Bijoy Kundu


Primary Appointment

Associate Professor, Radiology and Medical Imaging


  • BS, Physics, Bombay University
  • MS, Physics, Bombay University
  • PhD, Physics, Bhabha Atomic Research Center

Research Disciplines

Biomedical Engineering, Biotechnology, Metabolism

Research Description

Imaging the rodent heart is challenging due to the small size of the heart and the limited spatial intrinsic resolution of the microPET scanner. This results in severe partial volume averaging (PV) and spill-over (SP) of radioactivity from the LV blood pool to the myocardium at the early time points and vice-versa at the late time points in a dynamic PET scan of the rodent heart. Rapid heart motion results in further image blur confounding the effects of SP contamination in the image-derived blood input function. My laboratory focuses on the development of multi-parameter compartment models for simultaneous estimation of the blood input function with SP and PV corrections and the kinetic parameters from dynamic PET images of the heart, for quantifying myocardial glucose (using 18F-FDG) and fatty-acid (using 11C-Palmitate) metabolism and blood flow (using 13N-ammonia) in vivo. In collaboration with a number of investigators in the School of Medicine at UVA and UT in Houston, we have assembled a strong team to evaluate the time course of metabolic alterations in the hearts of spontaneously hypertensive rats (SHR) and relate these changes to the development of LVH and HF using advanced PET and MR imaging in vivo and ex vivo molecular and metabolic analysis in conjunction with hemodynamic measurements. The work in my laboratory is funded by the National Institute of Health's National Heart Lung and Blood Institute.

Personal Statement

The general goal of my laboratory is the development and application of novel Positron Emission Tomography (PET) imaging and quantification methods for non-invasive evaluation of metabolism and blood flow from time-resolved PET images of rodent heart in vivo.


  • Basic Cardiovascular Research Training Grant

Selected Publications


Seshadri, V., Zarroli, K. A., Schetlick, R. S., Massey, J. C., Reyes, J. M., Muttikal, T. J. E., . . . Quigg, M. (2021). Dynamic FDG-PET in localization of focal epilepsy: A pilot study. EPILEPSY & BEHAVIOR, 122. doi:10.1016/j.yebeh.2021.108204

Massey, J. C., Seshadri, V., Paul, S., Minczuk, K., Molinos, C., Li, J., & Kundu, B. K. (2021). Model Corrected Blood Input Function to Compute Cerebral FDG Uptake Rates From Dynamic Total-Body PET Images of Rats in vivo. FRONTIERS IN MEDICINE, 8. doi:10.3389/fmed.2021.618645


Li, J., Minczuk, K., Massey, J. C., Howell, N. L., Roy, R. J., Paul, S., . . . Kundu, B. K. (2020). Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(7). doi:10.1161/JAHA.119.015154


Huang, Q., Massey, J. C., Minczukh, K., Li, J., & Kundu, B. K. (2019). Non-invasive determination of blood input function to compute rate of myocardial glucose uptake from dynamic FDG PET images of rat heart in vivo: comparative study between the inferior vena cava and the left ventricular blood pool with spill over and partial volume corrections. PHYSICS IN MEDICINE AND BIOLOGY, 64(16). doi:10.1088/1361-6560/ab3238

Molinos, C., Sasser, T., Salmon, P., Gsell, W., Viertl, D., Massey, J. C., . . . Heidenreich, M. (2019). Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner. FRONTIERS IN MEDICINE, 6. doi:10.3389/fmed.2019.00088

Li, J., Kemp, B. A., Howell, N. L., Massey, J., Minczuk, K., Huang, Q., . . . Kundu, B. K. (2019). Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 8(4). doi:10.1161/JAHA.118.010926


Li, Y., & Kundu, B. K. (2018). An improved optimization algorithm of the three-compartment model with spillover and partial volume corrections for dynamic FDG PET images of small animal hearts in vivo.. Physics in medicine and biology, 63(5), 055003. doi:10.1088/1361-6560/aaac02

Li, Y., & Kundu, B. K. (2018). An improved optimization algorithm of the three-compartment model with spillover and partial volume corrections for dynamic FDG PET images of small animal hearts in vivo. PHYSICS IN MEDICINE AND BIOLOGY, 63(5). doi:10.1088/1361-6560/aaac02


Ladd, A. C., Brohawn, D. G., Thomas, R. R., Keeney, P. M., Berr, S. S., Khan, S. M., . . . Bennett, J. P. (2017). RNA-seq analyses reveal that cervical spinal cords and anterior motor neurons from amyotrophic lateral sclerosis subjects show reduced expression of mitochondrial DNA-encoded respiratory genes, and rhTFAM may correct this respiratory deficiency. BRAIN RESEARCH, 1667, 74-83. doi:10.1016/j.brainres.2017.05.010


Hamirani, Y. S., Kundu, B. K., Zhong, M., McBrid, A., Li, Y., Davogustto, G. E., . . . Bourque, J. M. (2016). Noninvasive Detection of Early Metabolic Left Venticular Remodeling Systemic Hypertension. CARDIOLOGY, 133(3), 157-162. doi:10.1159/000441276


Li, Y., Huang, T., Zhang, X., Zhong, M., Walker, N. N., He, J., . . . Kundu, B. K. (2015). Determination of Fatty Acid Metabolism with Dynamic [11C]Palmitate Positron Emission Tomography of Mouse Heart In Vivo.. Mol Imaging, 14(9), 7290201500024. doi:10.2310/7290.2015.00024

Li, Y., Huang, T., Zhang, X., Zhong, M., Walker, N. N., He, J., . . . Kundu, B. K. (2015). Determination of Fatty Acid Metabolism with Dynamic [11C]Palmitate Positron Emission Tomography of Mouse Heart In Vivo. MOLECULAR IMAGING, 14, 516-525. doi:10.2310/7290.2015.00024

Sanchez Jurado, R., Ferrer Rebolleda, J., Kundu, B., Majewski, S., Zhang, X., Li, Y., . . . Garcia, M. (2015). Dynamic F18-FDG studies with a dedicated breast-PET: Preliminary results.. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 42, S821.

Huang, T., Hu, P., Banizs, A., Kundu, B., & He, J. (2015). Initial evaluation of Cu-64 labeled PARPi-DOTA PET imaging in mice with mesothelioma. JOURNAL OF NUCLEAR MEDICINE, 56(3).

Kundu, B. K., Zhong, M., Sen, S., Davogustto, G., Keller, S. R., & Taegtmeyer, H. (2015). Remodeling of Glucose Metabolism Precedes Pressure Overload-Induced Left Ventricular Hypertrophy: Review of a Hypothesis. CARDIOLOGY, 130(4), 211-220. doi:10.1159/000369782


Zhang, Y., Kundu, B., Zhong, M., Huang, T., Li, J., Chordia, M. D., . . . Shi, W. (2015). PET imaging detection of macrophages with a formyl peptide receptor antagonist. NUCLEAR MEDICINE AND BIOLOGY, 42(4), 381-386. doi:10.1016/j.nucmedbio.2014.12.001



Zhong, M., & Kundu, B. K. (2013). Optimization of a Model Corrected Blood Input Function From Dynamic FDG-PET Images of Small Animal Heart In Vivo. IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 60(5), 3417-3422. doi:10.1109/TNS.2013.2269032

Zhong, M., Alonso, C. E., Taegtmeyer, H., & Kundu, B. K. (2013). Quantitative PET Imaging Detects Early Metabolic Remodeling in a Mouse Model of Pressure-Overload Left Ventricular Hypertrophy In Vivo. JOURNAL OF NUCLEAR MEDICINE, 54(4), 609-615. doi:10.2967/jnumed.112.108092

Sen, S., Kundu, B. K., Wu, H. C. -J., Hashmi, S. S., Guthrie, P., Locke, L. W., . . . Taegtmeyer, H. (2013). Glucose Regulation of Load-Induced mTOR Signaling and ER Stress in Mammalian Heart. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2(3). doi:10.1161/JAHA.113.004796


Xiao, L., Zhang, Y., Yang, Z., Xu, Y., Kundu, B., Chordia, M. D., & Pan, D. (2012). Synthesis of PECAM-1-specific 64Cu PET imaging agent: Evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(12), 4144-4147. doi:10.1016/j.bmcl.2012.04.059


Alonso, C., Zhong, M., Thornhill, B., Figler, R., Taegtmeyer, H., & Kundu, B. (2011). Metabolic Adaptation Precedes Maladaptive Response in Pressure Overload Induced Left Ventricular Hypertrophy in Mice: An In Vivo FDG-PET Study. CIRCULATION RESEARCH, 109(12), E62.

Locke, L. W., Williams, M. B., Fairchild, K. D., Zhong, M., Kundu, B. K., & Berr, S. S. (2011). FDG-PET Quantification of Lung Inflammation with Image-Derived Blood Input Function in Mice.. International journal of molecular imaging, 2011, 356730. doi:10.1155/2011/356730


Locke, L. W., Berr, S. S., & Kundu, B. K. (2011). Image-Derived Input Function from Cardiac Gated Maximum a Posteriori Reconstructed PET Images in Mice. MOLECULAR IMAGING AND BIOLOGY, 13(2), 342-347. doi:10.1007/s11307-010-0347-4

Kundu, B., Figler, R., & Taegtmeyer, H. (2010). Metabolic Adaptation of the Heart in a Mouse Model of Type 2 Diabetes Mellitus: A PET Imaging Study. CIRCULATION, 122(21).