Kyle L. Hoehn


Primary Appointment

Assistant Professor, Pharmacology


  • PhD, Colorado State University

Research Description

My laboratory investigates the mechanisms whereby alterations in cellular metabolism contribute to the pathophysiology of complex metabolic diseases including diabetes, obesity, and cancer. Three ongoing research areas in my lab include the regulation of fatty acid metabolism in the liver via protein acetylation, the role of glucose transporter 6 in endometrial cancer, and small molecule drug discovery for modulators of mitochondrial metabolism for the treatment of obesity and cancer.

Selected Publications

Byrne FL, Poon IK, Modesitt SC, Tomsig JL, Chow JD, Healy ME, Baker WD, Atkins KA, Lancaster JM, Marchion DC, Moley KH, Ravichandran KS, Slack-Davis JK, Hoehn KL, Metabolic Vulnerabilities in Endometrial Cancer., 2014; Cancer research. () . PMID: 25205105

Healy ME, Chow JD, Byrne FL, Breen DS, Leitinger N, Li C, Lackner C, Caldwell SH, Hoehn KL, Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine., 2014; Journal of hepatology. () . PMID: 25450719 | PMCID: PMC4336610

Laker RC, Xu P, Ryall KA, Sujkowski A, Kenwood BM, Chain KH, Zhang M, Royal MA, Hoehn KL, Driscoll M, Adler PN, Wessells RJ, Saucerman JJ, Yan Z, A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo., 2014; The Journal of biological chemistry. 289(17) 12005-15. PMID: 24644293 | PMCID: PMC4002107

Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Harris TE, Keller SR, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, Hoehn KL, Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle., 2014; Molecular metabolism. 3(2) 124-34. PMID: 24634818 | PMCID: PMC3953683

Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Lo RH, Cameron Coleman G, Columbus L, Yan Z, Saucerman JJ, Smith JS, Holmes JW, Lynch KR, Ravichandran KS, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, Hoehn KL, Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane., 2014; Molecular metabolism. 3(2) 114-23. PMID: 24634817 | PMCID: PMC3953706

Lee J, Walsh MC, Hoehn KL, James DE, Wherry EJ, Choi Y, Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity., 2014; Journal of immunology (Baltimore, Md. : 1950). 192(7) 3190-9. PMID: 24567531 | PMCID: PMC3965631

Laker RC, Lillard TS, Okutsu M, Zhang M, Hoehn KL, Connelly JJ, Yan Z, Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring., 2014; Diabetes. 63(5) 1605-11. PMID: 24430439

Bajwa A, Rosin DL, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey GR, Stevens BK, Jobin K, Kenwood BM, Hoehn KL, Lynch KR, Okusa MD, Sphingosine 1-Phosphate Receptor-1 Enhances Mitochondrial Function and Reduces Cisplatin-Induced Tubule Injury., 2014; Journal of the American Society of Nephrology : JASN. () . PMID: 25145931

Lira VA, Okutsu M, Zhang M, Greene NP, Laker RC, Breen DS, Hoehn KL, Yan Z, Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance., 2013; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(10) 4184-93. PMID: 23825228 | PMCID: PMC4046188

Franko A, von Kleist-Retzow JC, Böse M, Sanchez-Lasheras C, Brodesser S, Krut O, Kunz WS, Wiedermann D, Hoehn M, Stöhr O, Moll L, Freude S, Krone W, Schubert M, Wiesner RJ, Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle., 2012; Journal of molecular medicine (Berlin, Germany). 90(10) 1145-60. PMID: 22411022

Patel SA, Hoehn KL, Lawrence RT, Sawbridge L, Talbot NA, Tomsig JL, Turner N, Cooney GJ, Whitehead JP, Kraegen EW, Cleasby ME, Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity., 2012; Endocrinology. 153(11) 5231-46. PMID: 22989629 | PMCID: PMC3498583

Modesitt SC, Hsu JY, Chowbina SR, Lawrence RT, Hoehn KL, Not all fat is equal: differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer., 2012; International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 22(5) 732-41. PMID: 22635025

Caldwell S, Hoehn KL, Hahn YS, The strange and critical intersection of hepatitis c and lipoprotein metabolism: 'C-zing' the oil., 2012; Hepatology (Baltimore, Md.). () . PMID: 23055122

Hoehn KL, Turner N, Cooney GJ, James DE, Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice., 2012; The Journal of biological chemistry. 287(19) 15801; author reply 15802. PMID: 22563100 | PMCID: PMC3346128

Park D, Han CZ, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, Ravichandran KS, Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein., 2011; Nature. 477(7363) 220-4. PMID: 21857682 | PMCID: PMC3513690

Murrow BA, Hoehn KL, Mitochondrial regulation of insulin action., 2010; The international journal of biochemistry & cell biology. 42(12) 1936-9. PMID: 20837159

Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ, Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity., 2010; Cell metabolism. 11(1) 70-6. PMID: 20074529 | PMCID: PMC2824926

Larance M, Rowland AF, Hoehn KL, Humphreys DT, Preiss T, Guilhaus M, James DE, Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3., 2010; Molecular & cellular proteomics : MCP. 9(4) 682-94. PMID: 20051463 | PMCID: PMC2860230

Richards AA, Colgrave ML, Zhang J, Webster J, Simpson F, Preston E, Wilks D, Hoehn KL, Stephenson M, Macdonald GA, Prins JB, Cooney GJ, Xu A, Whitehead JP, Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation., 2009; Molecular endocrinology (Baltimore, Md.). 24(1) 229-39. PMID: 19855092

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE, Insulin resistance is a cellular antioxidant defense mechanism., 2009; Proceedings of the National Academy of Sciences of the United States of America. 106(42) 17787-92. PMID: 19805130 | PMCID: PMC2764908

Crowe S, Wu LE, Economou C, Turpin SM, Matzaris M, Hoehn KL, Hevener AL, James DE, Duh EJ, Watt MJ, Pigment epithelium-derived factor contributes to insulin resistance in obesity., 2009; Cell metabolism. 10(1) 40-7. PMID: 19583952

Yip MF, Ramm G, Larance M, Hoehn KL, Wagner MC, Guilhaus M, James DE, CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes., 2008; Cell metabolism. 8(5) 384-98. PMID: 19046570

Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE, IRS1-independent defects define major nodes of insulin resistance., 2008; Cell metabolism. 7(5) 421-33. PMID: 18460333 | PMCID: PMC2443409

Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ, Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents., 2007; Diabetes. 56(8) 2085-92. PMID: 17519422

Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA, Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance., 2007; Cell metabolism. 5(3) 167-79. PMID: 17339025

Holland WL, Knotts TA, Chavez JA, Wang LP, Hoehn KL, Summers SA, Lipid mediators of insulin resistance., 2007; Nutrition reviews. 65(6) S39-46. PMID: 17605313

Stratford S, Hoehn KL, Liu F, Summers SA, Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B., 2004; The Journal of biological chemistry. 279(35) 36608-15. PMID: 15220355

Hoehn KL, Hudachek SF, Summers SA, Florant GL, Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators., 2003; American journal of physiology. Regulatory, integrative and comparative physiology. 286(3) R498-504. PMID: 14656767

Hoehn KL, Summers SA, Assaying AKT/protein kinase B activity., 2003; Methods in molecular medicine. 83() 137-44. PMID: 12619725