Joseph Randall Moorman
- Email: rm3h@virginia.edu
- Phone: 434-982-3367
- Fax: 434-982-1998
Primary Appointment
Professor, Medicine- Cardiovascular Medicine
Education
- MD, Medicine, University of Mississippi
- Residency, Internal Medicine, Duke University Medical Center
- Chief Residency, Internal Medicine, Duke University Hospital
- Clinical Fellowship, Cardiology, Duke University Medical Center
Research Interests
Predictive analytics monitoring
Research Description
Our goal is to develop predictive monitoring for early diagnosis of subacute, potentially catastrophic illness. To date, our focus has been on premature infants in an intensive care unit.
The clinical problem that we first addressed is neonatal sepsis, a bacterial infection of the bloodstream in premature newborn infants in the intensive care unit. This illness is common and adds greatly to morbidity and mortality of these fragile patients, and is difficult to diagnose in its early and most treatable stages. We reasoned that continuous monitoring of a sensitive physiological measure like heart rate variability might show changes before obvious signs of a critical illness so advanced that therapy would not help.
We began by inspecting heart rate records over prolonged periods in infants at risk of sepsis. We found obvious changes in the heart rate characteristics of septic infants even before they were clinically ill, with reduced variability and transient decelerations similar to the findings in fetal distress. Since there were no measures available to detect these findings, we developed new mathematical techniques of sample entropy and sample asymmetry. We did clinical studies to develop predictive multivariate statistical models based on our new measures, and we validated them at a second medical center. We recently completed a multicenter randomized clinical trial of 3000 very low birthweight infants into to test the hypothesis that our monitoring system improves infantsâ outcomes. Indeed it does â monitored infants had a more than 20% reduction in mortality.
The scholarly output of this work has been more than 20 full-length clinical and mathematical papers, 2 Ph.D. degrees (Biomedical Engineering, Biophysics), and 5 Masters in Biomedical Engineering degrees funded by the National Institutes of Health, American Heart Association, Virginiaâs Center for Innovative Technology, the Coulter Foundation and the University of Virginia FEST Program and Childrenâs Medical Center.
We have 5 US, 2 European and 1 Canadian patents issued on this work, and more pending. Through the University of Virginia Patent Foundation, this technology was licensed in 1999, and is now in the hands of Medical Prediction Systems Corporation (MPSC), Charlottesville, with whom we have consulting and equity agreements. MPSC was formed as a Virginia C Corporation in 2002, successfully obtained 510(k) FDA clearance, and sells the HeRO (Heart Rate Observer) system with the indication of detecting reduced variability and transient decelerations in newborn infants. HeRO monitors are at work in more than 1000 beds in 17 NICUs.
The new work is to develop monitoring for neonatal apnea, another major cause of morbidity in the NICU. The current art is limited to clinical observations and to unwieldy bedside monitoring units. We have received an NIH GO grant to develop new mathematical algorithms for continuous quantitative analysis of apnea using sophisticated waveform analysis and statistical techniques.
We intend to carry these ideas into other clinical settings, especially hospital units in which continuous monitoring is already the standard of practice such as the CCU and SICU.
Another area of much interest and activity centers on atrial fibrillation, the most common sustained arrhythmia in adults. Here, the focus is on numerical analysis to lead to rapid diagnosis in implanted devices, and on clinical decision analysis using large databases of Holter monitor and comprehensive clinical features.
Personal Statement
The current effort focuses on early detection of imminent catastrophic deterioration in adult in ICUs and on hospital wards.
Selected Publications
2024
Barros, A., German-Mesner, I., Nguyen, N. R., & Moorman, J. R. (2024). Age Prediction From 12-lead Electrocardiograms Using Deep Learning: A Comparison of Four Models on a Contemporary, Freely Available Dataset.. medRxiv. doi:10.1101/2024.02.02.24302201
Barros, A., Lee, S. W., & Moorman, J. R. (2024). Cardiorespiratory Dynamics During Prone Positioning for Severe Ards: A Retrospective Cohort Study.. medRxiv. doi:10.1101/2024.01.30.24301935
Qiu, J., Di Fiore, J. M., Krishnamurthi, N., Indic, P., Carroll, J. L., Claure, N., . . . Lake, D. E. (2024). Highly comparative time series analysis of oxygen saturation and heart rate to predict respiratory outcomes in extremely preterm infants.. medRxiv. doi:10.1101/2024.01.24.24301724
2023
Formanack, A., Doshi, A., Valdez, R., Williams, I., Moorman, J. R., & Chernyavskiy, P. (2023). Race, Class, and Place Modify Mortality Rates for the Leading Causes of Death in the United States, 1999-2021. JOURNAL OF GENERAL INTERNAL MEDICINE, 38(12), 2686-2694. doi:10.1007/s11606-023-08062-1
Gadrey, S. M., Mohanty, P., Haughey, S. P., Jacobsen, B. A., Dubester, K. J., Webb, K. M., . . . Moorman, J. R. (2023). Overt and Occult Hypoxemia in Patients Hospitalized With COVID-19.. Critical care explorations, 5(1), e0825. doi:10.1097/cce.0000000000000825
Kausch, S. L., Brandberg, J. G., Qiu, J., Panda, A., Binai, A., Isler, J., . . . Sullivan, B. A. (2023). Cardiorespiratory signature of neonatal sepsis: development and validation of prediction models in 3 NICUs. PEDIATRIC RESEARCH, 93(7), 1913-1921. doi:10.1038/s41390-022-02444-7
Monfredi, O., Andris, R. T., Lake, D. E., & Moorman, J. R. (2023). A novel predictive analytics score reflecting accumulating disease burden-an investigation of the cumulative CoMET score. PHYSIOLOGICAL MEASUREMENT, 44(5). doi:10.1088/1361-6579/aca878
Horton, W. B. B., Hannah, E. E. E., Morales, F. L. L., Chaney, C. R. R., Krahn, K. N. N., Chernyavskiy, P., . . . Moorman, J. R. (2023). Accuracy of a Risk Alert Threshold for ICU Hypoglycemia: Retrospective Analysis of Alert Performance and Association With Clinical Deterioration Events. CRITICAL CARE MEDICINE, 51(1), 136-140. doi:10.1097/CCM.0000000000005713
Monfredi, O. J., Moore, C. C., Sullivan, B. A., Keim-Malpass, J., Fairchild, K. D., Loftus, T. J., . . . Clermont, G. (2023). Continuous ECG monitoring should be the heart of bedside AI-based predictive analytics monitoring for early detection of clinical deterioration. JOURNAL OF ELECTROCARDIOLOGY, 76, 35-38. doi:10.1016/j.jelectrocard.2022.10.011
2022
Gadrey, S. M., Mohanty, P., Haughey, S. P., Jacobsen, B. A., Dubester, K. J., Webb, K. M., . . . Moorman, J. R. (2022). Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019.. medRxiv. doi:10.1101/2022.06.14.22276166
Niestroy, J. C., Moorman, J. R., Levinson, M. A., Al Manir, S., Clark, T. W., Fairchild, K. D., & Lake, D. E. (2022). Discovery of signatures of fatal neonatal illness in vital signs using highly comparative time-series analysis. NPJ DIGITAL MEDICINE, 5(1). doi:10.1038/s41746-021-00551-z
Loftus, T. J., Tighe, P. J., Ozrazgat-Baslanti, T., Davis, J. P., Ruppert, M. M., Ren, Y., . . . Bihorac, A. (2022). Ideal algorithms in healthcare: Explainable, dynamic, precise, autonomous, fair, and reproducible.. PLOS digital health, 1(1), e0000006. doi:10.1371/journal.pdig.0000006
Spaeder, M. C. C., Moorman, J. R., Moorman, L. P., Adu-Darko, M. A. A., Keim-Malpass, J., Lake, D. E. E., & Clark, M. T. T. (2022). Signatures of illness in children requiring unplanned intubation in the pediatric intensive care unit: A retrospective cohort machine-learning study. FRONTIERS IN PEDIATRICS, 10. doi:10.3389/fped.2022.1016269
Loftus, T. J., Shickel, B., Balch, J. A., Tighe, P. J., Abbott, K. L., Fazzone, B., . . . Bihorac, A. (2022). Phenotype clustering in health care: A narrative review for clinicians. FRONTIERS IN ARTIFICIAL INTELLIGENCE, 5. doi:10.3389/frai.2022.842306
Ack, S. E., Loiseau, S. Y., Sharma, G., Goldstein, J. N., Lissak, I. A., Duffy, S. M., . . . Rosenthal, E. S. (2022). Neurocritical Care Performance Measures Derived from Electronic Health Record Data are Feasible and Reveal Site-Specific Variation: A CHoRUS Pilot Project. NEUROCRITICAL CARE, 37(SUPPL 2), 276-290. doi:10.1007/s12028-022-01497-0
Moorman, J. R. (2022). The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU. NPJ DIGITAL MEDICINE, 5(1). doi:10.1038/s41746-022-00584-y
Pokaprakarn, T., Kitzmiller, R. R., Moorman, J. R., Lake, D. E., Krishnamurthy, A. K., & Kosorok, M. R. (2022). Sequence to Sequence ECG Cardiac Rhythm Classification Using Convolutional Recurrent Neural Networks. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 26(2), 572-580. doi:10.1109/JBHI.2021.3098662
Ashe, W. B., Innis, S. E., Shanno, J. N., Hochheimer, C. J., Williams, R. D., Ratcliffe, S. J., . . . Gadrey, S. M. (2022). Analysis of respiratory kinematics: a method to characterize breaths from motion signals. PHYSIOLOGICAL MEASUREMENT, 43(1). doi:10.1088/1361-6579/ac4d1a
Horton, W. B., Barros, A. J., Andris, R. T., Clark, M. T., & Moorman, J. R. (2022). Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation. CRITICAL CARE MEDICINE, 50(3), E221-E230. doi:10.1097/CCM.0000000000005171
2021
Zimmet, A. M., Sullivan, B. A., Fairchild, K. D., Moorman, J. R., Isler, J. R., Wallman-Stokes, A. W., . . . Lake, D. E. (2021). Vital sign metrics of VLBW infants in three NICUs: implications for predictive algorithms. PEDIATRIC RESEARCH, 90(1), 125-130. doi:10.1038/s41390-021-01428-3
Callcut, R. A., Xu, Y., Moorman, J. R., Tsai, C., Villaroman, A., Robles, A. J., . . . Clark, M. T. (2021). External validation of a novel signature of illness in continuous cardiorespiratory monitoring to detect early respiratory deterioration of ICU patients. PHYSIOLOGICAL MEASUREMENT, 42(9). doi:10.1088/1361-6579/ac2264
Monfredi, O., Keim-Malpass, J., & Moorman, J. R. (2021). Continuous cardiorespiratory monitoring is a dominant source of predictive signal in machine learning for risk stratification and clinical decision support. PHYSIOLOGICAL MEASUREMENT, 42(9). doi:10.1088/1361-6579/ac2130
Levinson, M. A., Niestroy, J., Al Manir, S., Fairchild, K., Lake, D. E., Moorman, J. R., & Clark, T. (2021). FAIRSCAPE: a Framework for FAIR and Reproducible Biomedical Analytics. NEUROINFORMATICS. doi:10.1007/s12021-021-09529-4
Zimmet, A. M., Sullivan, B. A., Fairchild, K. D., Moorman, J. R., Isler, J. R., Wallman-Stokes, A. W., . . . Lake, D. E. (2021). Vital sign metrics of VLBW infants in three NICUs: implications for predictive algorithms (Mar, 10.1038/s41390021-01428-3, 2021). PEDIATRIC RESEARCH, 90(1), 233. doi:10.1038/s41390-021-01621-4
Keim-Malpass, J., Ratcliffe, S. J., Moorman, L. P., Clark, M. T., Krahn, K. N., Monfredi, O. J., . . . Bourque, J. M. (2021). Predictive Monitoring-Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial. JMIR RESEARCH PROTOCOLS, 10(7). doi:10.2196/29631
Laird, P., Wertz, A., Welter, G., Maslove, D., Hamilton, A., Heung Yoon, J., . . . Clermont, G. (2021). The critical care data exchange format: a proposed flexible data standard for combining clinical and high-frequency physiologic data in critical care. PHYSIOLOGICAL MEASUREMENT, 42(6). doi:10.1088/1361-6579/abfc9b
Kausch, S. L., Moorman, J. R., Lake, D. E., & Keim-Malpass, J. (2021). Physiological machine learning models for prediction of sepsis in hospitalized adults: An integrative review. INTENSIVE AND CRITICAL CARE NURSING, 65. doi:10.1016/j.iccn.2021.103035
Kowalski, R. L., Lee, L., Spaeder, M. C., Moorman, J. R., & Keim-Malpass, J. (2021). Accuracy and Monitoring of Pediatric Early Warning Score (PEWS) Scores Prior to Emergent Pediatric Intensive Care Unit (ICU) Transfer: Retrospective Analysis. JMIR PEDIATRICS AND PARENTING, 4(1). doi:10.2196/25991
Sullivan, B. A., Nagraj, V. P., Berry, K. L., Fleiss, N., Rambhia, A., Kumar, R., . . . Fairchild, K. D. (2021). Clinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs.. Journal of neonatal-perinatal medicine, 14(4), 553-561. doi:10.3233/npm-200578
Nagraj, V. P., Lake, D. E., Kuhn, L., Moorman, J. R., & Fairchild, K. D. (2021). Central Apnea of Prematurity: Does Sex Matter?. AMERICAN JOURNAL OF PERINATOLOGY, 38(13), 1428-1434. doi:10.1055/s-0040-1713405
2020
Davis, J. P., Wessells, D. A., & Moorman, J. R. (2020). Coronavirus Disease 2019 Calls for Predictive Analytics Monitoring-A New Kind of Illness Scoring System.. Critical care explorations, 2(12), e0294. doi:10.1097/cce.0000000000000294
Fairchild, K. D., Nagraj, V. P., Sullivan, B. A., Moorman, J. R., & Lake, D. E. (2020). Correction: Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia.. Pediatric research, 88(5), 820. doi:10.1038/s41390-020-0821-x
Nagraj, V. P., Sinkin, R. A., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2020). Correction: Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?. Pediatric research, 88(5), 821. doi:10.1038/s41390-020-0822-9
Zimmet, A. N., Clark, M. T., Gadrey, S. M., Bell, T. D., Zimmet, A. M., Moorman, J. R., & Moore, C. C. (2020). Pathophysiologic Signatures of Bloodstream Infection in Critically Ill Adults.. Critical care explorations, 2(10), e0191. doi:10.1097/cce.0000000000000191
Gadrey, S. M., Clay, R., Zimmet, A. N., Lawson, A. S., Oliver, S. F., Richardson, E. D., . . . Moorman, J. R. (2020). The Relationship Between Acuity of Organ Failure and Predictive Validity of Sepsis-3 Criteria.. Critical care explorations, 2(10), e0199. doi:10.1097/cce.0000000000000199
Blackwell, J. N., Keim-Malpass, J., Clark, M. T., Kowalski, R. L., Najjar, S. N., Bourque, J. M., . . . Moorman, J. R. (2020). Early Detection of In-Patient Deterioration: One Prediction Model Does Not Fit All.. Critical care explorations, 2(5), e0116. doi:10.1097/cce.0000000000000116
Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., . . . Maslove, D. M. (2020). Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. CRITICAL CARE MEDICINE, 48(5), 623-633. doi:10.1097/CCM.0000000000004246
Keim-Malpass, J., Sullivan, B. A., & Moorman, J. R. (2020). Continuous Pulse Oximetry Monitoring in Bronchiolitis Patients Not Receiving Oxygen. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 324(13), 1349-1350. doi:10.1001/jama.2020.12740
Lensen, I. S., Monfredi, O. J., Andris, R. T., Lake, D. E., & Moorman, J. R. (2020). Heart rate fragmentation gives novel insights into non-autonomic mechanisms governing beat-to-beat control of the heart's rhythm. JRSM CARDIOVASCULAR DISEASE, 9. doi:10.1177/2048004020948732
Zimmet, A. M., Sullivan, B. A., Moorman, J. R., Lake, D. E., & Ratcliffe, S. J. (2020). Trajectories of the heart rate characteristics index, a physiomarker of sepsis in premature infants, predict Neonatal ICU mortality. JRSM CARDIOVASCULAR DISEASE, 9. doi:10.1177/2048004020945142
Schelonka, R. L., Carlo, W. A., Bauer, C. R., Peralta-Carcelen, M., Phillips, V., Helderman, J., . . . O'Shea, T. M. (2020). Mortality and Neurodevelopmental Outcomes in the Heart Rate Characteristics Monitoring Randomized Controlled Trial. JOURNAL OF PEDIATRICS, 219, 48-53. doi:10.1016/j.jpeds.2019.12.066
Alonzo, C. J., Nagraj, V. P., Zschaebitz, J. V., Lake, D. E., Moorman, J. R., & Spaeder, M. C. (2020). Blood pressure ranges via non-invasive and invasive monitoring techniques in premature neonates using high resolution physiologic data.. Journal of neonatal-perinatal medicine, 13(3), 351-358. doi:10.3233/npm-190260
Keim-Malpass, J., Clark, M. T., Lake, D. E., & Moorman, J. R. (2020). Towards development of alert thresholds for clinical deterioration using continuous predictive analytics monitoring. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 34(4), 797-804. doi:10.1007/s10877-019-00361-5
2019
Gadrey, S. M., Lau, C. E., Clay, R., Rhodes, G. T., Lake, D. E., Moore, C. C., . . . Moorman, J. R. (2019). Imputation of partial pressures of arterial oxygen using oximetry and its impact on sepsis diagnosis. PHYSIOLOGICAL MEASUREMENT, 40(11). doi:10.1088/1361-6579/ab5154
Spaeder, M. C., Moorman, J. R., Tran, C. A., Keim-Malpass, J., Zschaebitz, J. V., Lake, D. E., & Clark, M. T. (2019). Predictive analytics in the pediatric intensive care unit for early identification of sepsis: capturing the context of age. PEDIATRIC RESEARCH, 86(5), 655-661. doi:10.1038/s41390-019-0518-1
Nagraj, V. P., Sinkin, R. A., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2019). Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?. PEDIATRIC RESEARCH, 86(5), 622-627. doi:10.1038/s41390-019-0488-3
Kitzmiller, R. R., Vaughan, A., Skeeles-Worley, A., Keim-Malpass, J., Yap, T. L., Lindberg, C., . . . Moorman, J. R. (2019). Diffusing an Innovation: Clinician Perceptions of Continuous Predictive Analytics Monitoring in Intensive Care. APPLIED CLINICAL INFORMATICS, 10(2), 295-306. doi:10.1055/s-0039-1688478
Dennery, P. A., Di Fiore, J. M., Ambalavanan, N., Bancalari, E., Carroll, J. L., Claure, N., . . . Moorman, J. R. (2019). Pre-Vent: the prematurity-related ventilatory control study. PEDIATRIC RESEARCH, 85(6), 769-776. doi:10.1038/s41390-019-0317-8
Fairchild, K. D., Nagraj, V. P., Sullivan, B. A., Moorman, J. R., & Lake, D. E. (2019). Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia. PEDIATRIC RESEARCH, 85(7), 987-993. doi:10.1038/s41390-018-0223-5
Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., . . . Vincent, J. -L. (2019). Control of Confounding and Reporting of Results in Causal Inference Studies Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals. ANNALS OF THE AMERICAN THORACIC SOCIETY, 16(1), 22-28. doi:10.1513/AnnalsATS.201808-564PS
Ruminski, C. M., Clark, M. T., Lake, D. E., Kitzmiller, R. R., Keim-Malpass, J., Robertson, M. P., . . . Calland, J. F. (2019). Impact of predictive analytics based on continuous cardiorespiratory monitoring in a surgical and trauma intensive care unit. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 33(4), 703-711. doi:10.1007/s10877-018-0194-4
2018
Vesoulis, Z. A., Bank, R. L., Lake, D., Wallman-Stokes, A., Sahni, R., Moorman, J. R., . . . Mathur, A. M. (2019). Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants. JOURNAL OF PERINATOLOGY, 39(1), 48-53. doi:10.1038/s41372-018-0236-2
Alonzo, C. J., Nagraj, V. P., Zschaebitz, J. V., Lake, D. E., Moorman, J. R., & Spaeder, M. C. (2018). Heart rate ranges in premature neonates using high resolution physiologic data. JOURNAL OF PERINATOLOGY, 38(9), 1242-1245. doi:10.1038/s41372-018-0156-1
Sullivan, B. A., Wallman-Stokes, A., Isler, J., Sahni, R., Moorman, J. R., Fairchild, K. D., & Lake, D. E. (2018). Early Pulse Oximetry Data Improves Prediction of Death and Adverse Outcomes in a Two-Center Cohort of Very Low Birth Weight Infants. AMERICAN JOURNAL OF PERINATOLOGY, 35(13), 1331-1338. doi:10.1055/s-0038-1654712
Blackburn, H. N., Clark, M. T., Moorman, J. R., Lake, D. E., & Calland, J. F. (2018). Identifying the low risk patient in surgical intensive and intermediate care units using continuous monitoring. SURGERY, 163(4), 811-818. doi:10.1016/j.surg.2017.08.022
Moorman, J. R. (2018). A crossroads in predictive analytics monitoring for clinical medicine. JOURNAL OF ELECTROCARDIOLOGY, 51(6), S52-S55. doi:10.1016/j.jelectrocard.2018.07.023
Keim-Malpass, J., Kitzmiller, R. R., Skeeles-Worley, A., Lindberg, C., Clark, M. T., Tai, R., . . . Anderson, R. A. (2018). Advancing Continuous Predictive Analytics Monitoring Moving from Implementation to Clinical Action in a Learning Health System. CRITICAL CARE NURSING CLINICS OF NORTH AMERICA, 30(2), 273-+. doi:10.1016/j.cnc.2018.02.009
2017
Moss, T. J., Calland, J. F., Enfield, K. B., Gomez-Manjarres, D. C., Ruminski, C., DiMarco, J. P., . . . Moorman, J. R. (2017). New-Onset Atrial Fibrillation in the Critically Ill. CRITICAL CARE MEDICINE, 45(5), 790-797. doi:10.1097/CCM.0000000000002325
De Pasquale, M., Moss, T. J., Cerutti, S., Calland, J. F., Lake, D. E., Moorman, J. R., & Ferrario, M. (2017). Hemorrhage Prediction Models in Surgical Intensive Care: Bedside Monitoring Data Adds Information to Lab Values. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 21(6), 1703-1710. doi:10.1109/JBHI.2017.2653849
Moss, T. J., Lake, D. E., & Moorman, J. R. (2017). An Overlook of New-Onset Atrial Fibrillation in the Critically Ill Using Automated Detection: Have We Over Looked at It? Reply. CRITICAL CARE MEDICINE, 45(11), E1195-E1196. doi:10.1097/CCM.0000000000002664
Moss, T. J., Clark, M. T., Calland, J. F., Enfield, K. B., Voss, J. D., Lake, D. E., & Moorman, J. R. (2017). Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: A retrospective cohort study. PLOS ONE, 12(8). doi:10.1371/journal.pone.0181448
Moorman, J. R., & Lake, D. E. (2017). An Ejection Fraction Measurement for the Masses. CRITICAL CARE MEDICINE, 45(7), 1240-1241. doi:10.1097/CCM.0000000000002492
Fairchild, K. D., Lake, D. E., Kattwinkel, J., Moorman, J. R., Bateman, D. A., Grieve, P. G., . . . Sahni, R. (2017). Vital signs and their cross-correlation in sepsis and NEC: a study of 1,065 very-low-birth-weight infants in two NICUs. PEDIATRIC RESEARCH, 81(2), 315-321. doi:10.1038/pr.2016.215
Blackburn, H. N., Clark, M. T., Moss, T. J., Young, J. S., Moorman, J. R., Lake, D. E., & Calland, J. F. (2017). External validation in an intermediate unit of a respiratory decompensation model trained in an intensive care unit. SURGERY, 161(3), 760-770. doi:10.1016/j.surg.2016.09.018
2016
Moss, T. J., Lake, D. E., Calland, J. F., Enfield, K. B., Delos, J. B., Fairchild, K. D., & Moorman, J. R. (2016). Signatures of Subacute Potentially Catastrophic Illness in the ICU: Model Development and Validation. CRITICAL CARE MEDICINE, 44(9), 1639-1648. doi:10.1097/CCM.0000000000001738
Moorman, J. R., Lake, D. E., & Ivanov, P. C. (2016). Early Detection of Sepsis-A Role for Network Physiology?. CRITICAL CARE MEDICINE, 44(5), E312-E313. doi:10.1097/CCM.0000000000001548
Sullivan, B. A., McClure, C., Hicks, J., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2016). Early Heart Rate Characteristics Predict Death and Morbidities in Preterm Infants. JOURNAL OF PEDIATRICS, 174, 57-62. doi:10.1016/j.jpeds.2016.03.042
Owens, J. E., Schorling, J., Plews-Ogan, M., Goodman, M., Moorman, R., Zaklin, R., & Dent, J. (2016). A randomized controlled trial evaluating Mindfulness-Based Stress Reduction (MBSR) for the treatment of palpitations: A pilot study. INTERNATIONAL JOURNAL OF CARDIOLOGY, 223, 25-27. doi:10.1016/j.ijcard.2016.08.183
Moorman, J. R., Lake, D. E., & Moss, T. J. (2016). Computers in White Coats: How to Devise Useful Clinical Decision Support Software. CRITICAL CARE MEDICINE, 44(7), 1449-1450. doi:10.1097/CCM.0000000000001781
DeMazumder, D., Limpitikul, W. B., Dorante, M., Dey, S., Mukhopadhyay, B., Zhang, Y., . . . Tomaselli, G. F. (2016). Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death. EUROPACE, 18(12), 1818-1828. doi:10.1093/europace/euv399
Patel, M., Mohr, M., Lake, D., Delos, J., Moorman, J. R., Sinkin, R. A., . . . Fairchild, K. (2016). Clinical associations with immature breathing in preterm infants: part 2-periodic breathing. PEDIATRIC RESEARCH, 80(1), 28-34. doi:10.1038/pr.2016.58
Fairchild, K., Mohr, M., Paget-Brown, A., Tabacaru, C., Lake, D., Delos, J., . . . Kattwinkel, J. (2016). Clinical associations of immature breathing in preterm infants: part 1-central apnea. PEDIATRIC RESEARCH, 80(1), 21-27. doi:10.1038/pr.2016.43
Clark, M. T., Delos, J. B., Lake, D. E., Lee, H., Fairchild, K. D., Kattwinkel, J., & Moorman, J. R. (2016). Stochastic modeling of central apnea events in preterm infants. PHYSIOLOGICAL MEASUREMENT, 37(4), 463-484. doi:10.1088/0967-3334/37/4/463
2015
Carrara, M., Carozzi, L., Moss, T. J., de Pasquale, M., Cerutti, S., Ferrario, M., . . . Moorman, J. R. (2015). Heart rate dynamics distinguish among atrial fibrillation, normal sinus rhythm and sinus rhythm with frequent ectopy. PHYSIOLOGICAL MEASUREMENT, 36(9), 1873-1888. doi:10.1088/0967-3334/36/9/1873
Moss, T. J., Clark, M. T., Lake, D. E., Moorman, J. R., & Calland, J. F. (2015). Heart rate dynamics preceding hemorrhage in the intensive care unit. JOURNAL OF ELECTROCARDIOLOGY, 48(6), 1075-1080. doi:10.1016/j.jelectrocard.2015.08.007
Carrara, M., Carozzi, L., Moss, T. J., de Pasquale, M., Cerutti, S., Lake, D. E., . . . Ferrario, M. (2015). Classification of cardiac rhythm using heart rate dynamical measures: validation in MIT-BIH databases. JOURNAL OF ELECTROCARDIOLOGY, 48(6), 943-946. doi:10.1016/j.jelectrocard.2015.08.002
Mohr, M. A., Fairchild, K. D., Patel, M., Sinkin, R. A., Clark, M. T., Moorman, J. R., . . . Delos, J. B. (2015). Quantification of periodic breathing in premature infants. PHYSIOLOGICAL MEASUREMENT, 36(7), 1415-1427. doi:10.1088/0967-3334/36/7/1415
Mohr, M. A., Vergales, B. D., Lee, H., Clark, M. T., Lake, D. E., Mennen, A. C., . . . Delos, J. B. (2015). Very long apnea events in preterm infants. JOURNAL OF APPLIED PHYSIOLOGY, 118(5), 558-568. doi:10.1152/japplphysiol.00144.2014
2014
Hussain, S., Moorman, L., Moorman, J. R., DiMarco, J. P., Malhotra, R., Darby, A., . . . Mason, P. K. (2015). Cost of a Recall of a Single-Center Experience Managing the Riata Defibrillator Lead. AMERICAN JOURNAL OF CARDIOLOGY, 115(2), 206-208. doi:10.1016/j.amjcard.2014.10.028
Bilchick, K. C., Kuruvilla, S., Hamirani, Y. S., Ramachandran, R., Clarke, S. A., Parker, K. M., . . . Epstein, F. H. (2014). Impact of Mechanical Activation, Scar, and Electrical Timing on Cardiac Resynchronization Therapy Response and Clinical Outcomes. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(16), 1657-1666. doi:10.1016/j.jacc.2014.02.533
Sullivan, B. A., Grice, S. M., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2014). Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. JOURNAL OF PEDIATRICS, 164(4), 775-780. doi:10.1016/j.jpeds.2013.11.038
Moorman, J. R. (2014). The modern age of Physiological Measurement. PHYSIOLOGICAL MEASUREMENT, 35(2), 93-94. doi:10.1088/0967-3334/35/2/93
Lake, D. E., Fairchild, K. D., & Moorman, J. R. (2014). Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 28(4), 329-339. doi:10.1007/s10877-013-9530-x
Fairchild, K. D., Sinkin, R. A., Davalian, F., Blackman, A. E., Swanson, J. R., Matsumoto, J. A., . . . Blackman, J. A. (2014). Abnormal heart rate characteristics are associated with abnormal neuroimaging and outcomes in extremely low birth weight infants. JOURNAL OF PERINATOLOGY, 34(5), 375-379. doi:10.1038/jp.2014.18
Moss, T. J., Lake, D. E., & Moorman, J. R. (2014). Local dynamics of heart rate: detection and prognostic implications. PHYSIOLOGICAL MEASUREMENT, 35(10), 1929-1942. doi:10.1088/0967-3334/35/10/1929
2013
Vergales, B. D., Zanelli, S. A., Matsumoto, J. A., Goodkin, H. P., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2014). Depressed Heart Rate Variability is Associated with Abnormal EEG, MRI, and Death in Neonates with Hypoxic Ischemic Encephalopathy. AMERICAN JOURNAL OF PERINATOLOGY, 31(10), 855-861. doi:10.1055/s-0033-1361937
Politano, A. D., Riccio, L. M., Lake, D. E., Rusin, C. G., Guin, L. E., Josef, C. S., . . . Calland, J. E. (2013). Predicting the need for urgent intubation in a surgical/trauma intensive care unit. SURGERY, 154(5), 1110-1116. doi:10.1016/j.surg.2013.05.025
Stone, M. L., Tatum, P. M., Weitkamp, J. -H., Mukherjee, A. B., Attridge, J., McGahren, E. D., . . . Fairchild, K. D. (2013). Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis. JOURNAL OF PERINATOLOGY, 33(11), 847-850. doi:10.1038/jp.2013.63
Vergales, B. D., Paget-Brown, A. O., Lee, H., Guin, L. E., Smoot, T. J., Rusin, C. G., . . . Kattwinkel, J. (2014). Accurate Automated Apnea Analysis in Preterm Infants. AMERICAN JOURNAL OF PERINATOLOGY, 31(2), 156-162. doi:10.1055/s-0033-1343769
DeMazumder, D., Lake, D. E., Cheng, A., Moss, T. J., Guallar, E., Weiss, R. G., . . . Moorman, J. R. (2013). Dynamic Analysis of Cardiac Rhythms for Discriminating Atrial Fibrillation From Lethal Ventricular Arrhythmias. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 6(3), 555-561. doi:10.1161/CIRCEP.113.000034
Clark, M. T., Vergales, B. D., Paget-Brown, A. O., Smoot, T. J., Lake, D. E., Hudson, J. L., . . . Moorman, J. R. (2013). Predictive Monitoring for respiratory decompensation leading to urgent unplanned intubation in the neonatal intensive care unit. PEDIATRIC RESEARCH, 73(1), 104-110. doi:10.1038/pr.2012.155
Fairchild, K. D., Schelonka, R. L., Kaufman, D. A., Carlo, W. A., Kattwinkel, J., Porcelli, P. J., . . . Moorman, J. R. (2013). Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial. PEDIATRIC RESEARCH, 74(5), 570-575. doi:10.1038/pr.2013.136
2012
Moorman, L. P., Moorman, J. R., DiMarco, J. P., Malhotra, R., Darby, A., Bilchick, K., . . . Mason, P. K. (2013). Increasing lead burden correlates with externalized cables during systematic fluoroscopic screening of Riata leads. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 37(1), 63-68. doi:10.1007/s10840-012-9760-8
Rusin, C., & Moorman, R. (2012). Distributed cluster computing system for recording and processing physiological data in the intensive care unit. Journal of Critical Care, 27(3), e4-e5. doi:10.1016/j.jcrc.2012.01.020
Mason, P. K., Lake, D. E., DiMarco, J. P., Ferguson, J. D., Mangrum, J. M., Bilchick, K., . . . Moorman, J. R. (2012). Impact of the CHA2DS2-VASc Score on Anticoagulation Recommendations for Atrial Fibrillation. AMERICAN JOURNAL OF MEDICINE, 125(6). doi:10.1016/j.amjmed.2011.09.030
Lake, D. E., Fairchild, K. D., Kattwinkel, J., & Moorman, J. R. (2012). Heart rate predicts sepsis Reply. JOURNAL OF PEDIATRICS, 161(4), 770-771. doi:10.1016/j.jpeds.2012.07.021
Lee, H., Rusin, C. G., Lake, D. E., Clark, M. T., Guin, L., Smoot, T. J., . . . Delos, J. B. (2012). A new algorithm for detecting central apnea in neonates. PHYSIOLOGICAL MEASUREMENT, 33(1), 1-17. doi:10.1088/0967-3334/33/1/1
DeMazumder, D., Limpitikul, W., Dorante, M., Mukhopadhyay, B., Dey, S., Berger, R. D., . . . Tomaselli, G. F. (2012). A Novel Strategy Based on Dynamic Analysis of Cardiac Repolarization Predicts Mortality in Patients with Implantable Cardioverter-Defibrillators. CIRCULATION, 126(21).
Clark, M. T., Rusin, C. G., Hudson, J. L., Lee, H., Delos, J. B., Guin, L. E., . . . Moorman, J. R. (2012). Breath-by-breath analysis of cardiorespiratory interaction for quantifying developmental maturity in premature infants. JOURNAL OF APPLIED PHYSIOLOGY, 112(5), 859-867. doi:10.1152/japplphysiol.01152.2011
Zagol, K., Lake, D. E., Vergales, B., Moorman, M. E., Paget-Brown, A., Lee, H., . . . Kattwinkel, J. (2012). Anemia, Apnea of Prematurity, and Blood Transfusions. JOURNAL OF PEDIATRICS, 161(3), 417-+. doi:10.1016/j.jpeds.2012.02.044
Raynor, L. L., Saucerman, J. J., Akinola, M. O., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2012). Cytokine screening identifies NICU patients with Gram-negative bacteremia. PEDIATRIC RESEARCH, 71(3), 261-266. doi:10.1038/pr.2011.45
2011
Moorman, J. R., Delos, J. B., Flower, A. A., Cao, H., Kovatchev, B. P., Richman, J. S., & Lake, D. E. (2011). Cardiovascular oscillations at the bedside: early diagnosis of neonatal sepsis using heart rate characteristics monitoring. PHYSIOLOGICAL MEASUREMENT, 32(11), 1821-1832. doi:10.1088/0967-3334/32/11/S08
Moorman, J. R., Carlo, W. A., Kattwinkel, J., Schelonka, R. L., Porcelli, P. J., Navarrete, C. T., . . . O'Shea, T. M. (2011). Mortality Reduction by Heart Rate Characteristic Monitoring in Very Low Birth Weight Neonates: A Randomized Trial. JOURNAL OF PEDIATRICS, 159(6), 900-U53. doi:10.1016/j.jpeds.2011.06.044
Mason, P. K., Dimarco, J. P., Ferguson, J. D., Mahapatra, S., Mangrum, J. M., Bilchick, K. C., . . . Bergin, J. D. (2011). Sonication of Explanted Cardiac Rhythm Management Devices for the Diagnosis of Pocket Infections and Asymptomatic Bacterial Colonization. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 34(2), 143-149. doi:10.1111/j.1540-8159.2010.02820.x
Fairchild, K. D., Srinivasan, V., Moorman, J. R., Gaykema, R. P. A., & Goehler, L. E. (2011). Pathogen-induced heart rate changes associated with cholinergic nervous system activation. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 300(2), R330-R339. doi:10.1152/ajpregu.00487.2010
Lake, D. E., Fairchild, K. D., Delos, J. B., Lee, H., Rusin, C. G., Guin, L. E., . . . Moorman, J. R. (2011). HEART RATE CHARACTERISTICS MONITORING AND CENTRAL NEONATAL APNEA. PEDIATRIC RESEARCH, 70, 689. doi:10.1038/pr.2011.914
Moorman, J. R., Carlo, W. A., Kattwinkel, J., Schelonka, R. L., Porcelli, P. J., Navarrete, C. T., . . . O'Shea, T. M. (2011). LONG-TERM FORECASTING OF DEATH IN THE NEONATAL ICU USING HEART RATE CHARACTERISTICS MONITORING AND CLINICAL DATA. PEDIATRIC RESEARCH, 70, 37. doi:10.1038/pr.2011.262
Lake, D. E., & Moorman, J. R. (2011). Accurate estimation of entropy in very short physiological time series: the problem of atrial fibrillation detection in implanted ventricular devices. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(1), H319-H325. doi:10.1152/ajpheart.00561.2010
Moorman, J. R., Rusin, C. E., Lee, H., Guin, L. E., Clark, M. T., Delos, J. B., . . . Lake, D. E. (2011). Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care. 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 5515-5518.
Keeley, E. C., Moorman, J. R., Liu, L., Gimple, L. W., Lipson, L. C., Ragosta, M., . . . Strieter, R. M. (2011). Plasma Chemokine Levels Are Associated with the Presence and Extent of Angiographic Coronary Collaterals in Chronic Ischemic Heart Disease. PLOS ONE, 6(6). doi:10.1371/journal.pone.0021174
Raynor, L. L., Saucerman, J. J., Akinola, M. O., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2011). CYTOKINE SCORE IDENTIFIES NICU PATIENTS WITH GRAM-NEGATIVE BACTEREMIA. PEDIATRIC RESEARCH, 70, 688. doi:10.1038/pr.2011.913
Seely, A. J. E., Kauffman, S. A., Bates, J. H. T., Macklem, P. T., Suki, B., Marshall, J. C., . . . Moorman, J. R. (2011). Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside. JOURNAL OF CRITICAL CARE, 26(3), 325-327. doi:10.1016/j.jcrc.2011.04.002
2010
Mason, P. K., Moorman, L., Lake, D. E., Mangrum, J. M., DiMarco, J. P., Ferguson, J. D., . . . Moorman, J. R. (2010). Gender and Racial Characteristics of Patients Referred to a Tertiary Atrial Fibrillation Center.. Journal of atrial fibrillation, 3(4), 301. doi:10.4022/jafib.301
Flower, A. A., Moorman, J. R., Lake, D. E., & Delos, J. B. (2010). Periodic heart rate decelerations in premature infants. EXPERIMENTAL BIOLOGY AND MEDICINE, 235(4), 531-538. doi:10.1258/ebm.2010.009336
Seely, A. J. E., Macklem, P. T., Suki, B., Goldberger, A., Godin, P., Batchinsky, A. I., . . . Nenadovic, V. (2010). The Wakefield roundtable discussion on complexity and variability at the bedside Introduction. JOURNAL OF CRITICAL CARE, 25(3), 536-537. doi:10.1016/j.jcrc.2010.08.006