Gordon W. Laurie

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Primary Appointment

Professor, Cell Biology

Education

  • BS, Biology, McMaster University
  • MS, Cell Biology, McGill University, Montreal, P.Q., CANADA
  • PhD, Cell Biology, McGill University, Montreal, P.Q., CANADA

Research Disciplines

Biochemistry, Biotechnology, Cell and Developmental Biology, Development, Stem Cells & Regeneration, Metabolism, Molecular Pharmacology, Translational Science

Research Interests

Restoration of Homeostasis in Disease

Research Description

My lab is interested in epithelial homeostasis, secretion and innate defense. We focus on the human prosecretory mitogen 'lacritin' that we discovered and named out of an unbiased screen for factors regulating ocular tearing (Sanghi et al, J Mol Biol '01). Tears are responsible for homeostasis of the surface of the eye and are essential for innate defense (Karnati et al, Exp Eye Res '13). Both functions are in whole or part contributed by lacritin (Wang et al, J Biol Chem â13) or by cleavage potentiated fragments of lacritin (McKown et al, J Biol Chem, '14). Truncation and point mutational analysis narrowed the active site in lacritin to an amphipathic alpha helix (Wang et al, J Cell Biol â06; J Biol Chem â13), represented by the nineteen amino acid synthetic peptide 'N-94/C-6' - now the subject of a 201 patient, 25 site randomized, placebo controlled phase 2 clinical trial in 'dry eye', the most common eye disease. The trial is sponsored by 'TearSolutions, Inc.' that I cofounded in 2013. Mass spec reveals that N-94/C-6-containing peptides are in plasma and cerebral spinal fluid, implying a potentially very broad hormone-like benefit. New areas of research under exploration include: (i) the lacritin signaling receptor and associated mediators via APEX2 labeling, and via a CRISPR/Cas9 genome-wide screen in collaboration with the Broad Institute, (ii) pro-homeostatic, and sensitivity targeting of IPSC-derived sensory neurons, (iii) lacritinâs cleavage-potentiated bactericidal activity (McKown et al, J Biol Chem '14) represented by the lacritin peptide N-104 (the subject of this application), and (iv) a potential benefit in restoring pancreatic islet function in type 1 diabetes. In 2002, I organized the multi-institutional Lacritin Consortium of collaborating labs (UVa, James Madison University, Eastern Virginia Medical School, Harvard University, University of Illinois at Chicago, Johns Hopkins, UCSF, UC-Berkeley, US Army at Fort Belvoir and others). The Consortium has continuously at least two times a year since to share data and explore new projects.

Personal Statement

We focus on homeostasis, particularly epithelial and neuronal homeostasis. 'Dry eye' disease is a disruption of ocular homeostasis. No one has addressed the biological basis of dry eye, except for its downstream inflammation. We did so and discovered/named 'lacritin' out of an unbiased biochemical screen using an in vitro tear secretion end point assay - later replicated in vivo. Independent of its activity as a tear secretagogue, lacritin was also found to counter inflammatory cytokine-induced death by transiently accelerating autophagy and restoring oxidative phosphorylation. Both activities are rationale for a large phase 2 clinical trial nationwide. Interestingly, lacritin's active domain is represented as fragments in plasma and CSF, raising the possibility that other organs may benefit.

Training

  • Biotechnology Training Grant

Selected Publications

Rao P, McKown RL, Laurie GW, Suvas S, Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis., 2019; Experimental eye research. 184() 101-106. PMID: 31009613

Wang W, Lee C, Pastuszka M, Laurie GW, MacKay JA, Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses., 2019; Pharmaceutics. 11(5) . PMID: 31067782

Laurie GW, Leblond CP, What is Known of the Production of Basement Membrane Components 12., 2017; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 31(1) 159-163. PMID: 28054851

Willcox MDP, Argüeso P, Georgiev GA, Holopainen JM, Laurie GW, Millar TJ, Papas EB, Rolland JP, Schmidt TA, Stahl U, Suarez T, Subbaraman LN, Uçakhan OÃ, Jones L, TFOS DEWS II Tear Film Report., 2017; The ocular surface. 15(3) 366-403. PMID: 28736338 | PMCID: PMC6035753

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM, Doran KS, D'Orazi G, Dorn GW, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÃF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÃB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, Harris AL, Harris J, Hasler U, Hasselblatt P, Hasui K, Hawley RG, Hawley TS, He C, He CY, He F, He G, He RR, He XH, He YW, He YY, Heath JK, Hébert MJ, Heinzen RA, Helgason GV, Hensel M, Henske EP, Her C, Herman PK, Hernández A, Hernandez C, Hernández-Tiedra S, Hetz C, Hiesinger PR, Higaki K, Hilfiker S, Hill BG, Hill JA, Hill WD, Hino K, Hofius D, Hofman P, Höglinger GU, Höhfeld J, Holz MK, Hong Y, Hood DA, Hoozemans JJ, Hoppe T, Hsu C, Hsu CY, Hsu LC, Hu D, Hu G, Hu HM, Hu H, Hu MC, Hu YC, Hu ZW, Hua F, Hua Y, Huang C, Huang HL, Huang KH, Huang KY, Huang S, Huang S, Huang WP, Huang YR, Huang Y, Huang Y, Huber TB, Huebbe P, Huh WK, Hulmi JJ, Hur GM, Hurley JH, Husak Z, Hussain SN, Hussain S, Hwang JJ, Hwang S, Hwang TI, Ichihara A, Imai Y, Imbriano C, Inomata M, Into T, Iovane V, Iovanna JL, Iozzo RV, Ip NY, Irazoqui JE, Iribarren P, Isaka Y, Isakovic AJ, Ischiropoulos H, Isenberg JS, Ishaq M, Ishida H, Ishii I, Ishmael JE, Isidoro C, Isobe K, Isono E, Issazadeh-Navikas S, Itahana K, Itakura E, Ivanov AI, Iyer AK, Izquierdo JM, Izumi Y, Izzo V, Jäättelä M, Jaber N, Jackson DJ, Jackson WT, Jacob TG, Jacques TS, Jagannath C, Jain A, Jana NR, Jang BK, Jani A, Janji B, Jannig PR, Jansson PJ, Jean S, Jendrach M, Jeon JH, Jessen N, Jeung EB, Jia K, Jia L, Jiang H, Jiang H, Jiang L, Jiang T, Jiang X, Jiang X, Jiang X, Jiang Y, Jiang Y, Jiménez A, Jin C, Jin H, Jin L, Jin M, Jin S, Jinwal UK, Jo EK, Johansen T, Johnson DE, Johnson GV, Johnson JD, Jonasch E, Jones C, Joosten LA, Jordan J, Joseph AM, Joseph B, Joubert AM, Ju D, Ju J, Juan HF, Juenemann K, Juhász G, Jung HS, Jung JU, Jung YK, Jungbluth H, Justice MJ, Jutten B, Kaakoush NO, Kaarniranta K, Kaasik A, Kabuta T, Kaeffer B, KÃ¥gedal K, Kahana A, Kajimura S, Kakhlon O, Kalia M, Kalvakolanu DV, Kamada Y, Kambas K, Kaminskyy VO, Kampinga HH, Kandouz M, Kang C, Kang R, Kang TC, Kanki T, Kanneganti TD, Kanno H, Kanthasamy AG, Kantorow M, Kaparakis-Liaskos M, Kapuy O, Karantza V, Karim MR, Karmakar P, Kaser A, Kaushik S, Kawula T, Kaynar AM, Ke PY, Ke ZJ, Kehrl JH, Keller KE, Kemper JK, Kenworthy AK, Kepp O, Kern A, Kesari S, Kessel D, Ketteler R, Kettelhut Ido, Khambu B, Khan MM, Khandelwal VK, Khare S, Kiang JG, Kiger AA, Kihara A, Kim AL, Kim CH, Kim DR, Kim DH, Kim EK, Kim HY, Kim HR, Kim JS, Kim JH, Kim JC, Kim JH, Kim KW, Kim MD, Kim MM, Kim PK, Kim SW, Kim SY, Kim YS, Kim Y, Kimchi A, Kimmelman AC, Kimura T, King JS, Kirkegaard K, Kirkin V, Kirshenbaum LA, Kishi S, Kitajima Y, Kitamoto K, Kitaoka Y, Kitazato K, Kley RA, Klimecki WT, Klinkenberg M, Klucken J, Knævelsrud H, Knecht E, Knuppertz L, Ko JL, Kobayashi S, Koch JC, Koechlin-Ramonatxo C, Koenig U, Koh YH, Köhler K, Kohlwein SD, Koike M, Komatsu M, Kominami E, Kong D, Kong HJ, Konstantakou EG, Kopp BT, Korcsmaros T, Korhonen L, Korolchuk VI, Koshkina NV, Kou Y, Koukourakis MI, Koumenis C, Kovács AL, Kovács T, Kovacs WJ, Koya D, Kraft C, Krainc D, Kramer H, Kravic-Stevovic T, Krek W, Kretz-Remy C, Krick R, Krishnamurthy M, Kriston-Vizi J, Kroemer G, Kruer MC, Kruger R, Ktistakis NT, Kuchitsu K, Kuhn C, Kumar AP, Kumar A, Kumar A, Kumar D, Kumar D, Kumar R, Kumar S, Kundu M, Kung HJ, Kuno A, Kuo SH, Kuret J, Kurz T, Kwok T, Kwon TK, Kwon YT, Kyrmizi I, La Spada AR, Lafont F, Lahm T, Lakkaraju A, Lam T, Lamark T, Lancel S, Landowski TH, Lane DJ, Lane JD, Lanzi C, Lapaquette P, Lapierre LR, Laporte J, Laukkarinen J, Laurie GW, Lavandero S, Lavie L, LaVoie MJ, Law BY, Law HK, Law KB, Layfield R, Lazo PA, Le Cam L, Le Roch KG, Le Stunff H, Leardkamolkarn V, Lecuit M, Lee BH, Lee CH, Lee EF, Lee GM, Lee HJ, Lee H, Lee JK, Lee J, Lee JH, Lee JH, Lee M, Lee MS, Lee PJ, Lee SW, Lee SJ, Lee SJ, Lee SY, Lee SH, Lee SS, Lee SJ, Lee S, Lee YR, Lee YJ, Lee YH, Leeuwenburgh C, Lefort S, Legouis R, Lei J, Lei QY, Leib DA, Leibowitz G, Lekli I, Lemaire SD, Lemasters JJ, Lemberg MK, Lemoine A, Leng S, Lenz G, Lenzi P, Lerman LO, Lettieri Barbato D, Leu JI, Leung HY, Levine B, Lewis PA, Lezoualc'h F, Li C, Li F, Li FJ, Li J, Li K, Li L, Li M, Li M, Li Q, Li R, Li S, Li W, Li W, Li X, Li Y, Lian J, Liang C, Liang Q, Liao Y, Liberal J, Liberski PP, Lie P, Lieberman AP, Lim HJ, Lim KL, Lim K, Lima RT, Lin CS, Lin CF, Lin F, Lin F, Lin FC, Lin K, Lin KH, Lin PH, Lin T, Lin WW, Lin YS, Lin Y, Linden R, Lindholm D, Lindqvist LM, Lingor P, Linkermann A, Liotta LA, Lipinski MM, Lira VA, Lisanti MP, Liton PB, Liu B, Liu C, Liu CF, Liu F, Liu HJ, Liu J, Liu JJ, Liu JL, Liu K, Liu L, Liu L, Liu Q, Liu RY, Liu S, Liu S, Liu W, Liu XD, Liu X, Liu XH, Liu X, Liu X, Liu X, Liu Y, Liu Y, Liu Z, Liu Z, Liuzzi JP, Lizard G, Ljujic M, Lodhi IJ, Logue SE, Lokeshwar BL, Long YC, Lonial S, Loos B, López-Otín C, López-Vicario C, Lorente M, Lorenzi PL, Lõrincz P, Los M, Lotze MT, Lovat PE, Lu B, Lu B, Lu J, Lu Q, Lu SM, Lu S, Lu Y, Luciano F, Luckhart S, Lucocq JM, Ludovico P, Lugea A, Lukacs NW, Lum JJ, Lund AH, Luo H, Luo J, Luo S, Luparello C, Lyons T, Ma J, Ma Y, Ma Y, Ma Z, Machado J, Machado-Santelli GM, Macian F, MacIntosh GC, MacKeigan JP, 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Wang W, Jashnani A, Aluri SR., Gustafson JA., Hsueh PY., Yarber F, McKown RL., Laurie GW., Hamm-Alvarez SF., MacKay JA., A thermo-responsive protein treatment for dry eyes, 2015; J Control Release. 199() 156-167. PMID: | PMCID: PMC4456095

Karnati R, Talla V, Peterson K, Laurie GW, Lacritin and other autophagy associated proteins in ocular surface health., 2015; Experimental eye research. 144() 4-13. PMID: 26318608 | PMCID: PMC4698016

Ferguson TA, Laurie GW, Introduction to Autophagy in the Eye (or "What's Eatin' You?")., 2015; Experimental eye research. 144() 1-3. PMID: 26348132 | PMCID: PMC4777279

Vijmasi T, Chen FY, Balasubbu S, Gallup M, McKown RL, Laurie GW, McNamara NA, Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease., 2014; Investigative ophthalmology & visual science. 55(8) 5401-9. PMID: 25034600 | PMCID: PMC4148924

McKown RL, Coleman Frazier EV, Zadrozny KK, Deleault AM, Raab RW, Ryan DS, Sia RK, Lee JK, Laurie GW, A cleavage-potentiated fragment of tear lacritin is bactericidal., 2014; The Journal of biological chemistry. 289(32) 22172-82. PMID: 24942736 | PMCID: PMC4139230

Feng MM, Baryla J, Liu H, Laurie GW, McKown RL, Ashki N, Bhayana D, Hutnik CM, Cytoprotective effect of lacritin on human corneal epithelial cells exposed to benzalkonium chloride in vitro., 2014; Current eye research. 39(6) 604-10. PMID: 24401093 | PMCID: PMC4371594

Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA, A thermo-responsive protein treatment for dry eyes., 2014; Journal of controlled release : official journal of the Controlled Release Society. 199() 156-67. PMID: 25481446 | PMCID: PMC4456095

Karnati R, Laurie DE, Laurie GW, Lacritin and the tear proteome as natural replacement therapy for dry eye., 2013; Experimental eye research. 117() 39-52. PMID: 23769845 | PMCID: PMC3844047

McKown RL, Raab RW, Kachelries P, Caldwell S, Laurie GW, Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin., 2013; Investigative ophthalmology & visual science. 54(3) 1979-87. PMID: 23422824 | PMCID: PMC3604909

Wang N, Zimmerman K, Raab RW, McKown RL, Hutnik CM, Talla V, Tyler MF, Lee JK, Laurie GW, Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism., 2013; The Journal of biological chemistry. 288(25) 18146-61. PMID: 23640897 | PMCID: PMC3689958

Zhang Y, Wang N, Raab RW, McKown RL, Irwin JA, Kwon I, van Kuppevelt TH, Laurie GW, Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity., 2013; The Journal of biological chemistry. 288(17) 12090-101. PMID: 23504321 | PMCID: PMC3636894

Velez V F, Romano JA, McKown RL, Green K, Zhang L, Raab RW, Ryan DS, Hutnik CM, Frierson HF, Laurie GW, Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity., 2013; Investigative ophthalmology & visual science. 54(3) 2123-32. PMID: 23425695 | PMCID: PMC3621506

Laurie DE, Splan RK, Green K, Still KM, McKown RL, Laurie GW, Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment., 2012; Investigative ophthalmology & visual science. 53(10) 6130-6. PMID: 22871838 | PMCID: PMC3441044

Seifert K, Gandia NC, Wilburn JK, Bower KS, Sia RK, Ryan DS, Deaton ML, Still KM, Vassilev VC, Laurie GW, McKown RL, Tear lacritin levels by age, sex, and time of day in healthy adults., 2012; Investigative ophthalmology & visual science. 53(10) 6610-6. PMID: 22918641 | PMCID: PMC3460390

Zhang Y, Ryan DS, Bower KS, Ilan N, Vlodavsky I, Laurie GW, Focus on molecules: heparanase., 2010; Experimental eye research. 91(4) 476-7. PMID: 20478306 | PMCID: PMC2933305

Zhang Y, McKown RL, Raab RW, Rapraeger AC, Laurie GW, Focus on molecules: syndecan-1., 2010; Experimental eye research. 93(4) 329-30. PMID: 20599970 | PMCID: PMC2955988

Samudre S, Lattanzio FA, Lossen V, Hosseini A, Sheppard JD, McKown RL, Laurie GW, Williams PB, Lacritin, a novel human tear glycoprotein, promotes sustained basal tearing and is well tolerated., 2010; Investigative ophthalmology & visual science. 52(9) 6265-70. PMID: 21087963 | PMCID: PMC3176019

Laurie GW, Olsakovsky LA, Conway BP, McKown RL, Kitagawa K, Nichols JJ, Dry eye and designer ophthalmics., 2008; Optometry and vision science : official publication of the American Academy of Optometry. 85(8) 643-52. PMID: 18677231 | PMCID: PMC2815326

McKown RL, Wang N, Raab RW, Karnati R, Zhang Y, Williams PB, Laurie GW, Lacritin and other new proteins of the lacrimal functional unit., 2008; Experimental eye research. 88(5) 848-58. PMID: 18840430 | PMCID: PMC2712882

Ma P, Wang N, McKown RL, Raab RW, Laurie GW, Focus on molecules: lacritin., 2007; Experimental eye research. 86(3) 457-8. PMID: 17412322 | PMCID: PMC2277456

Ma P, Beck SL, Raab RW, McKown RL, Coffman GL, Utani A, Chirico WJ, Rapraeger AC, Laurie GW, Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin., 2006; The Journal of cell biology. 174(7) 1097-106. PMID: 16982797 | PMCID: PMC1666580

Wang J, Wang N, Xie J, Walton SC, McKown RL, Raab RW, Ma P, Beck SL, Coffman GL, Hussaini IM, Laurie GW, Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways., 2006; The Journal of cell biology. 174(5) 689-700. PMID: 16923831 | PMCID: PMC1761701

Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF, Laurie GW, The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts., 2005; Investigative ophthalmology & visual science. 46(5) 1572-80. PMID: 15851553

Wang J, Laurie GW, Organogenesis of the exocrine gland., 2004; Developmental biology. 273(1) 1-22. PMID: 15302594

Kumar R, Huebner A, Laurie GW, Genetic separation of the human lacritin gene ("LACRT") and triple A (Allgrove) syndrome on 12q13., 2003; Advances in experimental medicine and biology. 506(0) 167-74. PMID: 12613904

Kumar R, Eastwood AL, Brown ML, Laurie GW, Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation., 2002; Journal of molecular biology. 319(3) 593-602. PMID: 12054857

Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ, Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression., 2002; The Journal of biological chemistry. 277(16) 13778-86. PMID: 11827968

Pogány G, Timár F, Oláh J, Harisi R, Polony G, Paku S, Bocsi J, Jeney A, Laurie GW, Role of the basement membrane in tumor cell dormancy and cytotoxic resistance., 2001; Oncology. 60(3) 274-81. PMID: 11340380

Sanghi S, Kumar R, Lumsden A, Dickinson D, Klepeis V, Trinkaus-Randall V, Frierson HF, Laurie GW, cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland., 2001; Journal of molecular biology. 310(1) 127-39. PMID: 11419941

Edlund M, Miyamoto T, Sikes RA, Ogle R, Laurie GW, Farach-Carson MC, Otey CA, Zhau HE, Chung LW, Integrin expression and usage by prostate cancer cell lines on laminin substrata., 2001; Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 12(2) 99-107. PMID: 11243469

Sanghi S, Kumar R, Walton S, Laurie GW, Quantitation of rat lacrimal secretion: a novel sandwich ELISA with high sensitivity., 2000; Experimental eye research. 70(5) 651-8. PMID: 10870523

Kumar R, Lumsden A, Ciclitira PJ, Ellis HJ, Laurie GW, Human genome search in celiac disease using gliadin cDNA as probe., 2000; Journal of molecular biology. 300(5) 1155-67. PMID: 10903861

Chen L, Glass JD, Walton SC, Laurie GW, Role of laminin-1, collagen IV, and an autocrine factor(s) in regulated secretion by lacrimal acinar cells., 1998; The American journal of physiology. 275(1) C278-84. PMID: 9688859

Scholz E, Pogany G, Ganzler K, Laurie GW, Characterization of a basement membrane protein (BM180) using capillary electrophoresis., 1998; Journal of capillary electrophoresis. 4(6) 287-92. PMID: 9827419

Asrani AC, Lumsden AJ, Kumar R, Laurie GW, Gene cloning of BM180, a lacrimal gland enriched basement membrane protein with a role in stimulated secretion., 1998; Advances in experimental medicine and biology. 438() 49-54. PMID: 9634862

Chen L, Shick V, Matter ML, Laurie SM, Ogle RC, Laurie GW, Laminin E8 alveolarization site: heparin sensitivity, cell surface receptors, and role in cell spreading., 1997; The American journal of physiology. 272(3) L494-503. PMID: 9124607

Laurie GW, Glass JD, Ogle RA, Stone CM, Sluss JR, Chen L, "BM180": a novel basement membrane protein with a role in stimulus-secretion coupling by lacrimal acinar cells., 1996; The American journal of physiology. 270(6) C1743-50. PMID: 8764158

Matter ML, Laurie GW, A putative sub-10-kDa basement membrane activity required for lung alveolar formation in vitro., 1996; The American journal of physiology. 271(3) L489-94. PMID: 8843800

Laurie GW, Ciclitira PJ, Ellis HJ, Pogany G, Immunological and partial sequence identity of mouse BM180 with wheat alpha-gliadin., 1995; Biochemical and biophysical research communications. 217(1) 10-5. PMID: 8526896

Chakravarti S, Horchar T, Jefferson B, Laurie GW, Hassell JR, Recombinant domain III of perlecan promotes cell attachment through its RGDS sequence., 1995; The Journal of biological chemistry. 270(1) 404-9. PMID: 7814401

Matter ML, Laurie GW, A novel laminin E8 cell adhesion site required for lung alveolar formation in vitro., 1994; The Journal of cell biology. 124(6) 1083-90. PMID: 8132708 | PMCID: PMC2119975

Laurie GW, Glass JD, Ogle RA, Basement membrane modulation of stimulated secretion by lacrimal acinar cells., 1994; Advances in experimental medicine and biology. 350() 37-44. PMID: 8030505

Laurie GW, Stone CM, Glass JD, Serum-free primary culture of harderian acinar cells., 1994; Experimental eye research. 58(3) 375-8. PMID: 8174657

Stone CM, Laurie GW, Cell-specific expression of LBP-32 mRNA in retina and other locations of newborn mouse eye as revealed by in situ hybridization., 1992; Current eye research. 11(9) 923-7. PMID: 1424732

Laurie GW, Stone CM, Yamada Y, Elevated 32-kDa LBP and low laminin mRNA expression in developing mouse cerebrum., 1991; Differentiation; research in biological diversity. 46(3) 173-9. PMID: 1833253

Stone CM, Laurie GW, Cellular expression of collagen IV mRNA in eye., 1991; Experimental eye research. 53(5) 677-80. PMID: 1743266

Taub M, Laurie GW, Martin GR, Kleinman HK, Altered basement membrane protein biosynthesis by primary cultures of cpk/cpk mouse kidney., 1990; Kidney international. 37(4) 1090-7. PMID: 2160557

Laurie GW, Horikoshi S, Killen PD, Segui-Real B, Yamada Y, In situ hybridization reveals temporal and spatial changes in cellular expression of mRNA for a laminin receptor, laminin, and basement membrane (type IV) collagen in the developing kidney., 1989; The Journal of cell biology. 109(3) 1351-62. PMID: 2527859 | PMCID: PMC2115755

Ebihara I, Killen PD, Laurie GW, Huang T, Yamada Y, Martin GR, Brown KS, Altered mRNA expression of basement membrane components in a murine model of polycystic kidney disease., 1988; Laboratory investigation; a journal of technical methods and pathology. 58(3) 262-9. PMID: 3279260

Laurie GW, Inoue S, Bing JT, Hassell JR, Visualization of the large heparan sulfate proteoglycan from basement membrane., 1988; The American journal of anatomy. 181(3) 320-6. PMID: 2452565

Hassell JM, Noonan DM, Ledbetter SR, Laurie GW, Biosynthesis and structure of the basement membrane proteoglycan containing heparan sulphate side-chains., 1986; Ciba Foundation symposium. 124() 204-22. PMID: 2949947

Kleinman HK, McGarvey ML, Hassell JR, Star VL, Cannon FB, Laurie GW, Martin GR, Basement membrane complexes with biological activity., 1986; Biochemistry. 25(2) 312-8. PMID: 2937447

Laurie GW, Bing JT, Kleinman HK, Hassell JR, Aumailley M, Martin GR, Feldmann RJ, Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen., 1986; Journal of molecular biology. 189(1) 205-16. PMID: 2946868

Chandrasekhar S, Laurie GW, Cannon FB, Martin GR, Kleinman HK, In vitro regulation of cartilage matrix assembly by a Mr 54,000 collagen-binding protein., 1986; Proceedings of the National Academy of Sciences of the United States of America. 83(14) 5126-30. PMID: 3014533 | PMCID: PMC323903

Laurie GW, Lack of heparan sulfate proteoglycan in a discontinuous and irregular placental basement membrane., 1985; Developmental biology. 108(2) 299-309. PMID: 2934285

Bohnsack JF, Tenner AJ, Laurie GW, Kleinman HK, Martin GR, Brown EJ, The C1q subunit of the first component of complement binds to laminin: a mechanism for the deposition and retention of immune complexes in basement membrane., 1985; Proceedings of the National Academy of Sciences of the United States of America. 82(11) 3824-8. PMID: 2987948 | PMCID: PMC397880

Kleinman HK, Cannon FB, Laurie GW, Hassell JR, Aumailley M, Terranova VP, Martin GR, DuBois-Dalcq M, Biological activities of laminin., 1985; Journal of cellular biochemistry. 27(4) 317-25. PMID: 3889019

Laurie GW, Leblond CP, Basement membrane nomenclature., 1985; Nature. 313(6000) 272. PMID: 3969140

Laurie GW, Leblond CP, Inoue S, Martin GR, Chung A, Fine structure of the glomerular basement membrane and immunolocalization of five basement membrane components to the lamina densa (basal lamina) and its extensions in both glomeruli and tubules of the rat kidney., 1984; The American journal of anatomy. 169(4) 463-81. PMID: 6375342

Laurie GW, Leblond CP, What is known of the production of basement membrane components., 1983; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 31(1) 159-63. PMID: 6186721

Laurie GW, Leblond CP, Martin GR, Light microscopic immunolocalization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin in the basement membranes of a variety of rat organs., 1983; The American journal of anatomy. 167(1) 71-82. PMID: 6346854

Inoué S, Leblond CP, Laurie GW, Ultrastructure of Reichert's membrane, a multilayered basement membrane in the parietal wall of the rat yolk sac., 1983; The Journal of cell biology. 97(5) 1524-37. PMID: 6226670 | PMCID: PMC2112687

Laurie GW, Leblond CP, Martin GR, Silver MH, Intracellular localization of basement membrane precursors in the endodermal cells of the rat parietal yolk sac. III. Immunostaining for laminin and its precursors., 1982; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 30(10) 991-8. PMID: 6752265

Laurie GW, Leblond CP, Martin GR, Localization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin to the basal lamina of basement membranes., 1982; The Journal of cell biology. 95(1) 340-4. PMID: 6216257 | PMCID: PMC2112347

Laurie GW, Leblond CP, Intracellular localization of basement membrane precursors in the endodermal cells of the rat parietal yolk sac. I. Ultrastructure and phosphatase activity of endodermal cells., 1982; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 30(10) 973-82. PMID: 6290565

Laurie GW, Leblond CP, Martin GR, Intracellular localization of basement membrane precursors in the endodermal cells of the rat parietal yolk sac. II. Immunostaining for type IV collagen and its precursors., 1982; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 30(10) 983-90. PMID: 6752264

Laurie GW, Leblond CP, Cournil I, Martin GR, Immunohistochemical evidence for the intracellular formation of basement membrane collagen (type IV) in developing tissues., 1980; The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 28(12) 1267-74. PMID: 6164715

Georgiev GeorgiA, Sharifian Gh Mohammad, Romano Jeff, Dias Teixeira KarinaL, Struble Craig, Ryan DeniseS, Sia Rose K, Kitt JayP, Harris JoelM, Hsu Ku-Lung, Libby Adam , Odrich MarcG, Suarez Tatiana, McKown RobertL, Laurie GordonW, Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis, ; . () . PMID: | PMCID: PMC7948570