Joseph Randall Moorman

Primary Appointment

Professor, Medicine- Cardiovascular Medicine

Education

  • MD, Medicine, University of Mississippi
  • Residency, Internal Medicine, Duke University Medical Center
  • Chief Residency, Internal Medicine, Duke University Hospital
  • Clinical Fellowship, Cardiology, Duke University Medical Center

Research Interests

Predictive analytics monitoring

Research Description


Our goal is to develop predictive monitoring for early diagnosis of subacute, potentially catastrophic illness.  To date, our focus has been on premature infants in an intensive care unit.
The clinical problem that we first addressed is neonatal sepsis, a bacterial infection of the bloodstream in premature newborn infants in the intensive care unit.  This illness is common and adds greatly to morbidity and mortality of these fragile patients, and is difficult to diagnose in its early and most treatable stages.  We reasoned that continuous monitoring of a sensitive physiological measure like heart rate variability might show changes before obvious signs of a critical illness so advanced that therapy would not help.
We began by inspecting heart rate records over prolonged periods in infants at risk of sepsis.  We found obvious changes in the heart rate characteristics of septic infants even before they were clinically ill, with reduced variability and transient decelerations similar to the findings in fetal distress.  Since there were no measures available to detect these findings, we developed new mathematical techniques of sample entropy and sample asymmetry.  We did clinical studies to develop predictive multivariate statistical models based on our new measures, and we validated them at a second medical center.  We recently completed a multicenter randomized clinical trial of 3000 very low birthweight infants into to test the hypothesis that our monitoring system improves infantsâ outcomes.  Indeed it does â monitored infants had a more than 20% reduction in mortality
The scholarly output of this work has been more than 20 full-length clinical and mathematical papers, 2 Ph.D. degrees (Biomedical Engineering, Biophysics), and 5 Masters in Biomedical Engineering degrees funded by the National Institutes of Health, American Heart Association, Virginiaâs Center for Innovative Technology, the Coulter Foundation and the University of Virginia FEST Program and Childrenâs Medical Center.
We have 5 US, 2 European and 1 Canadian patents issued on this work, and more pending.  Through the University of Virginia Patent Foundation, this technology was licensed in 1999, and is now in the hands of Medical Prediction Systems Corporation (MPSC), Charlottesville, with whom we have consulting and equity agreements.  MPSC was formed as a Virginia C Corporation in 2002, successfully obtained 510(k) FDA clearance, and sells the HeRO (Heart Rate Observer) system with the indication of detecting reduced variability and transient decelerations in newborn infants.  HeRO monitors are at work in more than 1000 beds in 17 NICUs.
The new work is to develop monitoring for neonatal apnea, another major cause of morbidity in the NICU.  The current art is limited to clinical observations and to unwieldy bedside monitoring units.  We have received an NIH GO grant to develop new mathematical algorithms for continuous quantitative analysis of apnea using sophisticated waveform analysis and statistical techniques.
We intend to carry these ideas into other clinical settings, especially hospital units in which continuous monitoring is already the standard of practice such as the CCU and SICU.
Another area of much interest and activity centers on atrial fibrillation, the most common sustained arrhythmia in adults.  Here, the focus is on numerical analysis to lead to rapid diagnosis in implanted devices, and on clinical decision analysis using large databases of Holter monitor and comprehensive clinical features.

Personal Statement

Since 2000, Dr. Moorman's major research efforts have been in the early detection of subacute potentially catastrophic illnesses using readily available bedside monitoring data. Dr. Moorman and his group discovered physiological signatures that predated signs of illness-- sepsis in premature infants--and developed mathematics to detect them. They tested the final product, a monitor that reports the fold-increase in risk of imminent illness, in a very large randomized trial, and found it reduced mortality by more than 20%.
The current effort focuses on early detection of imminent catastrophic deterioration in adult in ICUs and on hospital wards.

Selected Publications

2022

Monfredi, O. J., Moore, C. C., Sullivan, B. A., Keim-Malpass, J., Fairchild, K. D., Loftus, T. J., . . . Clermont, G. (2022). Continuous ECG monitoring should be the heart of bedside AI-based predictive analytics monitoring for early detection of clinical deterioration.. Journal of electrocardiology, 76, 35-38. doi:10.1016/j.jelectrocard.2022.10.011

Ack, S. E., Loiseau, S. Y., Sharma, G., Goldstein, J. N., Lissak, I. A., Duffy, S. M., . . . Rosenthal, E. S. (2022). Neurocritical Care Performance Measures Derived from Electronic Health Record Data are Feasible and Reveal Site-Specific Variation: A CHoRUS Pilot Project. NEUROCRITICAL CARE, 37(SUPPL 2), 276-290. doi:10.1007/s12028-022-01497-0

Gadrey, S. M., Mohanty, P., Haughey, S. P., Jacobsen, B. A., Dubester, K. J., Webb, K. M., . . . Moorman, J. R. (2022). Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019.. medRxiv. doi:10.1101/2022.06.14.22276166

Moorman, J. R. (2022). The principles of whole-hospital predictive analytics monitoring for clinical medicine originated in the neonatal ICU. NPJ DIGITAL MEDICINE, 5(1). doi:10.1038/s41746-022-00584-y

Horton, W. B., Barros, A. J., Andris, R. T., Clark, M. T., & Moorman, J. R. (2022). Pathophysiologic Signature of Impending ICU Hypoglycemia in Bedside Monitoring and Electronic Health Record Data: Model Development and External Validation. CRITICAL CARE MEDICINE, 50(3), E221-E230. doi:10.1097/CCM.0000000000005171

Pokaprakarn, T., Kitzmiller, R. R., Moorman, J. R., Lake, D. E., Krishnamurthy, A. K., & Kosorok, M. R. (2022). Sequence to Sequence ECG Cardiac Rhythm Classification Using Convolutional Recurrent Neural Networks. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 26(2), 572-580. doi:10.1109/JBHI.2021.3098662

Ashe, W. B., Innis, S. E., Shanno, J. N., Hochheimer, C. J., Williams, R. D., Ratcliffe, S. J., . . . Gadrey, S. M. (2022). Analysis of respiratory kinematics: a method to characterize breaths from motion signals. PHYSIOLOGICAL MEASUREMENT, 43(1). doi:10.1088/1361-6579/ac4d1a

Niestroy, J. C., Moorman, J. R., Levinson, M. A., Al Manir, S., Clark, T. W., Fairchild, K. D., & Lake, D. E. (2022). Discovery of signatures of fatal neonatal illness in vital signs using highly comparative time-series analysis. NPJ DIGITAL MEDICINE, 5(1). doi:10.1038/s41746-021-00551-z

2021

Nagraj, V. P., Lake, D. E., Kuhn, L., Moorman, J. R., & Fairchild, K. D. (2021). Central Apnea of Prematurity: Does Sex Matter?. AMERICAN JOURNAL OF PERINATOLOGY, 38(13), 1428-1434. doi:10.1055/s-0040-1713405

Callcut, R. A., Xu, Y., Moorman, J. R., Tsai, C., Villaroman, A., Robles, A. J., . . . Clark, M. T. (2021). External validation of a novel signature of illness in continuous cardiorespiratory monitoring to detect early respiratory deterioration of ICU patients. PHYSIOLOGICAL MEASUREMENT, 42(9). doi:10.1088/1361-6579/ac2264

Monfredi, O., Keim-Malpass, J., & Moorman, J. R. (2021). Continuous cardiorespiratory monitoring is a dominant source of predictive signal in machine learning for risk stratification and clinical decision support. PHYSIOLOGICAL MEASUREMENT, 42(9). doi:10.1088/1361-6579/ac2130

Kausch, S. L., Moorman, J. R., Lake, D. E., & Keim-Malpass, J. (2021). Physiological machine learning models for prediction of sepsis in hospitalized adults: An integrative review. INTENSIVE AND CRITICAL CARE NURSING, 65. doi:10.1016/j.iccn.2021.103035

Levinson, M. A., Niestroy, J., Al Manir, S., Fairchild, K., Lake, D. E., Moorman, J. R., & Clark, T. (2021). FAIRSCAPE: a Framework for FAIR and Reproducible Biomedical Analytics. NEUROINFORMATICS. doi:10.1007/s12021-021-09529-4

Zimmet, A. M., Sullivan, B. A., Fairchild, K. D., Moorman, J. R., Isler, J. R., Wallman-Stokes, A. W., . . . Lake, D. E. (2021). Vital sign metrics of VLBW infants in three NICUs: implications for predictive algorithms (Mar, 10.1038/s41390021-01428-3, 2021). PEDIATRIC RESEARCH, 90(1), 233. doi:10.1038/s41390-021-01621-4

Keim-Malpass, J., Ratcliffe, S. J., Moorman, L. P., Clark, M. T., Krahn, K. N., Monfredi, O. J., . . . Bourque, J. M. (2021). Predictive Monitoring-Impact in Acute Care Cardiology Trial (PM-IMPACCT): Protocol for a Randomized Controlled Trial. JMIR RESEARCH PROTOCOLS, 10(7). doi:10.2196/29631

Zimmet, A. M., Sullivan, B. A., Fairchild, K. D., Moorman, J. R., Isler, J. R., Wallman-Stokes, A. W., . . . Lake, D. E. (2021). Vital sign metrics of VLBW infants in three NICUs: implications for predictive algorithms. PEDIATRIC RESEARCH, 90(1), 125-130. doi:10.1038/s41390-021-01428-3

Laird, P., Wertz, A., Welter, G., Maslove, D., Hamilton, A., Heung Yoon, J., . . . Clermont, G. (2021). The critical care data exchange format: a proposed flexible data standard for combining clinical and high-frequency physiologic data in critical care. PHYSIOLOGICAL MEASUREMENT, 42(6). doi:10.1088/1361-6579/abfc9b

Kowalski, R. L., Lee, L., Spaeder, M. C., Moorman, J. R., & Keim-Malpass, J. (2021). Accuracy and Monitoring of Pediatric Early Warning Score (PEWS) Scores Prior to Emergent Pediatric Intensive Care Unit (ICU) Transfer: Retrospective Analysis. JMIR PEDIATRICS AND PARENTING, 4(1). doi:10.2196/25991

Sullivan, B. A., Nagraj, V. P., Berry, K. L., Fleiss, N., Rambhia, A., Kumar, R., . . . Fairchild, K. D. (2021). Clinical and vital sign changes associated with late-onset sepsis in very low birth weight infants at 3 NICUs.. Journal of neonatal-perinatal medicine, 14(4), 553-561. doi:10.3233/npm-200578

2020

Davis, J. P., Wessells, D. A., & Moorman, J. R. (2020). Coronavirus Disease 2019 Calls for Predictive Analytics Monitoring-A New Kind of Illness Scoring System.. Critical care explorations, 2(12), e0294. doi:10.1097/cce.0000000000000294

Fairchild, K. D., Nagraj, V. P., Sullivan, B. A., Moorman, J. R., & Lake, D. E. (2020). Correction: Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia.. Pediatric research, 88(5), 820. doi:10.1038/s41390-020-0821-x

Nagraj, V. P., Sinkin, R. A., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2020). Correction: Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?. Pediatric research, 88(5), 821. doi:10.1038/s41390-020-0822-9

Keim-Malpass, J., Sullivan, B. A., & Moorman, J. R. (2020). Continuous Pulse Oximetry Monitoring in Bronchiolitis Patients Not Receiving Oxygen. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 324(13), 1349-1350. doi:10.1001/jama.2020.12740

Zimmet, A. N., Clark, M. T., Gadrey, S. M., Bell, T. D., Zimmet, A. M., Moorman, J. R., & Moore, C. C. (2020). Pathophysiologic Signatures of Bloodstream Infection in Critically Ill Adults.. Critical care explorations, 2(10), e0191. doi:10.1097/cce.0000000000000191

Gadrey, S. M., Clay, R., Zimmet, A. N., Lawson, A. S., Oliver, S. F., Richardson, E. D., . . . Moorman, J. R. (2020). The Relationship Between Acuity of Organ Failure and Predictive Validity of Sepsis-3 Criteria.. Critical care explorations, 2(10), e0199. doi:10.1097/cce.0000000000000199

Lensen, I. S., Monfredi, O. J., Andris, R. T., Lake, D. E., & Moorman, J. R. (2020). Heart rate fragmentation gives novel insights into non-autonomic mechanisms governing beat-to-beat control of the heart's rhythm. JRSM CARDIOVASCULAR DISEASE, 9. doi:10.1177/2048004020948732

Zimmet, A. M., Sullivan, B. A., Moorman, J. R., Lake, D. E., & Ratcliffe, S. J. (2020). Trajectories of the heart rate characteristics index, a physiomarker of sepsis in premature infants, predict Neonatal ICU mortality. JRSM CARDIOVASCULAR DISEASE, 9. doi:10.1177/2048004020945142

Keim-Malpass, J., Clark, M. T., Lake, D. E., & Moorman, J. R. (2020). Towards development of alert thresholds for clinical deterioration using continuous predictive analytics monitoring. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 34(4), 797-804. doi:10.1007/s10877-019-00361-5

Blackwell, J. N., Keim-Malpass, J., Clark, M. T., Kowalski, R. L., Najjar, S. N., Bourque, J. M., . . . Moorman, J. R. (2020). Early Detection of In-Patient Deterioration: One Prediction Model Does Not Fit All.. Critical care explorations, 2(5), e0116. doi:10.1097/cce.0000000000000116

Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., . . . Maslove, D. M. (2020). Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals. CRITICAL CARE MEDICINE, 48(5), 623-633. doi:10.1097/CCM.0000000000004246

Schelonka, R. L., Carlo, W. A., Bauer, C. R., Peralta-Carcelen, M., Phillips, V., Helderman, J., . . . O'Shea, T. M. (2020). Mortality and Neurodevelopmental Outcomes in the Heart Rate Characteristics Monitoring Randomized Controlled Trial. JOURNAL OF PEDIATRICS, 219, 48-53. doi:10.1016/j.jpeds.2019.12.066

Alonzo, C. J., Nagraj, V. P., Zschaebitz, J. V., Lake, D. E., Moorman, J. R., & Spaeder, M. C. (2020). Blood pressure ranges via non-invasive and invasive monitoring techniques in premature neonates using high resolution physiologic data.. Journal of neonatal-perinatal medicine, 13(3), 351-358. doi:10.3233/npm-190260

2019

Gadrey, S. M., Lau, C. E., Clay, R., Rhodes, G. T., Lake, D. E., Moore, C. C., . . . Moorman, J. R. (2019). Imputation of partial pressures of arterial oxygen using oximetry and its impact on sepsis diagnosis. PHYSIOLOGICAL MEASUREMENT, 40(11). doi:10.1088/1361-6579/ab5154

Spaeder, M. C., Moorman, J. R., Tran, C. A., Keim-Malpass, J., Zschaebitz, J. V., Lake, D. E., & Clark, M. T. (2019). Predictive analytics in the pediatric intensive care unit for early identification of sepsis: capturing the context of age. PEDIATRIC RESEARCH, 86(5), 655-661. doi:10.1038/s41390-019-0518-1

Nagraj, V. P., Sinkin, R. A., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2019). Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?. PEDIATRIC RESEARCH, 86(5), 622-627. doi:10.1038/s41390-019-0488-3

Ruminski, C. M., Clark, M. T., Lake, D. E., Kitzmiller, R. R., Keim-Malpass, J., Robertson, M. P., . . . Calland, J. F. (2019). Impact of predictive analytics based on continuous cardiorespiratory monitoring in a surgical and trauma intensive care unit. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 33(4), 703-711. doi:10.1007/s10877-018-0194-4

Fairchild, K. D., Nagraj, V. P., Sullivan, B. A., Moorman, J. R., & Lake, D. E. (2019). Oxygen desaturations in the early neonatal period predict development of bronchopulmonary dysplasia. PEDIATRIC RESEARCH, 85(7), 987-993. doi:10.1038/s41390-018-0223-5

Dennery, P. A., Di Fiore, J. M., Ambalavanan, N., Bancalari, E., Carroll, J. L., Claure, N., . . . Moorman, J. R. (2019). Pre-Vent: the prematurity-related ventilatory control study. PEDIATRIC RESEARCH, 85(6), 769-776. doi:10.1038/s41390-019-0317-8

Kitzmiller, R. R., Vaughan, A., Skeeles-Worley, A., Keim-Malpass, J., Yap, T. L., Lindberg, C., . . . Moorman, J. R. (2019). Diffusing an Innovation: Clinician Perceptions of Continuous Predictive Analytics Monitoring in Intensive Care. APPLIED CLINICAL INFORMATICS, 10(2), 295-306. doi:10.1055/s-0039-1688478

Vesoulis, Z. A., Bank, R. L., Lake, D., Wallman-Stokes, A., Sahni, R., Moorman, J. R., . . . Mathur, A. M. (2019). Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants. JOURNAL OF PERINATOLOGY, 39(1), 48-53. doi:10.1038/s41372-018-0236-2

Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., . . . Vincent, J. -L. (2019). Control of Confounding and Reporting of Results in Causal Inference Studies Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals. ANNALS OF THE AMERICAN THORACIC SOCIETY, 16(1), 22-28. doi:10.1513/AnnalsATS.201808-564PS

2018

Sullivan, B. A., Wallman-Stokes, A., Isler, J., Sahni, R., Moorman, J. R., Fairchild, K. D., & Lake, D. E. (2018). Early Pulse Oximetry Data Improves Prediction of Death and Adverse Outcomes in a Two-Center Cohort of Very Low Birth Weight Infants. AMERICAN JOURNAL OF PERINATOLOGY, 35(13), 1331-1338. doi:10.1055/s-0038-1654712

Alonzo, C. J., Nagraj, V. P., Zschaebitz, J. V., Lake, D. E., Moorman, J. R., & Spaeder, M. C. (2018). Heart rate ranges in premature neonates using high resolution physiologic data. JOURNAL OF PERINATOLOGY, 38(9), 1242-1245. doi:10.1038/s41372-018-0156-1

Keim-Malpass, J., Kitzmiller, R. R., Skeeles-Worley, A., Lindberg, C., Clark, M. T., Tai, R., . . . Anderson, R. A. (2018). Advancing Continuous Predictive Analytics Monitoring Moving from Implementation to Clinical Action in a Learning Health System. CRITICAL CARE NURSING CLINICS OF NORTH AMERICA, 30(2), 273-+. doi:10.1016/j.cnc.2018.02.009

Blackburn, H. N., Clark, M. T., Moorman, J. R., Lake, D. E., & Calland, J. F. (2018). Identifying the low risk patient in surgical intensive and intermediate care units using continuous monitoring. SURGERY, 163(4), 811-818. doi:10.1016/j.surg.2017.08.022

Moorman, J. R. (2018). A crossroads in predictive analytics monitoring for clinical medicine. JOURNAL OF ELECTROCARDIOLOGY, 51(6), S52-S55. doi:10.1016/j.jelectrocard.2018.07.023

2017

De Pasquale, M., Moss, T. J., Cerutti, S., Calland, J. F., Lake, D. E., Moorman, J. R., & Ferrario, M. (2017). Hemorrhage Prediction Models in Surgical Intensive Care: Bedside Monitoring Data Adds Information to Lab Values. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 21(6), 1703-1710. doi:10.1109/JBHI.2017.2653849

Moss, T. J., Lake, D. E., & Moorman, J. R. (2017). An Overlook of New-Onset Atrial Fibrillation in the Critically Ill Using Automated Detection: Have We Over Looked at It? Reply. CRITICAL CARE MEDICINE, 45(11), E1195-E1196. doi:10.1097/CCM.0000000000002664

Moss, T. J., Clark, M. T., Calland, J. F., Enfield, K. B., Voss, J. D., Lake, D. E., & Moorman, J. R. (2017). Cardiorespiratory dynamics measured from continuous ECG monitoring improves detection of deterioration in acute care patients: A retrospective cohort study. PLOS ONE, 12(8). doi:10.1371/journal.pone.0181448

Moorman, J. R., & Lake, D. E. (2017). An Ejection Fraction Measurement for the Masses. CRITICAL CARE MEDICINE, 45(7), 1240-1241. doi:10.1097/CCM.0000000000002492

Moss, T. J., Calland, J. F., Enfield, K. B., Gomez-Manjarres, D. C., Ruminski, C., DiMarco, J. P., . . . Moorman, J. R. (2017). New-Onset Atrial Fibrillation in the Critically Ill. CRITICAL CARE MEDICINE, 45(5), 790-797. doi:10.1097/CCM.0000000000002325

Blackburn, H. N., Clark, M. T., Moss, T. J., Young, J. S., Moorman, J. R., Lake, D. E., & Calland, J. F. (2017). External validation in an intermediate unit of a respiratory decompensation model trained in an intensive care unit. SURGERY, 161(3), 760-770. doi:10.1016/j.surg.2016.09.018

Fairchild, K. D., Lake, D. E., Kattwinkel, J., Moorman, J. R., Bateman, D. A., Grieve, P. G., . . . Sahni, R. (2017). Vital signs and their cross-correlation in sepsis and NEC: a study of 1,065 very-low-birth-weight infants in two NICUs. PEDIATRIC RESEARCH, 81(2), 315-321. doi:10.1038/pr.2016.215

2016

DeMazumder, D., Limpitikul, W. B., Dorante, M., Dey, S., Mukhopadhyay, B., Zhang, Y., . . . Tomaselli, G. F. (2016). Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death. EUROPACE, 18(12), 1818-1828. doi:10.1093/europace/euv399

Owens, J. E., Schorling, J., Plews-Ogan, M., Goodman, M., Moorman, R., Zaklin, R., & Dent, J. (2016). A randomized controlled trial evaluating Mindfulness-Based Stress Reduction (MBSR) for the treatment of palpitations: A pilot study. INTERNATIONAL JOURNAL OF CARDIOLOGY, 223, 25-27. doi:10.1016/j.ijcard.2016.08.183

Moss, T. J., Lake, D. E., Calland, J. F., Enfield, K. B., Delos, J. B., Fairchild, K. D., & Moorman, J. R. (2016). Signatures of Subacute Potentially Catastrophic Illness in the ICU: Model Development and Validation. CRITICAL CARE MEDICINE, 44(9), 1639-1648. doi:10.1097/CCM.0000000000001738

Moorman, J. R., Lake, D. E., & Moss, T. J. (2016). Computers in White Coats: How to Devise Useful Clinical Decision Support Software. CRITICAL CARE MEDICINE, 44(7), 1449-1450. doi:10.1097/CCM.0000000000001781

Sullivan, B. A., McClure, C., Hicks, J., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2016). Early Heart Rate Characteristics Predict Death and Morbidities in Preterm Infants. JOURNAL OF PEDIATRICS, 174, 57-62. doi:10.1016/j.jpeds.2016.03.042

Patel, M., Mohr, M., Lake, D., Delos, J., Moorman, J. R., Sinkin, R. A., . . . Fairchild, K. (2016). Clinical associations with immature breathing in preterm infants: part 2-periodic breathing. PEDIATRIC RESEARCH, 80(1), 28-34. doi:10.1038/pr.2016.58

Fairchild, K., Mohr, M., Paget-Brown, A., Tabacaru, C., Lake, D., Delos, J., . . . Kattwinkel, J. (2016). Clinical associations of immature breathing in preterm infants: part 1-central apnea. PEDIATRIC RESEARCH, 80(1), 21-27. doi:10.1038/pr.2016.43

Moorman, J. R., Lake, D. E., & Ivanov, P. C. (2016). Early Detection of Sepsis-A Role for Network Physiology?. CRITICAL CARE MEDICINE, 44(5), E312-E313. doi:10.1097/CCM.0000000000001548

Clark, M. T., Delos, J. B., Lake, D. E., Lee, H., Fairchild, K. D., Kattwinkel, J., & Moorman, J. R. (2016). Stochastic modeling of central apnea events in preterm infants. PHYSIOLOGICAL MEASUREMENT, 37(4), 463-484. doi:10.1088/0967-3334/37/4/463

2015

Carrara, M., Carozzi, L., Moss, T. J., de Pasquale, M., Cerutti, S., Ferrario, M., . . . Moorman, J. R. (2015). Heart rate dynamics distinguish among atrial fibrillation, normal sinus rhythm and sinus rhythm with frequent ectopy. PHYSIOLOGICAL MEASUREMENT, 36(9), 1873-1888. doi:10.1088/0967-3334/36/9/1873

Mohr, M. A., Fairchild, K. D., Patel, M., Sinkin, R. A., Clark, M. T., Moorman, J. R., . . . Delos, J. B. (2015). Quantification of periodic breathing in premature infants. PHYSIOLOGICAL MEASUREMENT, 36(7), 1415-1427. doi:10.1088/0967-3334/36/7/1415

Mohr, M. A., Vergales, B. D., Lee, H., Clark, M. T., Lake, D. E., Mennen, A. C., . . . Delos, J. B. (2015). Very long apnea events in preterm infants. JOURNAL OF APPLIED PHYSIOLOGY, 118(5), 558-568. doi:10.1152/japplphysiol.00144.2014

Hussain, S., Moorman, L., Moorman, J. R., DiMarco, J. P., Malhotra, R., Darby, A., . . . Mason, P. K. (2015). Cost of a Recall of a Single-Center Experience Managing the Riata Defibrillator Lead. AMERICAN JOURNAL OF CARDIOLOGY, 115(2), 206-208. doi:10.1016/j.amjcard.2014.10.028

Moss, T. J., Clark, M. T., Lake, D. E., Moorman, J. R., & Calland, J. F. (2015). Heart rate dynamics preceding hemorrhage in the intensive care unit. JOURNAL OF ELECTROCARDIOLOGY, 48(6), 1075-1080. doi:10.1016/j.jelectrocard.2015.08.007

Carrara, M., Carozzi, L., Moss, T. J., de Pasquale, M., Cerutti, S., Lake, D. E., . . . Ferrario, M. (2015). Classification of cardiac rhythm using heart rate dynamical measures: validation in MIT-BIH databases. JOURNAL OF ELECTROCARDIOLOGY, 48(6), 943-946. doi:10.1016/j.jelectrocard.2015.08.002

2014

Vergales, B. D., Zanelli, S. A., Matsumoto, J. A., Goodkin, H. P., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2014). Depressed Heart Rate Variability is Associated with Abnormal EEG, MRI, and Death in Neonates with Hypoxic Ischemic Encephalopathy. AMERICAN JOURNAL OF PERINATOLOGY, 31(10), 855-861. doi:10.1055/s-0033-1361937

Moss, T. J., Lake, D. E., & Moorman, J. R. (2014). Local dynamics of heart rate: detection and prognostic implications. PHYSIOLOGICAL MEASUREMENT, 35(10), 1929-1942. doi:10.1088/0967-3334/35/10/1929

Lake, D. E., Fairchild, K. D., & Moorman, J. R. (2014). Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis. JOURNAL OF CLINICAL MONITORING AND COMPUTING, 28(4), 329-339. doi:10.1007/s10877-013-9530-x

Fairchild, K. D., Sinkin, R. A., Davalian, F., Blackman, A. E., Swanson, J. R., Matsumoto, J. A., . . . Blackman, J. A. (2014). Abnormal heart rate characteristics are associated with abnormal neuroimaging and outcomes in extremely low birth weight infants. JOURNAL OF PERINATOLOGY, 34(5), 375-379. doi:10.1038/jp.2014.18

Bilchick, K. C., Kuruvilla, S., Hamirani, Y. S., Ramachandran, R., Clarke, S. A., Parker, K. M., . . . Epstein, F. H. (2014). Impact of Mechanical Activation, Scar, and Electrical Timing on Cardiac Resynchronization Therapy Response and Clinical Outcomes. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 63(16), 1657-1666. doi:10.1016/j.jacc.2014.02.533

Sullivan, B. A., Grice, S. M., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2014). Infection and Other Clinical Correlates of Abnormal Heart Rate Characteristics in Preterm Infants. JOURNAL OF PEDIATRICS, 164(4), 775-780. doi:10.1016/j.jpeds.2013.11.038

Moorman, J. R. (2014). The modern age of Physiological Measurement. PHYSIOLOGICAL MEASUREMENT, 35(2), 93-94. doi:10.1088/0967-3334/35/2/93

Vergales, B. D., Paget-Brown, A. O., Lee, H., Guin, L. E., Smoot, T. J., Rusin, C. G., . . . Kattwinkel, J. (2014). Accurate Automated Apnea Analysis in Preterm Infants. AMERICAN JOURNAL OF PERINATOLOGY, 31(2), 156-162. doi:10.1055/s-0033-1343769

2013

Fairchild, K. D., Schelonka, R. L., Kaufman, D. A., Carlo, W. A., Kattwinkel, J., Porcelli, P. J., . . . Moorman, J. R. (2013). Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial. PEDIATRIC RESEARCH, 74(5), 570-575. doi:10.1038/pr.2013.136

Stone, M. L., Tatum, P. M., Weitkamp, J. -H., Mukherjee, A. B., Attridge, J., McGahren, E. D., . . . Fairchild, K. D. (2013). Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis. JOURNAL OF PERINATOLOGY, 33(11), 847-850. doi:10.1038/jp.2013.63

Politano, A. D., Riccio, L. M., Lake, D. E., Rusin, C. G., Guin, L. E., Josef, C. S., . . . Patients, P. M. (2013). Predicting the need for urgent intubation in a surgical/trauma intensive care unit. SURGERY, 154(5), 1110-1116. doi:10.1016/j.surg.2013.05.025

DeMazumder, D., Lake, D. E., Cheng, A., Moss, T. J., Guallar, E., Weiss, R. G., . . . Moorman, J. R. (2013). Dynamic Analysis of Cardiac Rhythms for Discriminating Atrial Fibrillation From Lethal Ventricular Arrhythmias. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 6(3), 555-561. doi:10.1161/CIRCEP.113.000034

Moorman, L. P., Moorman, J. R., DiMarco, J. P., Malhotra, R., Darby, A., Bilchick, K., . . . Mason, P. K. (2013). Increasing lead burden correlates with externalized cables during systematic fluoroscopic screening of Riata leads. JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY, 37(1), 63-68. doi:10.1007/s10840-012-9760-8

Clark, M. T., Vergales, B. D., Paget-Brown, A. O., Smoot, T. J., Lake, D. E., Hudson, J. L., . . . Moorman, J. R. (2013). Predictive Monitoring for respiratory decompensation leading to urgent unplanned intubation in the neonatal intensive care unit. PEDIATRIC RESEARCH, 73(1), 104-110. doi:10.1038/pr.2012.155

2012

DeMazumder, D., Limpitikul, W., Dorante, M., Mukhopadhyay, B., Dey, S., Berger, R. D., . . . Tomaselli, G. F. (2012). A Novel Strategy Based on Dynamic Analysis of Cardiac Repolarization Predicts Mortality in Patients with Implantable Cardioverter-Defibrillators. CIRCULATION, 126(21). Retrieved from https://www.webofscience.com/

Lake, D. E., Fairchild, K. D., Kattwinkel, J., & Moorman, J. R. (2012). Heart rate predicts sepsis Reply. JOURNAL OF PEDIATRICS, 161(4), 770-771. doi:10.1016/j.jpeds.2012.07.021

Zagol, K., Lake, D. E., Vergales, B., Moorman, M. E., Paget-Brown, A., Lee, H., . . . Kattwinkel, J. (2012). Anemia, Apnea of Prematurity, and Blood Transfusions. JOURNAL OF PEDIATRICS, 161(3), 417-+. doi:10.1016/j.jpeds.2012.02.044

Rusin, C., & Moorman, R. (2012). Distributed cluster computing system for recording and processing physiological data in the intensive care unit. Journal of Critical Care, 27(3), e4-e5. doi:10.1016/j.jcrc.2012.01.020

Mason, P. K., Lake, D. E., DiMarco, J. P., Ferguson, J. D., Mangrum, J. M., Bilchick, K., . . . Moorman, J. R. (2012). Impact of the CHA(2)DS(2)-VASc Score on Anticoagulation Recommendations for Atrial Fibrillation. AMERICAN JOURNAL OF MEDICINE, 125(6). doi:10.1016/j.amjmed.2011.09.030

Clark, M. T., Rusin, C. G., Hudson, J. L., Lee, H., Delos, J. B., Guin, L. E., . . . Moorman, J. R. (2012). Breath-by-breath analysis of cardiorespiratory interaction for quantifying developmental maturity in premature infants. JOURNAL OF APPLIED PHYSIOLOGY, 112(5), 859-867. doi:10.1152/japplphysiol.01152.2011

Raynor, L. L., Saucerman, J. J., Akinola, M. O., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2012). Cytokine screening identifies NICU patients with Gram-negative bacteremia. PEDIATRIC RESEARCH, 71(3), 261-266. doi:10.1038/pr.2011.45

Lee, H., Rusin, C. G., Lake, D. E., Clark, M. T., Guin, L., Smoot, T. J., . . . Delos, J. B. (2012). A new algorithm for detecting central apnea in neonates. PHYSIOLOGICAL MEASUREMENT, 33(1), 1-17. doi:10.1088/0967-3334/33/1/1

2011

Moorman, J. R., Carlo, W. A., Kattwinkel, J., Schelonka, R. L., Porcelli, P. J., Navarrete, C. T., . . . O'Shea, T. M. (2011). Mortality Reduction by Heart Rate Characteristic Monitoring in Very Low Birth Weight Neonates: A Randomized Trial. JOURNAL OF PEDIATRICS, 159(6), 900-U53. doi:10.1016/j.jpeds.2011.06.044

Lake, D. E., Fairchild, K. D., Delos, J. B., Lee, H., Rusin, C. G., Guin, L. E., . . . Moorman, J. R. (2011). HEART RATE CHARACTERISTICS MONITORING AND CENTRAL NEONATAL APNEA. PEDIATRIC RESEARCH, 70, 689. doi:10.1038/pr.2011.914

Moorman, J. R., Carlo, W. A., Kattwinkel, J., Schelonka, R. L., Porcelli, P. J., Navarrete, C. T., . . . O'Shea, T. M. (2011). LONG-TERM FORECASTING OF DEATH IN THE NEONATAL ICU USING HEART RATE CHARACTERISTICS MONITORING AND CLINICAL DATA. PEDIATRIC RESEARCH, 70, 37. doi:10.1038/pr.2011.262

Raynor, L. L., Saucerman, J. J., Akinola, M. O., Lake, D. E., Moorman, J. R., & Fairchild, K. D. (2011). CYTOKINE SCORE IDENTIFIES NICU PATIENTS WITH GRAM-NEGATIVE BACTEREMIA. PEDIATRIC RESEARCH, 70, 688. doi:10.1038/pr.2011.913

Moorman, J. R., Delos, J. B., Flower, A. A., Cao, H., Kovatchev, B. P., Richman, J. S., & Lake, D. E. (2011). Cardiovascular oscillations at the bedside: early diagnosis of neonatal sepsis using heart rate characteristics monitoring. PHYSIOLOGICAL MEASUREMENT, 32(11), 1821-1832. doi:10.1088/0967-3334/32/11/S08

Keeley, E. C., Moorman, J. R., Liu, L., Gimple, L. W., Lipson, L. C., Ragosta, M., . . . Strieter, R. M. (2011). Plasma Chemokine Levels Are Associated with the Presence and Extent of Angiographic Coronary Collaterals in Chronic Ischemic Heart Disease. PLOS ONE, 6(6). doi:10.1371/journal.pone.0021174

Seely, A. J. E., Kauffman, S. A., Bates, J. H. T., Macklem, P. T., Suki, B., Marshall, J. C., . . . Moorman, J. R. (2011). Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside. JOURNAL OF CRITICAL CARE, 26(3), 325-327. doi:10.1016/j.jcrc.2011.04.002

Fairchild, K. D., Srinivasan, V., Moorman, J. R., Gaykema, R. P. A., & Goehler, L. E. (2011). Pathogen-induced heart rate changes associated with cholinergic nervous system activation. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 300(2), R330-R339. doi:10.1152/ajpregu.00487.2010

Mason, P. K., Dimarco, J. P., Ferguson, J. D., Mahapatra, S., Mangrum, J. M., Bilchick, K. C., . . . Bergin, J. D. (2011). Sonication of Explanted Cardiac Rhythm Management Devices for the Diagnosis of Pocket Infections and Asymptomatic Bacterial Colonization. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 34(2), 143-149. doi:10.1111/j.1540-8159.2010.02820.x

Lake, D. E., & Moorman, J. R. (2011). Accurate estimation of entropy in very short physiological time series: the problem of atrial fibrillation detection in implanted ventricular devices. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(1), H319-H325. doi:10.1152/ajpheart.00561.2010

Moorman, J. R., Rusin, C. E., Lee, H., Guin, L. E., Clark, M. T., Delos, J. B., . . . IEEE. (2011). Predictive monitoring for early detection of subacute potentially catastrophic illnesses in critical care. 2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 5515-5518. Retrieved from https://www.webofscience.com/

2010

Mason, P. K., Moorman, L., Lake, D. E., Mangrum, J. M., DiMarco, J. P., Ferguson, J. D., . . . Moorman, J. R. (2010). Gender and Racial Characteristics of Patients Referred to a Tertiary Atrial Fibrillation Center.. Journal of atrial fibrillation, 3(4), 301. doi:10.4022/jafib.301

Seely, A. J. E., Macklem, P. T., Suki, B., Goldberger, A., Godin, P., Batchinsky, A. I., . . . Nenadovic, V. (2010). The Wakefield roundtable discussion on complexity and variability at the bedside Introduction. JOURNAL OF CRITICAL CARE, 25(3), 536-537. doi:10.1016/j.jcrc.2010.08.006

Flower, A. A., Moorman, J. R., Lake, D. E., & Delos, J. B. (2010). Periodic heart rate decelerations in premature infants. EXPERIMENTAL BIOLOGY AND MEDICINE, 235(4), 531-538. doi:10.1258/ebm.2010.009336

Xiao, Y., Griffin, M. P., Lake, D. E., & Moorman, J. R. (2010). Nearest-Neighbor and Logistic Regression Analyses of Clinical and Heart Rate Characteristics in the Early Diagnosis of Neonatal Sepsis. MEDICAL DECISION MAKING, 30(2), 258-266. doi:10.1177/0272989X09337791