Coleen A. McNamara

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Primary Appointment

Edward W. and Betty Knight Scripps Professor of Internal Medicine, Medicine- Cardiovascular Medicine

Education

  • Fellowship, Cardiovascular Medicine, University of Virginia
  • MD, Medical College of Ohio
  • Residency, Internal Medicine, University of Virginia

Research Disciplines

Biotechnology, Cardiovascular Biology, Immunology, Molecular Biology, Physiology, Translational Science

Research Interests

Immune System Regulation of Cardiometabolic Disease

Research Description

In recent years, obesity and diabetes have reached epidemic proportions. These diseases have many health consequences including stroke, heart attack and peripheral vascular disease. Common to all of these is atherosclerosis, which is the process by which lipids, cells and fibrous elements accumulate within the walls of arteries. Coordinated gene expression is essential to maintain normal vascular tissue structure and function and many transcription factors regulate these processes.
Our lab has recently identified the transcription factor Id3 as a major regulator of atherosclerosis and obesity. We have discovered that Id3 regulates the homing of B cells to the vasculature and that the loss of Id3 results in increased plaque formation. In ongoing research, we are utilizing different molecular imaging modalities to further explore and quantify the trafficking of B cells to the vessel wall and pursuing molecular strategies to further elucidate the mechanism by which Id3 affects the function of B cells in atherosclerosis.
In addition, studies from our lab have shown an important role for Id3 in the regulation of visceral adiposity. We have demonstrated the role of Id3 in the transcriptional regulation of adiponectin (an anti-inflammatory cytokine produced by adipocytes). Further studies are underway to investigate the mechanisms whereby Id3 deletion protects from high fat diet-induced obesity and glucose intolerance.

Personal Statement

In recent years, obesity and diabetes have reached epidemic proportions. These diseases have many health consequences including stroke, heart attack and peripheral vascular disease. Common to all of these is atherosclerosis, which is the process by which lipids, cells and fibrous elements accumulate within the walls of arteries. Coordinated gene expression is essential to maintain normal vascular tissue structure and function and many transcription factors regulate these processes. Our lab has recently identified the transcription factor Id3 as a major regulator of atherosclerosis and obesity. Our research currently focuses on these two areas, each of which includes several exciting projects:
Atherosclerosis:
Project 1: Id3 regulation of immune cell responses in atherosclerosis.
A variety of immune cells influence the development of atherosclerosis, including macrophages, T cells and B cells. While the role of B lymphocytes in atherosclerosis is understudied, they are generally thought to play a protective role. Using animal models, our lab has demonstrated that Id3 regulates the homing of B cells to the vasculature and that the loss of Id3 results in increased plaque formation. In ongoing research, we are utilizing different molecular imaging modalities to further explore and quantify the trafficking of radio-labeled cells to the vessel wall using intravital confocal microscopy, microSPECT/CT, and real-time imaging of cellular trafficking using a gamma camera. In addition, we hope to further elucidate the mechanism by which Id3 affects the function of these cells in disease.
Project 2: Id3 regulation of matrix formation and vascular remodeling.
Restenosis after stent deployment in atherosclerotic arteries is characterized by neointimal formation. Vascular smooth muscle cell migration, growth and matrix production are critical processes in atherosclerosis and restenosis. Our lab has previously demonstrated that Id3 is involved in vascular smooth muscle cell growth. Our data also indicates that Id3 plays a role in regulating extracellular matrix formation and matrix metalloproteinases, the enzymes that remodel matrix and facilitate cell migration. Using transgenic and knockout mice, and molecular and cellular biology techniques, our lab is currently investigating how Id3 regulates matrix protein production, and its remodeling by select matrix metalloproteinase enzymes.
Project 3: Id3 SNPs are associated with atherosclerosis.
Through strong collaborations with the UVA Center for Public Health Genomics, our lab is studying several SNPs that have been associated with various markers of atherosclerosis in diabetic and atherosclerotic populations. In ongoing research, we are determining the mechanism by which these SNPs alter Id3 function in order to understand how they might influence disease progression.
Obesity:
Project 4: Id3 regulation of adipose distribution and adipocyte function.
Studies from our lab have shown an important role for Id3 in the regulation of visceral adiposity in the mouse model. We have also demonstrated the role of Id3 in the transcriptional regulation of adiponectin (an anti-inflammatory cytokine produced by adipocytes). Further studies are underway to investigate the role of Id3 in the proliferation and differentiation of adipocytes and the role of Id3 in adipocyte function.

Training

  • Basic Cardiovascular Research Training Grant
  • Interdisciplinary Training Program in Immunology
  • Training in the Pharmacological Sciences

Selected Publications

2022

Mazimba, S., Mwansa, H., Breathett, K., Strickling, J. E., Shah, K., McNamara, C., . . . Bilchick, K. C. (2022). Systemic arterial pulsatility index (SAPi) predicts adverse outcomes in advanced heart failure patients. HEART AND VESSELS, 37(10), 1719-1727. doi:10.1007/s00380-022-02070-7

Srikakulapu, P., Pattarabanjird, T., Upadhye, A., Bontha, S. V., Osinski, V., Marshall, M. A., . . . McNamara, C. A. (2022). B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. FRONTIERS IN IMMUNOLOGY, 13. doi:10.3389/fimmu.2022.909475

Roy, P., Sidney, J., Lindestam Arlehamn, C. S., Phillips, E., Mallal, S., Armstrong Suthahar, S. S., . . . Ley, K. (2022). Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B. CIRCULATION RESEARCH, 131(3), 258-276. doi:10.1161/CIRCRESAHA.122.321116

Lempicki, M. D., Serbulea, V., Paul, S., Upchurch, C. M., Sahu, S., Gray, J. A., . . . Meher, A. K. (2022). BAFF 60-mer binding to BAFF receptor 3 utilizes the NF-κB1 signaling pathway to hyperactivate B cells.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 Suppl 1. doi:10.1096/fasebj.2022.36.s1.r2051

Pattarabanjird, T., Marshall, M., Upadhye, A., Srikakulapu, P., Garmey, J. C., Haider, A., . . . McNamara, C. A. (2022). B-1b Cells Possess Unique bHLH-Driven P62-Dependent Self-Renewal and Atheroprotection. CIRCULATION RESEARCH, 130(7), 981-993. doi:10.1161/CIRCRESAHA.121.320436

Pattarabanjird, T., Wilson, J. M., Erickson, L. D., Workman, L. J., Qiao, H., Ghosheh, Y., . . . McNamara, C. A. (2022). Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 8. doi:10.3389/fcvm.2021.791028

Osinski, V., Srikakulapu, P., Haider, Y. M., Marshall, M. A., Ganta, V. C., Annex, B. H., & McNamara, C. A. (2022). Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 42(1), 6-18. doi:10.1161/ATVBAHA.120.315501

2021

Spinosa, M. D., Montgomery, W. G., Lempicki, M., Srikakulapu, P., Johnsrude, M. J., McNamara, C. A., . . . Meher, A. K. (2021). B Cell-Activating Factor Antagonism Attenuates the Growth of Experimental Abdominal Aortic Aneurysm. AMERICAN JOURNAL OF PATHOLOGY, 191(12), 2231-2244. doi:10.1016/j.ajpath.2021.08.012

Gaddis, D. E., Padgett, L. E., Wu, R., Nguyen, A., McSkimming, C., Dinh, H. Q., . . . Hedrick, C. C. (2021). Atherosclerosis Impairs Naive CD4 T-Cell Responses via Disruption of Glycolysis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(9), 2387-2398. doi:10.1161/ATVBAHA.120.314189

Ruiz, H. H., Nguyen, A., Wang, C., He, L., Li, H., Hallowell, P., . . . Schmidt, A. M. (2021). AGE/RAGE/DIAPH1 axis is associated with immunometabolic markers and risk of insulin resistance in subcutaneous but not omental adipose tissue in human obesity. INTERNATIONAL JOURNAL OF OBESITY, 45(9), 2083-2094. doi:10.1038/s41366-021-00878-3

Kassiteridi, C., Cole, J. E., Griseri, T., Falck-Hansen, M., Goddard, M. E., Seneviratne, A. N., . . . Monaco, C. (2021). CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. CIRCULATION RESEARCH, 129(2), 280-295. doi:10.1161/CIRCRESAHA.119.316062

Pattarabanjird, T., Li, C., & McNamara, C. (2021). B Cells in Atherosclerosis Mechanisms and Potential Clinical Applications. JACC-BASIC TO TRANSLATIONAL SCIENCE, 6(6), 546-563. doi:10.1016/j.jacbts.2021.01.006

Feinstein, M. J., Doyle, M. F., Stein, J. H., Sitlani, C. M., Fohner, A. E., Huber, S. A., . . . Delaney, J. A. C. (2021). Nonclassical Monocytes (CD14dimCD16+) Are Associated With Carotid Intima-Media Thickness Progression for Men but Not Women The Multi-Ethnic Study of Atherosclerosis-Brief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(5), 1810-1817. doi:10.1161/ATVBAHA.120.315886

Keshavarz, B., Wiencek, J. R., Workman, L. J., Straesser, M. D., Muehling, L. M., Canderan, G., . . . Wilson, J. M. (2021). Quantitative Measurement of IgG to Severe Acute Respiratory Syndrome Coronavirus-2 Proteins Using ImmunoCAP. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 182(5), 417-424. doi:10.1159/000514203

Kothari, H., Williams, C. M., McSkimming, C., Drago, F., Marshall, M. A., Garmey, J., . . . McNamara, C. A. (2021). Identification of human immune cell subtypes most responsive to IL-1 beta-induced inflammatory signaling using mass cytometry. SCIENCE SIGNALING, 14(673). doi:10.1126/scisignal.abc5763

Srikakulapu, P., Upadhye, A., Drago, F., Perry, H. M., Bontha, S. V., McSkimming, C., . . . McNamara, C. A. (2021). Chemokine Receptor-6 Promotes B-1 Cell Trafficking to Perivascular Adipose Tissue, Local IgM Production and Atheroprotection. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.636013

Garmey, J. C., Hensien, J. M., Harmon, D. B., Osinski, V., McSkimming, C., Marshall, M. A., . . . Misiou, A. (2021). Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3) A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(2), 796-807. doi:10.1161/ATVBAHA.120.315588

Keshavarz, B., Wiencek, J., Bazydlo, L., Straesser, M., Workman, L., Platts-Mills, T., & Wilson, J. (2021). Quantitative Measurement of IgG to SARS-CoV-2 Proteins Using the Phadia ImmunoCAP 250. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147(2), AB150. Retrieved from https://www.webofscience.com/

2020

Pattarabanjird, T., Cress, C., Nguyen, A., Taylor, A., Bekiranov, S., & McNamara, C. (2020). A Machine Learning Model Utilizing a Novel SNP Shows Enhanced Prediction of Coronary Artery Disease Severity. GENES, 11(12). doi:10.3390/genes11121446

Padgett, L. E., Dinh, H. Q., Wu, R., Gaddis, D. E., Araujo, D. J., Winkels, H., . . . Hedrick, C. C. (2020). Naive CD8(+) T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(12), 2845-2859. doi:10.1161/ATVBAHA.120.315106

Alencar, G. F., Owsiany, K. M., Karnewar, S., Sukhavasi, K., Mocci, G., Nguyen, A. T., . . . Owens, G. K. (2020). Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. CIRCULATION, 142(21), 2045-2059. doi:10.1161/CIRCULATIONAHA.120.046672

Gilbertson, N. M., Gaitan, J. M., Osinski, V., Rexrode, E. A., Garmey, J. C., Mehaffey, J. H., . . . Malin, S. K. (2020). Pre-operative aerobic exercise on metabolic health and surgical outcomes in patients receiving bariatric surgery: A pilot trial. PLOS ONE, 15(10). doi:10.1371/journal.pone.0239130

Zernecke, A., Winkels, H., Cochain, C., Williams, J. W., Wolf, D., Soehnlein, O., . . . Ley, K. (2020). Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas. CIRCULATION RESEARCH, 127(3), 402-426. doi:10.1161/CIRCRESAHA.120.316903

Kroon, T., Harms, M., Maurer, S., Bonnet, L., Alexandersson, I., Lindblom, A., . . . Boucher, J. (2020). PPAR gamma and PPAR alpha synergize to induce robust browning of white fat in vivo. MOLECULAR METABOLISM, 36. doi:10.1016/j.molmet.2020.02.007

Bilchick, K., Kothari, H., Narayan, A., Garmey, J., Omar, A., Capaldo, B., & McNamara, C. (2020). Cardiac resynchronization therapy reduces expression of inflammation-promoting genes related to interleukin-1 beta in heart failure. CARDIOVASCULAR RESEARCH, 116(7), 1311-1322. doi:10.1093/cvr/cvz232

Srikakulapu, P., & McNamara, C. A. (2020). B Lymphocytes and Adipose Tissue Inflammation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(5), 1110-1122. doi:10.1161/ATVBAHA.119.312467

Upadhye, A., Sturek, J. M., & McNamara, C. A. (2020). 2019 Russell Ross Memorial Lecture in Vascular Biology B Lymphocyte-Mediated Protective Immunity in Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(2), 309-322. doi:10.1161/ATVBAHA.119.313064

Osinski, V., Bauknight, D. K., Dasa, S. S. K., Harms, M. J., Kroon, T., Marshall, M. A., . . . McNamara, C. A. (2020). In vivo liposomal delivery of PPAR alpha/gamma dual agonist tesaglitazar in a model of obesity enriches macrophage targeting and limits liver and kidney drug effects. THERANOSTICS, 10(2), 585-601. doi:10.7150/thno.36572

Cherepanova, O. A., Srikakulapu, P., Greene, E. S., Chaklader, M., Haskins, R. M., McCanna, M. E., . . . Owens, G. K. (2020). Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet-Fed, but Not Western Diet-Fed Apoe(-/-) Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 40(1), 206-219. doi:10.1161/ATVBAHA.119.312771

2019

Bauknight, D. K., Osinski, V., Dasa, S. S. K., Nguyen, A. T., Marshall, M. A., Hartman, J., . . . Kelly, K. A. (2019). Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects. PLOS ONE, 14(11). doi:10.1371/journal.pone.0224917

Upadhye, A., Srikakulapu, P., Gonen, A., Hendrikx, S., Perry, H. M., Nguyen, A., . . . McNamara, C. A. (2019). Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. CIRCULATION RESEARCH, 125(10), E55-E70. doi:10.1161/CIRCRESAHA.119.315786

Upadhye, A., Srikakulapu, P., & McNamara, C. A. (2019). Cell- and Sex-Specific Role of Fc gamma R (Fc gamma Receptor) IIb in Experimental Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(7), 1269-1271. doi:10.1161/ATVBAHA.119.312916

Shikatani, E. A., Besla, R., Ensan, S., Upadhye, A., Khyzha, N., Li, A., . . . Robbins, C. S. (2019). c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells. CELL REPORTS, 27(8), 2304-+. doi:10.1016/j.celrep.2019.04.090

Wilson, J. M., McNamara, C. A., & Platts-Mills, T. A. E. (2019). IgE, alpha-Gal and atherosclerosis. AGING-US, 11(7), 1900-1902. doi:10.18632/aging.101894

Gonen, A., Choi, S. -H., Miu, P., Agatisa-Boyle, C., Acks, D., Taylor, A. M., . . . Miller, Y. I. (2019). A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma(1)[S]. JOURNAL OF LIPID RESEARCH, 60(2), 436-445. doi:10.1194/jlr.D090852

Hamers, A. A. J., Dinh, H. Q., Thomas, G. D., Marcovecchio, P., Blatchley, A., Nakao, C. S., . . . Hedrick, C. C. (2019). Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(1), 25-36. doi:10.1161/ATVBAHA.118.311022

2018

Wilson, J. M., Nguyen, A. T., Schuyler, A. J., Commins, S. P., Taylor, A. M., Platts-Mills, T. A. E., & McNamara, C. A. (2018). IgE to the Mammalian Oligosaccharide Galactose--1,3-Galactose Is Associated With Increased Atheroma Volume and Plaques With Unstable CharacteristicsBrief Report. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(7), 1665-1669. doi:10.1161/ATVBAHA.118.311222

Kothari, H., Nguyen, A. T., Yang, X., Hisada, Y., Tsimikas, S., Mackman, N., . . . McNamara, C. A. (2018). Association of D-dimer with Plaque Characteristics and Plasma Biomarkers of Oxidation-Specific Epitopes in Stable Subjects with Coronary Artery Disease. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 11(3), 221-229. doi:10.1007/s12265-018-9790-4

Srikakulapu, P., Upadhye, A., Davy, J., & McNamara, C. A. (2018). Perivascular Adipose Tissue near Aortic Arch is a Major Site for Atheroprotective IgM Producing B-1 Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38. doi:10.1161/atvb.38.suppl_1.665

Osinski, V., Ganta, V. C., Nguyen, A. T., Annex, B. H., & McNamara, C. A. (2018). Helix-loop-helix Transcription Factor 1d3 Promotes lschemia-induced Angiogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38. doi:10.1161/atvb.38.suppl_1.342

Gaddis, D. E., Padgett, L. E., Wu, R., McSkimming, C., Romines, V., Taylor, A. M., . . . Hedrick, C. C. (2018). Apolipoprotein AI prevents regulatory to follicular helper T cell switching during atherosclerosis. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-03493-5

2017

Srikakulapu, P., Upadhye, A., Rosenfeld, S. M., Marshall, M. A., McSkimming, C., Hickman, A. W., . . . McNamara, C. A. (2017). Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells. FRONTIERS IN PHYSIOLOGY, 8. doi:10.3389/fphys.2017.00719

Thomas, G. D., Hamers, A. A. J., Nakao, C., Marcovecchio, P., Taylor, A. M., McSkimming, C., . . . Hedrick, C. C. (2017). Human Blood Monocyte Subsets A New Gating Strategy Defined Using Cell Surface Markers Identified by Mass Cytometry. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(8), 1548-+. doi:10.1161/ATVBAHA.117.309145

Malin, S. K., Kaplan, J. L., Meng, L., Garmey, J. C., Kirby, J. L., Taylor, A. M., . . . McNamara, C. A. (2017). Age increases MCP-1 level in association with bariatric surgery operating time and metabolic risk severity. OBESITY SCIENCE & PRACTICE, 3(2), 193-200. doi:10.1002/osp4.105

Srikakulapu, P., Upadhye, A., Rosenfeld, S. M., Kouhestani, K., Marshall, M., Prohaska, T. A., . . . McNamara, C. A. (2017). B-1b Cells Produce IgM to Malondialdehyde-Modified Low Density Lipoprotein in Perivascular Adipose Tissue in Response to Immunization And Attenuate Diet Induced Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

Kohlgrueber, S., Dyballa-Rukes, N., Metzger, S., Nguyen, A., Garmey, J., McNamara, C., . . . Altschmied, J. (2017). Expression, Phosphorylation and Interaction Partners of the Transcription Factor Grainyhead-like 3 in the Endothelium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

Osinski, V., Harms, M., Boucher, J., & McNamara, C. (2017). PPAR alpha/gamma Agonist Tesaglitazar Reduces Inflammatory Macrophage Numbers And Induces Adipose Ucp-1 Expression In Diabetic Ob/ob Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37. Retrieved from https://www.webofscience.com/

Srikakulapu, P., & McNamara, C. A. (2017). B cells and atherosclerosis. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 312(5), H1060-H1067. doi:10.1152/ajpheart.00859.2016

Kohlgrueber, S., Upadhye, A., Dyballa-Rukes, N., McNamara, C. A., & Altschmied, J. (2017). Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology. ANTIOXIDANTS & REDOX SIGNALING, 26(13), 679-699. doi:10.1089/ars.2016.6946

Marcovecchio, P. M., Thomas, G. D., Mikulski, Z., Ehinger, E., Mueller, K. A. L., Blatchley, A., . . . Hedrick, C. C. (2017). Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 37(11), 2043-+. doi:10.1161/ATVBAHA.117.309123

2016

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., . . . Mackman, N. (2016). Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays (vol 139, pg 90, 2016). THROMBOSIS RESEARCH, 147, 63. doi:10.1016/j.thromres.2016.09.009

Schaheen, B., Downs, E. A., Serbulea, V., Almenara, C. C. P., Spinosa, M., Su, G., . . . Ailawadi, G. (2016). B-Cell Depletion Promotes Aortic Infiltration of Immunosuppressive Cells and Is Protective of Experimental Aortic Aneurysm. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(11), 2191-+. doi:10.1161/ATVBAHA.116.307559

Cheng, H. -Y., Gaddis, D. E., Wu, R., McSkimming, C., Haynes, L. D., Taylor, A. M., . . . Hedrick, C. C. (2016). Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 126(9), 3236-3246. doi:10.1172/JCI83136

Srikakulapu, P., Hu, D., Yin, C., Mohanta, S. K., Bontha, S. V., Peng, L., . . . Habenicht, A. J. R. (2016). Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE(-/-) Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(6), 1174-+. doi:10.1161/ATVBAHA.115.306983

Harmon, D. B., Srikakulapu, P., Kaplan, J. L., Oldham, S. N., McSkimming, C., Garmey, J. C., . . . McNamara, C. A. (2016). Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(4), 682-691. doi:10.1161/ATVBAHA.116.307166

Hisada, Y., Alexander, W., Kasthuri, R., Voorhees, P., Mobarrez, F., Taylor, A., . . . Mackman, N. (2016). Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays. THROMBOSIS RESEARCH, 139, 90-97. doi:10.1016/j.thromres.2016.01.011

2015

Kaplan, J. L., Marshall, M. A., McSkimming, C. C., Harmon, D. B., Garmey, J. C., Oldham, S. N., . . . McNamara, C. A. (2015). Adipocyte progenitor cells initiate monocyte chemoattractant protein-1-mediated macrophage accumulation in visceral adipose tissue. MOLECULAR METABOLISM, 4(11), 779-794. doi:10.1016/j.molmet.2015.07.010

Adamson, S. E., Meher, A. K., Chiu, Y. -H., Sandilos, J. K., Oberholtzer, N. P., Walker, N. N., . . . Leitinger, N. (2015). Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. MOLECULAR METABOLISM, 4(9), 610-618. doi:10.1016/j.molmet.2015.06.009

Rosenfeld, S. M., Perry, H. M., Gonen, A., Prohaska, T. A., Srikakulapu, P., Grewal, S., . . . McNamara, C. A. (2015). B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. CIRCULATION RESEARCH, 117(3), E28-E39. doi:10.1161/CIRCRESAHA.117.306044

2014

Meher, A. K., Johnston, W. F., Lu, G., Pope, N. H., Bhamidipati, C. M., Harmon, D. B., . . . Ailawadi, G. (2014). B2 Cells Suppress Experimental Abdominal Aortic Aneurysms. AMERICAN JOURNAL OF PATHOLOGY, 184(11), 3130-3141. doi:10.1016/j.ajpath.2014.07.006

Manichaikul, A., Rich, S. S., Perry, H., Yeboah, J., Law, M., Davis, M., . . . Taylor, A. M. (2014). A Functionally Significant Polymorphism in ID3 Is Associated with Human Coronary Pathology. PLOS ONE, 9(3). doi:10.1371/journal.pone.0090222

Morris-Rosenfeld, S., Lipinski, M. J., & McNamara, C. A. (2014). Understanding the role of B cells in atherosclerosis: potential clinical implications. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 10(1), 77-89. doi:10.1586/1744666X.2014.857602

Nackiewicz, D., Dey, P., Szczerba, B., Mohammad, S., Kaplan, J. L., McNamara, C. A., . . . Bagavant, H. (2014). Inhibitor of Differentiation 3, a Transcription Factor, Regulates Hyperlipidemia-Associated Kidney Disease. NEPHRON EXPERIMENTAL NEPHROLOGY, 126(3), 141-147. doi:10.1159/000362452

2013

Choi, S. -H., Yin, H., Ravandi, A., Armando, A., Dumlao, D., Kim, J., . . . Miller, Y. I. (2013). Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages. PLOS ONE, 8(12). doi:10.1371/journal.pone.0083145

Perry, H. M., Oldham, S. N., Fahl, S. P., Que, X., Gonen, A., Harmon, D. B., . . . McNamara, C. A. (2013). Helix-Loop-Helix Factor Inhibitor of Differentiation 3 Regulates Interleukin-5 Expression and B-1a B Cell Proliferation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(12), 2771-2779. doi:10.1161/ATVBAHA.113.302571

Nackiewicz, D., Manichaikul, A., Szczerba, B., Dey, P., Rich, S., McNamara, C., . . . Bagavant, H. (2013). Inhibitor Of Differentiation 3, A Transcription Factor Regulates Susceptibility To Kidney Disease. ARTHRITIS AND RHEUMATISM, 65, S240. Retrieved from https://www.webofscience.com/

2012

Lipinski, M. J., Campbell, K. A., Duong, S. Q., Welch, T. J., Garmey, J. C., Doran, A. C., . . . McNamara, C. A. (2012). Loss of Id3 Increases VCAM-1 Expression, Macrophage Accumulation, and Atherogenesis in Ldlr(-/-) Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(12), 2855-+. doi:10.1161/ATVBAHA.112.300352

Perry, H. M., & McNamara, C. A. (2012). Refining the Role of B Cells in Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(7), 1548-1549. doi:10.1161/ATVBAHA.112.249235

Bourque, J. M., Schietinger, B. J., Kennedy, J. L., Pearce, E. A., Christopher, J. M., Taylor, A. M., . . . Kramer, C. M. (2012). Usefulness of Cardiovascular Magnetic Resonance Imaging of the Superficial Femoral Artery for Screening Patients With Diabetes Mellitus for Atherosclerosis. AMERICAN JOURNAL OF CARDIOLOGY, 110(1), 50-56. doi:10.1016/j.amjcard.2012.02.048

Campbell, K. A., Lipinski, M. J., Doran, A. C., Skaflen, M. D., Fuster, V., & McNamara, C. A. (2012). Lymphocytes and the Adventitial Immune Response in Atherosclerosis. CIRCULATION RESEARCH, 110(6), 889-900. doi:10.1161/CIRCRESAHA.111.263186

Cutchins, A., Harmon, D. B., Kirby, J. L., Doran, A. C., Oldham, S. N., Skaflen, M., . . . McNamara, C. A. (2012). Inhibitor of Differentiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(2), 317-U352. doi:10.1161/ATVBAHA.111.234856

Doran, A. C., Lipinski, M. J., Oldham, S. N., Garmey, J. C., Campbell, K. A., Skaflen, M. D., . . . McNamara, C. A. (2012). .B-Cell Aortic Homing and Atheroprotection Depend on Id3. CIRCULATION RESEARCH, 110(1), E1-U6. doi:10.1161/CIRCRESAHA.111.256438

Perry, H. M., Bender, T. P., & McNamara, C. A. (2012). B cell subsets in atherosclerosis. FRONTIERS IN IMMUNOLOGY, 3. doi:10.3389/fimmu.2012.00373

2011

Bagavant, H., Scindia, Y., Nackiewicz, D., Nandula, S. R., Doran, A., Cutchins, A., . . . McNamara, C. (2011). Deficiency of a Transcriptional Regulator, Inhibitor of Differentiation 3, Induces Glomerulonephritis in Apolipoprotein E-Deficient Mice A Model Linking Hyperlipidemia and Renal Disease. AMERICAN JOURNAL OF PATHOLOGY, 179(2), 651-660. doi:10.1016/j.ajpath.2011.04.029

Lipinski, M. J., Perry, H. M., Doran, A. C., Oldham, S. N., & McNamara, C. A. (2011). Comment on "Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis". JOURNAL OF IMMUNOLOGY, 186(1), 4. doi:10.4049/jimmunol.1090119

Deliri, H., Meller, N., Kadakkal, A., Malhotra, R., Brewster, J., Doran, A. C., . . . McNamara, C. A. (2011). Increased 12/15-Lipoxygenase Enhances Cell Growth, Fibronectin Deposition, and Neointimal Formation in Response to Carotid Injury. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(1), 110-+. doi:10.1161/ATVBAHA.110.212068

2010

Harmon, D. B., Cutchins, A., Oldham, S. N., Perry, H., & McNamara, C. A. (2010). Loss of Id3 Alters the Inflammatory Profile of Visceral Adipose Tissue in Mice Fed a High-Fat Diet. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11), E217. Retrieved from https://www.webofscience.com/

Deliri, H., Lipinski, M. J., Garmey, J. C., Oldham, S. N., Skaflen, M. D., & McNamara, C. A. (2010). Id3 and ABF1 Are Transcriptional Regulators of Matrix Metalloproteinase-9 in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(11), E319. Retrieved from https://www.webofscience.com/

Doran, A. C., Lehtinen, A. B., Meller, N., Lipinski, M. J., Slayton, R. P., Oldham, S. N., . . . McNamara, C. A. (2010). Id3 Is a Novel Atheroprotective Factor Containing a Functionally Significant Single-Nucleotide Polymorphism Associated With Intima-Media Thickness in Humans. CIRCULATION RESEARCH, 106(7), 1303-U299. doi:10.1161/CIRCRESAHA.109.210294

Yeboah, J., McNamara, C., Jiang, X. -C., Tabas, I., Herrington, D. M., Burke, G. L., & Shea, S. (2010). Association of Plasma Sphingomyelin Levels and Incident Coronary Heart Disease Events in an Adult Population Multi-Ethnic Study of Atherosclerosis. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(3), 628-633. doi:10.1161/ATVBAHA.109.199281

III, O. A. P., Subramanian, V., Moorleghen, J. J., Guo, Z., McNamara, C. A., Cassis, L. A., & Daugherty, A. (2010). Angiotensin II Induces a Region-Specific Hyperplasia of the Ascending Aorta Through Regulation of Inhibitor of Differentiation 3. CIRCULATION RESEARCH, 106(3), 611-U108. doi:10.1161/CIRCRESAHA.109.212837