkins Center for Nanomedicine

Training

  • Basic Cardiovascular Research Training Grant
  • Cancer Research Training in Molecular Biology
  • Predoctoral Training in Neuroscience

Selected Publications

Heuslein JL, McDonnell SP, Song J, Annex BH, Price RJ, MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion via Arteriogenesis., 2018; Frontiers in bioengineering and biotechnology. 6() 1. PMID: 29404323 | PMCID: PMC5786509

Gorick CM, Sheybani ND, Curley CT, Price RJ, Listening in on the Microbubble Crowd: Advanced Acoustic Monitoring for Improved Control of Blood-Brain Barrier Opening with Focused Ultrasound., 2018; Theranostics. 8(11) 2988-2991. PMID: 29897053 | PMCID: PMC5996352

Heuslein JL, Gorick CM, McDonnell SP, Song J, Annex BH, Price RJ, Exposure of Endothelium to Biomimetic Flow Waveforms Yields Identification of miR-199a-5p as a Potent Regulator of Arteriogenesis., 2018; Molecular therapy. Nucleic acids. 12() 829-844. PMID: 30153567 | PMCID: PMC6118158

Timbie KF, Afzal U, Date A, Zhang C, Song J, Wilson Miller G, Suk JS, Hanes J, Price RJ, MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound., 2017; Journal of controlled release : official journal of the Controlled Release Society. 263() 120-131. PMID: 28288892 | PMCID: PMC5593770

Dallapiazza RF, Timbie KF, Holmberg S, Gatesman J, Lopes MB, Price RJ, Miller GW, Elias WJ, Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound., 2017; Journal of neurosurgery. 128(3) 875-884. PMID: 28430035

Mead BP, Kim N, Miller GW, Hodges D, Mastorakos P, Klibanov AL, Mandell JW, Hirsh J, Suk JS, Hanes J, Price RJ, Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model., 2017; Nano letters. 17(6) 3533-3542. PMID: 28511006 | PMCID: PMC5539956

Curley CT, Sheybani ND, Bullock TN, Price RJ, Focused Ultrasound Immunotherapy for Central Nervous System Pathologies: Challenges and Opportunities., 2017; Theranostics. 7(15) 3608-3623. PMID: 29109764 | PMCID: PMC5667336

Heuslein JL, Gorick CM, Song J, Price RJ, DNA Methyltransferase 1-Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point., 2017; Journal of the American Heart Association. 6(12) . PMID: 29191807 | PMCID: PMC5779061

Mead BP, Mastorakos P, Suk JS, Klibanov AL, Hanes J, Price RJ, Targeted gene transfer to the brain via the delivery of brain-penetrating DNA nanoparticles with focused ultrasound., 2016; Journal of controlled release : official journal of the Controlled Release Society. 223() 109-117. PMID: 26732553 | PMCID: PMC4739627

Heuslein JL, Murrell KP, Leiphart RJ, Llewellyn RA, Meisner JK, Price RJ, Vascular growth responses to chronic arterial occlusion are unaffected by myeloid specific focal adhesion kinase (FAK) deletion., 2016; Scientific reports. 6() 27029. PMID: 27244251 | PMCID: PMC4886679

Heuslein JL, Li X, Murrell KP, Annex BH, Peirce SM, Price RJ, Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease., 2015; Microcirculation (New York, N.Y. : 1994). 22(5) 360-9. PMID: 25866235 | PMCID: PMC4506703

Moyer LC, Timbie KF, Sheeran PS, Price RJ, Miller GW, Dayton PA, High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles., 2015; Journal of therapeutic ultrasound. 3() 7. PMID: 26045964 | PMCID: PMC4455327

Heuslein JL, Meisner JK, Li X, Song J, Vincentelli H, Leiphart RJ, Ames EG, Blackman BR, Blackman BR, Price RJ, Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction., 2015; Arteriosclerosis, thrombosis, and vascular biology. 35(11) 2354-65. PMID: 26338297 | PMCID: PMC4618717

Timbie KF, Mead BP, Price RJ, Drug and gene delivery across the blood-brain barrier with focused ultrasound., 2015; Journal of controlled release : official journal of the Controlled Release Society. 219() 61-75. PMID: 26362698 | PMCID: PMC4656107

Hsiang YH, Song J, Price RJ, The partitioning of nanoparticles to endothelium or interstitium during ultrasound-microbubble-targeted delivery depends on peak-negative pressure., 2015; Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology. 17(8) . PMID: 26594129 | PMCID: PMC4651175

Meisner JK, Annex BH, Price RJ, Despite normal arteriogenic and angiogenic responses, hind limb perfusion recovery and necrotic and fibroadipose tissue clearance are impaired in matrix metalloproteinase 9-deficient mice., 2014; Journal of vascular surgery. () . PMID: 24582703 | PMCID: PMC4147032

Nance E, Timbie K, Miller GW, Song J, Louttit C, Klibanov AL, Shih TY, Swaminathan G, Tamargo RJ, Woodworth GF, Hanes J, Price RJ, Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood-brain barrier using MRI-guided focused ultrasound., 2014; Journal of controlled release : official journal of the Controlled Release Society. 189() 123-32. PMID: 24979210 | PMCID: PMC4125545

Meisner JK, Niu J, Sumer S, Price RJ, Trans-illuminated laser speckle imaging of collateral artery blood flow in ischemic mouse hindlimb., 2013; Journal of biomedical optics. 18(9) 096011. PMID: 24045691 | PMCID: PMC3775679

Meisner JK, Song J, Annex BH, Price RJ, Myoglobin overexpression inhibits reperfusion in the ischemic mouse hindlimb through impaired angiogenesis but not arteriogenesis., 2013; The American journal of pathology. 183(6) 1710-8. PMID: 24095922 | PMCID: PMC5746951

Burke CW, Alexander E, Timbie K, Kilbanov AL, Price RJ, Ultrasound-activated agents comprised of 5FU-bearing nanoparticles bonded to microbubbles inhibit solid tumor growth and improve survival., 2013; Molecular therapy : the journal of the American Society of Gene Therapy. 22(2) 321-8. PMID: 24172867 | PMCID: PMC3916048

Burke CW, Suk JS, Kim AJ, Hsiang YH, Klibanov AL, Hanes J, Price RJ, Markedly enhanced skeletal muscle transfection achieved by the ultrasound-targeted delivery of non-viral gene nanocarriers with microbubbles., 2012; Journal of controlled release : official journal of the Controlled Release Society. 162(2) 414-21. PMID: 22800583 | PMCID: PMC3438364

Meisner JK, Sumer S, Murrell KP, Higgins TJ, Price RJ, Laser speckle flowmetry method for measuring spatial and temporal hemodynamic alterations throughout large microvascular networks., 2012; Microcirculation (New York, N.Y. : 1994). 19(7) 619-31. PMID: 22591575 | PMCID: PMC3434303

Meisner JK, Song J, Price RJ, Arteriolar and Venular Remodeling Are Differentially Regulated by Bone Marrow-Derived Cell-Specific CX3CR1 and CCR2 Expression., 2012; PloS one. 7(9) e46312. PMID: 23029475 | PMCID: PMC3454326

Burke CW, Price RJ, Contrast ultrasound targeted treatment of gliomas in mice via drug-bearing nanoparticle delivery and microvascular ablation., 2011; Journal of visualized experiments : JoVE. (46) . PMID: 21206463 | PMCID: PMC3159678

Burke CW, Klibanov AL, Sheehan JP, Price RJ, Inhibition of glioma growth by microbubble activation in a subcutaneous model using low duty cycle ultrasound without significant heating., 2011; Journal of neurosurgery. 114(6) 1654-61. PMID: 21214331

Burke CW, Hsiang YH, Alexander E, Kilbanov AL, Price RJ, Covalently linking poly(lactic-co-glycolic acid) nanoparticles to microbubbles before intravenous injection improves their ultrasound-targeted delivery to skeletal muscle., 2011; Small (Weinheim an der Bergstrasse, Germany). 7(9) 1227-35. PMID: 21456081 | PMCID: PMC3092637

Meisner JK, Price RJ, Spatial and temporal coordination of bone marrow-derived cell activity during arteriogenesis: regulation of the endogenous response and therapeutic implications., 2010; Microcirculation (New York, N.Y. : 1994). 17(8) 583-99. PMID: 21044213 | PMCID: PMC2974339

Nickerson MM, Song J, Meisner JK, Bajikar S, Burke CW, Shuptrine CW, Owens GK, Skalak TC, Price RJ, Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling., 2009; Arteriosclerosis, thrombosis, and vascular biology. 29(11) 1794-801. PMID: 19734197 | PMCID: PMC2766019

Song J, Klibanov AL, Hossack JA, Price RJ, Acoustic attenuation by contrast agent microbubbles in superficial tissue markedly diminishes petechiae bioeffects in deep tissue., 2008; Investigative radiology. 43(5) 322-9. PMID: 18424953 | PMCID: PMC2714264

Anderson CR, Hastings NE, Blackman BR, Price RJ, Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling., 2008; The American journal of pathology. 173(4) 1220-8. PMID: 18772338 | PMCID: PMC2543088

Wieghaus KA, Nickerson MM, Petrie Aronin CE, Sefcik LS, Price RJ, Paige MA, Brown ML, Botchwey EA, Expansion of microvascular networks in vivo by phthalimide neovascular factor 1 (PNF1)., 2008; Biomaterials. 29(35) 4698-708. PMID: 18804278 | PMCID: PMC2885000

Chappell JC, Price RJ, Targeted therapeutic applications of acoustically active microspheres in the microcirculation., 2006; Microcirculation (New York, N.Y. : 1994). 13(1) 57-70. PMID: 16393947

Wieghaus KA, Capitosti SM, Anderson CR, Price RJ, Blackman BR, Brown ML, Botchwey EA, Small molecule inducers of angiogenesis for tissue engineering., 2006; Tissue engineering. 12(7) 1903-13. PMID: 16889520