Victor E. Laubach

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Primary Appointment

Professor, Surgery

Education

  • BA,BS, Biology, Pennsylvania State University, University Park, PA
  • PhD, Genetics, George Washington University School of Medicine

Research Disciplines

Cardiovascular Biology, Immunology, Molecular Biology, Physiology, Translational Science

Research Interests

Understanding mechanisms of ischemia-reperfusion (IR) injury after lung transplantation such as vascular inflammation, diagnosis via molecular imaging, and identifying therapeutic targets for the prevention or treatment of IR injury.

Research Description

My laboratory studies mechanisms and prevention of lung ischemia-reperfusion (IR) injury following transplantation. IR injury is a robust inflammatory response that leads to increased morbidity and mortality after lung transplant. Our research utilizes both in vivo and in vitro models to explore inflammatory signaling pathways in innate immune cells, alveolar epithelial cells and vascular endothelial cells as well as cross-talk among these cells. One project is aimed at defining the role of pannexin 1 (Panx1)-derived extracellular ATP in mediating lung IR injury through activation of endothelial cells, neutrophils, and alveolar macrophages via purinergic signaling pathways. A second project is the development of novel molecular imaging probes (to target specific cell populations) for non-invasive PET or SPECT imaging in order to provide early diagnosis of lung IR injury. Other projects in the lab include: 1) understanding the resolution of lung IR injury and how we can augment this protective pathway in transplanted lungs, 2) studying the role of NADPH oxidase (NOX2)-derived superoxide production in the activation of various pulmonary cell types during IR injury, and 3) defining the role of calcium uptake by various cells via TRPV4 channels during lung IR injury.

Personal Statement

Mechanisms of lung ischemia-reperfusion injury and vascular inflammation after transplantation.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

Yeudall S, Leitinger N, Laubach VE., Extracellular nucleotide signaling in solid organ transplantation, 2019; American Journal of Transplantation. 0(0) . PMID: | PMCID: 31605463

Daneva Z, Laubach VE, Sonkusare SK, Novel Regulators and Targets of Redox Signaling in Pulmonary Vasculature., 2019; Current opinion in physiology. 9() 87-93. PMID: 31406951 | PMCID: PMC6690609

Beller JP, Byler MR, Money DT, Chancellor WZ, Zhang A, Zhao Y, Stoler MH, Narahari AK, Shannon A, Mehaffey JH, Tribble CG, Laubach VE, Kron IL, Roeser ME, Reduced-flow ex vivo lung perfusion to rehabilitate lungs donated after circulatory death., 2019; The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39(1) 74-82. PMID: 31761511 | PMCID: PMC7001159

Charles EJ, Chordia MD, Zhao Y, Zhang Y, Mehaffey JH, Glover DK, Dimastromatteo J, Chancellor WZ, Sharma AK, Kron IL, Pan D, Laubach VE, SPECT imaging of lung ischemia-reperfusion injury using [99mTc]cFLFLF for molecular targeting of formyl peptide receptor 1., 2019; American journal of physiology. Lung cellular and molecular physiology. 318(2) L304-L313. PMID: 31800262

Sharma AK., Charles EJ., Zhao Y, Narahari AK., Baderdinni PK., Good ME., Lorenz UM., Kron IL., Bayliss DA., Ravichandran KS., Isakson BE., Laubach VE., Pannexin 1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury., 2018; American journal of physiology. Lung cellular and molecular physiology. 315(2) L301-L312. PMID: | PMCID: PMC6139659

Dimastromatteo J, Charles EJ, Laubach VE, Molecular imaging of pulmonary diseases., 2018; Respiratory research. 19(1) 17. PMID: 29368614 | PMCID: PMC5784614

Stone ML, Zhao Y, Robert Smith J, Weiss ML, Kron IL, Laubach VE, Sharma AK, Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death., 2017; Respiratory research. 18(1) 212. PMID: 29268735 | PMCID: PMC5740880

Huerter ME, Sharma AK, Zhao Y, Charles EJ, Kron IL, Laubach VE, Attenuation of Pulmonary Ischemia-Reperfusion Injury by Adenosine A2B Receptor Antagonism., 2016; The Annals of thoracic surgery. 102(2) 385-93. PMID: 27109193 | PMCID: PMC4958568

Charles EJ, Huerter ME, Wagner CE, Sharma AK, Zhao Y, Stoler MH, Mehaffey JH, Isbell JM, Lau CL, Tribble CG, Laubach VE, Kron IL, Donation After Circulatory Death Lungs Transplantable Up to Six Hours After Ex Vivo Lung Perfusion., 2016; The Annals of thoracic surgery. 102(6) 1845-1853. PMID: 27614736 | PMCID: PMC5112144

Laubach VE, Sharma AK, Mechanisms of lung ischemia-reperfusion injury., 2016; Current opinion in organ transplantation. () . PMID: 26945320 | PMCID: PMC4861054

Sharma AK, LaPar DJ, Stone ML, Zhao Y, Mehta CK, Kron IL, Laubach VE, NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A2A Receptor to Inhibit Lung Ischemia-Reperfusion Injury., 2016; American journal of respiratory and critical care medicine. 193(9) 988-99. PMID: 26757359 | PMCID: PMC4872653

Stone ML, Sharma AK, Mas VR, Gehrau RC, Mulloy DP, Zhao Y, Lau CL, Kron IL, Huerter ME, Laubach VE, Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death., 2015; Transplantation. 99(12) 2494-503. PMID: 26262504 | PMCID: PMC4668207

Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE, Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury., 2015; American journal of physiology. Lung cellular and molecular physiology. 308(12) L1245-52. PMID: 25910934 | PMCID: PMC4587601

Sharma AK, Mulloy DP, Le LT, Laubach VE, NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion., 2013; American journal of physiology. Lung cellular and molecular physiology. 306(1) L69-79. PMID: 24186876 | PMCID: PMC3920214

Sharma AK, LaPar DJ, Stone ML, Zhao Y, Kron IL, Laubach VE, Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia-reperfusion injury., 2013; American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13(9) 2255-67. PMID: 23865790 | PMCID: PMC3776006

Mulloy DP, Stone ML, Crosby IK, Lapar DJ, Sharma AK, Webb DV, Lau CL, Laubach VE, Kron IL, Ex vivo rehabilitation of non-heart-beating donor lungs in preclinical porcine model: delayed perfusion results in superior lung function., 2012; The Journal of thoracic and cardiovascular surgery. 144(5) 1208-15. PMID: 22944084 | PMCID: PMC3477251

Sharma AK, LaPar DJ, Zhao Y, Li L, Lau CL, Kron IL, Iwakura Y, Okusa MD, Laubach VE, Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury., 2011; American journal of respiratory and critical care medicine. 183(11) 1539-49. PMID: 21317314 | PMCID: PMC3137143

Lapar DJ, Hajzus VA, Zhao Y, Lau CL, French BA, Kron IL, Sharma AK, Laubach VE, Acute hyperglycemic exacerbation of lung ischemia-reperfusion injury is mediated by receptor for advanced glycation end-products signaling., 2011; American journal of respiratory cell and molecular biology. 46(3) 299-305. PMID: 21980055 | PMCID: PMC3326427

Laubach VE, French BA, Okusa MD, Targeting of adenosine receptors in ischemia-reperfusion injury., 2010; Expert opinion on therapeutic targets. 15(1) 103-18. PMID: 21110787 | PMCID: PMC3075429

Sharma AK, Linden J, Kron IL, Laubach VE, Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation., 2009; Respiratory research. 10() 58. PMID: 19558673 | PMCID: PMC2711962