Bijoy Kundu

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Primary Appointment

Associate Professor, Radiology and Medical Imaging

Education

  • BS, Physics, Bombay University
  • MS, Physics, Bombay University
  • PhD, Physics, Bhabha Atomic Research Center

Research Disciplines

Biomedical Engineering, Biotechnology, Metabolism

Research Interests

Positron Emission Tomography Imaging of Remodeling of Myocardial Glucose Metabolism in Pressure Overload Left Ventricular Hypertrophy

Research Description

Imaging the rodent heart is challenging due to the small size of the heart and the limited spatial intrinsic resolution of the microPET scanner. This results in severe partial volume averaging (PV) and spill-over (SP) of radioactivity from the LV blood pool to the myocardium at the early time points and vice-versa at the late time points in a dynamic PET scan of the rodent heart. Rapid heart motion results in further image blur confounding the effects of SP contamination in the image-derived blood input function. My laboratory focuses on the development of multi-parameter compartment models for simultaneous estimation of the blood input function with SP and PV corrections and the kinetic parameters from dynamic PET images of the heart, for quantifying myocardial glucose (using 18F-FDG) and fatty-acid (using 11C-Palmitate) metabolism and blood flow (using 13N-ammonia) in vivo. In collaboration with a number of investigators in the School of Medicine at UVA and UT in Houston, we have assembled a strong team to evaluate the time course of metabolic alterations in the hearts of spontaneously hypertensive rats (SHR) and relate these changes to the development of LVH and HF using advanced PET and MR imaging in vivo and ex vivo molecular and metabolic analysis in conjunction with hemodynamic measurements. The work in my laboratory is funded by the National Institute of Health's National Heart Lung and Blood Institute.

Personal Statement

The general goal of my laboratory is the development and application of novel Positron Emission Tomography (PET) imaging and quantification methods for non-invasive evaluation of metabolism and blood flow from time-resolved PET images of rodent heart in vivo.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

Li J, MinÄzuk K, Massey JC, Howell NL, Roy RJ, Paul S, Patrie JT, Kramer CM, Epstein FH, Carey RM, Taegtmeyer H, Keller SR, Kundu BK, Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats., 2020; Journal of the American Heart Association. 9(7) e015154. PMID: 32248762

Huang Q, Massey JC, MiÅczuk K, Li J, Kundu BK, Non-invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic FDG PET images of rat heart in vivo: comparative study between the inferior vena cava and the left ventricular blood pool with spill over and partial volume corrections., 2019; Physics in medicine and biology. 64(16) 165010. PMID: 31307015

Molinos C, Sasser T, Salmon P, Gsell W, Viertl D, Massey JC, MiÅczuk K, Li J, Kundu BK, Berr S, Correcher C, Bahadur A, Attarwala AA, Stark S, Junge S, Himmelreich U, Prior JO, Laperre K, Van Wyk S, Heidenreich M, Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner., 2019; Frontiers in medicine. 6() 88. PMID: 31131277 | PMCID: PMC6509903

Li J, Kemp BA, Howell NL, Massey J, MiÅczuk K, Huang Q, Chordia MD, Roy RJ, Patrie JT, Davogustto GE, Kramer CM, Epstein FH, Carey RM, Taegtmeyer H, Keller SR, Kundu BK, Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy., 2019; Journal of the American Heart Association. 8(4) e010926. PMID: 30764689 | PMCID: PMC6405673

Li Y, Kundu BK, An improved optimization algorithm of the three-compartment model with spillover and partial volume corrections for dynamic FDG PET images of small animal hearts in vivo., 2018; Physics in medicine and biology. 63(5) 055003. PMID: 29480159 | PMCID: PMC6342017

Hamirani YS, Kundu BK, Zhong M, McBride A, Li Y, Davogustto GE, Taegtmeyer H, Bourque JM, Noninvasive Detection of Early Metabolic Left Ventricular Remodeling in Systemic Hypertension., 2015; Cardiology. 133(3) 157-62. PMID: 26594908 | PMCID: PMC4677787

Li Y, Huang T, Zhang X, Zhong M, Walker NN, He J, Berr SS, Keller SR, Kundu BK, Determination of Fatty Acid Metabolism with Dynamic [11C]Palmitate Positron Emission Tomography of Mouse Heart In Vivo., 2015; Molecular imaging. 14() 516-25. PMID: 26462138 | PMCID: PMC4625801

Kundu BK, Zhong M, Sen S, Davogustto G, Keller SR, Taegtmeyer H, Remodeling of glucose metabolism precedes pressure overload-induced left ventricular hypertrophy: review of a hypothesis., 2015; Cardiology. 130(4) 211-20. PMID: 25791172 | PMCID: PMC4394867

Zhong M, Kundu BK, Optimization of a Model Corrected Blood Input Function from Dynamic FDG-PET Images of Small Animal Heart In Vivo., 2014; IEEE transactions on nuclear science. 60(5) 3417-3422. PMID: 24741130 | PMCID: PMC3985393

Zhong M, Alonso CE, Taegtmeyer H, Kundu BK, Quantitative PET imaging detects early metabolic remodeling in a mouse model of pressure-overload left ventricular hypertrophy in vivo., 2013; Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 54(4) 609-15. PMID: 23426760 | PMCID: PMC3727159

Sen S, Kundu BK, Wu HC, Hashmi SS, Guthrie P, Locke LW, Roy RJ, Matherne GP, Berr SS, Terwelp M, Scott B, Carranza S, Frazier OH, Glover DK, Dillmann WH, Gambello MJ, Entman ML, Taegtmeyer H, Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart., 2013; Journal of the American Heart Association. 2(3) e004796. PMID: 23686371 | PMCID: PMC3698799

Locke LW, Williams MB, Fairchild KD, Zhong M, Kundu BK, Berr SS, FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice., 2011; International journal of molecular imaging. 2011() 356730. PMID: 22187641 | PMCID: PMC3236466