Victor E. Laubach

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Primary Appointment

Professor, Surgery

Education

  • BS, Biology, Pennsylvania State University, University Park, PA
  • PhD, Genetics, George Washington University School of Medicine

Research Disciplines

Cardiovascular Biology, Immunology, Molecular Biology, Physiology, Translational Science

Research Interests

Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation to identifying therapeutic targets.

Research Description

My lab studies clinically relevant issues including lung ischemia-reperfusion injury after transplant, organ preservation, ex vivo lung perfusion (EVLP), and in vivo lung perfusion (IVLP) as a surgical treatment of ARDS. Specifically, we are focusing on mechanisms of vascular inflammation, endothelial and epithelial barriers, edema, and innate immune responses. Signaling pathways of interest include DAMP molecules, purinergic signaling, TRPV4, Panx1, and Piezo1 channels in pulmonary vascular endothelium, epithelium, macrophages, and neutrophils. We utilize various models including in vitro hypoxia-reoxygenation exposure, murine lung ischemia-reperfusion, porcine lung transplantation and ischemia-reperfusion, EVLP of porcine DCD donor lungs, and IVLP treatment of severe ARDS in pigs.

Personal Statement

My lab studies clinically relevant issues including lung ischemia-reperfusion injury after transplant, organ preservation, ex vivo lung perfusion (EVLP), in vivo lung perfusion (IVLP) as a surgical treatment of ARDS, and organ injury after cardiopulmonary bypass.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

2024

Ta, H. Q., Kuppusamy, M., Sonkusare, S. K., Roeser, M. E., & Laubach, V. E. (2024). The endothelium: gatekeeper to lung ischemia-reperfusion injury.. Respir Res, 25(1), 172. doi:10.1186/s12931-024-02776-4

2023

Kuppusamy, M., Ta, H. Q., Davenport, H. N., Bazaz, A., Kulshrestha, A., Daneva, Z., . . . Sonkusare, S. K. (2023). Purinergic P2Y2 receptor-induced activation of endothelial TRPV4 channels mediates lung ischemia-reperfusion injury. SCIENCE SIGNALING, 16(808). doi:10.1126/scisignal.adg1553

Daneva, Z., Chen, Y. -L., Ta, H. Q., Manchikalapudi, V., Bazaz, A., Laubach, V. E., & Sonkusare, S. K. (2023). Endothelial IK and SK channel activation decreases pulmonary arterial pressure and vascular remodeling in pulmonary hypertension. PULMONARY CIRCULATION, 13(1). doi:10.1002/pul2.12186

Ta, H. Q., Teman, N. R., Kron, I. L., Roeser, M. E., & Laubach, V. E. (2023). Steen solution protects pulmonary microvascular endothelial cells and preserves endothelial barrier after lipopolysaccharide-induced injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 165(1), E5-E20. doi:10.1016/j.jtcvs.2022.04.005

2022

Sonkusare, S. K., & Laubach, V. E. (2022). Endothelial TRPV4 channels in lung edema and injury. ROLE OF TRPV4 CHANNELS IN DIFFERENT ORGAN SYSTEMS, 89, 43-62. doi:10.1016/bs.ctm.2022.07.001

Rotar, E. P., Haywood, N. S., Mehaffey, J. H., Money, D. T., Ta, H. Q., Stoler, M. H., . . . Roeser, M. E. (2022). Gastric Aspiration and Ventilator-Induced Model of Acute Respiratory Distress Syndrome in Swine. JOURNAL OF SURGICAL RESEARCH, 280, 280-287. doi:10.1016/j.jss.2022.07.023

Kulkarni, H. S., Lee, J. S., Bastarache, J. A., Kuebler, W. M., Downey, G. P., Albaiceta, G. M., . . . Matute-Bello, G. (2022). Update on the Features and Measurements of Experimental Acute Lung Injury in Animals An Official American Thoracic Society Workshop Report. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 66(2), E1-E14. doi:10.1165/rcmb.2021.0531ST

Haywood, N., Ta, H. Q., Zhang, A., Charles, E. J., Rotar, E., Iv, S. N., . . . Laubach, V. E. (2022). Endothelial Transient Receptor Potential Vanilloid 4 Channels Mediate Lung Ischemia-Reperfusion Injury. ANNALS OF THORACIC SURGERY, 113(4), 1256-1264. doi:10.1016/j.athoracsur.2021.04.052

Haywood, N., Byler, M. R., Zhang, A., Rotar, E. P., Money, D., Gradecki, S. E., . . . Roeser, M. E. (2022). Secondary Burn Progression Mitigated by an Adenosine 2A Receptor Agonist. JOURNAL OF BURN CARE & RESEARCH, 43(1), 133-140. doi:10.1093/jbcr/irab053

Byler, M. R., Haywood, N. S., Money, D. T., Zhang, A., Beller, J. P., Charles, E. J., . . . Roeser, M. E. (2022). Two Hours of In Vivo Lung Perfusion Improves Lung Function in Sepsis-Induced Acute Respiratory Distress Syndrome. SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY, 34(1), 337-345. doi:10.1053/j.semtcvs.2021.02.034

2021

Daneva, Z., Marziano, C., Ottolini, M., Chen, Y. -L., Baker, T. M., Kuppusamy, M., . . . Sonkusare, S. K. (2021). Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(17). doi:10.1073/pnas.2023130118

Daneva, Z., Ottolini, M., Chen, Y. L., Klimentova, E., Kuppusamy, M., Shah, S. A., . . . Sonkusare, S. K. (2021). Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. ELIFE, 10. doi:10.7554/eLife.67777

Haywood, N., Ta, H. Q., Rotar, E., Daneva, Z., Sonkusare, S. K., & Laubach, V. E. (2021). Role of the purinergic signaling network in lung ischemia-reperfusion injury. CURRENT OPINION IN ORGAN TRANSPLANTATION, 26(2), 250-257. doi:10.1097/MOT.0000000000000854

2020

Haywood, N., Byler, M. R., Zhang, A., Roeser, M. E., Kron, I. L., & Laubach, V. E. (2020). Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(18). doi:10.3390/ijms21186820

Charles, E. J., Chordia, M. D., Zhao, Y., Zhang, Y., Mehaffey, J. H., Glover, D. K., . . . Laubach, V. E. (2020). SPECT imaging of lung ischemia-reperfusion injury using [99mTc]cFLFLF for molecular targeting of formyl peptide receptor 1. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 318(2), L304-L313. doi:10.1152/ajplung.00220.2018

Yeudall, S., Leitinger, N., & Laubach, V. E. (2020). Extracellular nucleotide signaling in solid organ transplantation. AMERICAN JOURNAL OF TRANSPLANTATION, 20(3), 633-640. doi:10.1111/ajt.15651

2019

Beller, J. P., Byler, M. R., Money, D. T., Chancellor, W. Z., Zhang, A., Zhao, Y., . . . Roeser, M. E. (2020). Reduced-flow ex vivo lung perfusion to rehabilitate lungs donated after circulatory death. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 39(1), 74-82. doi:10.1016/j.healun.2019.09.009

Mehaffey, J. H., Money, D., Charles, E. J., Schubert, S., Piñeros, A. F., Wu, D., . . . Roeser, M. E. (2019). Adenosine 2A Receptor Activation Attenuates Ischemia Reperfusion Injury During Extracorporeal Cardiopulmonary Resuscitation.. Annals of surgery, 269(6), 1176-1183. doi:10.1097/sla.0000000000002685

Narahari, A. K., Charles, E. J., Mehaffey, J. H., Hawkins, R. B., Sharma, A. K., Laubach, V. E., . . . Kron, I. L. (2019). Can Lung Transplant Surgeons Still Be Scientists? High Productivity Despite Competitive Funding. HEART SURGERY FORUM, 22(1), E1-E7. doi:10.1532/hsf.2024

Daneva, Z., Laubach, V. E., & Sonkusare, S. K. (2019). Novel regulators and targets of redox signaling in pulmonary vasculature. CURRENT OPINION IN PHYSIOLOGY, 9, 87-93. doi:10.1016/j.cophys.2019.04.026

Myc, L. A., Shim, Y. M., Laubach, V. E., & Dimastromatteo, J. (2019). Role of medical and molecular imaging in COPD. CLINICAL AND TRANSLATIONAL MEDICINE, 8. doi:10.1186/s40169-019-0231-z

Mehaffey, J. H., Money, D., Charles, E. J., Schubert, S., Pineros, A. F., Bontha, S. V., . . . Roeser, M. E. (2019). Adenosine 2A Receptor Activation Attenuates Ischemia Reperfusion Injury During Extracorporeal Cardiopulmonary Resuscitation. ANNALS OF SURGERY, 269(6), 1176-1183. doi:10.1097/SLA.0000000000002685

2018

Sharma, A. K., & Laubach, V. E. (2018). Protecting Donor Livers During Normothermic Machine Perfusion With Stem Cell Extracellular Vesicles. TRANSPLANTATION, 102(5), 725-726. doi:10.1097/TP.0000000000002124

Charles, E. J., Mehaffey, J. H., Huerter, M. E., Sharma, A. K., Stoler, M. H., Roeser, M. E., . . . Laubach, V. E. (2018). Ex Vivo Assessment of Porcine Donation After Circulatory Death Lungs That Undergo Increasing Warm Ischemia Times. TRANSPLANTATION DIRECT, 4(12). doi:10.1097/TXD.0000000000000845

Sharma, A. K., Charles, E. J., Zhao, Y., Narahari, A. K., Baderdinni, P. K., Good, M. E., . . . Laubach, V. E. (2018). Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 315(2), L301-L312. doi:10.1152/ajplung.00004.2018

Mehaffey, J. H., Charles, E. J., Narahari, A. K., Schubert, S., Laubach, V. E., Teman, N. R., . . . Sharma, A. K. (2018). Increasing circulating sphingosine-1-phosphate attenuates lung injury during ex vivo lung perfusion. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 156(2), 910-917. doi:10.1016/j.jtcvs.2018.02.090

Meher, A. K., Spinosa, M., Davis, J. P., Pope, N., Laubach, V. E., Su, G., . . . Upchurch, G. R. J. (2018). Novel Role of IL (Interleukin)-1β in Neutrophil Extracellular Trap Formation and Abdominal Aortic Aneurysms. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(4), 843-853. doi:10.1161/ATVBAHA.117.309897

Dimastromatteo, J., Charles, E. J., & Laubach, V. E. (2018). Molecular imaging of pulmonary diseases. RESPIRATORY RESEARCH, 19. doi:10.1186/s12931-018-0716-0

Mehaffey, J. H., Charles, E. J., Schubert, S., Salmon, M., Sharma, A. K., Money, D., . . . Kron, I. L. (2018). In vivo lung perfusion rehabilitates sepsis-induced lung injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 155(1), 440-+. doi:10.1016/j.jtcvs.2017.08.124

2017

Chancellor, W. Z., Charles, E. J., Mehaffey, J. H., Hawkins, R. B., Foster, C. A., Sharma, A. K., . . . Tribble, C. G. (2018). Expanding the donor lung pool: how many donation after circulatory death organs are we missing?. JOURNAL OF SURGICAL RESEARCH, 223, 58-63. doi:10.1016/j.jss.2017.09.029

Call, J. A., Donet, J., Martin, K. S., Sharma, A. K., Chen, X., Zhang, J., . . . Yan, Z. (2017). Muscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice. FREE RADICAL BIOLOGY AND MEDICINE, 113, 212-223. doi:10.1016/j.freeradbiomed.2017.09.029

Lama, V. N., Belperio, J. A., Christie, J. D., El-Chemaly, S., Fishbein, M. C., Gelman, A. E., . . . Nicolls, M. R. (2017). Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI INSIGHT, 2(9). doi:10.1172/jci.insight.93121

Stone, M. L., Zhao, Y., Smith, J. R., Weiss, M. L., Kron, I. L., Laubach, V. E., & Sharma, A. K. (2017). Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death. RESPIRATORY RESEARCH, 18. doi:10.1186/s12931-017-0704-9

Charles, E. J., Mehaffey, J. H., Sharma, A. K., Zhao, Y., Stoler, M. H., Isbell, J. M., . . . Kron, I. L. (2017). Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 154(5), 1811-1819. doi:10.1016/j.jtcvs.2017.02.072

Mehaffey, J. H., Charles, E. J., Sharma, A. K., Salmon, M., Money, D., Schubert, S., . . . Kron, I. L. (2017). Ex Vivo Lung Perfusion Rehabilitates Sepsis-Induced Lung Injury. ANNALS OF THORACIC SURGERY, 103(6), 1723-1729. doi:10.1016/j.athoracsur.2017.01.018

Mehaffey, J. H., Charles, E. J., Sharma, A. K., Money, D. T., Zhao, Y., Stoler, M. H., . . . Kron, I. L. (2017). Airway pressure release ventilation during ex vivo lung perfusion attenuates injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 153(1), 197-204. doi:10.1016/j.jtcvs.2016.09.029

2016

Laubach, V. E., & Sharma, A. K. (2016). Mechanisms of lung ischemia-reperfusion injury. CURRENT OPINION IN ORGAN TRANSPLANTATION, 21(3), 246-252. doi:10.1097/MOT.0000000000000304

Sharma, A. K., LaPar, D. J., Stone, M. L., Zhao, Y., Mehta, C. K., Kron, I. L., & Laubach, V. E. (2016). NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193(9), 988-999. doi:10.1164/rccm.201506-1253OC

Mewes, K. R., Fischer, A., Zoeller, N. N., Laubach, V., Bernd, A., Jacobs, A., . . . Petersohn, D. (2016). Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase I). TOXICOLOGY IN VITRO, 36, 238-253. doi:10.1016/j.tiv.2016.07.007

Charles, E. J., Huerter, M. E., Wagner, C. E., Sharma, A. K., Zhao, Y., Stoler, M. H., . . . Kron, I. L. (2016). Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion. ANNALS OF THORACIC SURGERY, 102(6), 1845-1853. doi:10.1016/j.athoracsur.2016.06.043

Huerter, M. E., Sharma, A. K., Zhao, Y., Charles, E. J., Kron, I. L., & Laubach, V. E. (2016). Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism. ANNALS OF THORACIC SURGERY, 102(2), 385-393. doi:10.1016/j.athoracsur.2016.02.060

Wagner, C. E., Pope, N. H., Charles, E. J., Huerter, M. E., Sharma, A. K., Salmon, M. D., . . . Kron, I. L. (2016). Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 151(2), 538-546. doi:10.1016/j.jtcvs.2015.07.075

2015

Stone, M. L., Sharma, A. K., Mas, V. R., Gehrau, R. C., Mulloy, D. P., Zhao, Y., . . . Laubach, V. E. (2015). Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. TRANSPLANTATION, 99(12), 2494-2503. doi:10.1097/TP.0000000000000830

Laubach, V. E. (2015). Invited Commentary.. The Annals of thoracic surgery, 100(2), 486. doi:10.1016/j.athoracsur.2015.02.137

Stone, M. L., Sharma, A. K., Zhao, Y., Charles, E. J., Huerter, M. E., Johnston, W. F., . . . Laubach, V. E. (2015). Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 308(12), L1245-L1252. doi:10.1152/ajplung.00302.2014

2014

Nicolls, M. R., & Laubach, V. E. (2014). Traumatic Brain Injury: Lungs in a RAGE. SCIENCE TRANSLATIONAL MEDICINE, 6(252). doi:10.1126/scitranslmed.3010259

Lisle, T. C., Gazoni, L. M., Fernandez, L. G., Sharma, A. K., Bellizzi, A. M., Shifflett, G. D., . . . Kron, I. L. (2014). Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A(2A) receptor activation (vol 136, pg 1280, 2008). JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 148(2), 756.

Sharma, A. K., Mulloy, D. P., Le, L. T., & Laubach, V. E. (2014). NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 306(1), L69-L79. doi:10.1152/ajplung.00205.2013

2013

Mulloy, D. P., Sharma, A. K., Fernandez, L. G., Zhao, Y., Lau, C. L., Kron, I. L., & Laubach, V. E. (2013). Adenosine A3 Receptor Activation Attenuates Lung Ischemia-Reperfusion Injury. ANNALS OF THORACIC SURGERY, 95(5), 1762-1767. doi:10.1016/j.athoracsur.2013.01.059

Fernandez, L. G., Sharma, A. K., LaPar, D. J., Kron, I. L., & Laubach, V. E. (2013). Adenosine A1 receptor activation attenuates lung ischemia-reperfusion injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(6), 1654-1659. doi:10.1016/j.jtcvs.2013.01.006

Sharma, A. K., LaPar, D. J., Stone, M. L., Zhao, Y., Kron, I. L., & Laubach, V. E. (2013). Receptor for Advanced Glycation End Products (RAGE) on iNKT Cells Mediates Lung Ischemia-Reperfusion Injury. AMERICAN JOURNAL OF TRANSPLANTATION, 13(9), 2255-2267. doi:10.1111/ajt.12368

Bhamidipati, C. M., Mehta, G. S., Moehle, C. W., Meher, A. K., Su, G., Vigneshwar, N. G., . . . Ailawadi, G. (2013). Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms. FASEB JOURNAL, 27(6), 2122-2131. doi:10.1096/fj.12-214197

2012

Sharma, A. K., Lu, G., Jester, A., Johnston, W. F., Zhao, Y., Hajzus, V. A., . . . Upchurch, G. R. J. (2012). Experimental Abdominal Aortic Aneurysm Formation Is Mediated by IL-17 and Attenuated by Mesenchymal Stem Cell Treatment. CIRCULATION, 126(11), S38-S45. doi:10.1161/CIRCULATIONAHA.111.083451

Konkalmatt, P. R., Beyers, R., Xu, Y., & French, B. A. (2012). Cardiac-specific Expression of iNOS using an AAV9 Vector in Combination with the Cardiac Troponin-T Promoter Inhibits LV Remodeling after Reperfused Myocardial Infarction. CIRCULATION, 126(21).

Mulloy, D. P., Stone, M. L., Crosby, I. K., Lapar, D. J., Sharma, A. K., Webb, D. V., . . . Kron, I. L. (2012). Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: Delayed perfusion results in superior lung function. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 144(5), 1208-1216. doi:10.1016/j.jtcvs.2012.07.056

2011

Emaminia, A., LaPar, D. J., Zhao, Y., Steidle, J. F., Harris, D. A., Laubach, V. E., . . . Lau, C. L. (2011). Adenosine A2A Agonist Improves Lung Function During Ex Vivo Lung Perfusion. ANNALS OF THORACIC SURGERY, 92(5), 1840-1846. doi:10.1016/j.athoracsur.2011.06.062

LaPar, D. J., Hajzus, V. A., Zhao, Y., Lau, C. L., French, B. A., Kron, I. L., . . . Laubach, V. E. (2012). Acute Hyperglycemic Exacerbation of Lung Ischemia-Reperfusion Injury Is Mediated by Receptor for Advanced Glycation End-Products Signaling. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 46(3), 299-305. doi:10.1165/rcmb.2011-0247OC

Sharma, A. K., Lapar, D. J., Zhao, Y., Li, L., Lau, C. L., Kron, I. L., . . . Laubach, V. E. (2011). Natural Killer T Cell-derived IL-17 Mediates Lung Ischemia-Reperfusion Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(11), 1539-1549. doi:10.1164/rccm.201007-1173OC

Samlowski, W. E., Kondapaneni, M., Tharkar, S., McGregor, J. R., Laubach, V. E., & Salvemini, D. (2011). Endothelial Nitric Oxide Synthase Is a Key Mediator of Interleukin-2-Induced Hypotension and Vascular Leak Syndrome. JOURNAL OF IMMUNOTHERAPY, 34(5), 419-427. doi:10.1097/CJI.0b013e31821dcb50

Sun, J., Cardani, A., Sharma, A. K., Laubach, V. E., Jack, R. S., Mueller, W., & Braciale, T. J. (2011). Autocrine Regulation of Pulmonary Inflammation by Effector T-Cell Derived IL-10 during Infection with Respiratory Syncytial Virus. PLOS PATHOGENS, 7(8). doi:10.1371/journal.ppat.1002173

LaPar, D. J., Laubach, V. E., Emaminia, A., Crosby, I. K., Hajzus, V. A., Sharma, A. K., . . . Kron, I. L. (2011). Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 142(4), 887-894. doi:10.1016/j.jtcvs.2011.06.015

Zhao, Y., Sharma, A. K., LaPar, D. J., Kron, I. L., Ailawadi, G., Liu, Y., . . . Lau, C. L. (2011). Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 300(5), L718-L729. doi:10.1152/ajplung.00227.2010

2010

Laubach, V. E., French, B. A., & Okusa, M. D. (2011). Targeting of adenosine receptors in ischemia-reperfusion injury. EXPERT OPINION ON THERAPEUTIC TARGETS, 15(1), 103-118. doi:10.1517/14728222.2011.541441

Anvari, F., Sharma, A. K., Fernandez, L. G., Hranjec, T., Ravid, K., Kron, I. L., & Laubach, V. E. (2010). Tissue-derived proinflammatory effect of adenosine A2B receptor in lung ischemia-reperfusion injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140(4), 871-877. doi:10.1016/j.jtcvs.2010.06.051

Laubach, V. E. (2010). Invited commentary.. The Annals of thoracic surgery, 89(6), 1771-1772. doi:10.1016/j.athoracsur.2010.03.001

Laubach, V. E. (2010). Therapeutic Potential for CD39 in Renal Transplantation: There is Hope. AMERICAN JOURNAL OF TRANSPLANTATION, 10(12), 2567-2568. doi:10.1111/j.1600-6143.2010.03300.x

Smith, R. S., Piras, B. A., Farber, C. R., Laubach, V. E., Kron, I. L., & French, B. A. (2010). Acute Hyperglycemia Synergizes with Myocardial Infarction to Induce Significant Changes in Leukocyte Gene Expression Profiles. CIRCULATION, 122(21).

Sharma, A. K., Laubach, V. E., Ramos, S. I., Zhao, Y., Stukenborg, G., Linden, J., . . . Yang, Z. (2010). Adenosine A2A receptor activation on CD4+T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 139(2), 474-482. doi:10.1016/j.jtcvs.2009.08.033

Gazoni, L. M., Walters, D. M., Unger, E. B., Linden, J., Kron, I. L., & Laubach, V. E. (2010). Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 140(2), 440-446. doi:10.1016/j.jtcvs.2010.03.002