Shayn M. Peirce-Cottler

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Primary Appointment

Professor, Biomedical Engineering

Education

  • BS, Biomedical Engineering, Johns Hopkins University
  • PhD, Biomedical Engineering, University of Virginia

Research Disciplines

Biomedical Engineering, Biophysics, Biotechnology, Cardiovascular Biology, Computational Biology, Physiology, Translational Science

Research Interests

Tissue Engineering and Regeneration, Computational Systems Biology, Vascular Growth and Remodeling, Stem Cell Therapies

Research Description

The Important Role of the Microcirculation:
Every organ in the body is dependent on blood flow to provide the necessary oxygen and nutrients in order to stay alive. The circulatory system is responsible for delivering blood to and from all of the tissues, and the microcirculation is the set of the smallest blood vessels in the body. (Microvessels are less than 100 micrometers in diameter, and they can only be visualized using a microscope!) Our research is interested in understanding how microvessels grow and remodel during normal physiological development and in the setting of different important diseases where their involvement in disease progression is absolutely central, such as heart disease, peripheral vascular disease, diabetic retinopathy, cancer, and chronic wound formation.
The Microcirculation in Tissue Engineering and Regenerative Medicine:
We are are also interested in applying our knowledge of the microcirculation in order to grow new tissues (tissue engineering) and regenerate damaged tissues in the body (tissue regeneration). In fact, without a blood supply (ie. without microvessels) tissues beyond the small size of 1 cubic millimeter cannot survive in the body. Therefore, our research aims to address a critical bottleneck for all of tissue engineering and regenerative medicine aspirations: growing new functional and sustainable microvessels that can deliver blood to the tissues that we are trying to heal and/or replace.
Specific Research Goals:
The overarching goals of our research are to: 1) understand how tissues, or collections of biological cells and their extracellular matrix environment, grow and adapt in response to physiological and pathological environmental (i.e. biochemical and mechanical) stimuli, and 2) use this information to develop therapeutic strategies for invoking/promoting tissue regeneration and repair. We are predominantly interested in pursuing these goals within the context of the adult microvascular system, which is essential in many human diseases, including heart disease, cancer, and chronic wounds. All of our projects combine multi-cell computational modeling with experimental analyses.

Personal Statement

Microvascular Tissue Engineering

Every tissue in the body needs a blood supply, and that demand is met by a network of interconnected blood vessels called the microcirculation. The microcirculation is a highly adaptable system of small blood vessels that are a tenth of the diameter of a human hairâ-you need a microscope to see themâ-and there are over a million microvessels in a single gram of tissue. Microvascular growth and remodeling are important processes in nearly every major disease, including diabetes, heart disease, peripheral vascular disease, stroke, neurodegenerative diseases, and cancer. In our lab, we develop and use experimental and computational techniques to study and design new approaches for growing and regenerating injured and diseased tissues by manipulating the structure and composition of the microvasculature.

        

Human progenitor cells as therapeutic targets for tissue engineering:

Vascular growth and remodeling in adult mammals involves numerous cell types and cellular behaviors, and is critical for adaptation to exercise, therapeutic revascularization of ischemic tissues, and tissue engineering. A growing body of literature suggests that human adipose-derived cells possess previously unrecognized developmental plasticity, in vitro and in vivo. In collaboration with Dr. Adam Katz (UVa Plastic Surgery Dept.), we investigate the capacity for human adipose-derived progenitor cells to behave as perivascular support cells,  their contribution to in vivo remodeling,  and their therapeutic potential in revascularization. To this end, our studies characterize their structural and morphological interactions with microvessels, their proliferative activity, and their phenotypic changes in the in vivo tissue environment. This data allows us to further determine their effects on microvascular growth, maintenance, and capillary permeability. Since human adipose-derived cells are readily available,  characterization of their behavior may yield novel therapeutic approaches to many vascular diseases as well as knowledge of how perivascular support cells, in general, participate in microvascular remodeling.

Arterial/Venous Polarity:

The arterial and venous components of the circulation differ fundamentally in physiological function, cellular composition, and flow dynamics. Identifying the cell phenotypes associated with arterial/venous (A/V) determination is critical for understanding how the circulation develops, matures, functions to deliver blood to and from the tissues, and adapts to pathological stimuli. Recently, the discovery of A/V phenotypic markers has provided insight into vascular tree development and microvascular remodeling in the adult. We have identified a proteoglycan that is differentially expressed in arterioles vs. venules in rat tissues. Using the differential expression of this marker and the expression of other vascular-specific markers, our lab tries to understand the signals responsible for conferring an artery or vein phenotype to new and pre-existing vessels and maintaining that phenotype as the tissue undergoes adaptation and growth.

Training

  • Basic Cardiovascular Research Training Grant
  • Biotechnology Training Grant
  • Training in Cell and Molecular Biology
  • Training in Molecular Biophysics
  • Training in the Pharmacological Sciences

Selected Publications

Hannan RT, Peirce SM, Barker TH, Fibroblasts: Diverse Cells Critical to Biomaterials Integration., 2019; ACS biomaterials science & engineering. 4(4) 1223-1232. PMID: 31440581 | PMCID: PMC6705602

Hess DL, Kelly-Goss MR, Cherepanova OA, Nguyen AT, Baylis RA, Tkachenko S, Annex BH, Peirce SM, Owens GK, Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis., 2019; Nature communications. 10(1) 967. PMID: 30814500 | PMCID: PMC6393549

Renardy M, Wessler T, Blemker S, Linderman J, Peirce S, Kirschner D, Data-Driven Model Validation Across Dimensions., 2019; Bulletin of mathematical biology. 81(6) 1853-1866. PMID: 30830675 | PMCID: PMC6494696

Lee JJ, Talman L, Peirce SM, Holmes JW, Spatial scaling in multiscale models: methods for coupling agent-based and finite-element models of wound healing., 2019; Biomechanics and modeling in mechanobiology. 18(5) 1297-1309. PMID: 30968216

Sun N, Ning B, Bruce AC, Cao R, Seaman SA, Wang T, Fritsche-Danielson R, Carlsson LG, Peirce SM, Hu S, In vivo imaging of hemodynamic redistribution and arteriogenesis across microvascular network., 2019; Microcirculation (New York, N.Y. : 1994). () e12598. PMID: 31660674

Corliss BA, Delalio LJ, Stevenson Keller TC, Keller AS, Keller DA, Corliss BH, Beers JM, Peirce SM, Isakson BE, Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver., 2019; Frontiers in physiology. 10() 1389. PMID: 31780954 | PMCID: PMC6861181

Suarez-Martinez AD, Peirce SM, Isakson BE, Nice M, Wang J, Lounsbury KM, Scallan JP, Murfee WL, Induction of microvascular network growth in the mouse mesentery., 2018; Microcirculation (New York, N.Y. : 1994). 25(8) e12502. PMID: 30178505

Corliss BA, Ray HC, Patrie JT, Mansour J, Kesting S, Park JH, Rohde G, Yates PA, Janes KA, Peirce SM, CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures., 2018; Bioinformatics (Oxford, England). 35(4) 720-721. PMID: 30289437 | PMCID: PMC6379036

Corliss BA, Mathews C, Doty R, Rohde G, Peirce SM, Methods to label, image, and analyze the complex structural architectures of microvascular networks., 2018; Microcirculation (New York, N.Y. : 1994). 26(5) e12520. PMID: 30548558 | PMCID: PMC6561846

Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, Mäkinen T, Lammert E, Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth., 2018; The EMBO journal. 38(2) . PMID: 30518533 | PMCID: PMC6331728

Sun N, Ning B, Hansson KM, Bruce AC, Seaman SA, Zhang C, Rikard M, DeRosa CA, Fraser CL, Wågberg M, Fritsche-Danielson R, Wikström J, Chien KR, Lundahl A, Hölttä M, Carlsson LG, Peirce SM, Hu S, Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing., 2018; Scientific reports. 8(1) 17509. PMID: 30504800 | PMCID: PMC6269526

Corliss BA, Ray HC, Patrie JT, Mansour J, Kesting S, Park JH, Rohde G, Yates PA, Janes KA, Peirce SM, CIRCOAST: a statistical hypothesis test for cellular colocalization with network structures., 2018; Bioinformatics (Oxford, England). 35(3) 506-514. PMID: 30032263 | PMCID: PMC6361237

Virgilio KM, Martin KS, Peirce SM, Blemker SS, Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle., 2018; Journal of applied physiology (Bethesda, Md. : 1985). 125(5) 1424-1439. PMID: 30070607 | PMCID: PMC6295486

Tavakol DN, Broshkevitch CJ, Guilford WH, Peirce SM, Design and implementation of a student-taught course on research in regenerative medicine., 2018; Advances in physiology education. 42(2) 360-367. PMID: 29761714

Haskins RM, Nguyen AT, Alencar GF, Billaud M, Kelly-Goss MR, Good ME, Bottermann K, Klibanov AL, French BA, Harris TE, Peirce SM, Isakson BE, Owens GK, Klf4 has an unexpected protective role in perivascular cells within the microvasculature., 2018; American journal of physiology. Heart and circulatory physiology. 315(2) H402-H414. PMID: 29631369 | PMCID: PMC6139624

Danan D, Lehman CE, Mendez RE, Langford B, Koors PD, Dougherty MI, Peirce SM, Gioeli DG, Jameson MJ, Effect of Adipose-Derived Stem Cells on Head and Neck Squamous Cell Carcinoma., 2018; Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 158(5) 882-888. PMID: 29313435

Urner S, Kelly-Goss M, Peirce SM, Lammert E, Mechanotransduction in Blood and Lymphatic Vascular Development and Disease., 2018; Advances in pharmacology (San Diego, Calif.). 81() 155-208. PMID: 29310798

Janes KA, Chandran PL, Ford RM, Lazzara MJ, Papin JA, Peirce SM, Saucerman JJ, Lauffenburger DA, An engineering design approach to systems biology., 2017; Integrative biology : quantitative biosciences from nano to macro. 9(7) 574-583. PMID: 28590470 | PMCID: PMC6534349

Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE, Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke., 2017; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(5) 2381-2394. PMID: 29269399 | PMCID: PMC5901383

Call JA, Donet J, Martin KS, Sharma AK, Chen X, Zhang J, Cai J, Galarreta CA, Okutsu M, Du Z, Lira VA, Zhang M, Mehrad B, Annex BH, Klibanov AL, Bowler RP, Laubach VE, Peirce SM, Yan Z, Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice., 2017; Free radical biology & medicine. 113() 212-223. PMID: 28982599 | PMCID: PMC5740866

Henry CC, Martin KS, Ward BB, Handsfield GG, Peirce SM, Blemker SS, Spatial and age-related changes in the microstructure of dystrophic and healthy diaphragms., 2017; PloS one. 12(9) e0183853. PMID: 28877195 | PMCID: PMC5587283

Kelly-Goss MR, Ning B, Bruce AC, Tavakol DN, Yi D, Hu S, Yates PA, Peirce SM, Dynamic, heterogeneous endothelial Tie2 expression and capillary blood flow during microvascular remodeling., 2017; Scientific reports. 7(1) 9049. PMID: 28831080 | PMCID: PMC5567377

Walpole J, Mac Gabhann F, Peirce SM, Chappell JC, Agent-based computational model of retinal angiogenesis simulates microvascular network morphology as a function of pericyte coverage., 2017; Microcirculation (New York, N.Y. : 1994). 24(8) . PMID: 28791758 | PMCID: PMC5673505

Olenczak JB, Seaman SA, Lin KY, Pineros-Fernandez A, Davis CE, Salopek LS, Peirce SM, Cottler PS, Effects of Collagenase Digestion and Stromal Vascular Fraction Supplementation on Volume Retention of Fat Grafts., 2017; Annals of plastic surgery. 78(6) S335-S342. PMID: 28525415

Olingy CE, San Emeterio CL, Ogle ME, Krieger JR, Bruce AC, Pfau DD, Jordan BT, Peirce SM, Botchwey EA, Non-classical monocytes are biased progenitors of wound healing macrophages during soft tissue injury., 2017; Scientific reports. 7(1) 447. PMID: 28348370 | PMCID: PMC5428475

DeRosa CA, Seaman SA, Mathew AS, Gorick CM, Fan Z, Demas JN, Peirce SM, Fraser CL, Oxygen Sensing Difluoroboron β-Diketonate Polylactide Materials with Tunable Dynamic Ranges for Wound Imaging., 2017; ACS sensors. 1(11) 1366-1373. PMID: 28042606 | PMCID: PMC5189914

Adamson SE, Montgomery G, Seaman SA, Peirce-Cottler SM, Leitinger N, Myeloid P2Y2 receptor promotes acute inflammation but is dispensable for chronic high-fat diet-induced metabolic dysfunction., 2017; Purinergic signalling. 14(1) 19-26. PMID: 29086245 | PMCID: PMC5842150

Varhue WB, Langman L, Kelly-Goss M, Lataillade M, Brayman KL, Peirce-Cottler S, Swami NS, Deformability-based microfluidic separation of pancreatic islets from exocrine acinar tissue for transplant applications., 2017; Lab on a chip. 17(21) 3682-3691. PMID: 28975176

DeGeorge BR, Ning B, Salopek LS, Pineros-Fernandez A, Rodeheaver GT, Peirce-Cottler S, Hu S, Cottler PS, Campbell CA, Advanced Imaging Techniques for Investigation of Acellular Dermal Matrix Biointegration., 2017; Plastic and reconstructive surgery. 139(2) 395-405. PMID: 28121875

Murfee WL, Peirce SM, Microfluidics Technologies and Approaches for Studying the Microcirculation., 2017; Microcirculation (New York, N.Y. : 1994). 24(5) . PMID: 28470950

Martin KS, Virgilio KM, Peirce SM, Blemker SS, Computational Modeling of Muscle Regeneration and Adaptation to Advance Muscle Tissue Regeneration Strategies., 2016; Cells, tissues, organs. 202(3) 250-266. PMID: 27825162

Keller TC, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, Yeager M, Peirce SM, Hu S, Doctor A, Barrett E, Le TH, Columbus L, Isakson BE, Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX)., 2016; Hypertension (Dallas, Tex. : 1979). 68(6) 1494-1503. PMID: 27802421 | PMCID: PMC5159279

Seaman SA, Cao Y, Campbell CA, Peirce SM, Arteriogenesis in murine adipose tissue is contingent on CD68+ /CD206+ macrophages., 2016; Microcirculation (New York, N.Y. : 1994). 24(4) . PMID: 27976451 | PMCID: PMC5432396

Bruce AC, Cao Y, Henry C, Peirce SM, Laughon K, Preclinical Assessment of Safety and Efficacy of Fluorescent Dye for Detecting Dermal Injuries (the injuries were both abrasions and incision) in a Murine Model., 2016; Journal of forensic sciences. 61(6) 1493-1497. PMID: 27500887

Kingsmore KM, Logsdon DK, Floyd DH, Peirce SM, Purow BW, Munson JM, Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms., 2016; Integrative biology : quantitative biosciences from nano to macro. 8(12) 1246-1260. PMID: 27775742

Martin KS, Kegelman CD, Virgilio KM, Passipieri JA, Christ GJ, Blemker SS, Peirce SM, In Silico and In Vivo Experiments Reveal M-CSF Injections Accelerate Regeneration Following Muscle Laceration., 2016; Annals of biomedical engineering. 45(3) 747-760. PMID: 27718091

Chappell JC, Cluceru JG, Nesmith JE, Mouillesseaux KP, Bradley VB, Hartland CM, Hashambhoy-Ramsay YL, Walpole J, Peirce SM, Mac Gabhann F, Bautch VL, Flt-1 (VEGFR-1) coordinates discrete stages of blood vessel formation., 2016; Cardiovascular research. 111(1) 84-93. PMID: 27142980 | PMCID: PMC4909163

Cronk SM, Kelly-Goss MR, Ray HC, Mendel TA, Hoehn KL, Bruce AC, Dey BK, Guendel AM, Tavakol DN, Herman IM, Peirce SM, Yates PA, Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy., 2015; Stem cells translational medicine. 4(5) 459-67. PMID: 25769654 | PMCID: PMC4414213

Virgilio KM, Martin KS, Peirce SM, Blemker SS, Multiscale models of skeletal muscle reveal the complex effects of muscular dystrophy on tissue mechanics and damage susceptibility., 2015; Interface focus. 5(2) 20140080. PMID: 25844152 | PMCID: PMC4342948

Heuslein JL, Li X, Murrell KP, Annex BH, Peirce SM, Price RJ, Computational Network Model Prediction of Hemodynamic Alterations Due to Arteriolar Rarefaction and Estimation of Skeletal Muscle Perfusion in Peripheral Arterial Disease., 2015; Microcirculation (New York, N.Y. : 1994). 22(5) 360-9. PMID: 25866235 | PMCID: PMC4506703

Murfee WL, Sweat RS, Tsubota K, Mac Gabhann F, Khismatullin D, Peirce SM, Applications of computational models to better understand microvascular remodelling: a focus on biomechanical integration across scales., 2015; Interface focus. 5(2) 20140077. PMID: 25844149 | PMCID: PMC4342945

Seaman SA, Tannan SC, Cao Y, Peirce SM, Lin KY, Differential Effects of Processing Time and Duration of Collagenase Digestion on Human and Murine Fat Grafts., 2015; Plastic and reconstructive surgery. 136(2) 189e-99e. PMID: 26218393

Martin KS, Blemker SS, Peirce SM, Agent-based computational model investigates muscle-specific responses to disuse-induced atrophy., 2015; Journal of applied physiology (Bethesda, Md. : 1985). 118(10) 1299-309. PMID: 25722379 | PMCID: PMC4436981

Corliss BA, Azimi MS, Munson JM, Peirce SM, Murfee WL, Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis., 2015; Microcirculation (New York, N.Y. : 1994). 23(2) 95-121. PMID: 26614117 | PMCID: PMC4744134

Seaman SA, Cao Y, Campbell CA, Peirce SM, Macrophage Recruitment and Polarization During Collateral Vessel Remodeling in Murine Adipose Tissue., 2015; Microcirculation (New York, N.Y. : 1994). 23(1) 75-87. PMID: 26638986 | PMCID: PMC4707992

Seaman SA, Tannan SC, Cao Y, Peirce SM, Gampper TJ, Paradoxical Adipose Hyperplasia and Cellular Effects After Cryolipolysis: A Case Report., 2015; Aesthetic surgery journal. 36(1) NP6-13. PMID: 26590197 | PMCID: PMC4678995

Adamson SE, Meher AK, Chiu YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N, Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes., 2015; Molecular metabolism. 4(9) 610-8. PMID: 26413467 | PMCID: PMC4563021

Walpole J, Chappell JC, Cluceru JG, Mac Gabhann F, Bautch VL, Peirce SM, Agent-based model of angiogenesis simulates capillary sprout initiation in multicellular networks., 2015; Integrative biology : quantitative biosciences from nano to macro. () . PMID: 26158406

Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA, Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning., 2014; Acta biomaterialia. 10(11) 4704-14. PMID: 25128750 | PMCID: PMC4529737

Bruce AC, Kelly-Goss MR, Heuslein JL, Meisner JK, Price RJ, Peirce SM, Monocytes are recruited from venules during arteriogenesis in the murine spinotrapezius ligation model., 2014; Arteriosclerosis, thrombosis, and vascular biology. 34(9) 2012-22. PMID: 24969773 | PMCID: PMC4373588

Agrawal H, Shang H, Sattah AP, Yang N, Peirce SM, Katz AJ, Human adipose-derived stromal/stem cells demonstrate short-lived persistence after implantation in both an immunocompetent and an immunocompromised murine model., 2014; Stem cell research & therapy. 5(6) 142. PMID: 25523792 | PMCID: PMC4445497

Okutsu M, Call JA, Lira VA, Zhang M, Donet JA, French BA, Martin KS, Peirce-Cottler SM, Rembold CM, Annex BH, Yan Z, Extracellular superoxide dismutase ameliorates skeletal muscle abnormalities, cachexia, and exercise intolerance in mice with congestive heart failure., 2014; Circulation. Heart failure. 7(3) 519-30. PMID: 24523418 | PMCID: PMC4080303

Guendel AM, Martin KS, Cutts J, Foley PL, Bailey AM, Mac Gabhann F, Cardinal TR, Peirce SM, Murine spinotrapezius model to assess the impact of arteriolar ligation on microvascular function and remodeling., 2013; Journal of visualized experiments : JoVE. (73) e50218. PMID: 23486360 | PMCID: PMC3622090

Walpole J, Papin JA, Peirce SM, Multiscale computational models of complex biological systems., 2013; Annual review of biomedical engineering. 15() 137-54. PMID: 23642247 | PMCID: PMC3970111

Mendel TA, Clabough EB, Kao DS, Demidova-Rice TN, Durham JT, Zotter BC, Seaman SA, Cronk SM, Rakoczy EP, Katz AJ, Herman IM, Peirce SM, Yates PA, Pericytes derived from adipose-derived stem cells protect against retinal vasculopathy., 2013; PloS one. 8(5) e65691. PMID: 23741506 | PMCID: PMC3669216

Kelly-Goss MR, Sweat RS, Stapor PC, Peirce SM, Murfee WL, Targeting pericytes for angiogenic therapies., 2013; Microcirculation (New York, N.Y. : 1994). 21(4) 345-57. PMID: 24267154 | PMCID: PMC4079092

Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E, Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis., 2013; Proceedings of the National Academy of Sciences of the United States of America. 110(34) 13785-90. PMID: 23918395 | PMCID: PMC3752259

Taylor AC, Mendel TA, Mason KE, Degen KE, Yates PA, Peirce SM, Attenuation of ephrinB2 reverse signaling decreases vascularized area and preretinal vascular tuft formation in the murine model of oxygen-induced retinopathy., 2012; Investigative ophthalmology & visual science. 53(9) 5462-70. PMID: 22789927 | PMCID: PMC3948501

Yang M, Stapor PC, Peirce SM, Betancourt AM, Murfee WL, Rat mesentery exteriorization: a model for investigating the cellular dynamics involved in angiogenesis., 2012; Journal of visualized experiments : JoVE. (63) e3954. PMID: 22643964 | PMCID: PMC3466932

Peirce SM, Mac Gabhann F, Bautch VL, Integration of experimental and computational approaches to sprouting angiogenesis., 2012; Current opinion in hematology. 19(3) 184-91. PMID: 22406822 | PMCID: PMC4132663

Billaud M, Ross JA, Greyson MA, Bruce AC, Seaman SA, Heberlein KR, Han J, Best AK, Peirce SM, Isakson BE, A new method for in vivo visualization of vessel remodeling using a near-infrared dye., 2011; Microcirculation (New York, N.Y. : 1994). 18(3) 163-71. PMID: 21418375 | PMCID: PMC3081403

Seaman ME, Peirce SM, Kelly K, Rapid analysis of vessel elements (RAVE): a tool for studying physiologic, pathologic and tumor angiogenesis., 2011; PloS one. 6(6) e20807. PMID: 21694777 | PMCID: PMC3111429

Thorne BC, Hayenga HN, Humphrey JD, Peirce SM, Toward a multi-scale computational model of arterial adaptation in hypertension: verification of a multi-cell agent based model., 2011; Frontiers in physiology. 2() 20. PMID: 21720536 | PMCID: PMC3118494

Hayenga HN, Thorne BC, Peirce SM, Humphrey JD, Ensuring congruency in multiscale modeling: towards linking agent based and continuum biomechanical models of arterial adaptation., 2011; Annals of biomedical engineering. 39(11) 2669-82. PMID: 21809144 | PMCID: PMC3207323

Amos PJ, Mulvey CL, Seaman SA, Walpole J, Degen KE, Shang H, Katz AJ, Peirce SM, Hypoxic culture and in vivo inflammatory environments affect the assumption of pericyte characteristics by human adipose and bone marrow progenitor cells., 2011; American journal of physiology. Cell physiology. 301(6) C1378-88. PMID: 21865587 | PMCID: PMC3233793

Bruce AC, Peirce SM, Exogenous thrombin delivery promotes collateral capillary arterialization and tissue reperfusion in the murine spinotrapezius muscle ischemia model., 2011; Microcirculation (New York, N.Y. : 1994). 19(2) 143-54. PMID: 21954923 | PMCID: PMC3262124

Hashambhoy YL, Chappell JC, Peirce SM, Bautch VL, Mac Gabhann F, Computational modeling of interacting VEGF and soluble VEGF receptor concentration gradients., 2011; Frontiers in physiology. 2() 62. PMID: 22007175 | PMCID: PMC3185289

Morris E, Kesser BW, Peirce-Cottler S, Keeley M, Development and validation of a novel ear simulator to teach pneumatic otoscopy., 2011; Simulation in healthcare : journal of the Society for Simulation in Healthcare. 7(1) 22-6. PMID: 21937958

Glaw JT, Skalak TC, Peirce SM, Inhibition of canonical Wnt signaling increases microvascular hemorrhaging and venular remodeling in adult rats., 2010; Microcirculation (New York, N.Y. : 1994). 17(5) 348-57. PMID: 20618692 | PMCID: PMC2904644

Benedict KF, Mac Gabhann F, Amanfu RK, Chavali AK, Gianchandani EP, Glaw LS, Oberhardt MA, Thorne BC, Yang JH, Papin JA, Peirce SM, Saucerman JJ, Skalak TC, Systems analysis of small signaling modules relevant to eight human diseases., 2010; Annals of biomedical engineering. 39(2) 621-35. PMID: 21132372 | PMCID: PMC3033523

Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA, Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth., 2010; Tissue engineering. Part A. 17(5) 617-29. PMID: 20874260 | PMCID: PMC3043977

Mac Gabhann F, Peirce SM, Collateral capillary arterialization following arteriolar ligation in murine skeletal muscle., 2010; Microcirculation (New York, N.Y. : 1994). 17(5) 333-47. PMID: 20618691 | PMCID: PMC2907254

Taylor AC, Seltz LM, Yates PA, Peirce SM, Chronic whole-body hypoxia induces intussusceptive angiogenesis and microvascular remodeling in the mouse retina., 2010; Microvascular research. 79(2) 93-101. PMID: 20080108 | PMCID: PMC2828864

Bailey AM, Lawrence MB, Shang H, Katz AJ, Peirce SM, Agent-based model of therapeutic adipose-derived stromal cell trafficking during ischemia predicts ability to roll on P-selectin., 2009; PLoS computational biology. 5(2) e1000294. PMID: 19247427 | PMCID: PMC2636895

Volsky PG, Hughley BB, Peirce SM, Kesser BW, Construct validity of a simulator for myringotomy with ventilation tube insertion., 2009; Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 141(5) 603-608.e1. PMID: 19861198

Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA, FTY720 promotes local microvascular network formation and regeneration of cranial bone defects., 2009; Tissue engineering. Part A. 16(6) 1801-9. PMID: 20038198 | PMCID: PMC2949231

Amos PJ, Kapur SK, Stapor PC, Shang H, Bekiranov S, Khurgel M, Rodeheaver GT, Peirce SM, Katz AJ, Human adipose-derived stromal cells accelerate diabetic wound healing: impact of cell formulation and delivery., 2009; Tissue engineering. Part A. 16(5) 1595-606. PMID: 20038211 | PMCID: PMC2952117

Bailey AM, O'Neill TJ, Morris CE, Peirce SM, Arteriolar remodeling following ischemic injury extends from capillary to large arteriole in the microcirculation., 2008; Microcirculation (New York, N.Y. : 1994). 15(5) 389-404. PMID: 18574742 | PMCID: PMC3129987

Chavali AK, Gianchandani EP, Tung KS, Lawrence MB, Peirce SM, Papin JA, Characterizing emergent properties of immunological systems with multi-cellular rule-based computational modeling., 2008; Trends in immunology. 29(12) 589-99. PMID: 18964301

Birchenough SA, Rodeheaver GT, Morgan RF, Peirce SM, Katz AJ, Topical poloxamer-188 improves blood flow following thermal injury in rat mesenteric microvasculature., 2008; Annals of plastic surgery. 60(5) 584-8. PMID: 18434836

Peirce SM, Computational and mathematical modeling of angiogenesis., 2008; Microcirculation (New York, N.Y. : 1994). 15(8) 739-51. PMID: 18720228 | PMCID: PMC3125711

Amos PJ, Bailey AM, Shang H, Katz AJ, Lawrence MB, Peirce SM, Functional binding of human adipose-derived stromal cells: effects of extraction method and hypoxia pretreatment., 2008; Annals of plastic surgery. 60(4) 437-44. PMID: 18362576 | PMCID: PMC2829884

Thorne BC, Bailey AM, DeSimone DW, Peirce SM, Agent-based modeling of multicell morphogenic processes during development., 2008; Birth defects research. Part C, Embryo today : reviews. 81(4) 344-53. PMID: 18228259

Amos PJ, Shang H, Bailey AM, Taylor A, Katz AJ, Peirce SM, IFATS collection: The role of human adipose-derived stromal cells in inflammatory microvascular remodeling and evidence of a perivascular phenotype., 2008; Stem cells (Dayton, Ohio). 26(10) 2682-90. PMID: 18436860 | PMCID: PMC2672107

Thorne BC, Bailey AM, Peirce SM, Combining experiments with multi-cell agent-based modeling to study biological tissue patterning., 2007; Briefings in bioinformatics. 8(4) 245-57. PMID: 17584763

Bailey AM, Thorne BC, Peirce SM, Multi-cell agent-based simulation of the microvasculature to study the dynamics of circulating inflammatory cell trafficking., 2007; Annals of biomedical engineering. 35(6) 916-36. PMID: 17436112

Taylor AC, Murfee WL, Peirce SM, EphB4 expression along adult rat microvascular networks: EphB4 is more than a venous specific marker., 2007; Microcirculation (New York, N.Y. : 1994). 14(3) 253-67. PMID: 17454677

Robertson SH, Smith CK, Langhans AL, McLinden SE, Oberhardt MA, Jakab KR, Dzamba B, DeSimone DW, Papin JA, Peirce SM, Multiscale computational analysis of Xenopus laevis morphogenesis reveals key insights of systems-level behavior., 2007; BMC systems biology. 1() 46. PMID: 17953751 | PMCID: PMC2190763

Murfee WL, Rehorn MR, Peirce SM, Skalak TC, Perivascular cells along venules upregulate NG2 expression during microvascular remodeling., 2006; Microcirculation (New York, N.Y. : 1994). 13(3) 261-73. PMID: 16627368

Murfee WL, Skalak TC, Peirce SM, Differential arterial/venous expression of NG2 proteoglycan in perivascular cells along microvessels: identifying a venule-specific phenotype., 2005; Microcirculation (New York, N.Y. : 1994). 12(2) 151-60. PMID: 15824037

Peirce SM, Van Gieson EJ, Skalak TC, Multicellular simulation predicts microvascular patterning and in silico tissue assembly., 2004; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(6) 731-3. PMID: 14766791

Longo D, Peirce SM, Skalak TC, Davidson L, Marsden M, Dzamba B, DeSimone DW, Multicellular computer simulation of morphogenesis: blastocoel roof thinning and matrix assembly in Xenopus laevis., 2004; Developmental biology. 271(1) 210-22. PMID: 15196962

Peirce SM, Price RJ, Skalak TC, Spatial and temporal control of angiogenesis and arterialization using focal applications of VEGF164 and Ang-1., 2003; American journal of physiology. Heart and circulatory physiology. 286(3) H918-25. PMID: 14604856

Peirce SM, Skalak TC, Microvascular remodeling: a complex continuum spanning angiogenesis to arteriogenesis., 2003; Microcirculation (New York, N.Y. : 1994). 10(1) 99-111. PMID: 12610666

Hirschi KK, Skalak TC, Peirce SM, Little CD, Vascular assembly in natural and engineered tissues., 2002; Annals of the New York Academy of Sciences. 961() 223-42. PMID: 12081906

Peirce SM, Skalak TC, Rieger JM, Macdonald TL, Linden J, Selective A(2A) adenosine receptor activation reduces skin pressure ulcer formation and inflammation., 2001; American journal of physiology. Heart and circulatory physiology. 281(1) H67-74. PMID: 11406470

Peirce SM, Skalak TC, Rodeheaver GT, Ischemia-reperfusion injury in chronic pressure ulcer formation: a skin model in the rat., 2000; Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 8(1) 68-76. PMID: 10760216