Brant Isakson

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Primary Appointment

Professor, Molecular Physiology and Biological Physics

Education

  • PhD, University of Wyoming

Research Disciplines

Biotechnology, Cardiovascular Biology, Metabolism, Molecular Pharmacology, Physiology, Translational Science

Research Interests

Translating our discoveries in the microcirculation to tangible benefits in patients.

Research Description

The etiology of many cardiovascular diseases can be traced to the microcirculation, which is the primary focus of the Isakson lab. For example, high blood pressure as well as strokes or heart attacks are all due to dysfunction at some level in the microcirculation. As the name implies, the microcirculation consists of the smallest arteries and veins, and these small blood vessels are responsible for modulating blood pressure, delivery of oxygen to tissue, and regulating the inflammatory response. The Isakson lab has made important discoveries in each of these areas that includes development of genetically modified mouse models, several patented products, as well as research disclosures. Our research has shown that by altering particular proteins in the blood vessels of the microcirculation, we can drastically lower blood pressure; if we focus on a different set of proteins, we can severely reduce inflammation and damage incurred by stroke or heart attack. We have an ongoing IRB to recruit human volunteers to further test these ideas and pull our research into an eventual treatment modality.

Personal Statement

Cell-cell communication in the blood vessel wall

Training

  • Basic Cardiovascular Research Training Grant
  • Biotechnology Training Grant
  • Training in Cell and Molecular Biology
  • Training in Molecular Biophysics
  • Training in the Pharmacological Sciences

Selected Publications

2024

Pavelec, C. M., Young, A. P., Luviano, H. L., Orrell, E. E., Szagdaj, A., Poudel, N., . . . Leitinger, N. (2024). Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure.. bioRxiv. doi:10.1101/2023.12.29.573679

Dunaway, L. S., Loeb, S. A., Petrillo, S., Tolosano, E., & Isakson, B. E. (2024). Heme metabolism in nonerythroid cells.. The Journal of biological chemistry, 300(4), 107132. doi:10.1016/j.jbc.2024.107132

Dunaway, L. S., Luse, M. A., Nyshadham, S., Bulut, G., Alencar, G. F., Chavkin, N. W., . . . Isakson, B. E. (2024). Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium.. Physiological genomics, 56(2), 113-127. doi:10.1152/physiolgenomics.00109.2023

Wolpe, A. G., Luse, M. A., Baryiames, C., Schug, W. J., Wolpe, J. B., Johnstone, S. R., . . . Isakson, B. E. (2024). Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress. SCIENCE SIGNALING, 17(821). doi:10.1126/scisignal.adg2622

2023

Koval, M., Schug, W. J., & Isakson, B. E. (2023). Pharmacology of pannexin channels. CURRENT OPINION IN PHARMACOLOGY, 69. doi:10.1016/j.coph.2023.102359

Luse, M. A., Jackson, M. G., Juskiewicz, Z. J., & Isakson, B. E. (2023). Physiological functions of caveolae in endothelium. CURRENT OPINION IN PHYSIOLOGY, 35. doi:10.1016/j.cophys.2023.100701

Sveeggen, T. M., Isakson, B. E., Straub, A. C., & Bagher, P. (2023). Bedding as a variable affecting fasting blood glucose and vascular physiology in mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 325(2), H338-H345. doi:10.1152/ajpheart.00168.2023

Shah, S. A., Reagan, C. E., Bresticker, J. E., Wolpe, A. G., Good, M. E., Macal, E. H., . . . Epstein, F. H. (2023). Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition. JACC-BASIC TO TRANSLATIONAL SCIENCE, 8(5), 501-514. doi:10.1016/j.jacbts.2022.11.005

Ruddiman, C. A., Peckham, R., Luse, M. A., Chen, Y. -L., Kuppusamy, M., Corliss, B. A., . . . Isakson, B. E. (2023). Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1. JCI INSIGHT, 8(9). doi:10.1172/jci.insight.165715

Ragland, T. J., Heiston, E. M., Ballantyne, A., Stewart, N. R., La Salvia, S., Musante, L., . . . Malin, S. K. (2023). Extracellular vesicles and insulin-mediated vascular function in metabolic syndrome. PHYSIOLOGICAL REPORTS, 11(1). doi:10.14814/phy2.15530

Dunaway, L. S., Billaud, M., Macal, E., Good, M. E., Medina, C. B., Lorenz, U., . . . Isakson, B. E. (2023). Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction. HYPERTENSION, 80(2), 416-425. doi:10.1161/HYPERTENSIONAHA.122.20280

Chu, P. -L., Gigliotti, J. C., Cechova, S., Bodonyi-Kovacs, G., Wang, Y. T., Chen, L., . . . Le, T. H. (2023). Collectrin (Tmem27) deficiency in proximal tubules causes hypertension in mice and a TMEM27 variant associates with blood pressure in males in a Latino cohort. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 324(1), F30-F42. doi:10.1152/ajprenal.00176.2022

Baldwin, S. N., Forrester, E. A., Homer, N. Z. M., Andrew, R., Barrese, V., Stott, J. B., . . . Greenwood, I. A. (2023). Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1. BRITISH JOURNAL OF PHARMACOLOGY, 180(2), 174-193. doi:10.1111/bph.15947

2022

Keller, T. C. S., Lechauve, C., Keller, A. S., Broseghini-Filho, G. B., Butcher, J. T., Page, H. R. A., . . . Isakson, B. E. (2022). Endothelial alpha globin is a nitrite reductase. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-34154-3

Luse, M. A., Pavelic, C., Tessema, R., Cochran, J., Minshall, R. D., Leitinger, N., & Isakson, B. E. (2022). Genetic deletion of endothelial Caveolin-1 is protective against metabolic disease.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36 Suppl 1. doi:10.1096/fasebj.2022.36.s1.r5416

Luse, M. A., Kruger, N., Good, M. E., Biwer, L. A., Serbulea, V., Salamon, A., . . . Isakson, B. E. (2022). Smooth muscle cell FTO regulates contractile function. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(6), H1212-H1220. doi:10.1152/ajpheart.00427.2022

King, D. R., Sedovy, M. W., Eaton, X., Dunaway, L. S., Good, M. E., Isakson, B. E., & Johnstone, S. R. (2022). Cell-to-cell Communication in the Resistance Vasculature. COMPREHENSIVE PHYSIOLOGY, 12(4), 3833-3867. doi:10.1002/cphy.c210040

Granade, M. E., Hargett, S. R., Lank, D. S., Lemke, M. C., Luse, M. A., Isakson, B. E., . . . Harris, T. E. (2022). Feeding desensitizes A1 adenosine receptors in adipose through FOXO1-mediated transcriptional regulation. MOLECULAR METABOLISM, 63. doi:10.1016/j.molmet.2022.101543

Cortese-Krott, M. M., Suvorava, T., Leo, F., Heuser, S. K., LoBue, A., Li, J., . . . Kelm, M. (2022). Red blood cell eNOS is cardioprotective in acute myocardial infarction. REDOX BIOLOGY, 54. doi:10.1016/j.redox.2022.102370

Wolpe, A. G., Luse, M. A., Johnstone, S. R., Xue, J., Sabapathy, V., Wakefield, B., . . . Isakson, B. E. (2022). Endothelial Pannexin 3-B Cell Lymphoma-6 Interactions Protect Against Oxidative Stress. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.R5405

Molina, S. A., Maier-Begandt, D., Isakson, B. E., & Koval, M. (2022). Electrophysiological Measurements of Isolated Blood Vessels. BIO-PROTOCOL, 12(6). doi:10.21769/BioProtoc.4359

Filiberto, A. C., Spinosa, M. D., Elder, C. T., Su, G., Leroy, V., Ladd, Z., . . . Sharma, A. K. (2022). Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-29233-4

Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2022). Reply to Boedtkjer and Aalkjaer. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(4), H687-H688. doi:10.1152/ajpheart.00117.2022

Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2022). Reply to De Mey et al.. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(4), H683-H684. doi:10.1152/ajpheart.00086.2022

Kiger, L., Keith, J., Freiwan, A., Fernandez, A. G., Tillman, H., Isakson, B. E., . . . Lechauve, C. (2022). Redox-Regulation of α-Globin in Vascular Physiology. ANTIOXIDANTS, 11(1). doi:10.3390/antiox11010159

Keller, T. C. S., Lechauve, C., Keller, A. S., Brooks, S., Weiss, M. J., Columbus, L., . . . Isakson, B. E. (2022). THE ROLE OF GLOBINS IN CARDIOVASCULAR PHYSIOLOGY. PHYSIOLOGICAL REVIEWS, 102(2), 859-892. doi:10.1152/physrev.00037.2020

2021

Grimmer, B., Krauszman, A., Hu, X., Kabir, G., Connelly, K. A., Li, M., . . . Kuebler, W. M. (2022). Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction. CARDIOVASCULAR RESEARCH, 118(11), 2535-2547. doi:10.1093/cvr/cvab326

Bisht, K., Okojie, K. A., Sharma, K., Lentferink, D. H., Sun, Y. -Y., Chen, H. -R., . . . Eyo, U. B. (2021). Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25590-8

Daneva, Z., Marziano, C., Ottolini, M., Chen, Y. -L., Baker, T. M., Kuppusamy, M., . . . Sonkusare, S. K. (2021). Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(17). doi:10.1073/pnas.2023130118

Thakore, P., Alvarado, M. G., Ali, S., Mughal, A., Pires, P. W., Yamasaki, E., . . . Earley, S. (2021). Brain endothelial cell TRPA1 channels initiate neurovascular coupling. ELIFE, 10. doi:10.7554/eLife.63040

King, D. R., Sedovy, M. W., Leng, X., Xue, J., Lamouille, S., Koval, M., . . . Johnstone, S. R. (2021). Mechanisms of Connexin Regulating Peptides. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19). doi:10.3390/ijms221910186

Daneva, Z., Ottolini, M., Chen, Y. L., Klimentova, E., Kuppusamy, M., Shah, S. A., . . . Sonkusare, S. K. (2021). Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. ELIFE, 10. doi:10.7554/eLife.67777

Koval, M., Cwiek, A., Carr, T., Good, M. E., Lohman, A. W., & Isakson, B. E. (2021). Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury. PURINERGIC SIGNALLING, 17(4), 521-531. doi:10.1007/s11302-021-09804-8

Leo, F., Suvorava, T., Heuser, S. K., Li, J., LoBue, A., Barbarino, F., . . . Cortese-Krott, M. M. (2021). Red Blood Cell and Endothelial eNOS Independently Regulate Circulating Nitric Oxide Metabolites and Blood Pressure. CIRCULATION, 144(11), 870-889. doi:10.1161/CIRCULATIONAHA.120.049606

Wenceslau, C. F., McCarthy, C. G., Earley, S., England, S. K., Filosa, J. A., Goulopoulou, S., . . . Webb, R. C. (2021). Guidelines for the measurement of vascular function and structure in isolated arteries and veins. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 321(1), H77-H111. doi:10.1152/ajpheart.01021.2020

Maier-Begandt, D., Comstra, H. S., Molina, S. A., Krueger, N., Ruddiman, C. A., Chen, Y. -L., . . . Isakson, B. E. (2021). A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability. SCIENCE SIGNALING, 14(672). doi:10.1126/scisignal.aba2940

Good, M. E., Young, A. P., Wolpe, A. G., Ma, M., Hall, P. J., Duffy, C. K., . . . Isakson, B. E. (2021). Endothelial Pannexin 1 Regulates Cardiac Response to Myocardial Infarction. CIRCULATION RESEARCH, 128(8), 1211-1213. doi:10.1161/CIRCRESAHA.120.317272

Wolpe, A. G., Ruddiman, C. A., Hall, P. J., & Isakson, B. E. (2021). Polarized Proteins in Endothelium and Their Contribution to Function. JOURNAL OF VASCULAR RESEARCH, 58(2), 65-91. doi:10.1159/000512618

2020

DeLalio, L. J., Masati, E., Mendu, S., Ruddiman, C. A., Yang, Y., Johnstone, S. R., . . . Isakson, B. E. (2020). Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis. KIDNEY INTERNATIONAL, 98(3), 630-644. doi:10.1016/j.kint.2020.04.041

Luse, M. A., Heiston, E. M., Malin, S. K., & Isakson, B. E. (2020). Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium. CURRENT PHARMACEUTICAL DESIGN, 26(30), 3760-3767. doi:10.2174/1381612826666200721002735

Wischmann, P., Kuhn, V., Suvorava, T., Muessig, J. M., Fischer, J. W., Isakson, B. E., . . . Kelm, M. (2020). Anaemia is associated with severe RBC dysfunction and a reduced circulating NO pool: vascular and cardiac eNOS are crucial for the adaptation to anaemia. BASIC RESEARCH IN CARDIOLOGY, 115(4). doi:10.1007/s00395-020-0799-x

Bories, G. F. P., Yeudall, S., Serbulea, V., Fox, T. E., Isakson, B. E., & Leitinger, N. (2020). Macrophage metabolic adaptation to heme detoxification involves CO-dependent activation of the pentose phosphate pathway. BLOOD, 136(13), 1535-1548. doi:10.1182/blood.2020004964

Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., . . . Okusa, M. D. (2020). Epithelial and endothelial pannexin1 channels mediate AKI (vol 29, pg 1887, 2018). JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 31(1), 231. doi:10.1681/ASN.2019111140

Garcia, V., Park, E. J., Siragusa, M., Frohlich, F., Haque, M. M., Pascale, J. V., . . . Sessa, W. C. (2020). Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(17), 9497-9507. doi:10.1073/pnas.1918761117

Yang, Y., Delalio, L. J., Best, A. K., Macal, E., Milstein, J., Donnelly, I., . . . Johnstone, S. R. (2020). Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium. JOURNAL OF IMMUNOLOGY, 204(11), 2995-3007. doi:10.4049/jimmunol.1901089

Biwer, L. A., Askew-Page, H. R., Hong, K., Milstein, J., Johnstone, S. R., Macal, E., . . . Isakson, B. E. (2020). Endothelial calreticulin deletion impairs endothelial function in aged mice. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 318(5), H1041-H1048. doi:10.1152/ajpheart.00586.2019

Leo, F., Krenz, T., Wolff, G., Weidenbach, M., Heiss, C., Kelm, M., . . . Cortese-Krott, M. M. (2020). Assessment of tissue perfusion and vascular function in mice by scanning laser Doppler perfusion imaging. BIOCHEMICAL PHARMACOLOGY, 176. doi:10.1016/j.bcp.2020.113893

McCallinhart, P. E., Biwer, L. A., Clark, O. E., Isakson, B. E., Lilly, B., & Trask, A. J. (2020). Myoendothelial Junctions of Mature Coronary Vessels Express Notch Signaling Proteins. FRONTIERS IN PHYSIOLOGY, 11. doi:10.3389/fphys.2020.00029

Ottolini, M., Hong, K., Cope, E. L., Daneva, Z., DeLalio, L. J., Sokolowski, J. D., . . . Sonkusare, S. K. (2020). Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. CIRCULATION, 141(16), 1318-1333. doi:10.1161/CIRCULATIONAHA.119.043385

Leo, F., Hutzler, B., Ruddiman, C. A., Isakson, B. E., & Cortese-Krott, M. M. (2020). Cellular microdomains for nitric oxide signaling in endothelium and red blood cells. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 96, 44-53. doi:10.1016/j.niox.2020.01.002

Kruger, N., Biwer, L. A., Good, M. E., Ruddiman, C. A., Wolpe, A. G., DeLalio, L. J., . . . Isakson, B. E. (2020). Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. CIRCULATION RESEARCH, 126(2), 232-242. doi:10.1161/CIRCRESAHA.119.315531

Good, M. E., Musante, L., La Salvia, S., Howell, N. L., Carey, R. M., Le, T. H., . . . Erdbruegger, U. (2020). Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries. HYPERTENSION, 75(1), 218-228. doi:10.1161/HYPERTENSIONAHA.119.13363

2019

DeLalio, L. J., Billaud, M., Ruddiman, C. A., Johnstone, S. R., Butcher, J. T., Wolpe, A. G., . . . Isakson, B. E. (2019). Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. JOURNAL OF BIOLOGICAL CHEMISTRY, 294(17), 6940-6956. doi:10.1074/jbc.RA118.006982

Corliss, B. A., Delalio, L. J., Keller, T. C. S., Keller, A. S., Keller, D. A., Corliss, B. H., . . . Isakson, B. E. (2019). Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver. FRONTIERS IN PHYSIOLOGY, 10. doi:10.3389/fphys.2019.01389

Rival, C. M., Xu, W., Shankman, L. S., Morioka, S., Arandjelovic, S., Lee, C. S., . . . Ravichandran, K. S. (2019). Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-12406-z

Li, J., Cechova, S., Wang, L., Isakson, B. E., Le, T. H., & Shi, W. (2019). Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 316(6), F1141-F1150. doi:10.1152/ajprenal.00567.2018

Shu, X., Ruddiman, C. A., Keller, T. C. S., Keller, A. S., Yang, Y., Good, M. E., . . . Isakson, B. E. (2019). Heterocellular Contact Can Dictate Arterial Function. CIRCULATION RESEARCH, 124(10), 1473-1481. doi:10.1161/CIRCRESAHA.118.313926

Novielli-Kuntz, N. M., Jelen, M., Barr, K., DeLalio, L. J., Feng, Q., Isakson, B. E., . . . Laird, D. W. (2019). Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice. BIOSCIENCE REPORTS, 39. doi:10.1042/BSR20182350

2018

Lechauve, C., Butcher, J. T., Freiwan, A., Biwer, L. A., Keith, J. M., Good, M. E., . . . Weiss, M. J. (2018). Endothelial cell α-globin and its molecular chaperone α-hemoglobin-stabilizing protein regulate arteriolar contractility. JOURNAL OF CLINICAL INVESTIGATION, 128(11), 5073-5082. doi:10.1172/JCI99933

Artamonov, M. V., Sonkusare, S. K., Good, M. E., Momotani, K., Eto, M., Isakson, B. E., . . . Somlyo, A. V. (2018). RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. SCIENCE SIGNALING, 11(554). doi:10.1126/scisignal.aar3924

Good, M. E., & Isakson, B. E. (2018). "Yin and Yang" for Notch signaling in the mature vasculature. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 315(6), H1789-H1790. doi:10.1152/ajpheart.00626.2018

Brown, I. A. M., Diederich, L., Good, M. E., DeLalio, L. J., Murphy, S. A., Cortese-Krott, M. M., . . . Isakson, B. E. (2018). Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(9), 1969-1985. doi:10.1161/ATVBAHA.118.311229

Suarez-Martinez, A. D., Peirce, S. M., Isakson, B. E., Nice, M., Wang, J., Lounsbury, K. M., . . . Murfee, W. L. (2018). Induction of microvascular network growth in the mouse mesentery. MICROCIRCULATION, 25(8). doi:10.1111/micc.12502

DeLalio, L. J., Keller, A. S., Chen, J., Boyce, A. K. J., Artamonov, M. V., Askew-Page, H. R., . . . Isakson, B. E. (2018). Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(9), 2065-2078. doi:10.1161/ATVBAHA.118.311290

Keller, A. S., Keller, T. C. S., DeLalio, L. J., Shahab, G., Yang, Y., Murphy, S. A., . . . Isakson, B. E. (2018). Replacement Therapies in Metabolic Disease. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 19(5), 382-399. doi:10.2174/1389201019666180619151413

Molica, F., Figueroa, X. F., Kwak, B. R., Isakson, B. E., & Gibbins, J. M. (2018). Connexins and Pannexins in Vascular Function and Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(6). doi:10.3390/ijms19061663

Jankowski, J., Perry, H. M., Medina, C. B., Huang, L., Yao, J., Bajwa, A., . . . Okusa, M. D. (2018). Epithelial and Endothelial Pannexin1 Channels Mediate AKI. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 29(7), 1887-1899. doi:10.1681/ASN.2017121306

Good, M. E., Chiu, Y. -H., Poon, I. K. H., Jaffe, I. Z., Bayliss, D. A., Isakson, B. E., & Ravichandran, K. S. (2018). Response by Good et al to Letter Regarding Article, "Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone". CIRCULATION RESEARCH, 122(11), E88-E89. doi:10.1161/CIRCRESAHA.118.313080

Diederich, L., Suvorava, T., Sansone, R., Keller, T. C. S., Barbarino, F., Sutton, T. R., . . . Cortese-Krott, M. M. (2018). On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability. FRONTIERS IN PHYSIOLOGY, 9. doi:10.3389/fphys.2018.00332

Sharma, A. K., Charles, E. J., Zhao, Y., Narahari, A. K., Baderdinni, P. K., Good, M. E., . . . Laubach, V. E. (2018). Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 315(2), L301-L312. doi:10.1152/ajplung.00004.2018

Haskins, R. M., Nguyen, A. T., Alencar, G. F., Billaud, M., Kelly-Goss, M. R., Good, M. E., . . . Owens, G. K. (2018). Klf4 has an unexpected protective role in perivascular cells within the microvasculature. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 315(2), H402-H414. doi:10.1152/ajpheart.00084.2018

Johnstone, S. R., & Isakson, B. E. (2018). "Gaps' in targeted ischaemic injury therapies in ST-elevation myocardial infarction. HEART, 104(19), 1557-1558. doi:10.1136/heartjnl-2018-313084

Good, M. E., Eucker, S. A., Li, J., Bacon, H. M., Lang, S. M., Butcher, J. T., . . . Isakson, B. E. (2018). Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. JCI INSIGHT, 3(6). doi:10.1172/jci.insight.96272

Hong, K., Cope, E. L., DeLalio, L. J., Marziano, C., Isakson, B. E., & Sonkusare, S. K. (2018). TRPV4 (Transient Receptor Potential Vanilloid 4) Channel-Dependent Negative Feedback Mechanism Regulates Gq Protein-Coupled Receptor-Induced Vasoconstriction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(3), 542-554. doi:10.1161/ATVBAHA.117.310038

Nyberg, M., Piil, P., Kiehn, O. T., Maagaard, C., Jorgensen, T. S., Egelund, J., . . . Hellsten, Y. (2018). Probenecid Inhibits -Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature. HYPERTENSION, 71(1), 151-159. doi:10.1161/HYPERTENSIONAHA.117.10251

Biwer, L. A., Good, M. E., Hong, K., Patel, R. K., Agrawal, N., Looft-Wilson, R., . . . Isakson, B. E. (2018). Non-Endoplasmic Reticulum-Based Calr (Calreticulin) Can Coordinate Heterocellular Calcium Signaling and Vascular Function. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 38(1), 120-130. doi:10.1161/ATVBAHA.117.309886

Nyberg, M., Piil, P., Kiehn, O. T., Maagaard, C., Jørgensen, T. S., Egelund, J., . . . Hellsten, Y. (2018). Probenecid Inhibits α-Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature.. Hypertension (Dallas, Tex. : 1979), 71(1), 151-159. doi:10.1161/hypertensionaha.117.10251

2017

Good, M. E., Chiu, Y. -H., Poon, I. K. H., Medina, C. B., Butcher, J. T., Mendu, S. K., . . . Ravichandran, K. S. (2018). Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone. CIRCULATION RESEARCH, 122(4), 606-615. doi:10.1161/CIRCRESAHA.117.312380

Biwer, L. A., Lechauve, C., Vanhoose, S., Weiss, M. J., & Isakson, B. E. (2017). A Cell Culture Model of Resistance Arteries. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (127). doi:10.3791/55992

Keller, A. S., & Isakson, B. E. (2017). The Evolving Role of Diverse Gaseous Transmitters Mediating Heterocellular Communication Within the Vasculature. ANTIOXIDANTS & REDOX SIGNALING, 26(16), 881-885. doi:10.1089/ars.2017.7059

Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lueckstaedt, W., Panknin, C., . . . Cortese-Krott, M. M. (2017). Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia. ANTIOXIDANTS & REDOX SIGNALING, 26(13), 718-742. doi:10.1089/ars.2016.6954

Isakson, B. (2017). A review of the current state of pannexin channels as they relate to the blood vessel wall. Journal of Medical Sciences, 37(5), 179. doi:10.4103/jmedsci.jmedsci_43_17

Marziano, C., Hong, K., Cope, E. L., Kotlikoff, M. I., Isakson, B. E., & Sonkusare, S. K. (2017). Nitric Oxide-Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(12). doi:10.1161/JAHA.117.007157

Keller, A. S., Diederich, L., Panknin, C., DeLalio, L. J., Drake, J. C., Sherman, R., . . . Isakson, B. E. (2017). Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 313(6), C593-C603. doi:10.1152/ajpcell.00178.2017

DeLalio, L. J., & Isakson, B. E. (2017). ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design. BRITISH JOURNAL OF PHARMACOLOGY, 174(15), 2606-2607. doi:10.1111/bph.13891

Durgin, B. G., Cherepanova, O. A., Gomez, D., Karaoli, T., Alencar, G. F., Butcher, J. T., . . . Connelly, J. J. (2017). Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 312(5), H943-H958. doi:10.1152/ajpheart.00029.2017

Begandt, D., Good, M. E., Keller, A. S., DeLalio, L. J., Rowley, C., Isakson, B. E., & Figueroa, X. F. (2017). Pannexin channel and connexin hemichannel expression in vascular function and inflammation. BMC CELL BIOLOGY, 18. doi:10.1186/s12860-016-0119-3

2016

Biwer, L. A., Taddeo, E. P., Kenwood, B. M., Hoehn, K. L., Straub, A. C., & Isakson, B. E. (2016). Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(7), 671-679. doi:10.1016/j.bbalip.2016.04.014

Biwer, L. A., & Isakson, B. E. (2017). Endoplasmic reticulum-mediated signalling in cellular microdomains. ACTA PHYSIOLOGICA, 219(1), 162-175. doi:10.1111/apha.12675

Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2016). Corrigendum: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.. Nature medicine, 22(2), 217. doi:10.1038/nm0216-217a

Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2016). KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis (vol 21, pg 628, 2015). NATURE MEDICINE, 22(2), 217. doi:10.1038/nm0216-217a

Keller, T. C. S., Butcher, J. T., Broseghini-Filho, G. B., Marziano, C., DeLalio, L. J., Rogers, S., . . . Isakson, B. E. (2016). Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbX). HYPERTENSION, 68(6), 1494-1503. doi:10.1161/HYPERTENSIONAHA.116.08171

Liu, S., DeLalio, L. J., Isakson, B. E., & Wang, T. T. (2016). AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus. CIRCULATION RESEARCH, 119(11), 1183-+. doi:10.1161/CIRCRESAHA.116.309866

Kauffenstein, G., Tamareille, S., Prunier, F., Roy, C., Ayer, A., Toutain, B., . . . Henrion, D. (2016). Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(8), 1598-1606. doi:10.1161/ATVBAHA.116.307739

Good, M. E., Begandt, D., DeLalio, L. J., Johnstone, S. R., & Isakson, B. E. (2016). Small Interfering RNA-Mediated Connexin Gene Knockdown in Vascular Endothelial and Smooth Muscle Cells. GAP JUNCTION PROTOCOLS, 1437, 71-82. doi:10.1007/978-1-4939-3664-9_5

Ivanov, S., Scallan, J. P., Kim, K. -W., Werth, K., Johnson, M. W., Saunders, B. T., . . . Randolph, G. J. (2016). CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability. JOURNAL OF CLINICAL INVESTIGATION, 126(4), 1581-1591. doi:10.1172/JCI84518

2015

Adamson, S. E., Meher, A. K., Chiu, Y. -H., Sandilos, J. K., Oberholtzer, N. P., Walker, N. N., . . . Leitinger, N. (2015). Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. MOLECULAR METABOLISM, 4(9), 610-618. doi:10.1016/j.molmet.2015.06.009

Good, M. E., Begandt, D., DeLalio, L. J., Keller, A. S., Billaud, M., & Isakson, B. E. (2015). Emerging concepts regarding pannexin 1 in the vasculature. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 495-501. doi:10.1042/BST20150045

Shankman, L. S., Gomez, D., Cherepanova, O. A., Salmon, M., Alencar, G. F., Haskins, R. M., . . . Owens, G. K. (2015). KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. NATURE MEDICINE, 21(6), 628-637. doi:10.1038/nm.3866

Butcher, J., DeLalio, L., Biwer, L., Lang, S., Weaver, R., Best-Campbell, A., . . . Isakson, B. (2015). Endothelial Cell Hbα Can Regulate Blood Pressure. FASEB JOURNAL, 29.

Shu, X., Keller, T. C. S., Begandt, D., Butcher, J. T., Biwer, L., Keller, A. S., . . . Isakson, B. E. (2015). Endothelial nitric oxide synthase in the microcirculation. CELLULAR AND MOLECULAR LIFE SCIENCES, 72(23), 4561-4575. doi:10.1007/s00018-015-2021-0

Chen, C. -H., Mayo, J. N., Gourdie, R. G., Johnstone, S. R., Isakson, B. E., & Bearden, S. E. (2015). The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 309(9), C600-C607. doi:10.1152/ajpcell.00155.2015

Lohman, A. W., Leskov, I. L., Butcher, J. T., Johnstone, S. R., Stokes, T. A., Begandt, D., . . . Isakson, B. E. (2015). Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms8965

Billaud, M., Chiu, Y. -H., Lohman, A. W., Parpaite, T., Butcher, J. T., Mutchler, S. M., . . . Isakson, B. E. (2015). A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. SCIENCE SIGNALING, 8(364). doi:10.1126/scisignal.2005824

Kavoussi, P. K., Heberlein, K., Straub, A. C., Lowe, G. J., Oliver, J. L., Smith, R. P., . . . Lysiak, J. J. (2015). Recombinant PAI-1 therapy restores myoendothelial junctions and erectile function in PAI-1-deficient mice. ANDROLOGIA, 47(10), 1147-1152. doi:10.1111/and.12395

2014

Straub, A. C., Butcher, J. T., Billaud, M., Mutchler, S. M., Artamonov, M. V., Nguyen, A. T., . . . Isakson, B. E. (2014). Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 34(12), 2594-2600. doi:10.1161/ATVBAHA.114.303974

Lohman, A. W., & Isakson, B. E. (2014). Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS LETTERS, 588(8), 1379-1388. doi:10.1016/j.febslet.2014.02.004

Butcher, J. T., DeLalio, L. J., Biwer, L. A., Weaver, R. B., & Isakson, B. E. (2014). Endothelial Hemoglobin Alpha by the HBA1 Gene Is Crucial to Release of NO-Derived Metabolites into Tissue and Blood. FREE RADICAL BIOLOGY AND MEDICINE, 76, S42. doi:10.1016/j.freeradbiomed.2014.10.390

Kauffenstein, G., Grimaud, L., Ayer, A., Toutain, B., Loufrani, L., Billaud, M., . . . Henrion, D. (2014). Signaling by extracellular nucleotides in resistance arteries-focus on myogenic tone. PURINERGIC SIGNALLING, 10(4), 798-799.

Isakson, B. E. (2014). Pannexin 1 channels on smooth muscle cell regulates α1-adrenergic vasoconstriction and blood pressure. PURINERGIC SIGNALLING, 10(4), 671.

Lohman, A., & Isakson, B. (2014). Pannexin 1-dependent ATP release from venous endothelium promotes acute vascular inflammation. FASEB JOURNAL, 28(1).

Biwer, L., Straub, A., & Isakson, B. (2014). Subcellular enrichment of calreticulin at myoendothelial junctions. FASEB JOURNAL, 28(1).

Straub, A., Anh, N., Mutchler, S., & Isakson, B. (2014). Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 42, 141. doi:10.1016/j.niox.2014.09.126

Straub, A. C., Zeigler, A. C., & Isakson, B. E. (2014). The Myoendothelial Junction: Connections That Deliver the Message. PHYSIOLOGY, 29(4), 242-249. doi:10.1152/physiol.00042.2013

Isakson, B. E. (2014). Secreting von Willebrand factor in a Gα-SNAP. BLOOD, 123(3), 312-313. doi:10.1182/blood-2013-10-531913

Penuela, S., Lohman, A. W., Lai, W., Gyenis, L., Litchfield, D. W., Isakson, B. E., & Laird, D. W. (2014). Diverse post-translational modifications of the pannexin family of channel-forming proteins. CHANNELS, 8(2), 124-130. doi:10.4161/chan.27422

Billaud, M., Lohman, A. W., Johnstone, S. R., Biwer, L. A., Mutchler, S., & Isakson, B. E. (2014). Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall. PHARMACOLOGICAL REVIEWS, 66(2), 513-569. doi:10.1124/pr.112.007351

Koval, M., Isakson, B. E., & Gourdie, R. G. (2014). Connexins, pannexins and innexins: Protein cousins with overlapping functions. FEBS LETTERS, 588(8), 1185. doi:10.1016/j.febslet.2014.03.001

Isakson, B. E., & Thompson, R. J. (2014). Pannexin-1 as a potentiator of ligand-gated receptor signaling. CHANNELS, 8(2), 118-123. doi:10.4161/chan.27978

Butcher, J. T., Johnson, T., Beers, J., Columbus, L., & Isakson, B. E. (2014). Hemoglobin α in the blood vessel wall. FREE RADICAL BIOLOGY AND MEDICINE, 73, 136-142. doi:10.1016/j.freeradbiomed.2014.04.019

2013

Adhikari, N., Billaud, M., Carlson, M., Lake, S. P., Montaniel, K. R. C., Staggs, R., . . . Hall, J. L. (2014). Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1. MOLECULAR AND CELLULAR BIOCHEMISTRY, 385(1-2), 225-238. doi:10.1007/s11010-013-1831-3

Cechova, S., Zeng, Q., Billaud, M., Mutchler, S., Rudy, C. K., Straub, A. C., . . . Le, T. H. (2013). Loss of Collectrin, an Angiotensin-Converting Enzyme 2 Homolog, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction. CIRCULATION, 128(16), 1770-1780. doi:10.1161/CIRCULATIONAHA.113.003301

Isakson, B. (2013). REGULATION OF NO BY HEMOGLOBIN IN THE ENDOTHELIUM. FREE RADICAL BIOLOGY AND MEDICINE, 65, S8. doi:10.1016/j.freeradbiomed.2013.10.404

2012

Straub, A. C., Lohman, A. W., Billaud, M., Johnstone, S. R., Dwyer, S. T., Lee, M. Y., . . . Isakson, B. E. (2012). Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. NATURE, 491(7424), 473-477. doi:10.1038/nature11626

Wang, L., Yin, J., Nickles, H. T., Ranke, H., Tabuchi, A., Hoffmann, J., . . . Kuebler, W. M. (2012). Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. JOURNAL OF CLINICAL INVESTIGATION, 122(11), 4218-4230. doi:10.1172/JCI59176

Kauffenstein, G., Ayer, A., Toutain, B., Grimaud, L., Billaud, M., Isakson, B., . . . Henrion, D. (2012). 767 SIGNALING BY EXTRACELLULAR NUCLEOTIDES IN THE VASCULATURE â FOCUS ON MYOGENIC TONE. Journal of Hypertension, 30(Supplement 1), e221. doi:10.1097/01.hjh.0000420734.45312.8b

Johnstone, S. R., Billaud, M., Lohman, A. W., Taddeo, E. P., & Isakson, B. E. (2012). Posttranslational Modifications in Connexins and Pannexins. JOURNAL OF MEMBRANE BIOLOGY, 245(5-6), 319-332. doi:10.1007/s00232-012-9453-3

Montaniel, K. R. C., Billaud, M., Graham, C., Kim, S. K., Carlson, M., Zeng, W., . . . Adhikari, N. (2012). Smooth Muscle Specific Deletion of Ndst1 Leads to Decreased Vessel Luminal Area and No Change in Blood Pressure in Conscious Mice. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 5(3), 274-279. doi:10.1007/s12265-012-9369-4

Billaud, M., Lohman, A. W., Straub, A. C., Parpaite, T., Johnstone, S. R., & Isakson, B. E. (2012). Characterization of the Thoracodorsal Artery: Morphology and Reactivity. MICROCIRCULATION, 19(4), 360-372. doi:10.1111/j.1549-8719.2012.00172.x

Billaud, M., Sandilos, J. K., & Isakson, B. E. (2012). Pannexin 1 in the Regulation of Vascular Tone. TRENDS IN CARDIOVASCULAR MEDICINE, 22(3), 68-72. doi:10.1016/j.tcm.2012.06.014

Straub, A., Dwyer, S., Gaston, B., & Isakson, B. (2012). Endothelial cell expression of hemoglobin a regulates nitric oxide signaling. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 27, S13. doi:10.1016/j.niox.2012.04.048

Montaniel, K. R. C., Adhikari, N., Lake, S., Billaud, M., Carlson, M., Isakson, B. E., . . . Hall, J. L. (2012). Smooth Muscle Specific Deletion of N-deacetylase-sulfotransferase1 (Ndst1) Results in Altered Arterial Elasticity. CIRCULATION, 126(21).

Billaud, M., Lohman, A. W., Chiu, Y. -H., Sandilos, J. K., Bayliss, D. A., & Isakson, B. E. (2012). Exclusive interaction between α1D-adrenergic receptor and pannexin 1 can mediate vasoconstriction. FASEB JOURNAL, 26.

Lohman, A. W., Weaver, J. L., Billaud, M., Bayliss, D. A., & Isakson, B. E. (2012). Complex interplay between Pannexin 1 cysteine residues and channel regulation. FASEB JOURNAL, 26.

Straub, A., Lohman, A., Billaud, M., Dwyer, S., Best, A., Gaston, B., & Isakson, B. (2012). Cytochrome B 5 reductase 3 regulates nitric oxide signaling at the myoendothelial by controlling hemoglobin redox cycling. FASEB JOURNAL, 26.

Johnstone, S. R., Kroncke, B. M., Straub, A. C., Best, A. K., Dunn, C. A., Koval, M., . . . Isakson, B. E. (2012). MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. FASEB JOURNAL, 26.

Straub, A., Lohman, A., Billaud, M., Johnstone, S., Dwyer, S., Lee, M., . . . Isakson, B. (2012). Hemoglobin expression at the myoendothelial junction regulates nitric oxide scavenging and vasomotor tone. FASEB JOURNAL, 26.

Lohman, A. W., Billaud, M., Straub, A. C., Best, A. K., Lee, M., Barr, K., . . . Isakson, B. E. (2012). Expression of pannexin isoforms in the murine arterial network. FASEB JOURNAL, 26.

Lowe, G., Kavoussi, P., Straub, A., Steers, W., Costabile, R., Isakson, B., & Lysiak, J. (2012). MYOENDOTHELIAL JUNCTIONS IN THE CORPUS CAVERNOSUM ARE LOST AFTER CAVERNOUS NERVE INJURY. JOURNAL OF SEXUAL MEDICINE, 9, 11.

Looft-Wilson, R. C., Billaud, M., Johnstone, S. R., Straub, A. C., & Isakson, B. E. (2012). Interaction between nitric oxide signaling and gap junctions: Effects on vascular function. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1818(8), 1895-1902. doi:10.1016/j.bbamem.2011.07.031

Billaud, M., Johnstone, S. R., & Isakson, B. E. (2012). Loss of Compliance in Small Arteries, but Not in Conduit Arteries, After 6 Weeks Exposure to High Fat Diet. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 5(3), 256-263. doi:10.1007/s12265-012-9354-y

Heberlein, K. R., Han, J., Straub, A. C., Best, A. K., Kaun, C., Wojta, J., & Isakson, B. E. (2012). A Novel mRNA Binding Protein Complex Promotes Localized Plasminogen Activator Inhibitor-1 Accumulation at the Myoendothelial Junction. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 32(5), 1271-+. doi:10.1161/ATVBAHA.112.246371

Johnstone, S. R., Kroncke, B. M., Straub, A. C., Best, A. K., Dunn, C. A., Mitchell, L. A., . . . Isakson, B. E. (2012). MAPK Phosphorylation of Connexin 43 Promotes Binding of Cyclin E and Smooth Muscle Cell Proliferation. CIRCULATION RESEARCH, 111(2), 201-U205. doi:10.1161/CIRCRESAHA.112.272302

Lohman, A. W., Billaud, M., Straub, A. C., Johnstone, S. R., Best, A. K., Lee, M., . . . Isakson, B. E. (2012). Expression of Pannexin Isoforms in the Systemic Murine Arterial Network. JOURNAL OF VASCULAR RESEARCH, 49(5), 405-416. doi:10.1159/000338758

Lohman, A. W., Billaud, M., & Isakson, B. E. (2012). Mechanisms of ATP release and signalling in the blood vessel wall. CARDIOVASCULAR RESEARCH, 95(3), 269-280. doi:10.1093/cvr/cvs187

Lohman, A. W., Weaver, J. L., Billaud, M., Sandilos, J. K., Griffiths, R., Straub, A. C., . . . Isakson, B. E. (2012). S-Nitrosylation Inhibits Pannexin 1 Channel Function. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(47). doi:10.1074/jbc.M112.397976

2011

Koval, M., Billaud, M., Straub, A. C., Johnstone, S. R., Zarbock, A., Duling, B. R., & Isakson, B. E. (2011). Spontaneous Lung Dysfunction and Fibrosis in Mice Lacking Connexin 40 and Endothelial Cell Connexin 43. AMERICAN JOURNAL OF PATHOLOGY, 178(6), 2536-2546. doi:10.1016/j.ajpath.2011.02.045

Billaud, M., Ross, J. A., Greyson, M. A., Bruce, A. C., Seaman, S. A., Heberlein, K. R., . . . Isakson, B. E. (2011). A New Method for In Vivo Visualization of Vessel Remodeling Using a Near-Infrared Dye. MICROCIRCULATION, 18(3), 163-171. doi:10.1111/j.1549-8719.2011.00085.x

Sandilos, J. K., Chekeni, F. B., Elliott, M. R., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Bayliss, D. A. (2011). Caspases Mediate Pannexin 1 Channel Activation in Apoptotic Cells. Biophysical Journal, 100(3), 101a. doi:10.1016/j.bpj.2010.12.759

Straub, A. C., Billaud, M., Best, A. K., & Isakson, B. E. (2011). Apical and basal endothelial nitric oxide release each regulate distinct subcellular functions within the vessel wall. FASEB JOURNAL, 25.

Isakson, B. E., Billaud, M., Lohman, A. W., Straub, A. C., Sandilos, J. K., & Bayliss, D. A. (2011). S-nitrosylation of pannexin 1 reduces channel permeability, potentially regulating vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 8.

Heberlein, K., Straub, A. C., Best, A. K., Wojta, J., & Isakson, B. E. (2011). Nicotinamide phosphoribosyl transferase coordinates stabilization of plasminogen activator inhibitor-1 mRNA at the myoendothelial junction. FASEB JOURNAL, 25.

Billaud, M., Lohman, A. W., Sandilos, J. K., Bayliss, D. A., & Isakson, B. E. (2011). Exclusive interaction between α1D-adrenergic receptor and pannexin 1 can mediate vasoconstriction. JOURNAL OF VASCULAR RESEARCH, 48, 118.

Straub, A., Billaud, M., Johnstone, S. R., Best, A. K., Looft-Wilson, R., Gaston, B., . . . Isakson, B. E. (2011). Compartmentalized redox signaling at the myoendothelial junction regulates heterocellular communication in the vessel wall. FASEB JOURNAL, 25.

Isakson, B. E., & Billaud, M. (2011). Expression and function of pannexins in the vasculature. JOURNAL OF VASCULAR RESEARCH, 48, 6.

Cechova, S., Zeng, Q., Billaud, M., Straub, A., Isakson, B., & Thu, L. (2011). Deletion Of Collectrin, An Ace-2 Homologue, Results In Altered eNOS Expression And Impaired Endothelium-dependent Vasorelaxation. HYPERTENSION, 58(5), E150.

Straub, A. C., Billaud, M., Johnstone, S. R., Best, A. K., Yemen, S., Dwyer, S. T., . . . Isakson, B. E. (2011). Compartmentalized Connexin 43 S-Nitrosylation/Denitrosylation Regulates Heterocellular Communication in the Vessel Wall. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(2), 399-U353. doi:10.1161/ATVBAHA.110.215939

Billaud, M., Lohman, A. W., Straub, A. C., Looft-Wilson, R., Johnstone, S. R., Araj, C. A., . . . Isakson, B. E. (2011). Pannexin1 Regulates α1-Adrenergic Receptor-Mediated Vasoconstriction. CIRCULATION RESEARCH, 109(1), 80-U284. doi:10.1161/CIRCRESAHA.110.237594

2010

Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., . . . Ravichandran, K. S. (2010). Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. NATURE, 467(7317), 863-U136. doi:10.1038/nature09413

Johnstone, S. R., Best, A. K., Wright, C. S., Isakson, B. E., Errington, R. J., & Martin, P. E. (2010). Enhanced Connexin 43 Expression Delays Intra-Mitoitc Duration and Cell Cycle Traverse Independently of Gap Junction Channel Function. JOURNAL OF CELLULAR BIOCHEMISTRY, 110(3), 772-782. doi:10.1002/jcb.22590

Heberlein, K. R., Straub, A. C., Best, A. K., Greyson, M. A., Looft-Wilson, R. C., Sharma, P. R., . . . Isakson, B. E. (2010). Plasminogen Activator Inhibitor-1 Regulates Myoendothelial Junction Formation. CIRCULATION RESEARCH, 106(6), 1092-1102. doi:10.1161/CIRCRESAHA.109.215723

Wang, L., Yin, J., Isakson, B., de Wit, C., & Kuebler, W. M. (2010). A critical role for connexin 40 in hypoxia induced pulmonary vasoconstriction. FASEB JOURNAL, 24.

Straub, A. C., Johnstone, S. R., Best, A. K., Palmer, L., & Isakson, B. E. (2010). Compartmentalized nitric oxide signaling at the myoendothelial junction can regulate gap junction communication. FASEB JOURNAL, 24.

Heberlein, K., Han, J., Zorn, G., Kaun, C., Straub, A. C., Best, A. K., . . . Isakson, B. E. (2010). The potential for localized translation and induction of plasminogen activator inhibitor-1 at the myoendothelial junction in response to TNF-alpha. FASEB JOURNAL, 24.

Chen, C. -H., Beard, R. S., Straub, A. C., Heberlein, K., Isakson, B. E., & Bearden, S. E. (2010). Homocysteine Modulates the Density and Composition of Myoendothelial Junctions. CIRCULATION, 122(21).

Straub, A. C., Johnstone, S. R., Heberlein, K. R., Rizzo, M. J., Best, A. K., Boitano, S., & Isakson, B. E. (2010). Site-Specific Connexin Phosphorylation Is Associated with Reduced Heterocellular Communication between Smooth Muscle and Endothelium. JOURNAL OF VASCULAR RESEARCH, 47(4), 277-286. doi:10.1159/000265562

Kadl, A., Meher, A. K., Sharma, P. R., Lee, M. Y., Doran, A. C., Johnstone, S. R., . . . Leitinger, N. (2010). Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2. CIRCULATION RESEARCH, 107(6), 737-U155. doi:10.1161/CIRCRESAHA.109.215715