Brent A. French

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Primary Appointment

Professor, Biomedical Engineering

Research Disciplines

Cardiovascular Biology, Experimental Pathology, Molecular Pharmacology, Physiology, Translational Science

Research Interests

Novel Therapies for Treating and Preventing Ischemic Heart Disease

Research Description

Our interests focus on developing gene therapy for treating and preventing cardio-vascular disease. An interdisciplinary approach is used to integrate recent technical advances with gene therapy research. In particular, cutting-edge imaging techniques such as MRI are used to expedite research by providing an accurate measure of gene therapy's efficacy against cardiovascular disease.
Current research projects in our lab focus on using gene therapy against myocardial infarction and heart failure. Recent work shows that the biological messenger nitric oxide plays a multifunctional role in protecting the heart against ischemic damage. Thus one project seeks to determine whether gene therapy with nitric oxide synthase can protect the heart against myocardial infarction.
One of the most damaging properties of superoxide is its ability to react with (and thereby inactivate) nitric oxide. Not only does this reaction deplete endogenous levels of nitric oxide, but it also yields a reaction product (peroxynitrite) that is severely damaging to biomolecules. We recently developed an antioxidant gene therapy, based on superoxide dismutase, which confers cardioprotection against myocardial infarction and has the potential to protect high-risk patients against the ravages of heart attack.

Personal Statement

Our interests focus on developing gene therapy for treating and preventing cardio-vascular disease. An interdisciplinary approach is used to integrate recent technical advances with gene therapy research. In particular, cutting-edge imaging techniques such as MRI are used to expedite research by providing an accurate measure of gene therapyâs efficacy against cardiovascular disease.
Current research projects in our lab focus on using gene therapy against myocardial infarction and heart failure. Recent work shows that the biological messenger nitric oxide plays a multifunctional role in protecting the heart against ischemic damage. Thus one project seeks to determine whether gene therapy with nitric oxide synthase can protect the heart against myocardial infarction.
One of the most damaging properties of superoxide is its ability to react with (and thereby inactivate) nitric oxide. Not only does this reaction deplete endogenous levels of nitric oxide, but it also yields a reaction product (peroxynitrite) that is severely damaging to biomolecules. We recently developed an antioxidant gene therapy, based on superoxide dismutase, which confers cardioprotection against myocardial infarction and has the potential to protect high-risk patients against the ravages of heart attack.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

2022

Yu, G., Chakrabarti, S., Tischenko, M., Chen, A. -L., Wang, Z., Cho, H., . . . Wang, Q. K. (2022). Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy. SCIENCE TRANSLATIONAL MEDICINE, 14(648). doi:10.1126/scitranslmed.abf3136

Ma, X., Rawnsley, D. R., Kovacs, A., Islam, M., Murphy, J. T., Zhao, C., . . . Diwan, A. (2022). TRAF2, an Innate Immune Sensor, Reciprocally Regulates Mitophagy and Inflammation to Maintain Cardiac Myocyte Homeostasis. JACC-BASIC TO TRANSLATIONAL SCIENCE, 7(3), 223-243. doi:10.1016/j.jacbts.2021.12.002

Becker, A. B., Chen, L., Ning, B., Hu, S., Hossack, J. A., Klibanov, A. L., . . . French, B. A. (2022). CONTRAST-ENHANCED ULTRASOUND REVEALS PARTIAL PERFUSION RECOVERY AFTER HINDLIMB ISCHEMIA AS OPPOSED TO FULL RECOVERY BY LASER DOPPLER PERFUSION IMAGING. ULTRASOUND IN MEDICINE AND BIOLOGY, 48(6), 1058-1069. doi:10.1016/j.ultrasmedbio.2022.02.002

2021

Hayes, D., French, B., & Tan, S. L. (2021). Objective Improvement in Cognitive Function following Aortic Coarctation Repair in an Adult.. Aorta (Stamford, Conn.), 9(1), 33-34. doi:10.1055/s-0041-1724004

Shah, S. A., Reagan, C. E., French, B. A., & Epstein, F. H. (2021). Molecular Mechanisms of Adenosine Stress T1 Mapping. CIRCULATION-CARDIOVASCULAR IMAGING, 14(3), 210-220. doi:10.1161/CIRCIMAGING.120.011774

2020

Straub, T., Nave, J., Bouvain, P., Akbarzadeh, M., Dasa, S. S. K., Kistner, J., . . . Temme, S. (2020). MRI-based molecular imaging of epicardium-derived stromal cells (EpiSC) by peptide-mediated active targeting. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-78600-y

Shah, S. A., Cui, S. X., Waters, C. D., Sano, S., Wang, Y., Doviak, H., . . . Epstein, F. H. (2020). Nitroxide-enhanced MRI of cardiovascular oxidative stress. NMR IN BIOMEDICINE, 33(9). doi:10.1002/nbm.4359

Yang, Z., Tian, Y., Berr, S. S., & French, B. A. (2020). Therapeutic Efficacy of Alpha-Lipoic Acid against Acute Myocardial Infarction and Chronic Left Ventricular Remodeling in Mice. CARDIOLOGY RESEARCH AND PRACTICE, 2020. doi:10.1155/2020/6759808

2019

Ma, X., Mani, K., Liu, H., Kovacs, A., Murphy, J. T., Foroughi, L., . . . Diwan, A. (2019). Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 8(4). doi:10.1161/JAHA.118.010866

Boutagy, N. E., Ravera, S., Papademetris, X., Onofrey, J. A., Zhuang, Z. W., Wu, J., . . . Sinusas, A. J. (2019). Noninvasive In Vivo Quantification of Adeno-Associated Virus Serotype 9-Mediated Expression of the Sodium/Iodide Symporter Under Hindlimb Ischemia and Neuraminidase Desialylation in Skeletal Muscle Using Single-Photon Emission Computed Tomography/Computed Tomography. CIRCULATION-CARDIOVASCULAR IMAGING, 12(7). doi:10.1161/CIRCIMAGING.119.009063

French, B. A., & Holmes, J. W. (2019). Implications of scar structure and mechanics for post-infarction cardiac repair and regeneration. EXPERIMENTAL CELL RESEARCH, 376(1), 98-103. doi:10.1016/j.yexcr.2019.01.001

Tian, Y., Charles, E. J., Yan, Z., Wu, D., French, B. A., Kron, I. L., & Yang, Z. (2019). The myocardial infarct-exacerbating effect of cell-free DNA is mediated by the high-mobility group box 1-receptor for advanced glycation end products-Toll-like receptor 9 pathway. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 157(6), 2256-+. doi:10.1016/j.jtcvs.2018.09.043

2018

Zhu, H., Wang, T., Lye, R. J., French, B. A., & Annex, B. H. (2018). Neuraminidase-mediated desialylation augments AAV9-mediated gene expression in skeletal muscle. JOURNAL OF GENE MEDICINE, 20(9). doi:10.1002/jgm.3049

Ni, Y., Liang, D., Tian, Y., Kron, I. L., French, B. A., & Yang, Z. (2018). Infarct-Sparing Effect of Adenosine A2B Receptor Agonist Is Primarily Due to Its Action on Splenic Leukocytes Via a PI3K/Akt/IL-10 Pathway. JOURNAL OF SURGICAL RESEARCH, 232, 442-449. doi:10.1016/j.jss.2018.06.042

Tian, Y., Miao, B., Charles, E. J., Wu, D., Kron, I. L., French, B. A., & Yang, Z. (2018). Stimulation of the Beta2 Adrenergic Receptor at Reperfusion Limits Myocardial Reperfusion Injury via an Interleukin-10-Dependent Anti-Inflammatory Pathway in the Spleen. CIRCULATION JOURNAL, 82(11), 2829-2836. doi:10.1253/circj.CJ-18-0061

Haskins, R. M., Nguyen, A. T., Alencar, G. F., Billaud, M., Kelly-Goss, M. R., Good, M. E., . . . Owens, G. K. (2018). Klf4 has an unexpected protective role in perivascular cells within the microvasculature. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 315(2), H402-H414. doi:10.1152/ajpheart.00084.2018

2017

Dasa, S. S. K., Suzuki, R., Mugler, E., Chen, L., Jansson-Lofmark, R., Michaelsson, E., . . . Kelly, K. A. (2017). Evaluation of pharmacokinetic and pharmacodynamic profiles of liposomes for the cell type-specific delivery of small molecule drugs. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 13(8), 2565-2574. doi:10.1016/j.nano.2017.07.005

2016

Tian, Y., Pan, D., Chordia, M. D., French, B. A., Kron, I. L., & Yang, Z. (2016). The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE. BASIC RESEARCH IN CARDIOLOGY, 111(6). doi:10.1007/s00395-016-0583-0

Totzeck, M., Hendgen-Cotta, U. B., French, B. A., & Rassaf, T. (2016). A practical approach to remote ischemic preconditioning and ischemic preconditioning against myocardial ischemia/reperfusion injury.. Journal of biological methods, 3(4), e57. doi:10.14440/jbm.2016.149

O'Connor, D. M., Smith, R. S., Piras, B. A., Beyers, R. J., Lin, D., Hossack, J. A., & French, B. A. (2016). Heart Rate Reduction With Ivabradine Protects Against Left Ventricular Remodeling by Attenuating Infarct Expansion and Preserving Remote-Zone Contractile Function and Synchrony in a Mouse Model of Reperfused Myocardial Infarction. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 5(4). doi:10.1161/JAHA.115.002989

Rammos, C., Hendgen-Cotta, U. B., Totzeck, M., Pohl, J., Luedike, P., Floegel, U., . . . Rassaf, T. (2016). Impact of dietary nitrate on age-related diastolic dysfunction. EUROPEAN JOURNAL OF HEART FAILURE, 18(6), 599-610. doi:10.1002/ejhf.535

Piras, B. A., Tian, Y., Xu, Y., Thomas, N. A., O'Connor, D. M., & French, B. A. (2016). Systemic injection of AAV9 carrying a periostin promoter targets gene expression to a myofibroblast-like lineage in mouse hearts after reperfused myocardial infarction. GENE THERAPY, 23(5), 469-478. doi:10.1038/gt.2016.20

Fu, H. Y., Sanada, S., Matsuzaki, T., Liao, Y., Okuda, K., Yamato, M., . . . Minamino, T. (2016). Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction. CIRCULATION RESEARCH, 118(5), 798-809. doi:10.1161/CIRCRESAHA.115.307604

2015

Naresh, N. K., Chen, X., Moran, E., Tian, Y., French, B. A., & Epstein, F. H. (2016). Repeatability and Variability of Myocardial Perfusion Imaging Techniques in Mice: Comparison of Arterial Spin Labeling and First-Pass Contrast-Enhanced MRI. MAGNETIC RESONANCE IN MEDICINE, 75(6), 2394-2405. doi:10.1002/mrm.25769

Dasa, S. S. K., Suzuki, R., Gutknecht, M., Brinton, L. T., Tian, Y., Michaelsson, E., . . . Kelly, K. A. (2015). Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. JOURNAL OF CONTROLLED RELEASE, 220, 556-567. doi:10.1016/j.jconrel.2015.06.017

Tian, Y., Piras, B. A., Kron, I. L., French, B. A., & Yang, Z. (2015). Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015. doi:10.1155/2015/585297

Tian, Y., French, B. A., Kron, I. L., & Yang, Z. (2015). Splenic leukocytes mediate the hyperglycemic exacerbation of myocardial infarct size in mice. BASIC RESEARCH IN CARDIOLOGY, 110(4). doi:10.1007/s00395-015-0496-3

O'Connor, D. M., Naresh, N. K., Piras, B. A., Xu, Y., Smith, R. S., Epstein, F. H., . . . French, B. A. (2015). A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction. PHYSIOLOGICAL REPORTS, 3(3). doi:10.14814/phy2.12351

Tian, Y., Marshall, M., French, B. A., Linden, J., & Yang, Z. (2015). The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A2A receptors. BASIC RESEARCH IN CARDIOLOGY, 110(2). doi:10.1007/s00395-015-0473-x

2014

Lin, D., French, B. A., Xu, Y., Hossack, J. A., & Holmes, J. W. (2015). AN ULTRASOUND-DRIVEN KINEMATIC MODEL FOR DEFORMATION OF THE INFARCTED MOUSE LEFT VENTRICLE INCORPORATING A NEAR-INCOMPRESSIBILITY CONSTRAINT. ULTRASOUND IN MEDICINE AND BIOLOGY, 41(2), 532-541. doi:10.1016/j.ultrasmedbio.2014.09.002

Tian, Y., Linden, J., French, B. A., & Yang, Z. (2014). Atorvastatin at Reperfusion Reduces Myocardial Infarct Size in Mice by Activating eNOS in Bone Marrow-Derived Cells. PLOS ONE, 9(12). doi:10.1371/journal.pone.0114375

French, B. A., & Annex, B. H. (2014). AAV9 and Cre: a one-two punch for a quick cardiac knockout. CARDIOVASCULAR RESEARCH, 104(1), 3-4. doi:10.1093/cvr/cvu200

Okutsu, M., Call, J. A., Lira, V. A., Zhang, M., Donet, J. A., French, B. A., . . . Yan, Z. (2014). Extracellular Superoxide Dismutase Ameliorates Skeletal Muscle Abnormalities, Cachexia, and Exercise Intolerance in Mice with Congestive Heart Failure. CIRCULATION-HEART FAILURE, 7(3), 519-U268. doi:10.1161/CIRCHEARTFAILURE.113.000841

2013

Naresh, N. K., Chen, X., Antkowiak, P., Xu, Y., French, B. A., & Epstein, F. H. (2013). Accelerated dual-contrast quantitative first-pass perfusion MRI of the mouse heart with compressed sensing. Journal of Cardiovascular Magnetic Resonance, 15, W17. doi:10.1186/1532-429x-15-s1-w17

Wang, F., Xu, Y., Michaelsson, E., & French, B. A. (2013). Inhibition of PARP1 Reduces Infarct Size and Attenuates Acute Left Ventricular Dilation in Mice After Mytocardial Ischemia/Reperfusion Injury. CIRCULATION, 128(22).

Lin, D., Xu, Y., Hossack, J. A., & French, B. A. (2013). Inducible Nitric Oxide Synthase Knockout Mice Exhibit Reduced Left Ventricular Dyssynchrony and Remodeling When Assessed Using High Frequency Ultrasound. CIRCULATION, 128(22).

Katwal, A. B., Konkalmatt, P. R., Piras, B. A., Hazarika, S., Li, S. S., Lye, R. J., . . . French, B. A. (2013). Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery. GENE THERAPY, 20(9), 930-938. doi:10.1038/gt.2013.16

Konkalmatt, P. R., Beyers, R. J., O'Connor, D. M., Xu, Y., Seaman, M. E., & French, B. A. (2013). Cardiac-Selective Expression of Extracellular Superoxide Dismutase After Systemic Injection of Adeno-Associated Virus 9 Protects the Heart Against Post-Myocardial Infarction Left Ventricular Remodeling. CIRCULATION-CARDIOVASCULAR IMAGING, 6(3), 478-+. doi:10.1161/CIRCIMAGING.112.000320

Konkalmatt, P. R., Deng, D., Thomas, S., Wu, M. T., Logsdon, C. D., French, B. A., & Kelly, K. A. (2013). Plectin-1 targeted AAV vector for the molecular imaging of pancreatic cancer. FRONTIERS IN ONCOLOGY, 3. doi:10.3389/fonc.2013.00084

Piras, B. A., O'Connor, D. M., & French, B. A. (2013). Systemic Delivery of shRNA by AAV9 Provides Highly Efficient Knockdown of Ubiquitously Expressed GFP in Mouse Heart, but Not Liver. PLOS ONE, 8(9). doi:10.1371/journal.pone.0075894

Liu, Y., & Chen, X. J. (2013). Adenine Nucleotide Translocase, Mitochondrial Stress, and Degenerative Cell Death. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2013. doi:10.1155/2013/146860

2012

Naresh, N. K., Xu, Y., Klibanov, A. L., Vandsburger, M. H., Meyer, C. H., Leor, J., . . . Epstein, F. H. (2012). Monocyte and/or Macrophage Infiltration of Heart after Myocardial Infarction: MR Imaging by Using T1-shortening Liposomes. RADIOLOGY, 264(2), 428-435. doi:10.1148/radiol.12111863

Jehle, A. B., Xu, Y., DiMaria, J. M., French, B. A., Epstein, F. H., Berr, S. S., . . . Kramer, C. M. (2012). A Nonpeptide Angiotensin II Type 2 Receptor Agonist Does Not Attenuate Postmyocardial Infarction Left Ventricular Remodeling in Mice. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 59(4), 363-368. doi:10.1097/FJC.0b013e3182444110

Beyers, R. J., Smith, R. S., Xu, Y., Piras, B. A., Salerno, M., Berr, S. S., . . . Epstein, F. H. (2012). T2âweighted MRI of postâinfarct myocardial edema in mice. Magnetic Resonance in Medicine, 67(1). doi:10.1002/mrm.24160

French, B. A. (2012). Animal Models in Cardiovascular MRI Research: Value and Limitations. CURRENT CARDIOVASCULAR IMAGING REPORTS, 5(2), 99-108. doi:10.1007/s12410-012-9128-6

Lin, D., Xu, Y., French, B. A., & Hossack, J. A. (2012). Comparison of Displacement-Based and Radial Uniformity Ratio Estimate Dyssynchrony Metrics in Serial Echocardiography of Post-Infarct Mice. CIRCULATION, 126(21).

Konkalmatt, P. R., Beyers, R., Xu, Y., & French, B. A. (2012). Cardiac-specific Expression of iNOS using an AAV9 Vector in Combination with the Cardiac Troponin-T Promoter Inhibits LV Remodeling after Reperfused Myocardial Infarction. CIRCULATION, 126(21).

O'Connor, D. M., Smith, R. S., Piras, B. A., Lin, D., Hossack, J. A., & French, B. A. (2012). Heart Rate Reduction with Ivabradine Improves Regional Contractile Function and LV Dyssynchrony in a Mouse Model of Reperfused Myocardial Infarction. CIRCULATION, 126(21).

Vandsburger, M. H., French, B. A., Kramer, C. M., Zhong, X., & Epstein, F. H. (2012). Displacement-encoded and manganese-enhanced cardiac MRI reveal that nNOS, not eNOS, plays a dominant role in modulating contraction and calcium influx in the mammalian heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 302(2), H412-H419. doi:10.1152/ajpheart.00705.2011

Konkalmatt, P. R., Wang, F., Piras, B. A., Xu, Y., O'Connor, D. M., Beyers, R. J., . . . French, B. A. (2012). Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling. JOURNAL OF GENE MEDICINE, 14(9-10), 609-620. doi:10.1002/jgm.2673

2011

LaPar, D. J., Hajzus, V. A., Zhao, Y., Lau, C. L., French, B. A., Kron, I. L., . . . Laubach, V. E. (2012). Acute Hyperglycemic Exacerbation of Lung Ischemia-Reperfusion Injury Is Mediated by Receptor for Advanced Glycation End-Products Signaling. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 46(3), 299-305. doi:10.1165/rcmb.2011-0247OC

Li, Y., Garson, C. D., Xu, Y., Helm, P. A., Hossack, J. A., & French, B. A. (2011). SERIAL ULTRASOUND EVALUATION OF INTRAMYOCARDIAL STRAIN AFTER REPERFUSED MYOCARDIAL INFARCTION REVEALS THAT REMOTE ZONE DYSSYNCHRONY DEVELOPS IN CONCERT WITH LEFT VENTRICULAR REMODELING. ULTRASOUND IN MEDICINE AND BIOLOGY, 37(7), 1073-1086. doi:10.1016/j.ultrasmedbio.2011.04.002

Prasad, K. -M. R., Smith, R. S., Xu, Y., & French, B. A. (2011). A single direct injection into the left ventricular wall of an adeno-associated virus 9 (AAV9) vector expressing extracellular superoxide dismutase from the cardiac troponin-T promoter protects mice against myocardial infarction. JOURNAL OF GENE MEDICINE, 13(6), 333-341. doi:10.1002/jgm.1576

Beyers, R. J., Smith, R. S., Xu, Y., Piras, B. A., Salerno, M., Berr, S. S., . . . Epstein, F. H. (2012). T2-weighted MRI of post-infarct myocardial edema in mice. MAGNETIC RESONANCE IN MEDICINE, 67(1), 201-209. doi:10.1002/mrm.22975

Wang, F., Prasad, K. -M. R., Xu, Y., Hossack, J. A., & French, B. A. (2011). High Frequency Speckle Tracking Echocardiography as a Sensitive Measure for Evaluating the Effects of Gene Therapy on LV Function after Myocardial Infarction in Mice. CIRCULATION, 124(21).

O'Connor, D. M., Xu, Y., Smith, R. S., Prasad, K. -M. R., Ogle, R. C., Hossack, J. A., & French, B. A. (2011). A Novel Cardiac Muscle-Derived Extracellular Matrix Extract Reduces Dyskinesia and Post-Infarct Left Ventricular Remodeling in a Mouse Model of Myocardial Infarction. CIRCULATION, 124(21).

Smith, R. S., O'Connor, D. M., Piras, B. A., Hossack, J. A., & French, B. A. (2011). Ivabradine Protects Against Left Ventricular Remodeling in a Mouse Model of Reperfused Myocardial Infarction. CIRCULATION, 124(21).

Mauldin, F. W., French, B. A., & Hossack, J. A. (2011). Reduction of Medical Ultrasound Reverberation Artifacts in Cardiac Imaging Using a Data-Adaptive Signal Separation Scheme. CIRCULATION, 124(21).

Prasad, K. -M. R., Xu, Y., Yang, Z., Acton, S. T., & French, B. A. (2011). Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution. GENE THERAPY, 18(1), 43-52. doi:10.1038/gt.2010.105

Saqib, A., Prasad, K. -M. R., Katwal, A. B., Sanders, J. M., Lye, R. J., French, B. A., & Annex, B. H. (2011). Adeno-associated virus serotype 9-mediated overexpression of extracellular superoxide dismutase improves recovery from surgical hind-limb ischemia in BALB/c mice. JOURNAL OF VASCULAR SURGERY, 54(3), 810-818. doi:10.1016/j.jvs.2011.03.278

Zhong, X., Gibberman, L. B., Spottiswoode, B. S., Gilliam, A. D., Meyer, C. H., French, B. A., & Epstein, F. H. (2011). Comprehensive Cardiovascular magnetic resonance of myocardial mechanics in mice using three-dimensional cine DENSE. JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 13. doi:10.1186/1532-429X-13-83

2010

Laubach, V. E., French, B. A., & Okusa, M. D. (2011). Targeting of adenosine receptors in ischemia-reperfusion injury. EXPERT OPINION ON THERAPEUTIC TARGETS, 15(1), 103-118. doi:10.1517/14728222.2011.541441

Vandsburger, M. H., Janiczek, R. L., Xu, Y., French, B. A., Meyer, C. H., Kramer, C. M., & Epstein, F. H. (2010). Improved Arterial Spin Labeling After Myocardial Infarction in Mice Using Cardiac and Respiratory Gated Look-Locker Imaging With Fuzzy C-Means Clustering. MAGNETIC RESONANCE IN MEDICINE, 63(3), 648-657. doi:10.1002/mrm.22280

Saqib, A., Prasad, K. -M. R., Katwal, A. B., Lye, R. J., French, B. A., & Annex, B. H. (2010). AAV9-Mediated Over-Expression of Extracellular Superoxide Dismutase Improves Recovery from Hindlimb Ischemia in BALB/c Mice. CIRCULATION, 122(21).

Piras, B. A., Prasad, K. -M. R., Smith, R. S., & French, B. A. (2010). Highly-Efficient in vivo Knock-Down of Ubiquitously Expressed eGFP in the Murine Heart with siRNA Delivered by a Pseudotyped AAV9 Vector. CIRCULATION, 122(21).

Ebner, B., Behm, P., Jacoby, C., Burghoff, S., French, B. A., Schrader, J., & Floegel, U. (2010). Early Assessment of Pulmonary Inflammation by 19F MRI In Vivo. CIRCULATION-CARDIOVASCULAR IMAGING, 3(2), 202-U109. doi:10.1161/CIRCIMAGING.109.902312

Kramer, C. M., Sinusas, A. J., Sosnovik, D. E., French, B. A., & Bengel, F. M. (2010). Multimodality Imaging of Myocardial Injury and Remodeling. JOURNAL OF NUCLEAR MEDICINE, 51, 107S-121S. doi:10.2967/jnumed.109.068221

Vandsburger, M. H., French, B. A., Kramer, C. M., & Epstein, F. H. (2010). Cine DENSE and Manganese-enhanced MRI Demonstrate that nNOS, and not eNOS, Plays a Dominant Role in Modulating EC-coupling in the Mouse Heart.. CIRCULATION, 122(21).

Smith, R. S., Piras, B. A., Farber, C. R., Laubach, V. E., Kron, I. L., & French, B. A. (2010). Acute Hyperglycemia Synergizes with Myocardial Infarction to Induce Significant Changes in Leukocyte Gene Expression Profiles. CIRCULATION, 122(21).