Victor H. Engelhard

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Primary Appointment

Professor, Microbiology, Immunology, and Cancer Biology

Education

  • BA, Biochemistry, Rice University, Houston, TX
  • MS, Biochemistry, University of Illinois, Urbana, IL
  • PhD, Biochemistry, University of Illinois, Urbana, IL
  • Postdoc, Immunology, Harvard University, Cambridge, MA

Research Disciplines

Biotechnology, Cancer Biology, Immunology, Translational Science

Research Interests

Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Tertiary lymphoid structures and intratumoral immunity

Research Description

The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work has increasingly focused on tumor-derived antigens and cancer immunology. Current activities in the laboratory are focused on the role of different homing receptors in enabling T cell infiltration into tumors, control of expression of homing receptor ligands on tumor associated vasculature, and the factors driving development of tertiary lymphoid structures in tumors. We have identified the homing receptors that are upregulated on effector CD8 T cells in different lymph nodes, and have established their role in infiltration of effector cells into inflamed and resting peripheral tissues, non-contiguous lymph nodes, and tumors. We have evaluated expression of homing receptor ligands on endothelial cells in melanoma tumors and have established that they are often suboptimal. We are currently studying their regulation by aspects of the tumor microenvironment, including pro-inflammatory cytokines and angiogenic growth factors. We have also uncovered mechanisms that regulate the development of tumor vasculature that resembles that of lymph node high endothelial venules. We have established that this vasculature enables naïve T cells to infiltrate tumors, and in some cases, to form tumor-associated tertiary lymphoid structures. Following this, we have established that development of these structures involves cross-talk between B lymphocytes and tumor associated fibroblasts. Altogether, these activities reflect an ongoing commitment to understand the limits on, and improve the entry of, T cells into tumors. My activities have led to 200 peer-reviewed and invited publications. I have been recognized as an ISI Highly Cited Researcher©, placing me among the top 250 of scientists and scholars worldwide cited in 21 broad subject categories in sciences and medicine.

Personal Statement

The work of my laboratory over the last 40 years has been broadly concerned with the recognition of antigens by CD8 T cells. In the last 20 years, that work has increasingly focused on tumor-derived antigens and cancer immunology. Current activities in the laboratory are focused on the role of different homing receptors in enabling T cell infiltration into tumors, control of expression of homing receptor ligands on tumor associated vasculature, and the factors driving development of tertiary lymphoid structures in tumors. We have identified the homing receptors that are upregulated on effector CD8 T cells in different lymph nodes, and have established their role in infiltration of effector cells into inflamed and resting peripheral tissues, non-contiguous lymph nodes, and tumors. We have evaluated expression of homing receptor ligands on endothelial cells in melanoma tumors and have established that they are often suboptimal. We are currently studying their regulation by aspects of the tumor microenvironment, including pro-inflammatory cytokines and angiogenic growth factors. We have also uncovered mechanisms that regulate the development of tumor vasculature that resembles that of lymph node high endothelial venules. We have established that this vasculature enables naïve T cells to infiltrate tumors, and in some cases, to form tumor-associated tertiary lymphoid structures. Following this, we have established that development of these structures involves cross-talk between B lymphocytes and tumor associated fibroblasts. Altogether, these activities reflect an ongoing commitment to understand the limits on, and improve the entry of, T cells into tumors. My activities have led to 200 peer-reviewed and invited publications. I have been recognized as an ISI Highly Cited Researcher©, placing me among the top 250 of scientists and scholars worldwide cited in 21 broad subject categories in sciences and medicine.
I have trained 65 graduate students, postdoctoral fellows, and visiting scientists in my laboratory. In recognition, I was awarded the Robert J Kadner Distinguished Teaching Award in 2008, and the David A. Harrison Distinguished Educator Award in 2006. I am currently Director of the Immunology Training Program at the University of Virginia, and Principal Investigator on the NIH-sponsored Training Grant that supports its activities. I have significant experience mentoring students from underrepresented groups, including two trainees in my laboratory who received NIH F31 fellowships. I am Co-Director of the University of Virginia Human Immune Therapy Center, and formerly, Co-Leader of the Immunology and Immunotherapy Program of the University of Virginia Cancer Center, and Director of the Carter Immunology Center at the University of Virginia. In these leadership roles, I have promoted research in Immunology broadly, but with particular emphasis on the immune response to cancer. I believe that these leadership and administrative accomplishments demonstrate my ability to take scientific responsibility for the work proposed, to promote the research activities and careers of trainees, and to effectively collaborate and interact with other others.

Training

  • Basic Cardiovascular Research Training Grant
  • Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Sciences
  • Biotechnology Training Grant
  • Interdisciplinary Training Program in Immunology
  • Training in Cell and Molecular Biology

Selected Publications

2022

Jaiswal, A., Verma, A., Dannenfelser, R., Melssen, M., Tirosh, I., Izar, B., . . . Anandasabapathy, N. (2022). An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes. CANCER CELL, 40(5), 524-+. doi:10.1016/j.ccell.2022.04.005

Rodriguez, A. B., Parriott, G., & Engelhard, V. H. (2022). Tumor necrosis factor receptor regulation of peripheral node addressin biosynthetic components in tumor endothelial cells.. Frontiers in immunology, 13, 1009306. doi:10.3389/fimmu.2022.1009306

2021

Lulu, A. M., Cummings, K. L., Jeffery, E. D., Myers, P. T., Underwood, D., Lacy, R. M., . . . Engelhard, V. H. (2021). Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients. CANCER IMMUNOLOGY RESEARCH, 9(11), 1327-1341. doi:10.1158/2326-6066.CIR-21-0111

Kwak, M., Erdag, G., Leick, K. M., Bekiranov, S., Engelhard, V. H., & Slingluff, C. L. (2021). Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163(+) myeloid cell infiltrates. JOURNAL OF TRANSLATIONAL MEDICINE, 19(1). doi:10.1186/s12967-021-03044-5

Pinczewski, J., Obeng, R. C., Jr, S. C. L., & Engelhard, V. H. (2021). Phospho-beta-catenin expression in primary and metastatic melanomas and in tumor-free visceral tissues, and associations with expression of PD-L1 and PD-L2. PATHOLOGY RESEARCH AND PRACTICE, 224. doi:10.1016/j.prp.2021.153527

Rodriguez, A. B., Peske, J. D., Woods, A. N., Leick, K. M., Mauldin, I. S., Meneveau, M. O., . . . Engelhard, V. H. (2021). Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts. CELL REPORTS, 36(3). doi:10.1016/j.celrep.2021.109422

Lynch, K. T., Young, S. J., Meneveau, M. O., Wages, N. A., Engelhard, V. H., Jr, S. C. L., & Mauldin, I. S. (2021). Heterogeneity in tertiary lymphoid structure B-cells correlates with patient survival in metastatic melanoma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(6). doi:10.1136/jitc-2020-002273

Melssen, M. M., Lindsay, R. S., Stasiak, K., Rodriguez, A. B., Briegel, A. M., Cyranowski, S., . . . Engelhard, V. H. (2021). Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8(+) T Cells. CANCER IMMUNOLOGY RESEARCH, 9(5), 583-597. doi:10.1158/2326-6066.CIR-20-0427

2020

Rodriguez, A. B., & Engelhard, V. H. (2020). Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy. CANCER IMMUNOLOGY RESEARCH, 8(11), 1338-1345. doi:10.1158/2326-6066.CIR-20-0432

Lulu, A. M., Cummings, K. L., & Engelhard, V. H. (2020). Evidence of ongoing immune surveillance to cancer-associated phosphopeptides in healthy individuals. In JOURNAL OF IMMUNOLOGY Vol. 204. Retrieved from https://www.webofscience.com/

Stasiak, K., Lindsay, R., & Engelhard, V. H. (2020). Low immunogenicity of intracranial tumors limits immune response to brain malignancies. In JOURNAL OF IMMUNOLOGY Vol. 204. Retrieved from https://www.webofscience.com/

Lulu, A. M., Cummings, K. L., & Engelhard, V. H. (2020). Pre-existing immune memory to cancer-associated phosphopeptides in healthy donors.. In CANCER IMMUNOLOGY RESEARCH Vol. 8 (pp. 114-115). Retrieved from https://www.webofscience.com/

Dellacecca, E. R., Cosgrove, C., Mukhatayev, Z., Akhtar, S., Engelhard, V. H., Rademaker, A. W., . . . Le Poole, I. C. (2020). Antibiotics Drive Microbial Imbalance and Vitiligo Development in Mice. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 140(3), 676-+. doi:10.1016/j.jid.2019.08.435

Curley, C. T., Stevens, A. D., Mathew, A. S., Stasiak, K., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound. THERANOSTICS, 10(19), 8821-8833. doi:10.7150/thno.47983

Engelhard, V. H., Obeng, R. C., Cummings, K. L., Petroni, G. R., Ambakhutwala, A. L., Chianese-Bullock, K. A., . . . Jr, S. C. L. (2020). MHC-restricted phosphopeptide antigens: preclinical validation and first-in-humans clinical trial in participants with high-risk melanoma. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8(1). doi:10.1136/jitc-2019-000262

2019

Leick, K. M., Rodriguez, A. B., Melssen, M. M., Benamar, M., Lindsay, R. S., Eki, R., . . . Jr, S. C. L. (2019). The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis. ANNALS OF SURGERY, 270(4), 712-722. doi:10.1097/SLA.0000000000003522

Cosgrove, P., Dellacecca, E. R., Akhtar, S., Engelhard, V. H., Knight, K. L., & Le Poole, I. C. (2019). Antibiotics modify outcomes in vitiligo. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 139 (pp. S306). doi:10.1016/j.jid.2019.07.449

Leick, K. M., Pinczewski, J., Mauldin, I. S., Young, S. J., Deacon, D. H., Woods, A. N., . . . Jr, S. C. L. (2019). Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumors. In CANCER IMMUNOLOGY IMMUNOTHERAPY Vol. 68 (pp. 1121-1132). doi:10.1007/s00262-019-02345-5

Santambrogio, L., Berendam, S. J., & Engelhard, V. H. (2019). The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.01033

Dellacecca, E., Cosgrove, C., Mukhatayev, Z., Akhtar, S., Engelhard, V. H., Rademaker, A. W., . . . Le Poole, I. C. (2019). 521 Ampicillin drives gut dysbiosis and progressive depigmentation in a mouse model of vitiligo.. In Journal of Investigative Dermatology Vol. 139 (pp. S89). Elsevier BV. doi:10.1016/j.jid.2019.03.597

Dellacecca, E., Cosgrove, C., Mukhatayev, Z., Akhtar, S., Engelhard, V. H., Rademaker, A. W., . . . Le Poole, I. C. (2019). Ampicillin drives gut dysbiosis and progressive depigmentation in a mouse model of vitiligo. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 139 (pp. S89). Retrieved from https://www.webofscience.com/

Berendam, S. J., Koeppel, A. F., Godfrey, N. R., Rouhani, S. J., Woods, A. N., Rodriguez, A. B., . . . Engelhard, V. H. (2019). Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells. FRONTIERS IN IMMUNOLOGY, 10. doi:10.3389/fimmu.2019.00816

2018

Rodriguez, A. B., Peske, J. D., Woods, A. N., Melssen, M. M., Cyranowski, S., Parriott, G. R., & Engelhard, V. H. (2018). Cellular and molecular mechanisms regulating the development of tertiary lymphoid structures in tumor. In JOURNAL OF IMMUNOLOGY Vol. 200. Retrieved from https://www.webofscience.com/

Hailemichael, Y., Woods, A., Fu, T., He, Q., Nielsen, M. C., Hasan, F., . . . Overwijk, W. W. (2018). Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. JOURNAL OF CLINICAL INVESTIGATION, 128(4), 1338-1354. doi:10.1172/JCI93303

Engelhard, V. H., Rodriguez, A. B., Mauldin, I. S., Woods, A. N., Peske, J. D., & Jr, S. C. L. (2018). Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity. JOURNAL OF IMMUNOLOGY, 200(2), 432-442. doi:10.4049/jimmunol.1701269

Melssen, M. M., Olson, W., Wages, N. A., Capaldo, B. J., Mauldin, I. S., Mahmutovic, A., . . . Jr, S. C. L. (2018). Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma. ONCOIMMUNOLOGY, 7(10). doi:10.1080/2162402X.2018.1490855

Rodriguez, A. B., Peske, J. D., & Engelhard, V. H. (2018). Identification and Characterization of Tertiary Lymphoid Structures in Murine Melanoma. TERTIARY LYMPHOID STRUCTURES: METHODS AND PROTOCOLS, 1845, 241-257. doi:10.1007/978-1-4939-8709-2_14

2017

Woods, A. N., Wilson, A. L., Srivinisan, N., Zeng, J., Dutta, A. B., Peske, J. D., . . . Engelhard, V. H. (2017). Differential Expression of Homing Receptor Ligands on Tumor-Associated Vasculature that Control CD8 Effector T-cell Entry. CANCER IMMUNOLOGY RESEARCH, 5(12), 1062-1073. doi:10.1158/2326-6066.CIR-17-0190

Mohammed, F., Stones, D. H., Zarling, A. L., Willcox, C. R., Shabanowitz, J., Cummings, K. L., . . . Willcox, B. E. (2017). The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status.. Oncotarget, 8(33), 54160-54172. doi:10.18632/oncotarget.16952

Mohammed, F., Stones, D. H., Zarling, A. L., Willcox, C. R., Shabanowitz, J., Cummings, K. L., . . . Willcox, B. E. (2017). The antigenic identity of human class I MHC phosphopeptides is critically dependent upon phosphorylation status. ONCOTARGET, 8(33), 54160-54172. doi:10.18632/oncotarget.16952

Uduman, M., Khattar, M., Joshi, B., Tanne, A., Morin, B., Karapetyan, A., . . . Castle, J. (2017). Abstract 4609: Agenusâ next generation cancer vaccine platforms. In Immunology. American Association for Cancer Research. doi:10.1158/1538-7445.am2017-4609

Devi, K., Melssen, M., Tirosh, I., Izar, B., Olson, W., Engelhard, V., . . . Anandasabapathy, N. (2017). Human melanoma TILs share phenotypic and transcriptional properties with tissue resident memory T cells. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 137 (pp. S11). doi:10.1016/j.jid.2017.02.075

Akhtar, S., Dellacecca, E., Engelhard, V., Knight, K., & Le Poole, C. (2017). Dysbiosis of gut microbiota by ampicillin exacerbates vitiligo. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 137 (pp. S142). doi:10.1016/j.jid.2017.02.853

Malaker, S. A., Ferracane, M. J., Depontieu, F. R., Zarling, A. L., Shabanowitz, J., Bai, D. L., . . . Hunt, D. F. (2017). Identification and Characterization of Complex Glycosylated Peptides Presented by the MHC Class II Processing Pathway in Melanoma. JOURNAL OF PROTEOME RESEARCH, 16(1), 228-237. doi:10.1021/acs.jproteome.6b00496

2016

Hailemichael, Y., Fu, T., Woods, A., Roszik, J., Schluns, K. S., Engelhard, V. H., . . . Overwijk, W. W. (2016). Abstract A031: Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. In Antigens and Vaccines. American Association for Cancer Research. doi:10.1158/2326-6066.imm2016-a031

Hailemichael, Y., Fu, T., Woods, A., Schluns, K., Engelhard, V. H., Sharma, P., & Overwijk, W. W. (2016). Effect of cancer vaccine formulation on synergy with anti-CTLA-4 and anti-PD-L1 checkpoint blockade therapy of cancer. In JOURNAL OF CLINICAL ONCOLOGY Vol. 34. doi:10.1200/JCO.2016.34.15_suppl.3094

Melssen, M. M., Rodriguez, A. B., Slingluff, C. L., & Engelhard, V. H. (2016). CD49a and CD103 expression on tumor infiltrating lymphocytes in B16-OVA tumors depends on location and is correlated with a naive phenotype. In JOURNAL OF IMMUNOLOGY Vol. 196. Retrieved from https://www.webofscience.com/

Wilson, A. L., Woods, A. N., & Engelhard, V. H. (2016). Immunosuppression limits CD8(+) T cell entry. In JOURNAL OF IMMUNOLOGY Vol. 196. Retrieved from https://www.webofscience.com/

Woods, A. N., Wilson, A. L., Srivinasan, N., & Engelhard, V. H. (2016). Effector CD8 T cells use different homing receptor/ligand interactions to enter subcutaneous and intraperitoneal B16 melanoma tumors. In JOURNAL OF IMMUNOLOGY Vol. 196. Retrieved from https://www.webofscience.com/

Rodriguez, A. B., Peske, J. D., Woods, A. N., & Engelhard, V. H. (2016). Regulation of peripheral node addressin in tumor-associated CD31(+) vascular endothelial cells.. In JOURNAL OF IMMUNOLOGY Vol. 196. Retrieved from https://www.webofscience.com/

Ager, C., Reilley, M., Nicholas, C., Bartkowiak, T., Jaiswal, A., Curran, M., . . . Kortylewski, M. (2016). 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016.. In Journal for immunotherapy of cancer Vol. 4 (pp. 107-221). doi:10.1186/s40425-016-0173-6

2015

Cohen, J. N., Rouhani, S. J., Tewalt, E. F., Buonomo, E. L., Bruce, A. N., Riccardi, P., . . . Engelhard, V. H. (2015). Induction of peripheral tolerance in CD8 and CD4 T cells by lymphatic endothelial cells. In MOLECULAR IMMUNOLOGY Vol. 68 (pp. 154). Retrieved from https://www.webofscience.com/

Engelhard, V. H., Peske, D., Woods, A., Srinivasan, N., Brinkman, C., & Ferguson, A. (2015). Abstract IA23: T cell trafficking in lymphoid and non-lymphoid tissues. In Immunometabolism and Immunoregulation. American Association for Cancer Research. doi:10.1158/2326-6074.tumimm14-ia23

Woods, A., Srivinasan, N., & Engelhard, V. (2015). Effector T-CD8 use different homing receptor/ligand interactions to enter subcutaneous and intraperitoneal B16 melanoma tumors. In JOURNAL OF IMMUNOLOGY Vol. 194. Retrieved from https://www.webofscience.com/

Peske, J., Thompson, E., Gemta, L., Baylis, R., Fu, Y., & Engelhard, V. (2015). Effector lymphocytes induce lymph node-like vasculature in tumors, which enables naive T cell infiltration and enhanced anti-tumor immunity. In JOURNAL OF IMMUNOLOGY Vol. 194. Retrieved from https://www.webofscience.com/

Peske, J. D., Thompson, E. D., Gemta, L., Baylis, R. A., Fu, Y. -X., & Engelhard, V. H. (2015). Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms8114

Rouhani, S. J., Eccles, J. D., Riccardi, P., Peske, J. D., Tewalt, E. F., Cohen, J. N., . . . Engelhard, V. H. (2015). Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms7771

Peske, J. D., Woods, A. B., & Engelhard, V. H. (2015). Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment. IMMUNOTHERAPY OF CANCER, 128, 263-307. doi:10.1016/bs.acr.2015.05.001

2014

Zarling, A. L., Obeng, R. C., Desch, A. N., Pinczewski, J., Cummings, K. L., Deacon, D. H., . . . Engelhard, V. H. (2014). MHC-restricted phosphopeptides from insulin receptor substrate-2 and CDC25b offer broad-based immunotherapeutic agents for cancer.. Cancer research, 74(23), 6784-6795. doi:10.1158/0008-5472.can-14-0043

Zarling, A. L., Obeng, R. C., Desch, A. N., Pinczewski, J., Cummings, K. L., Deacon, D. H., . . . Engelhard, V. H. (2014). MHC-Restricted Phosphopeptides from Insulin Receptor Substrate-2 and CDC25b Offer Broad-Based Immunotherapeutic Agents for Cancer. CANCER RESEARCH, 74(23), 6784-6795. doi:10.1158/0008-5472.CAN-14-0043

Eby, J. M., Kang, H. -K., Klarquist, J., Chatterjee, S., Mosenson, J. A., Nishimura, M. I., . . . Le Poole, I. C. (2014). Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation. PIGMENT CELL & MELANOMA RESEARCH, 27(6), 1075-1085. doi:10.1111/pcmr.12284

Eby, J. M., Kang, H. -K., Klarquist, J., Chatterjee, S., Mosenson, J. A., Nishimura, M. I., . . . Le Poole, I. C. (2014). Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation.. Pigment cell & melanoma research, 27(6), 1075-1085. doi:10.1111/pcmr.12284

Brinkman, C. C., Rouhani, S. J., Srinivasan, N., & Engelhard, V. H. (2014). Correction: Peripheral Tissue Homing Receptors Enable T Cell Entry into Lymph Nodes and Affect the Anatomical Distribution of Memory Cells. The Journal of Immunology, 192(8), 3992-3995. doi:10.4049/jimmunol.1490008

Cohen, J. N., Tewalt, E. F., Rouhani, S. J., Buonomo, E. L., Bruce, A. N., Xu, X., . . . Engelhard, V. H. (2014). Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment. PLOS ONE, 9(2). doi:10.1371/journal.pone.0087740

Rouhani, S. J., Eccles, J. D., Tewalt, E. F., & Engelhard, V. H. (2014). Regulation of T-cell Tolerance by Lymphatic Endothelial Cells. . Journal of clinical & cellular immunology, 5, 1000242. doi:10.4172/2155-9899.1000242

2013

Brinkman, C. C., Rouhani, S. J., Srinivasan, N., & Engelhard, V. H. (2013). Correction: Peripheral Tissue Homing Receptors Enable T Cell Entry into Lymph Nodes and Affect the Anatomical Distribution of Memory Cells. The Journal of Immunology, 191(12), 6292. doi:10.4049/jimmunol.1390066

Rival, C., Wheeler, K., Jeffrey, S., Qiao, H., Luu, B., Tewalt, E. F., . . . Tung, K. (2013). Regulatory T cells and vasectomy. JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 100(1), 66-75. doi:10.1016/j.jri.2013.08.004

Cobbold, M., De La Pena, H., Norris, A., Polefrone, J. M., Qian, J., English, A. M., . . . Engelhard, V. H. (2013). MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia. SCIENCE TRANSLATIONAL MEDICINE, 5(203). doi:10.1126/scitranslmed.3006061

Brinkman, C. C., Rouhani, S. J., Srinivasan, N., & Engelhard, V. H. (2013). Peripheral Tissue Homing Receptors Enable T Cell Entry into Lymph Nodes and Affect the Anatomical Distribution of Memory Cells. JOURNAL OF IMMUNOLOGY, 191(5), 2412-2425. doi:10.4049/jimmunol.1300651

Rouhani, S., Tewalt, E., Davis, H., Chen, L., & Engelhard, V. (2013). Lymphatic endothelial cells induce anergy of beta-galactosidase specific CD4 T cells by providing antigen to CD11c cells. In JOURNAL OF IMMUNOLOGY Vol. 190. Retrieved from https://www.webofscience.com/

Engels, B., Engelhard, V. H., Sidney, J., Sette, A., Binder, D. C., Liu, R. B., . . . Schreiber, H. (2013). Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity. CANCER CELL, 23(4), 516-526. doi:10.1016/j.ccr.2013.03.018

Brinkman, C. C., Peske, J. D., & Engelhard, V. H. (2013). Peripheral tissue homing receptor control of naive, effector, and memory CD8 T cell localization in lymphoid and non-lymphoid tissues. FRONTIERS IN IMMUNOLOGY, 4. doi:10.3389/fimmu.2013.00241

2012

Tewalt, E. F., Cohen, J. N., Rouhani, S. J., Guidi, C. J., Qiao, H., Fahl, S. P., . . . Engelhard, V. H. (2012). Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells. BLOOD, 120(24), 4772-4782. doi:10.1182/blood-2012-04-427013

Cohen, J., Fu, Y. -X., & Engelhard, V. (2012). Tolerogenic properties of lymphatic endothelial cells are controlled by the lymph node microenvironment. In JOURNAL OF IMMUNOLOGY Vol. 188. Retrieved from https://www.webofscience.com/

Tewalt, E., Cohen, J., Rouhani, S., Guidi, C., Qiao, H., Fahl, S., . . . Engelhard, V. (2012). Peripheral tolerance induction by PD-L1+lymphatic endothelial cell is due to deficient costimulation that leads to rapid, high-level expression of PD-1 on CD8 T cells. In JOURNAL OF IMMUNOLOGY Vol. 188. Retrieved from https://www.webofscience.com/

Tewalt, E., Cohen, J., Rouhani, S., Guidi, C., Qiao, H., Fahl, S., . . . Engelhard, V. (2012). Peripheral tolerance induction by PD-L1+lymphatic endothelial cell is due to deficient costimulation that leads to rapid, high-level expression of PD-1 on CD8 T cells. In JOURNAL OF IMMUNOLOGY Vol. 188. Retrieved from https://www.webofscience.com/

Zarling, A. L., Obeng, R. C., Cummings, K. L., Desch, A. N., English, A. M., Cottine, J. M., . . . Engelhard, V. H. (2012). MHC-restricted phosphopeptides as broad-based immunotherapeutic targets for cancer. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-1584

De La Pena, H., Turner, J. E., Butler, T., Buka, R., Morton, L., Penny, S., . . . Cobbold, M. (2012). Leukemia-specific immunity in healthy individuals and patients post-transplant targets phosphorylated tumor antigens. In CANCER RESEARCH Vol. 72. doi:10.1158/1538-7445.AM2012-512

Tewalt, E. F., Cohen, J. N., Rouhani, S. J., & Engelhard, V. H. (2012). Lymphatic endothelial cells - key players in regulation of tolerance and immunity. FRONTIERS IN IMMUNOLOGY, 3. doi:10.3389/fimmu.2012.00305

2011

Obeng, R., Zarling, A., & Engelhard, V. (2011). A modified form of a tumor-associated phosphorylated peptide derived from BCAR3 generates CD8 T cells that are highly crossreactive to the natural phosphopeptide and capable of recognizing tumor cells. In JOURNAL OF IMMUNOLOGY Vol. 186. Retrieved from https://www.webofscience.com/

2010

Mohammed, F., Stones, D. H., Zarling, A. L., Hunt, D. F., Engelhard, V. H., Cobbold, M., & Willcox, B. E. (2010). Phosphorylation induces radical conformational changes in naturally processed class I MHC phosphopeptide antigens. In IMMUNOLOGY Vol. 131 (pp. 147). Retrieved from https://www.webofscience.com/

De La Pena, H., Butler, T., Huang, H. -W., Jakhira, T., Joseph, C. -Y., Penny, S., . . . Cobbold, M. (2010). Immunologically Targeting the Leukaemia Phosphoproteome. In BLOOD Vol. 116 (pp. 446-447). Retrieved from https://www.webofscience.com/

Thompson, E. D., Enriquez, H. L., Fu, Y. -X., & Engelhard, V. H. (2010). Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. JOURNAL OF EXPERIMENTAL MEDICINE, 207(8), 1791-1804. doi:10.1084/jem.20092454

Li, Y., Depontieu, F. R., Sidney, J., Salay, T. M., Engelhard, V. H., Hunt, D. F., . . . Mariuzza, R. A. (2010). Structural Basis for the Presentation of Tumor-Associated MHC Class II-Restricted Phosphopeptides to CD4(+) T Cells. JOURNAL OF MOLECULAR BIOLOGY, 399(4), 596-603. doi:10.1016/j.jmb.2010.04.037

Ferguson, A. R., & Engelhard, V. H. (2010). CD8 T Cells Activated in Distinct Lymphoid Organs Differentially Express Adhesion Proteins and Coexpress Multiple Chemokine Receptors. JOURNAL OF IMMUNOLOGY, 184(8), 4079-4086. doi:10.4049/jimmunol.0901903

Cohen, J. N., Guidi, C. J., Tewalt, E. F., Qiao, H., Rouhani, S. J., Ruddell, A., . . . Engelhard, V. H. (2010). Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation. JOURNAL OF EXPERIMENTAL MEDICINE, 207(4), 681-688. doi:10.1084/jem.20092465

Obeng, R. C., Le Poole, I. C., Hunt, D. F., & Engelhard, V. H. (2010). Abstract B14: A phosphorylated β-catenin peptide that is presented by HLA-A2 MHC molecules generates strong phosphospecific T cell responses against melanoma. In Immunotherapy. American Association for Cancer Research. doi:10.1158/1078-0432.tcme10-b14

Obeng, R., Le Poole, I., Hunt, D., & Engelhard, V. (2010). A phosphorylated beta-catenin peptide that is presented by HLA-A2 generates strong phosphospecific T cell responses against melanoma. In JOURNAL OF IMMUNOLOGY Vol. 184. Retrieved from https://www.webofscience.com/

Gregg, R. K., Nichols, L., Chen, Y., Lu, B., & Engelhard, V. H. (2010). Mechanisms of Spatial and Temporal Development of Autoimmune Vitiligo in Tyrosinase-Specific TCR Transgenic Mice. JOURNAL OF IMMUNOLOGY, 184(4), 1909-1917. doi:10.4049/jimmunol.0902778

Hulse, K. E., Reefer, A. J., Engelhard, V. H., Patrie, J. T., Ziegler, S. F., Chapman, M. D., & Woodfolk, J. A. (2010). Targeting allergen to Fc gamma RI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 125(1), 247-256. doi:10.1016/j.jaci.2009.10.027

2009

Depontieu, F. R., Qian, J., Zarling, A. L., McMiller, T. L., Salay, T. M., Norris, A., . . . Topalian, S. L. (2009). Identification of tumor-associated, MHC class II-restricted phosphopeptides as targets for immunotherapy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(29), 12073-12078. doi:10.1073/pnas.0903852106

Depontieu, F., Qian, J., Zarling, A., McMiller, T., Shabanowitz, J., Hunt, D., . . . Topalian, S. (2009). Tumor-associated MHC II-restricted phosphopeptides: Identification of new immunological targets. In CANCER RESEARCH Vol. 69. Retrieved from http://gateway.webofknowledge.com/

Depontieu, F., Qian, J., Zarling, A., McMiller, T., Shabanowitz, J., Hunt, D., . . . Topalian, S. (2009). Tumor-associated MHC II-restricted phosphopeptides: Identification of new immunological targets. In CANCER RESEARCH Vol. 69. Retrieved from https://www.webofscience.com/

Ostankovitch, M., Altrich-VanLith, M., Robila, V., & Engelhard, V. H. (2009). N-Glycosylation Enhances Presentation of a MHC Class I-Restricted Epitope from Tyrosinase. JOURNAL OF IMMUNOLOGY, 182(8), 4830-4835. doi:10.4049/jimmunol.0802902

Vincent, I. S., Linden, J. M., & Engelhard, V. H. (2009). Deletion of adenosine A(2A) receptors on CD8 T cells enhances their accumulation in tumors and tumor-draining lymph nodes, as well as their ability to control tumor outgrowth. In JOURNAL OF IMMUNOLOGY Vol. 182. Retrieved from https://www.webofscience.com/

Nicholls, S., Piper, K. P., Mohammed, F., Dafforn, T. R., Tenzer, S., Salim, M., . . . Willcox, B. E. (2009). Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(10), 3889-3894. doi:10.1073/pnas.0900411106

Hulse, K. E., Reefer, A. J., Satinover, S. M., Chapman, M. D., Engelhard, V. H., & Woodfolk, J. A. (2009). Thymic Stromal Lymphopoietin Potentiates the Immunomodulatory Effects of H22-Fel d 1 in Highly Atopic Subjects. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 123 (pp. S95). doi:10.1016/j.jaci.2008.12.339

2008

Mohammed, F., Cobbold, M., Zarling, A. L., Salim, M., Barrett-Wilt, G. A., Shabanowitz, J., . . . Willcox, B. E. (2008). Phosphorylation-dependent interaction of antigenic peptides with class I MHC: a molecular basis for the presentation of transformed self. In IMMUNOLOGY Vol. 125 (pp. 51). Retrieved from https://www.webofscience.com/

Cobbold, M., Barrett-Wilt, G. A., Polefrome, J. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2008). Global assessment of HLA-A2 peptide display: improving epitope prediction. In IMMUNOLOGY Vol. 125 (pp. 76). Retrieved from https://www.webofscience.com/

Nicholls, S., Piper, K. P., Mohammed, F., Dafforn, T. R., Tenzer, S., Salim, M., . . . Willcox, B. E. (2008). Immunological targeting of the cancer phosphoproteome. In IMMUNOLOGY Vol. 125 (pp. 51-52). Retrieved from https://www.webofscience.com/

Robila, V., Ostankovitch, M., Altrich-VanLith, M. L., Theos, A. C., Drover, S., Marks, M. S., . . . Engelhard, V. H. (2008). MHC Class II Presentation of gp100 Epitopes in Melanoma Cells Requires the Function of Conventional Endosomes and Is Influenced by Melanosomes. JOURNAL OF IMMUNOLOGY, 181(11), 7843-7852. doi:10.4049/jimmunol.181.11.7843

Cobbold, M., Qian, J., Polefrome, J. M., Zarling, A. L., Norris, A., Shabanowitz, J., . . . Engelhard, V. H. (2008). Immunological targeting of the cancer phosphoproteome.. In IMMUNOLOGY Vol. 125 (pp. 51). Retrieved from https://www.webofscience.com/

Mohammed, F., Cobbold, M., Zarling, A. L., Salim, M., Barrett-Wilt, G. A., Shabanowitz, J., . . . Willcox, B. E. (2008). Phosphorylation-dependent interaction between antigenic peptides and MHC class I: a molecular basis for the presentation of transformed self. NATURE IMMUNOLOGY, 9(11), 1236-1243. doi:10.1038/ni.1660

Brinkman, C. C., Sheasley-O'Neill, S. L., Ferguson, A. R., & Engelhard, V. H. (2008). Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics. JOURNAL OF IMMUNOLOGY, 181(3), 1814-1824. doi:10.4049/jimmunol.181.3.1814

Cobbold, M., Polefrone, J. M., Qian, J., Mohammed, F., Norris, A., De Santis, A., . . . Engelhard, V. (2008). Immune targeting of the phosphoproteome in hematolymphoid malignancy. In ANNALS OF ONCOLOGY Vol. 19 (pp. 158). Retrieved from https://www.webofscience.com/

Depontieu, F., Qian, J., Zarling, A. L., McMiller, T. L., Shabanowitz, J., Hunt, D. F., . . . Topalian, S. L. (2008). Tumor-associated MHC II-restricted phosphopeptides: New targets for immune recognition. In FASEB JOURNAL Vol. 22. Retrieved from https://www.webofscience.com/

Ferguson, A. R., Nichols, L. A., Zarling, A. L., Thompson, E. D., Brinkman, C. C., Hargadon, K. M., . . . Engelhard, V. H. (2008). Strategies and challenges in eliciting immunity to melanoma. IMMUNOLOGICAL REVIEWS, 222, 28-42. doi:10.1111/j.1600-065X.2008.00620.x

Hulse, K. E., Reefer, A. J., Engelhard, V. H., Satinover, S. M., Patrie, J. T., Chapman, M. D., & Woodfolk, J. A. (2008). Targeting Fel d 1 to Fc gamma RI induces a novel variation of the T(H)2 response in subjects with cat allergy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 121(3), 756-762. doi:10.1016/j.jaci.2007.10.016

Hulse, K. E., Reefer, A. J., Satinover, S. M., Chapman, M. D., Engelhard, V. H., & Woodfolk, J. A. (2008). Targeting fel d 1 to Fc gamma RI: Single cell analysis reveals a novel variation of the Th2 response in cat-allergic subjects. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 121 (pp. S145). doi:10.1016/j.jaci.2007.12.1114

Lengagne, R., Graff-Dubois, S., Garcette, M., Renia, L., Kato, M., Guillet, J. -G., . . . Prevost-Blondel, A. (2008). Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases. JOURNAL OF IMMUNOLOGY, 180(1), 130-137. doi:10.4049/jimmunol.180.1.130

2007

Cobbold, M., Polefrone, J. M., Qian, J., Mohammed, F., Norris, A., De Santis, A. M., . . . Engelhard, V. H. (2007). Immune targeting of the phosphoproteome in lymphoma and leukemia. In BLOOD Vol. 110 (pp. 91A). doi:10.1182/blood.V110.11.285.285

Hunt, D. F., Henderson, R. A., Shabanowitz, J., Sakaguchi, K., Michel, H., Sevilir, N., . . . Engelhard, V. H. (2007). Characterization of peptides bound to the class I MHC molecule HLA-A2.1 by mass spectrometry (Reprinted from Science, vol 255, March 6, 1992). JOURNAL OF IMMUNOLOGY, 179(5), 2669-2671. doi:10.1126/science.1546328

Nichols, L. A., Chen, Y., Colella, T. A., Bennett, C. L., Clausen, B. E., & Engelhard, V. H. (2007). Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes. JOURNAL OF IMMUNOLOGY, 179(2), 993-1003. doi:10.4049/jimmunol.179.2.993

Li, L., Huang, L., Sung, S. -S. J., Lobo, P. I., Brown, M. G., Gregg, R. K., . . . Okusa, M. D. (2007). NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. JOURNAL OF IMMUNOLOGY, 178(9), 5899-5911. doi:10.4049/jimmunol.178.9.5899

Sheasley-O'Neill, S. L., Brinkman, C. C., Ferguson, A. R., Dispenza, M. C., & Engelhard, V. H. (2007). Dendritic cell immunization route determines integrin expression and lymphoid and nonlymphoid tissue distribution of CD8 T cells. JOURNAL OF IMMUNOLOGY, 178(3), 1512-1522. doi:10.4049/jimmunol.178.3.1512

Engelhard, V. H. (2007). The contributions of mass spectrometry to understanding of immune recognition by T lymphocytes. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 259(1-3), 32-39. doi:10.1016/j.ijms.2006.08.009

Hulse, K., Reefer, A. J., Satinover, S. M., Chapman, M. D., Engelhard, V., & Woodfolk, J. A. (2007). Analysis of T cell skewing by a receptor targeted allergen variant reveals selective enhancement of Th1-promoting cytokines at the APC level. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 119 (pp. S91). doi:10.1016/j.jaci.2006.11.382

2006

Lappas, C. M., Day, Y. -J., Marshall, M. A., Engelhard, V. H., & Linden, J. (2006). Adenosine A(2A) receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. JOURNAL OF EXPERIMENTAL MEDICINE, 203(12), 2639-2648. doi:10.1084/jem.20061097

Lappas, C. M., Day, Y. -J., Marshall, M. A., Engelhard, V. H., & Linden, J. (2006). Adenosine A2Areceptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. In The Journal of Cell Biology (Vol. 175, Iss. 4, pp. i9). Rockefeller University Press. doi:10.1083/jcb1754oia9

Hargadon, K. M., Brinkman, C. C., Sheasley-O'Neill, S. L., Nichols, L. A., Bullock, T. N. J., & Engelhard, V. H. (2006). Incomplete differentiation of antigen-specific CD8 T cells in tumor-draining lymph nodes. JOURNAL OF IMMUNOLOGY, 177(9), 6081-6090. doi:10.4049/jimmunol.177.9.6081

Altrich-VanLith, M. L., Ostankovitch, M., Polefrone, J. M., Mosse, C. A., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2006). Processing of a class I-restricted epitope from tyrosinase requires peptide N-glycanase and the cooperative action of endoplasmic reticulum aminopeptidase 1 and cytosolic proteases. JOURNAL OF IMMUNOLOGY, 177(8), 5440-5450. doi:10.4049/jimmunol.177.8.5440

Zarling, A. L., Polefrone, J. M., Evans, A. M., Mikesh, L. M., Shabanowitz, J., Lewis, S. T., . . . Hunt, D. F. (2006). Identification of class I MHC-associated phosphopeptides as targets for cancer immunotherapy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(40), 14889-14894. doi:10.1073/pnas.0604045103

Graff-Dubois, S., Lengagne, R., Garcette, M., Kato, M., Nakashima, I., Engelhard, V., . . . Prevost-Blondel, A. (2006). CD8T cells do not prevent tumor outgrowth, but delay disease progression in a spontaneous melanoma model. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 126 (pp. 53). Retrieved from https://www.webofscience.com/

Brickner, A. G., Evans, A. M., Mito, J. K., Xuereb, S. M., Feng, X., Nishida, T., . . . Warren, E. H. (2006). The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. BLOOD, 107(9), 3779-3786. doi:10.1182/blood-2005-08-3501

Mullins, D. W., & Engelhard, V. H. (2006). Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes. JOURNAL OF IMMUNOLOGY, 176(8), 4535-4542. doi:10.4049/jimmunol.176.8.4535

Slingluff, C. L., Engelhard, V. H., & Ferrone, S. (2006). Peptide and dendritic cell vaccines. CLINICAL CANCER RESEARCH, 12(7), 2342S-2345S. doi:10.1158/1078-0432.CCR-05-2541

Hulse, K., Reefer, A. J., Satinover, S., Chapman, M. D., Engelhard, V., & Woodfolk, J. A. (2006). Investigating the effects of receptor-targeted allergen on in vitro T cell responses. In JOURNAL OF IMMUNOLOGY Vol. 176 (pp. S286). Retrieved from https://www.webofscience.com/

Engelhard, V. H., Altrich-Vanlith, M., Ostankovitch, M., & Zarling, A. L. (2006). Post-translational modifications of naturally processed MHC-binding epitopes. CURRENT OPINION IN IMMUNOLOGY, 18(1), 92-97. doi:10.1016/j.coi.2005.11.015

Hulse, K., Reefer, A. J., Satinover, S. M., Chapman, M. D., Engelhard, V., & Woodfolk, J. A. (2006). Immunomodulation of T cells by targeting allergen to antigen presenting cells. In JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Vol. 117 (pp. S177). doi:10.1016/j.jaci.2005.12.707

Slingluff, C. L., Chianese-Bullock, K. A., Bullock, T. N. J., Grosh, W. W., Mullins, D. W., Nichols, L., . . . Engelhard, V. H. (2006). Immunity to melanoma antigens: From self-tolerance to immunotherapy. ADVANCES IN IMMUNOLOGY, VOL 90, 90, 243-295. doi:10.1016/S0065-2776(06)90007-8

2005

Kharel, Y., Lee, S., Snyder, A. H., Sheasley-O'Neill, S. L., Morris, M. A., Setiady, Y., . . . Lynch, K. R. (2005). Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(44), 36865-36872. doi:10.1074/jbc.M506293200

Yamshchikov, G. V., Mullins, D. W., Chang, C. C., Ogino, T., Thompson, L., Presley, J., . . . Slingluff, C. L. (2005). Sequential immune escape and shifting of T cell responses in a long-term survivor of melanoma. JOURNAL OF IMMUNOLOGY, 174(11), 6863-6871. doi:10.4049/jimmunol.174.11.6863

Ostankovitch, M., Robila, V., & Engelhard, V. H. (2005). Regulated folding of tyrosinase in the endoplasmic reticulum demonstrates that misfolded full-length proteins are efficient substrates for class I processing and presentation. JOURNAL OF IMMUNOLOGY, 174(5), 2544-2551. doi:10.4049/jimmunol.174.5.2544

Hopkins, L. M., Polefrone, J. M., Zarling, A. L., Evans, A. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2005). Differential expression of HLA-A2 and HLA-B7 phosphorylated peptides on cancer and non-cancer cells: New candidates for immunotherapy. In HUMAN IMMUNOLOGY Vol. 66 (pp. S117). Retrieved from https://www.webofscience.com/

2004

Brickner, A. G., Evans, A. M., Mito, J. K., Xuereb, S. M., Feng, X., Hunt, D. F., . . . Warren, E. H. (2004). The immunogenicity of a human lymphoid cell-restricted minor histocompatibility antigen results from differential protein translation.. In BLOOD Vol. 104 (pp. 91A). Retrieved from https://www.webofscience.com/

Ostankovitch, M., Robila, V., & Engelhard, V. (2004). The folding state of tyrosinase in the endoplasmic reticulum regulates its processing and epitope presentation. In FASEB JOURNAL Vol. 18 (pp. C129). Retrieved from https://www.webofscience.com/

Zarling, A., Evans, A., Shabanowitz, J., Hunt, D., & Engelhard, V. (2004). Phosphorylated class I MHC associated peptides are differentially displayed by cancer cells. In FASEB JOURNAL Vol. 18 (pp. C101). Retrieved from https://www.webofscience.com/

Engelhard, V. H. (2004). Creating new peptide antigens by slicing and splicing proteins. NATURE IMMUNOLOGY, 5(2), 128-129. doi:10.1038/ni0204-128

Hogan, K. T., Coppola, M. A., Gatlin, C. L., Thompson, L. W., Shabanowitz, J., Hunt, D. F., . . . Slingluff, C. L. (2004). Identification of novel and widely expressed cancer/testis gene isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to melanoma. CANCER RESEARCH, 64(3), 1157-1163. doi:10.1158/0008-5472.CAN-03-2209

Mullins, D., & Engelhard, V. (2004). Immunization maneuvers to circumvent the limited capacity of peripheral lymph nodes for exogenous DC and enhance immunologic control of tumors. In JOURNAL OF IMMUNOTHERAPY Vol. 27 (pp. S28). doi:10.1097/00002371-200411000-00101

Thompson, L. W., Hogan, K. T., Caldwell, J. A., Pierce, R. A., Hendrickson, R. C., Deacon, D. H., . . . Slingluff, C. L. (2004). Preventing the spontaneous modification of an HLA-A2-restricted peptide at an N-terminal glutamine or an internal cysteine residue enhances peptide antigenicity. JOURNAL OF IMMUNOTHERAPY, 27(3), 177-183. doi:10.1097/00002371-200405000-00001

Thompson, L. W., Garbee, C. F., Hibbitts, S., Brinckerhoff, L. H., Pierce, R. A., Chianese-Bullock, K. A., . . . Slingluff, C. L. (2004). Competition among peptides in melanoma vaccines for binding to MHC molecules. JOURNAL OF IMMUNOTHERAPY, 27(6), 425-431. doi:10.1097/00002371-200411000-00002

2003

Hogan, K. T., Coppola, M. A., Gatlin, C. L., Thompson, L. W., Shabanowitz, J., Hunt, D. F., . . . Ross, M. M. (2003). Identification of a shared epitope recognized by melanoma-specific, HLA-A3-restricted cytotoxic T lymphocytes. IMMUNOLOGY LETTERS, 90(2-3), 131-135. doi:10.1016/j.imlet.2003.08.003

Brickner, A. G., Evans, A. M., Mito, J. K., Xuereb, S. M., Feng, X., Hunt, D. F., . . . Warren, E. H. (2003). An alternative transcript of the C22orf18 gene encodes a minor histocompatibility antigen that is selectively expressed in B-lymphoid cells.. In BLOOD Vol. 102 (pp. 947A). Retrieved from https://www.webofscience.com/

Zarling, A. L., Luckey, C. J., Marto, J. A., White, F. M., Brame, C. J., Evans, A. M., . . . Engelhard, V. H. (2003). Tapasin is a facilitator, not an editor, of class I MHC peptide binding. JOURNAL OF IMMUNOLOGY, 171(10), 5287-5295. doi:10.4049/jimmunol.171.10.5287

Akatsuka, Y., Warren, E. H., Gooley, T. A., Brickner, A. G., Lin, M. T., Hansen, J. A., . . . Riddell, S. R. (2003). Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling. BRITISH JOURNAL OF HAEMATOLOGY, 123(4), 671-675. doi:10.1046/j.1365-2141.2003.04676.x

Slingluff, C. L., Petroni, G. R., Yamshchikov, G. V., Barnd, D. L., Eastham, S., Galavotti, H., . . . Engelhard, V. H. (2003). Clinical and immunologic results of a randomized phase II trial of vaccination using four melanoma peptides either administered in granulocyte-macrophage colony-stimulating factor in adjuvant or pulsed on dendritic cells. JOURNAL OF CLINICAL ONCOLOGY, 21(21), 4016-4026. doi:10.1200/JCO.2003.10.005

Mullins, D. W., Sheasley, S. L., Ream, R. M., Bullock, T. N. J., Fu, Y. X., & Engelhard, V. H. (2003). Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. JOURNAL OF EXPERIMENTAL MEDICINE, 198(7), 1023-1034. doi:10.1084/jem.20021348

Spierings, E., Brickner, A. G., Caldwell, J. A., Zegveld, S., Tatsis, N., Blokland, E., . . . Engelhard, V. H. (2003). The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein. BLOOD, 102(2), 621-629. doi:10.1182/blood-2003-01-0260

Mullins, D. W., & Engelhard, V. H. (2003). Dendritic cell immunization route determines the location of T cell activation, patterns of memory T cell homing, and anti-tumor efficacy. In FASEB JOURNAL Vol. 17 (pp. C330). Retrieved from https://www.webofscience.com/

Zarling, A. L., Luckey, C. J., Mart, J. A., White, F. M., Lehner, P. J., Cresswell, P., . . . Engelhard, V. H. (2003). Tapasin is a facilitator, not an editor, of HLA-B8 peptide binding. In FASEB JOURNAL Vol. 17 (pp. C120). Retrieved from https://www.webofscience.com/

Bullock, T. N. J., Mullins, D. W., & Engelhard, V. H. (2003). Antigen density presented by dendritic cells in vivo differentially affects the number and avidity of primary, memory, and recall CD8(+) T cells. JOURNAL OF IMMUNOLOGY, 170(4), 1822-1829. doi:10.4049/jimmunol.170.4.1822

Hogan, K., Coppola, M., Gatlin, C., Thompson, L., Shabanowitz, J., Hunt, D., . . . Slingluff, C. (2003). Identification of a novel cancer/testis antigen recognized by melanoma reactive cytotoxic T lymphocytes. In JOURNAL OF IMMUNOTHERAPY Vol. 26 (pp. S7-S8). Retrieved from https://www.webofscience.com/

Yamshchikov, G., Thompson, L., Mullins, D., Ferrone, S., Ogino, T., Chang, C. C., . . . Slingluff, C. (2003). Immune escape, immune editing, and immune adaptation in a long-term survivor of metastatic melanoma. In JOURNAL OF IMMUNOTHERAPY Vol. 26 (pp. S45). Retrieved from https://www.webofscience.com/

2002

Lippolis, J. D., White, F. M., Marto, J. A., Luckey, C. J., Bullock, T. N. J., Shabanowitz, J., . . . Engelhard, V. H. (2002). Analysis of MHC class II antigen processing by quantitation of peptides that constitute nested sets. JOURNAL OF IMMUNOLOGY, 169(9), 5089-5097. doi:10.4049/jimmunol.169.9.5089

Norton, E. J., Diekman, A. B., Westbrook, V. A., Mullins, D. W., Klotz, K. L., Gilmer, L. L., . . . Herr, J. C. (2002). A male genital tract-specific carbohydrate epitope on human CD52: Implications for immunocontraception. TISSUE ANTIGENS, 60(5), 354-364. doi:10.1034/j.1399-0039.2002.600502.x

Engelhard, V. H., Brickner, A. G., & Zarling, A. L. (2002). Insights into antigen processing gained by direct analysis of the naturally processed class I MHC associated peptide repertoire. MOLECULAR IMMUNOLOGY, 39(3-4), 127-137. doi:10.1016/S0161-5890(02)00096-2

Engelhard, V. H., Bullock, T. N. J., Colella, T. A., Sheasley, S. L., & Mullins, D. W. (2002). Antigens derived from melanocyte differentiation proteins: self-tolerance, autoimmunity, and use for cancer immunotherapy. IMMUNOLOGICAL REVIEWS, 188, 136-146. doi:10.1034/j.1600-065X.2002.18812.x

Luckey, C. J., Marto, J. A., White, F., Lippolis, J., Nepom, G. T., Masewicz, S., . . . Engelhard, V. H. (2002). Identifying clinically relevant class I and class II peptides using small-scale immuno-precipitation and novel mass spectrometric techniques.. In CLINICAL IMMUNOLOGY Vol. 103 (pp. S131). Retrieved from https://www.webofscience.com/

Flyer, D. C., Ramakrishna, V., Miller, C., Myers, H., McDaniel, M., Root, K., . . . White, F. M. (2002). Identification by mass spectrometry of CD8(+)-T-cell Mycobacterium tuberculosis epitopes within the Rv0341 gene product. INFECTION AND IMMUNITY, 70(6), 2926-2932. doi:10.1128/IAI.70.6.2926-2932.2002

Warren, E. H., Otterud, B. E., Linterman, R. W., Brickner, A. G., Engelhard, V. H., Leppert, M. F., . . . Riddell, S. R. (2002). Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens. TISSUE ANTIGENS, 59(4), 293-303. doi:10.1034/j.1399-0039.2002.590407.x

Sheasley, S. L., Mullins, D. W., Ream, R. M., & Engelhard, V. H. (2002). Immunization route with peptide-pulsed dendritic cells impacts the location of primary and memory T cell activation. In FASEB JOURNAL Vol. 16 (pp. A334-A335). Retrieved from https://www.webofscience.com/

Mullins, D. W., Bullock, T. N. J., Sheasley, S. L., & Engelhard, V. H. (2002). Control of tumor outgrowth by regional immunization with peptide-pulsed dendritic cells depends on epitope density. In FASEB JOURNAL Vol. 16 (pp. A334). Retrieved from https://www.webofscience.com/

Le Gal, F. A., Prevost-Blondel, A., Lengagne, R., Bossus, M., Farace, F., Chaboissier, A., . . . Gahery-Segard, H. (2002). Lipopeptide-based melanoma cancer vaccine induced a strong MART-27-35-cytotoxic T lymphocyte response in a preclinal study. INTERNATIONAL JOURNAL OF CANCER, 98(2), 221-227. doi:10.1002/ijc.10186

Brickner, A. G., Caldwell, J. A., Spierings, E., Blokland, E., Pierce, R., Mollah, S., . . . Engelhard, V. H. (2002). Identification and initial characterization of the human minor histocompatibility antigen HA-3. In TISSUE ANTIGENS Vol. 59 (pp. 5). Retrieved from https://www.webofscience.com/

Warren, E. H., Otterud, B. E., Linterman, R. W., Brickner, A. G., Engelhard, V. H., Leppert, M. F., . . . Riddell, S. R. (2002). Feasibility of using genetic linkage analysis to identify the genes encoding T cell-defined minor histocompatibility antigens. In TISSUE ANTIGENS Vol. 59 (pp. 44). Retrieved from https://www.webofscience.com/

Vermeulen, C. J., Spierings, E., Brickner, A. G., Engelhard, V. H., & Goulmy, E. (2002). HLA-B7 can present a variety of minor histocompatibility antigens within a single patient. In TISSUE ANTIGENS Vol. 59 (pp. 124). Retrieved from https://www.webofscience.com/

2001

Bullock, T. N. J., Mullins, D. W., Colella, T. A., & Engelhard, V. H. (2001). Manipulation of avidity to improve effectiveness of adoptively transferred CD8(+) T cells for melanoma immunotherapy in human MHC class I-transgenic mice. JOURNAL OF IMMUNOLOGY, 167(10), 5824-5831. doi:10.4049/jimmunol.167.10.5824

Mullins, D. W., Bullock, T. N. J., Colella, T. A., Robila, V. V., & Engelhard, V. H. (2001). Immune responses to the HLA-A*0201-restricted epitopes of tyrosinase and glycoprotein 100 enable control of melanoma outgrowth in HLA-A*0201-transgenic mice. JOURNAL OF IMMUNOLOGY, 167(9), 4853-4860. doi:10.4049/jimmunol.167.9.4853

Slingluff, C. L., Yamshchikov, G., Neese, P., Galavotti, H., Eastham, S., Engelhard, V. H., . . . Ross, W. G. (2001). Phase I trial of a melanoma vaccine with gp100(280-288) peptide and tetanus helper peptide in adjuvant: Immunologic and clinical outcomes. CLINICAL CANCER RESEARCH, 7(10), 3012-3024. Retrieved from https://www.webofscience.com/

Pierce, R. A., Field, E. D., Mutis, T., Golovina, T. N., Von Kap-Herr, C., Wilke, M., . . . Engelhard, V. H. (2001). The HA-2 minor histocompatibility antigen is derived from a diallelic gene encoding a novel human class I myosin protein. JOURNAL OF IMMUNOLOGY, 167(6), 3223-3230. doi:10.4049/jimmunol.167.6.3223

Luckey, C. J., Marto, J. A., Partridge, M., Hall, E., White, F. M., Lippolis, J. D., . . . Engelhard, V. H. (2001). Differences in the expression of human class I MHC alleles and their associated peptides in the presence of proteasome inhibitors. JOURNAL OF IMMUNOLOGY, 167(3), 1212-1221. doi:10.4049/jimmunol.167.3.1212

Mosse, C. A., Hsu, W., & Engelhard, V. H. (2001). Tyrosinase degradation via two pathways during reverse translocation to the cytosol. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 285(2), 313-319. doi:10.1006/bbrc.2001.5153

Yamshchikov, G. V., Barnd, D. L., Eastham, S., Galavotti, H., Patterson, J. W., Deacon, D. H., . . . Slingluff, G. L. (2001). Evaluation of peptide vaccine immunogenicity in draining lymph nodes and peripheral blood of melanoma patients. INTERNATIONAL JOURNAL OF CANCER, 92(5), 703-711. doi:10.1002/1097-0215(20010601)92:5<703::AID-IJC1250>3.3.CO;2-X

Arichi, T., Saito, T., Major, M. E., Belyakov, I. M., Shirai, M., Engelhard, V. H., . . . Berzofsky, J. A. (2001). Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model, (Retraction of vol 97, pg 297, 2000). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(10), 5943. doi:10.1073/pnas.101132998

Guimezanes, A., Barrett-Wilt, G. A., Gulden-Thompson, P., Shabanowitz, J., Engelhard, V. H., Hunt, D. F., & Schmitt-Verhulst, A. M. (2001). Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive cytotoxic T lymphocytes: distinct characterictics correlated with CD8 dependence (vol 31, pg 421, 2001). EUROPEAN JOURNAL OF IMMUNOLOGY, 31(4), 1298. Retrieved from https://www.webofscience.com/

Akatsuka, Y., Warren, E. H., Brickner, A. G., Engelhard, V. H., & Riddell, S. R. (2001). Determination of intronic sequences adjacent to an exon using polymerase chain reaction and genomic DNA library constructed by TA cloning. ANALYTICAL BIOCHEMISTRY, 289(2), 289-292. doi:10.1006/abio.2000.4897

Nepom, G. T., Lippolis, J. D., White, F. M., Masewicz, S., Marto, J. A., Herman, A., . . . Nepom, B. S. (2001). Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 98(4), 1763-1768. doi:10.1073/pnas.98.4.1763

Guimezanes, A., Barrett-Wilt, G. A., Gulden-Thompson, P., Shabanowitz, J., Engelhardt, V. H., Hunt, D. F., & Schmitt-Verhulst, A. M. (2001). Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive cytotoxic T lymphocytes: distinct characteristics correlated with CD8 dependence. EUROPEAN JOURNAL OF IMMUNOLOGY, 31(2), 421-432. doi:10.1002/1521-4141(200102)31:2<421::AID-IMMU421>3.0.CO;2-4

Guimezanes, A., Barrett-Wilt, G. A., Gulden-Thompson, P., Shabanowitz, J., Engelhardt, V. H., Hunt, D. F., & Schmitt-Verhulst, A. -M. (2001). Identification of endogenous peptides recognized by in vivo or in vitro generated alloreactive cytotoxic T lymphocytes: distinct characteristics correlated with CD8 dependence. European Journal of Immunology, 31(2), 421-432. doi:10.1002/1521-4141(200102)31:2<421::aid-immu421>3.3.co;2-w

Brickner, A. G., Warren, E. H., Caldwell, J. A., Akatsuka, Y., Golovina, T. N., Zarling, A. L., . . . Riddell, S. R. (2001). The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing. JOURNAL OF EXPERIMENTAL MEDICINE, 193(2), 195-205. doi:10.1084/jem.193.2.195

2000

Zarling, A. L., Ficarro, S. B., White, F. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2000). Phosphorylated peptides are naturally processed and presented by major histocompatibility complex class I molecules in vivo. JOURNAL OF EXPERIMENTAL MEDICINE, 192(12), 1755-1762. doi:10.1084/jem.192.12.1755

Akatsuka, Y., Warren, E. H., Brickner, A. G., Lin, M. T., Gooly, T., Martin, P. J., . . . Riddell, S. R. (2000). Effect of disparity in the newly identified minor histocompatibility antigen SKH13 on the development of graft-versus-host disease after marrow transplantation from an HLA-identical sibling.. In BLOOD Vol. 96 (pp. 202A). Retrieved from https://www.webofscience.com/

Arichi, T., Major, M. E., Saito, T., Nishioka, M., Engelhard, V. H., Feinstone, S. M., & Berzolsky, J. A. (2000). Application of epitope enhancement to a prophylactic DNA vaccine for hepatitis C virus (HCV) in an HLA-A2.1 transgenic mouse model: Enhanced HCV specific CTL induction and protection from HCV-recombinant vaccinia infection.. In HEPATOLOGY Vol. 32 (pp. 373A). Retrieved from https://www.webofscience.com/

Lippolis, J. D., Denis-Mize, K. S., Brinckerhoff, L. H., Slingluff, C. L., Galloway, D. R., & Engelhard, V. H. (2000). Pseudomonas exotoxin-mediated delivery of exogenous antigens to MHC class I and class II processing pathways. CELLULAR IMMUNOLOGY, 203(2), 75-83. doi:10.1006/cimm.2000.1685

Crotzer, V. L., Christian, R. E., Brooks, J. M., Shabanowitz, J., Settlage, R. E., Marto, J. A., . . . Engelhard, V. H. (2000). Immunodominance among EBV-derived epitopes restricted by HLA-B27 does not correlate with epitope abundance in EBV-transformed B-lymphoblastoid cell lines. JOURNAL OF IMMUNOLOGY, 164(12), 6120-6129. doi:10.4049/jimmunol.164.12.6120

Engelhard, V. H., Bullock, T. N. V., Colella, T. A., & Mullins, D. W. (2000). Direct identification of human tumor-associated peptide antigens and a preclinical model to evaluate their use. CANCER JOURNAL, 6, S272-S280. Retrieved from https://www.webofscience.com/

Warren, E. H., Caldwell, J. A., Shabanowitz, J., Hunt, D. F., Riddell, S. R., & Engelhard, V. H. (2000). Identification of a new HLA-A*0201-restricted human minor histocompatibility antigen.. In FASEB JOURNAL Vol. 14 (pp. A1070). Retrieved from https://www.webofscience.com/

Pierce, R. A., Field, E. D., den Haan, J. M., Caldwell, J. A., White, F. M., Marto, J. A., . . . Engelhard, V. H. (2000). Identification of the HLA-A*0101 restricted HY minor histocompatibility antigen using a novel mass spectrometric technique. In FASEB JOURNAL Vol. 14 (pp. A1071). Retrieved from https://www.webofscience.com/

Colella, T. A., Bullock, T. N. J., Russell, L. B., Mullins, D. W., Overwijk, W. W., Luckey, C. J., . . . Engelhard, V. H. (2000). Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: Implications for tumor immunotherapy. JOURNAL OF EXPERIMENTAL MEDICINE, 191(7), 1221-1231. doi:10.1084/jem.191.7.1221

Bullock, T. N. J., Colella, T. A., & Engelhard, V. H. (2000). The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice. JOURNAL OF IMMUNOLOGY, 164(5), 2354-2361. doi:10.4049/jimmunol.164.5.2354

Slingluff, C. L., Colella, T. A., Thompson, L., Graham, D. D., Skipper, J. C. A., Caldwell, J., . . . Engelhard, V. H. (2000). Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens. CANCER IMMUNOLOGY IMMUNOTHERAPY, 48(12), 661-672. doi:10.1007/s002620050015

Arichi, T., Saito, T., Major, M. E., Belyakov, I. M., Shirai, M., Engelhard, V. H., . . . Berzofsky, J. A. (2000). Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model (Retracted Article. See vol 98, pg 5943, 2001). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 97(1), 297-302. doi:10.1073/pnas.97.1.297

1999

Pierce, R. A., Field, E. D., den Haan, J. M. M., Caldwell, J. A., White, F. M., Marto, J. A., . . . Engelhard, V. H. (1999). Cutting edge: The HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique. JOURNAL OF IMMUNOLOGY, 163(12), 6360-6364. Retrieved from https://www.webofscience.com/

Brinckerhoff, L. H., Kalashnikov, V. V., Thompson, L. W., Yamshchikov, G. V., Pierce, R. A., Galavotti, H. S., . . . Slingluff, C. L. (1999). Terminal modifications inhibit proteolytic degradation of an immunogenic MART-1(27-35) peptide: Implications for peptide vaccines. INTERNATIONAL JOURNAL OF CANCER, 83(3), 326-334. doi:10.1002/(SICI)1097-0215(19991029)83:3<326::AID-IJC7>3.0.CO;2-X

Arichi, T., Saito, T., Major, M. E., Shirai, M., Engelhard, V. H., Feinstone, S. M., & Berzofsky, J. A. (1999). A DNA vaccine as a prophylaxis for hepatitis C virus (HCV) infection. HCV specific CTL induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model.. In HEPATOLOGY Vol. 30 (pp. 409A). Retrieved from https://www.webofscience.com/

Skipper, J. C. A., Gulden, P. H., Hendrickson, R. C., Harthun, N., Caldwell, J. A., Shabanowitz, J., . . . Slingluff, C. L. (1999). Mass-spectrometric evaluation of HLA-A*0201-associated peptides identifies dominant naturally processed forms of CTL epitopes from MART-1 and gp100. INTERNATIONAL JOURNAL OF CANCER, 82(5), 669-677. doi:10.1002/(SICI)1097-0215(19990827)82:5<669::AID-IJC9>3.0.CO;2-#

Wang, W., Gulden, P. H., Pierce, R. A., Shabanowitz, J. A., Man, S. T., Hunt, D. F., & Engelhard, V. H. (1999). A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8(+) cytotoxic T cell with apparent high affinity (vol 158, pg 5797, 1997). JOURNAL OF IMMUNOLOGY, 162(5), 3106. Retrieved from https://www.webofscience.com/

Kittlesen, D. J., Thompson, L. W., Gulden, P. H., Skipper, J. C. A., Colella, T. A., Shabanowitz, J., . . . Slingluff, C. L. (1999). Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: Implications for tumor vaccine development (vol 160, pg 2099, 1998). In JOURNAL OF IMMUNOLOGY Vol. 162 (pp. 3106). Retrieved from https://www.webofscience.com/

1998

Hogan, K. T., Eisinger, D. P., Cupp, S. B., Lekstrom, K. J., Deacon, D. D., Shabanowitz, J., . . . Ross, M. M. (1998). The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated Elongation Factor 2 gene. CANCER RESEARCH, 58(22), 5144-5150. Retrieved from https://www.webofscience.com/

Sarobe, P., Pendleton, C. D., Akatsuka, T., Lau, D., Engelhard, V. H., Feinstone, S. M., & Berzofsky, J. A. (1998). Enhanced in vitro potency and in vivo immunogenicity of a CTL epitope from hepatitis C virus core protein following amino acid replacement at secondary HLA-A2.1 binding positions. JOURNAL OF CLINICAL INVESTIGATION, 102(6), 1239-1248. doi:10.1172/JCI3714

Luckey, C. J., King, G. M., Marto, J. A., Venketeswaran, S., Maier, B. F., Crotzer, V. L., . . . Engelhard, V. H. (1998). Proteasomes can either generate or destroy MHC class I epitopes: Evidence for nonproteasomal epitope generation in the cytosol. JOURNAL OF IMMUNOLOGY, 161(1), 112-121. Retrieved from https://www.webofscience.com/

Colella, T. A., Kittlesen, D. J., Luckey, C. J., Thompson, L. W., Slingluff, C. L., & Engelhard, V. H. (1998). The presentation of peptide antigens derived from melanocyte-differentiation proteins by cultured melanocytes: Implications for tumor immunotherapy.. In FASEB JOURNAL Vol. 12 (pp. A289). Retrieved from https://www.webofscience.com/

Kittlesen, D. J., Thompson, L. W., Gulden, P. H., Skipper, J. C. A., Colella, T. A., Shabanowitz, J. A., . . . Slingluff, C. L. (1998). Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: Implications for tumor vaccine development. JOURNAL OF IMMUNOLOGY, 160(5), 2099-2106. Retrieved from https://www.webofscience.com/

den Haan, J. M. M., Meadows, L. M., Wang, W., Pool, J., Blokland, E., Bishop, T. L., . . . Goulmy, E. (1998). The minor histocompatibility antigen HA-1: A diallelic gene with a single amino acid polymorphism. SCIENCE, 279(5353), 1054-1057. doi:10.1126/science.279.5353.1054

Wang, W., Man, S., Gulden, P. H., Hunt, D. F., & Engelhard, V. H. (1998). Class I-restricted alloreactive cytotoxic T lymphocytes recognize a complex array of specific MHC-associated peptides. JOURNAL OF IMMUNOLOGY, 160(3), 1091-1097. Retrieved from https://www.webofscience.com/

Mosse, C. A., Meadows, L., Luckey, C. J., Kittlesen, D. J., Huczko, E. L., Slingluff, C. L., . . . Engelhard, V. H. (1998). The class I antigen-processing pathway for the membrane protein tyrosinase involves translation in the endoplasmic reticulum and processing in the cytosol. JOURNAL OF EXPERIMENTAL MEDICINE, 187(1), 37-48. doi:10.1084/jem.187.1.37

1997

Genestier, L., Paillot, R., BonnefoyBerard, N., Meffre, G., Flacher, M., Fevre, D., . . . Revillard, J. P. (1997). Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I alpha 1 domain. BLOOD, 90(9), 3629-3639. doi:10.1182/blood.V90.9.3629

Williams, N. S., & Engelhard, V. H. (1997). Perforin-dependent cytotoxic activity and lymphokine secretion by CD4(+) T cells are regulated by CD8(+) T cells. JOURNAL OF IMMUNOLOGY, 159(5), 2091-2099. Retrieved from https://www.webofscience.com/

Smith, K. D., Huczko, E., Engelhard, V. H., Li, Y. Y., & Lutz, C. T. (1997). Alloreactive cytotoxic T lymphocytes focus on specific major histocompatibility complex-bound peptides. TRANSPLANTATION, 64(2), 351-359. doi:10.1097/00007890-199707270-00030

Wang, W., Gulden, P. H., Pierce, R. A., Shabanowitz, J. A., Man, S. T., Hunt, D. F., & Engelhard, V. H. (1997). A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8(+) cytotoxic T cell with apparent high affinity. JOURNAL OF IMMUNOLOGY, 158(12), 5797-5804. Retrieved from https://www.webofscience.com/

den Haan, J. M. M., Wang, W., Meadows, L. R., Blokland, E., Reinhardus, C., Engelhard, V. H., . . . Goulmy, E. (1997). Identification of the human minor histocompatibility antigen HA-1. Immunology Letters, 56, 464. doi:10.1016/s0165-2478(97)88898-0

Loftus, D. J., Chen, Y., Covell, D. G., Engelhard, V. H., & Appella, E. (1997). Differential contact of disparate class I peptide complexes as the basis for epitope cross-recognition by a single T cell receptor. JOURNAL OF IMMUNOLOGY, 158(8), 3651-3658. Retrieved from https://www.webofscience.com/

Meadows, L., Wang, W., denHaan, J. M. M., Blokland, E., Reinhardus, C., Drijfhout, J. W., . . . Engelhard, V. H. (1997). The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. IMMUNITY, 6(3), 273-281. doi:10.1016/S1074-7613(00)80330-1

Dubey, P., Hendrickson, R. C., Meredith, S. C., Siegel, C. T., Shabanowitz, J., Skipper, J. C. A., . . . Schreiber, H. (1997). The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68. JOURNAL OF EXPERIMENTAL MEDICINE, 185(4), 695-705. doi:10.1084/jem.185.4.695

1996

Skipper, J. C. A., Kittlesen, D. J., Hendrickson, R. C., Deacon, D. D., Harthun, N. L., Wagner, S. N., . . . Slingluff, C. L. (1996). Shaved epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100. JOURNAL OF IMMUNOLOGY, 157(11), 5027-5033. Retrieved from https://www.webofscience.com/

Skipper, J. C., Kittlesen, D. J., Hendrickson, R. C., Deacon, D. D., Harthun, N. L., Wagner, S. N., . . . Slingluff, C. L. (1996). Shared epitopes for HLA-A3-restricted melanoma-reactive human CTL include a naturally processed epitope from Pmel-17/gp100.. Journal of immunology (Baltimore, Md. : 1950), 157(11), 5027-5033.

Slingluff, C. L., Engelhard, V. H., Neese, P., & Cohen, R. (1996). Vaccination of Patients with High-risk Melanoma in the Adjuvant Setting with a Purified gp 100 peptide: Trial Design and Preliminary Findings. In Journal of Immunotherapy Vol. 19 (pp. 457). Ovid Technologies (Wolters Kluwer Health). doi:10.1097/00002371-199611000-00016

Kittlesen, D., Skipper, J., Hendrickson, R., Colella, T., Gulden, P., Hunt, D., . . . Slingluff, C. (1996). Melanoma Patient CTL REcognize HLA-A3 and HLA-A1 Restricted Epitopes Derived From the Melanocyte Differentiation Antigens Pmel-17/gp100 and Tyrosinase. In Journal of Immunotherapy Vol. 19 (pp. 460). Ovid Technologies (Wolters Kluwer Health). doi:10.1097/00002371-199611000-00025

Slingluff, C. L., Graham, D. D., Skipper, J., Kittlesen, D., Deacon, D. H., Colella, T. A., . . . Engelhard, V. H. (1996). Immunologic Escape Variant (IEV) Melanomas with Normal MHC Expression and Antigen Processing Lack Multiple Melanocytic Differentiation Antigens. In Journal of Immunotherapy Vol. 19 (pp. 460). Ovid Technologies (Wolters Kluwer Health). doi:10.1097/00002371-199611000-00027

denHaan, J. M. M., Bontrop, R. E., Pool, J., Sherman, N., Blokland, E., Engelhard, V. H., . . . Goulmy, E. (1996). Conservation of minor histocompatibility antigens between human and non-human primates. EUROPEAN JOURNAL OF IMMUNOLOGY, 26(11), 2680-2685. doi:10.1002/eji.1830261120

Schumacher, I. K., Newberg, M. H., Jackson, J. D., Hammel, J. M., Rubocki, R. J., Engelhard, V. H., & Fox, I. J. (1996). Use of gene therapy to suppress the antigen-specific immune responses in mice to an HLA antigen. TRANSPLANTATION, 62(6), 831-836. doi:10.1097/00007890-199609270-00022

Smith, K. D., Mace, B. E., Valenzuela, A., Vigna, J. L., McCutcheon, J. A., Barbosa, J. A., . . . Lutz, C. T. (1996). Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies. JOURNAL OF IMMUNOLOGY, 157(6), 2470-2478. Retrieved from https://www.webofscience.com/

Huang, A. Y. C., Gulden, P. H., Woods, A. S., Thomas, M. C., Tong, C. D., Wang, W., . . . Jaffee, E. M. (1996). The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93(18), 9730-9735. doi:10.1073/pnas.93.18.9730

Engelhard, V. H. (1996). Direct identification of tumor-associated peptide antigens. SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 18(2), 171-183. doi:10.1007/BF00820664

Gulden, P. H., Fischer, P., Sherman, N. E., Wang, W., Engelhard, V. H., Shabanowitz, J., . . . Pamer, E. G. (1996). A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule. IMMUNITY, 5(1), 73-79. doi:10.1016/S1074-7613(00)80311-8

Wang, W., Gulden, P. E., Pierce, R. A., Hunt, D. F., & Engelhard, V. H. (1996). A naturally processed peptide presented by HLA-A2.1 is recognized by an alloreactive CD8+ cytotoxic T cell with high affinity. In FASEB JOURNAL Vol. 10 (pp. 2735). Retrieved from https://www.webofscience.com/

Williams, N. S., & Engelhard, V. H. (1996). Regulation of the development of perforin-dependent cytotoxicity in CD4(+) T cells by CD8(+) T cells. In FASEB JOURNAL Vol. 10 (pp. 221). Retrieved from https://www.webofscience.com/

Huczko, E. L., Rumpel, C. A., Chen, Y., & Engelhard, V. H. (1996). Priming of HLA-A2 restricted responses in transgenic mice. In FASEB JOURNAL Vol. 10 (pp. 2704). Retrieved from https://www.webofscience.com/

Mosse, C. A., Kittlesen, D. J., Skipper, J. C. A., Hendrickson, R., Hunt, D. F., Slingluff, C. L., & Engelhard, V. H. (1996). A tyrosinase epitope is processed after translation into the endoplasmic reticulum. In FASEB JOURNAL Vol. 10 (pp. 2523). Retrieved from https://www.webofscience.com/

Kittlesen, D., Graham, D., Deacon, D., Colella, T., Huczko, E., Skipper, J., . . . Slingluff, C. (1996). HLA-A2+ melanoma tumor antigen loss variants expressing multiple phenotypes. In FASEB JOURNAL Vol. 10 (pp. 2703). Retrieved from https://www.webofscience.com/

denHaan, J. M. M., Blokland, E., Reinhardus, C., Wang, W., Meadows, L. R., Engelhard, V. H., . . . Goulmy, E. (1996). Identification of human minor histocompatibility antigens. In HUMAN IMMUNOLOGY Vol. 47 (pp. P86). Retrieved from https://www.webofscience.com/

de Haan, J. M. M., Blokland, E., Reinhardus, C., Wang, W., Meadows, L. R., Engelhard, V. H., . . . Goulmy, E. (1996). Identification of human minor histocompatibility antigens. Human Immunology, 47(1-2), 19. doi:10.1016/0198-8859(96)84781-1

Newberg, M. H., Smith, D. H., Haertel, S. B., Vining, D. R., Lacy, E., & Engelhard, V. H. (1996). Importance of MHC class I alpha 2 and alpha 3 domains in the recognition of self and non-self MHC molecules. JOURNAL OF IMMUNOLOGY, 156(7), 2473-2480. Retrieved from https://www.webofscience.com/

Skipper, J. C. A., Hendrickson, R. C., Gulden, P. H., Brichard, V., VanPel, A., Chen, Y., . . . Engelhard, V. H. (1996). An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. JOURNAL OF EXPERIMENTAL MEDICINE, 183(2), 527-534. doi:10.1084/jem.183.2.527

Williams, N. S., & Engelhard, V. H. (1996). Identification of a population of CD4(+) CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism. JOURNAL OF IMMUNOLOGY, 156(1), 153-159. Retrieved from https://www.webofscience.com/

1995

ENGELHARD, V. (1995). HOT PAPERS - TUMOR IMMUNOLOGY - IDENTIFICATION OF A PEPTIDE RECOGNIZED BY 5 MELANOMA-SPECIFIC HUMAN CYTOTOXIC T-CELL LINES - BY COX,A.L., SKIPPER,J., CHEN,Y., HENDERSON,R.A., ENGELHARD,V.H., HUNT,D.F., SLINGLUFF,D.F. - COMMENTS. In SCIENTIST Vol. 9 (pp. 15). Retrieved from https://www.webofscience.com/

WANG, W., MEADOWS, L. R., DENHAAN, J. M. M., SHERMAN, N. E., CHEN, Y., BLOKLAND, E., . . . ENGELHARD, V. H. (1995). HUMAN H-Y - A MALE-SPECIFIC HISTOCOMPATIBILITY ANTIGEN DERIVED FROM THE SMCY PROTEIN. SCIENCE, 269(5230), 1588-1590. doi:10.1126/science.7667640

DENHAAN, J. M. M., SHERMAN, N. E., BLOKLAND, E., HUCZKO, E., KONING, F., DRIJFHOUT, J. W., . . . GOULMY, E. (1995). IDENTIFICATION OF A GRAFT-VERSUS-HOST DISEASE-ASSOCIATED HUMAN MINOR HISTOCOMPATIBILITY ANTIGEN. SCIENCE, 268(5216), 1476-1480. doi:10.1126/science.7539551

MAN, S., NEWBERG, M. H., CROTZER, V. L., LUCKEY, C. J., WILLIAMS, N. S., CHEN, Y., . . . ENGELHARD, V. H. (1995). DEFINITION OF A HUMAN T-CELL EPITOPE FROM INFLUENZA-A NONSTRUCTURAL PROTEIN-1 USING HLA-A2.1 TRANSGENIC MICE. INTERNATIONAL IMMUNOLOGY, 7(4), 597-605. doi:10.1093/intimm/7.4.597

SHIRAI, M., ARICHI, T., NISHIOKA, M., NOMURA, T., IKEDA, K., KAWANISHI, K., . . . BERZOFSKY, J. A. (1995). CTL RESPONSES OF HLA-A2.1-TRANSGENIC MICE SPECIFIC FOR HEPATITIS-C VIRAL PEPTIDES PREDICT EPITOPES FOR CTL OF HUMANS CARRYING HLA-A2.1. JOURNAL OF IMMUNOLOGY, 154(6), 2733-2742. Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., MAN, S., NEWBERG, M. H., CROTZER, V. L., LUCKEY, C. J., WILLIAMS, N. S., . . . RIDGE, J. P. (1995). DEFINITION OF A HUMAN T-CELL EPITOPE FROM INFLUENZA-A NONSTRUCTURAL PROTEIN-1 USING HLA-A2.1 TRANSGENIC MICE. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 295). Retrieved from https://www.webofscience.com/

SIDNEY, J., DELGUERCIO, M. F., SOUTHWOOD, S., ENGELHARD, V. H., APPELLA, E., RAMMENSEE, H. G., . . . SETTE, A. (1995). SEVERAL HLA ALLELES SHARE OVERLAPPING PEPTIDE SPECIFICITIES. JOURNAL OF IMMUNOLOGY, 154(1), 247-259. Retrieved from https://www.webofscience.com/

1994

MAN, S., RIDGE, J. P., & ENGELHARD, V. H. (1994). DIVERSITY AND DOMINANCE AMONG TCR RECOGNIZING HLA-A2.1(+) INFLUENZA MATRIX PEPTIDE IN HUMAN MHC CLASS-I TRANSGENIC MICE. JOURNAL OF IMMUNOLOGY, 153(10), 4458-4467. Retrieved from https://www.webofscience.com/

SLINGLUFF, C. L., HUNT, D. F., & ENGELHARD, V. H. (1994). DIRECT ANALYSIS OF TUMOR-ASSOCIATED PEPTIDE ANTIGENS. CURRENT OPINION IN IMMUNOLOGY, 6(5), 733-740. doi:10.1016/0952-7915(94)90077-9

SMITH, D. M., BLUESTONE, J. A., JEYARAJAH, D. R., NEWBERG, M. H., ENGELHARD, V. H., THISTLETHWAITE, J. R., & WOODLE, E. S. (1994). INHIBITION OF T-CELL ACTIVATION BY A MONOCLONAL-ANTIBODY REACTIVE AGAINST THE ALPHA-3 DOMAIN OF HUMAN MHC CLASS-I MOLECULES. JOURNAL OF IMMUNOLOGY, 153(3), 1054-1067. Retrieved from https://www.webofscience.com/

ENGELHARD, V. H. (1994). HOW CELLS PROCESS ANTIGENS. SCIENTIFIC AMERICAN, 271(2), 54-61. doi:10.1038/scientificamerican0894-54

SLINGLUFF, C. L., COX, A. L., STOVER, J. M., MOORE, M. M., HUNT, D. F., & ENGELHARD, V. H. (1994). CYTOTOXIC T-LYMPHOCYTE RESPONSE TO AUTOLOGOUS HUMAN SQUAMOUS-CELL CANCER OF THE LUNG - EPITOPE RECONSTITUTION WITH PEPTIDES EXTRACTED FROM HLA-AW68. CANCER RESEARCH, 54(10), 2731-2737. Retrieved from https://www.webofscience.com/

COX, A. L., SKIPPER, J., CHEN, Y., HENDERSON, R. A., DARROW, T. L., SHABANOWITZ, J., . . . SLINGLUFF, C. L. (1994). IDENTIFICATION OF A PEPTIDE RECOGNIZED BY 5 MELANOMA-SPECIFIC HUMAN CYTOTOXIC T-CELL LINES. SCIENCE, 264(5159), 716-719. doi:10.1126/science.7513441

BEIER, D. C., COX, J. H., VINING, D. R., CRESSWELL, P., & ENGELHARD, V. H. (1994). ASSOCIATION OF HUMAN CLASS-I MHC ALLELES WITH THE ADENOVIRUS E3/19K PROTEIN. JOURNAL OF IMMUNOLOGY, 152(8), 3862-3872. Retrieved from https://www.webofscience.com/

CHEN, Y., SIDNEY, J., SOUTHWOOD, S., COX, A. L., SAKAGUCHI, K., HENDERSON, R. A., . . . ENGELHARD, V. H. (1994). NATURALLY PROCESSED PEPTIDES LONGER THAN 9 AMINO-ACID-RESIDUES BIND TO THE CLASS-I MHC MOLECULE HLA-A2.1 WITH HIGH-AFFINITY AND IN DIFFERENT CONFORMATIONS. JOURNAL OF IMMUNOLOGY, 152(6), 2874-2881. Retrieved from https://www.webofscience.com/

ENGELHARD, V. H. (1994). STRUCTURE OF PEPTIDES ASSOCIATED WITH MHC CLASS-I MOLECULES. CURRENT OPINION IN IMMUNOLOGY, 6(1), 13-23. doi:10.1016/0952-7915(94)90028-0

LOFTUS, D. J., SAKAGUCHI, K., YE, C., SAKAMOTO, H., SETTE, A., ENGELHARD, V. H., & APPELLA, E. (1994). ANALYSIS OF TCR RECOGNITION OF A CLASS-1 PEPTIDE EPITOPE AIDED BY THE USE OF A SYNTHETIC, COMBINATORIAL PEPTIDE LIBRARY. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 291). Retrieved from https://www.webofscience.com/

YE, C., SIDNEY, J., SOUTHWOOD, S., BENJAMIN, D., COX, A. L., SAKAGUCHI, K., . . . ENGELHARD, V. H. (1994). NATURALLY PROCESSED PEPTIDES LONGER THAN 9 AMINO-ACID-RESIDUES BIND TO THE CLASS-I MHC MOLECULE HLA-A2.1 WITH HIGH-AFFINITY AND IN DIFFERENT CONFORMATION. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 289). Retrieved from https://www.webofscience.com/

LUTZ, C. T., SMITH, K. D., HUCZKO, E. L., & ENGELHARD, V. H. (1994). AN HLA-B7 LEADER PEPTIDE IS RECOGNIZED BY AN HLA-B7-REACTIVE CTL CLONE. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 335). Retrieved from https://www.webofscience.com/

NEWBERG, M. H., SMITH, D., LACY, L., & ENGELHARD, V. H. (1994). SPECIES-SPECIFIC T-CELL RECOGNITION OF BOTH THE ALPHA-2 AND ALPHA-3 DOMAINS OF MHC CLASS-I AND THE ROLE OF CD8. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 344). Retrieved from https://www.webofscience.com/

ENGELHARD, V. H. (1994). STRUCTURE OF PEPTIDES ASSOCIATED WITH CLASS-I AND CLASS-II MHC MOLECULES. ANNUAL REVIEW OF IMMUNOLOGY, 12, 181-207. doi:10.1146/annurev.immunol.12.1.181

WILLIAMS, N. S., GRAHAM, M. B., BRACIALE, T. J., & ENGELHARD, V. H. (1994). DEVELOPMENT OF CYTOTOXICITY AND PERFORIN GENE-EXPRESSION IN CD4+ AND CD8+ CELLS FROM NAIVE MURINE SPLENOCYTES. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 363). Retrieved from https://www.webofscience.com/

1993

HENDERSON, R. A., COX, A. L., SAKAGUCHI, K., APPELLA, E., SHABANOWITZ, J., HUNT, D. F., & ENGELHARD, V. H. (1993). DIRECT IDENTIFICATION OF AN ENDOGENOUS PEPTIDE RECOGNIZED BY MULTIPLE HLA-A2.1-SPECIFIC CYTOTOXIC T-CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 90(21), 10275-10279. doi:10.1073/pnas.90.21.10275

HUCZKO, E. L., BODNAR, W. M., BENJAMIN, D., SAKAGUCHI, K., ZHU, N. Z., SHABANOWITZ, J., . . . ENGELHARD, V. H. (1993). CHARACTERISTICS OF ENDOGENOUS PEPTIDES ELUTED FROM THE CLASS-I MHC MOLECULE HLA-B7 DETERMINED BY MASS-SPECTROMETRY AND COMPUTER MODELING. JOURNAL OF IMMUNOLOGY, 151(5), 2572-2587. Retrieved from https://www.webofscience.com/

SLINGLUFF, C. L., COX, A. L., HENDERSON, R. A., HUNT, D. F., & ENGELHARD, V. H. (1993). RECOGNITION OF HUMAN-MELANOMA CELLS BY HLA-A2.1-RESTRICTED CYTOTOXIC T-LYMPHOCYTES IS MEDIATED BY AT LEAST 6 SHARED PEPTIDE EPITOPES. JOURNAL OF IMMUNOLOGY, 150(7), 2955-2963. Retrieved from https://www.webofscience.com/

MAN, S., RIDGE, J. P., & ENGELHARD, V. H. (1993). T-CELL RECEPTOR USAGE OF INFLUENZA SPECIFIC HLA-A2.1 RESTRICTED CYTOTOXIC T-LYMPHOCYTES FROM HLA-A2.1 TRANSGENIC MICE. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 52). Retrieved from https://www.webofscience.com/

HENDERSON, R. A., COX, A. L., SAKAGUCHI, K., APPELLA, E., SHABANOWITZ, J., ENGELHARD, V. H., & HUNT, D. F. (1993). IDENTIFICATION OF HLA-A2.1-RESTRICTED T-CELL EPITOPES USING TANDEM MASS-SPECTROMETRY. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 104). Retrieved from https://www.webofscience.com/

HUCZKO, E. L., BODNER, W., BENJAMIN, D., SAKAGUCHI, K., ZHOU, N. Z., SHABANOWITZ, J., . . . ENGELHARD, V. H. (1993). PEPTIDES BOUND TO HLA-B7 DETERMINED BY MASS-SPECTROMETRY. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 105). Retrieved from https://www.webofscience.com/

SLINGLUFF, C. L., COX, A. L., HENDERSON, R. A., HUNT, D. F., & ENGELHARD, V. H. (1993). MULTIPLE SHARED HLA-A2.1 ASSOCIATED PEPTIDE EPITOPES FOR MELANOMA-SPECIFIC CTL. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 112). Retrieved from https://www.webofscience.com/

Slingluff, C. L., Cox, A. L., Henderson, R. A., Hunt, D. F., & Engelhard, V. H. (1993). Multiple shared HLA-A2.1 associated peptide epitopes for melanoma-specific CTL. In Melanoma Research Vol. 3 (pp. 22). Ovid Technologies (Wolters Kluwer Health). doi:10.1097/00008390-199303000-00074

ENGELHARD, V. H., HUCZKO, E. L., BODNER, W., BENJAMIN, D., SAKAGUCHI, K., ZHOU, N. Z., . . . HUNT, D. F. (1993). PEPTIDES BOUND TO HLA-B7 DETERMINED BY MASS-SPECTROMETRY. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 56). Retrieved from https://www.webofscience.com/

BEIER, D. C., COX, J. H., CRESSWELL, P., & ENGELHARD, V. H. (1993). DEFINING THE INTERACTION BETWEEN HLA-A2.1 AND THE ADENOVIRUS E3/19K PROTEIN. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 53). Retrieved from https://www.webofscience.com/

Engelhard, V. H., Appella, E., Benjamin, D. C., Bodnar, W. M., Cox, A. L., Chen, Y., . . . Hunt, D. F. (1993). Mass Spectrometric Analysis of Peptides Associated with the Human Class I MHC Molecules HLA-A2.1 and HLA-B7 and Identification of Structural Features that Determine Binding. In Chemical Immunology and Allergy (pp. 39-62). KARGER. doi:10.1159/000319180

HUNT, D. F., SHABANOWITZ, J., MICHEL, H., COX, A. L., DICKINSON, T., DAVIS, T., . . . SETTE, A. (1993). SEQUENCE-ANALYSIS OF PEPTIDES PRESENTED TO THE IMMUNE-SYSTEM BY CLASS-I AND CLASS-II MHC MOLECULES. In METHODS IN PROTEIN SEQUENCE ANALYSIS (pp. 127-133). Retrieved from https://www.webofscience.com/

Engelhard, V. H., Appella, E., Benjamin, D. C., Bodnar, W. M., Cox, A. L., Chen, Y., . . . Sakaguichi, K. (1993). Mass spectrometric analysis of peptides associated with the human class I MHC molecules HLA-A2.1 and HLA-B7 and identification of structural features that determine binding.. Chemical immunology, 57, 39-62.

1992

Hunt, D. F., Shabanowitz, J., Michel, H., Cox, A. L., Dickinson, T., Davis, T., . . . Sette, A. (1992). Sequence analysis of peptides presented to the immune system by class I and class II MHC molecules. Journal of Protein Chemistry, 11(4), 377-378. doi:10.1007/bf01673734

NEWBERG, M. H., RIDGE, J. P., VINING, D. R., SALTER, R. D., & ENGELHARD, V. H. (1992). SPECIES SPECIFICITY IN THE INTERACTION OF CD8 WITH THE ALPHA-3 DOMAIN OF MHC CLASS-I MOLECULES. JOURNAL OF IMMUNOLOGY, 149(1), 136-142. Retrieved from https://www.webofscience.com/

BARZAGAGILBERT, E., GRASS, D., LAWRANCE, S. K., PETERSON, P. A., LACY, E., & ENGELHARD, V. H. (1992). SPECIES SPECIFICITY AND AUGMENTATION OF RESPONSES TO CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX-MOLECULES IN HUMAN CD4 TRANSGENIC MICE. JOURNAL OF EXPERIMENTAL MEDICINE, 175(6), 1707-1715. doi:10.1084/jem.175.6.1707

CRUMPACKER, D. B., ALEXANDER, J., CRESSWELL, P., & ENGELHARD, V. H. (1992). ROLE OF ENDOGENOUS PEPTIDES IN MURINE ALLOGENEIC CYTOTOXIC T-CELL RESPONSES ASSESSED USING TRANSFECTANTS OF THE ANTIGEN-PROCESSING MUTANT 174XCEM.T2. JOURNAL OF IMMUNOLOGY, 148(10), 3004-3011. Retrieved from https://www.webofscience.com/

HUNT, D. F., HENDERSON, R. A., SHABANOWITZ, J., SAKAGUCHI, K., MICHEL, H., SEVILIR, N., . . . ENGELHARD, V. H. (1992). CHARACTERIZATION OF PEPTIDES BOUND TO THE CLASS-I MHC MOLECULE HLA-A2.1 BY MASS-SPECTROMETRY. SCIENCE, 255(5049), 1261-1263. doi:10.1126/science.1546328

HENDERSON, R. A., MICHEL, H., SAKAGUCHI, K., SHABANOWITZ, J., APPELLA, E., HUNT, D. F., & ENGELHARD, V. H. (1992). HLA-A2.1-ASSOCIATED PEPTIDES FROM A MUTANT-CELL LINE - A 2ND PATHWAY OF ANTIGEN PRESENTATION. SCIENCE, 255(5049), 1264-1266. doi:10.1126/science.1546329

MAN, S., SALTER, R. D., & ENGELHARD, V. H. (1992). ROLE OF ENDOGENOUS PEPTIDE IN HUMAN ALLOREACTIVE CYTOTOXIC T-CELL RESPONSES. INTERNATIONAL IMMUNOLOGY, 4(3), 367-375. doi:10.1093/intimm/4.3.367

1991

HAVERSTICK, D. M., ENGELHARD, V. H., & GRAY, L. S. (1991). 3 INTRACELLULAR SIGNALS FOR CYTOTOXIC LYMPHOCYTE-T-MEDIATED KILLING - INDEPENDENT ROLES FOR PROTEIN-KINASE-C, CA2+ INFLUX, AND CA2+ RELEASE FROM INTERNAL STORES. JOURNAL OF IMMUNOLOGY, 146(10), 3306-3313. Retrieved from https://www.webofscience.com/

MAN, S., SALTER, R. D., & ENGELHARD, V. H. (1991). DEPENDENCE OF HLA-A2 SPECIFIC ALLOREACTIVE CTL RESPONSES UPON ENDOGENOUS PEPTIDES. In FASEB JOURNAL Vol. 5 (pp. A1461). Retrieved from https://www.webofscience.com/

HENDERSON, R. A., BARBOSA, J. A., & ENGELHARD, V. H. (1991). ENDOGENOUS PEPTIDE DEPENDENCE OF MURINE HLA-A2.1 SPECIFIC CTL CLONES ASSESSED BY THE ANTIGEN PROCESSING MUTANT 174XCEMT2. In FASEB JOURNAL Vol. 5 (pp. A1683). Retrieved from https://www.webofscience.com/

BARZAGAGILBERT, E., GRASS, D., LAWRANCE, S., LACY, E., & ENGELHARD, V. H. (1991). T-CELL RESPONSES TO HUMAN CLASS-II MOLECULES IN HUMAN CD4 TRANSGENIC MICE. In FASEB JOURNAL Vol. 5 (pp. A1336). Retrieved from https://www.webofscience.com/

NEWBERG, M. H., RIDGE, J. P., SALTER, R. D., & ENGELHARD, V. H. (1991). SPECIES SPECIFICITY IN THE INTERACTION OF CD8 WITH THE ALPHA-3 DOMAIN OF MHC CLASS I MOLECULES. In FASEB JOURNAL Vol. 5 (pp. A1378). Retrieved from https://www.webofscience.com/

CRUMPACKER, D., ALEXANDER, J., CRESSWELL, P., & ENGELHARD, V. H. (1991). ENDOGENOUS PEPTIDE DEPENDENCE OF MURINE ALLOGENEIC CTL RESPONSES ASSESSED USING TRANSFECTANTS OF THE ANTIGEN PROCESSING MUTANT 174XCEM.T2. In FASEB JOURNAL Vol. 5 (pp. A725). Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., LACY, E., & RIDGE, J. P. (1991). INFLUENZA A-SPECIFIC, HLA-A2.1-RESTRICTED CYTOTOXIC LYMPHOCYTES-T FROM HLA-A2.1 TRANSGENIC MICE RECOGNIZE FRAGMENTS OF THE M1-PROTEIN. JOURNAL OF IMMUNOLOGY, 146(4), 1226-1232. Retrieved from https://www.webofscience.com/

1990

SPITS, H., PALIARD, X., ENGELHARD, V. H., & DEVRIES, J. E. (1990). CYTOTOXIC ACTIVITY AND LYMPHOKINE PRODUCTION OF T-CELL RECEPTOR (TCR)-ALPHA-BETA+ AND TCR-GAMMA-DELTA+ CYTOTOXIC LYMPHOCYTE-T (CTL) CLONES RECOGNIZING HLA-A2 AND HLA-A2 MUTANTS - RECOGNITION OF TCR-GAMMA-DELTA+ CTL CLONES IS AFFECTED BY MUTATIONS AT POSITION-152 AND POSITION-156. JOURNAL OF IMMUNOLOGY, 144(11), 4156-4162. Retrieved from https://www.webofscience.com/

Engelhard, V. H., Bernhard, E. J., Holterman, M. J., Le, A. -X. T., Henderson, R., Ridge, J. P., . . . Lacy, E. (1990). Cytotoxic T Cell Responses Against Human Class I Molecules in Normal and HLA-A2.1 Transgenic Mice. In Transgenic Mice and Mutants in MHC Research (pp. 179-190). Springer Berlin Heidelberg. doi:10.1007/978-3-642-75442-5_25

Hogan, K. T., Clayberger, C., Shimojo, N., Biddison, W. E., Krensky, A. M., & Engelhard, V. H. (1990). The Role of Amino Acid Position and Side Chain Structure in Serological and CTL-Defined Epitopes on the HLA-A2.1 Molecule. In Transgenic Mice and Mutants in MHC Research (pp. 77-88). Springer Berlin Heidelberg. doi:10.1007/978-3-642-75442-5_12

1989

SHIMOJO, N., COWAN, E. P., ENGELHARD, V. H., MALOY, W. L., COLIGAN, J. E., & BIDDISON, W. E. (1989). A SINGLE AMINO-ACID SUBSTITUTION IN HLA-A2 CAN ALTER THE SELECTION OF THE CYTO-TOXIC LYMPHOCYTE-T REPERTOIRE THAT RESPONDS TO INFLUENZA-VIRUS MATRIX PEPTIDE 55-73. JOURNAL OF IMMUNOLOGY, 143(2), 558-564. Retrieved from https://www.webofscience.com/

SCHAIN, D. C., PETRI, W. A., ENGELHARD, V. H., ROCHE, J. K., & RAVDIN, J. I. (1989). IMMUNIZATION WITH ENTAMOEBA-HISTOLYTICA ADHERENCE LECTIN ELICITS AN AMEBICIDAL CELL-MEDIATED IMMUNE-RESPONSE. In CLINICAL RESEARCH Vol. 37 (pp. A439). Retrieved from https://www.webofscience.com/

HOGAN, K. T., CLAYBERGER, C., BERNHARD, E. J., WALK, S. F., RIDGE, J. P., PARHAM, P., . . . ENGELHARD, V. H. (1989). A PANEL OF UNIQUE HLA-A2 MUTANT MOLECULES DEFINE EPITOPES RECOGNIZED BY HLA-A2-SPECIFIC ANTIBODIES AND CYTO-TOXIC LYMPHOCYTES-T. JOURNAL OF IMMUNOLOGY, 142(6), 2097-2104. Retrieved from https://www.webofscience.com/

GRAY, L. S., HUBER, K. S., GRAY, M. C., HEWLETT, E. L., & ENGELHARD, V. H. (1989). PERTUSSIS TOXIN EFFECTS ON LYMPHOCYTES-T ARE MEDIATED THROUGH CD3 AND NOT BY PERTUSSIS TOXIN CATALYZED MODIFICATION OF A G-PROTEIN. JOURNAL OF IMMUNOLOGY, 142(5), 1631-1638. Retrieved from https://www.webofscience.com/

LE, A. X. T., BERNHARD, E. J., HOLTERMAN, M. J., STRUB, S., PARHAM, P., LACY, E., & ENGELHARD, V. H. (1989). CYTO-TOXIC T-CELL RESPONSES IN HLA-A2.1 TRANSGENIC MICE - RECOGNITION OF HLA ALLOANTIGENS AND UTILIZATION OF HLA-A2.1 AS A RESTRICTION ELEMENT. JOURNAL OF IMMUNOLOGY, 142(4), 1366-1371. Retrieved from https://www.webofscience.com/

Engelhard, V. H., Holterman, M., & Le, A. -X. T. (1989). Weak Stimulation of Murine Cytotoxic T Cells by Human Class I Molecules Maps to the αl + α2 Domains. In Immunobiology of HLA (pp. 140-142). Springer Berlin Heidelberg. doi:10.1007/978-3-662-39946-0_36

Hogan, K. T., Ridge, J. P., Walk, S. F., Engelhard, V. H., & Parham, P. (1989). Mapping of Serologic and CTL-Defined Epitopes on HLA-A2 by Site-Directed Mutagenesis. In Immunobiology of HLA (pp. 101-103). Springer Berlin Heidelberg. doi:10.1007/978-3-662-39946-0_15

1988

HOGAN, K. T., CLAYBERGER, C., LE, A. T., WALK, S. F., RIDGE, J. P., PARHAM, P., . . . ENGELHARD, V. H. (1988). CYTO-TOXIC LYMPHOCYTE-T-DEFINED EPITOPE DIFFERENCES BETWEEN HLA-A2.1 AND HLA-A2.2 MAP TO 2 DISTINCT REGIONS OF THE MOLECULE. JOURNAL OF IMMUNOLOGY, 141(11), 4005-4011. Retrieved from https://www.webofscience.com/

NORMENT, A. M., SALTER, R. D., PARHAM, P., ENGELHARD, V. H., & LITTMAN, D. R. (1988). CELL-CELL ADHESION MEDIATED BY CD8 AND MHC CLASS-I MOLECULES. NATURE, 336(6194), 79-81. doi:10.1038/336079a0

HOGAN, K. T., CLAYBERGER, C., BERNHARD, E. J., WALK, S. F., RIDGE, J. P., PARHAM, P., . . . ENGELHARD, V. H. (1988). IDENTIFICATION BY SITE-DIRECTED MUTAGENESIS OF AMINO-ACID RESIDUES CONTRIBUTING TO SEROLOGIC AND CTL-DEFINED EPITOPE DIFFERENCES BETWEEN HLA-A2.1 AND HLA-A2.3. JOURNAL OF IMMUNOLOGY, 141(7), 2519-2525. Retrieved from https://www.webofscience.com/

GRAY, L. S., GNARRA, J. R., SULLIVAN, J. A., MANDELL, G. L., & ENGELHARD, V. H. (1988). SPATIAL AND TEMPORAL CHARACTERISTICS OF THE INCREASE IN INTRACELLULAR CA2+ INDUCED IN CYTO-TOXIC LYMPHOCYTES-T BY CELLULAR ANTIGEN. JOURNAL OF IMMUNOLOGY, 141(7), 2424-2430. Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., LE, A. X. T., & HOLTERMAN, M. J. (1988). SPECIES-SPECIFIC STRUCTURAL DIFFERENCES IN THE ALPHA-1 + ALPHA-2 DOMAINS DETERMINE THE FREQUENCY OF MURINE CYTO-TOXIC T-CELL PRECURSORS STIMULATED BY HUMAN AND MURINE CLASS-I MOLECULES. JOURNAL OF IMMUNOLOGY, 141(6), 1835-1839. Retrieved from https://www.webofscience.com/

BERNHARD, E. J., LE, A. X. T., BARBOSA, J. A., LACY, E., & ENGELHARD, V. H. (1988). CYTO-TOXIC LYMPHOCYTES-T FROM HLA-A2 TRANSGENIC MICE SPECIFIC FOR HLA-A2 EXPRESSED ON HUMAN-CELLS. JOURNAL OF EXPERIMENTAL MEDICINE, 168(3), 1157-1162. doi:10.1084/jem.168.3.1157

ENGELHARD, V. H., GNARRA, J. R., SULLIVAN, J., MANDELL, G. L., & GRAY, L. S. (1988). EARLY EVENTS IN TARGET-CELL LYSIS BY CYTO-TOXIC T-CELLS. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 532, 303-313. doi:10.1111/j.1749-6632.1988.tb36348.x

HOGAN, K. T., SHIMOJO, N., WALK, S. F., ENGELHARD, V. H., MALOY, W. L., COLIGAN, J. E., & BIDDISON, W. E. (1988). MUTATIONS IN THE ALPHA-2 HELIX OF HLA-A2 AFFECT PRESENTATION BUT DO NOT INHIBIT BINDING OF INFLUENZA-VIRUS MATRIX PEPTIDE. JOURNAL OF EXPERIMENTAL MEDICINE, 168(2), 725-736. doi:10.1084/jem.168.2.725

GRAY, L. S., GNARRA, J., HEWLETT, E. L., & ENGELHARD, V. H. (1988). INCREASED INTRACELLULAR CYCLIC ADENOSINE-MONOPHOSPHATE INHIBITS LYMPHOCYTE-T MEDIATED CYTOLYSIS BY 2 DISTINCT MECHANISMS. JOURNAL OF EXPERIMENTAL MEDICINE, 167(6), 1963-1968. doi:10.1084/jem.167.6.1963

HOGAN, K. T., PARHAM, P., & ENGELHARD, V. H. (1988). SITE-DIRECTED MUTAGENESIS OF HLA-A2 IDENTIFIES AMINO-ACID RESIDUES THAT ARE CRITICAL IN THE FORMATION OF SEROLOGIC AND CTL-DEFINED EPITOPES. In FASEB JOURNAL Vol. 2 (pp. A1446). Retrieved from https://www.webofscience.com/

BERNHARD, E. J., LE, A. T., LACY, E., & ENGELHARD, V. H. (1988). CYTO-TOXIC T-CELLS FROM HLA-A2 EXPRESSING TRANSGENIC MICE RESPOND TO HLA-A2 EXPRESSED ON HUMAN-CELLS. In FASEB JOURNAL Vol. 2 (pp. A1447). Retrieved from https://www.webofscience.com/

Scott, J., Engelhard, V. H., & Benjamin, D. C. (1988). Prevention of diabetes in the BB rat by injection of major histocompatibility complex- (MHC-) compatible bone marrow cells.. Advances in experimental medicine and biology, 246, 387-395. doi:10.1007/978-1-4684-5616-5_47

Scott, J., Benjamin, D. C., Herr, J. C., & Engelhard, V. H. (1988). Sites of the defects leading to autoimmunity in the spontaneously diabetic BB rat.. Advances in experimental medicine and biology, 246, 53-62. doi:10.1007/978-1-4684-5616-5_7

1987

BERNHARD, E. J., LE, A. X. T., YANNELLI, J. R., HOLTERMAN, M. J., HOGAN, K. T., PARHAM, P., & ENGELHARD, V. H. (1987). THE ABILITY OF CYTOTOXIC T-CELLS TO RECOGNIZE HLA-A2.1 OR HLA-B7 ANTIGENS EXPRESSED ON MURINE CELLS CORRELATES WITH THEIR EPITOPE SPECIFICITY. JOURNAL OF IMMUNOLOGY, 139(11), 3614-3621. Retrieved from https://www.webofscience.com/

SCOTT, J., ENGELHARD, V. H., & BENJAMIN, D. C. (1987). BONE-MARROW IRRADIATION CHIMERAS IN THE BB RAT - EVIDENCE SUGGESTING 2 DEFECTS LEADING TO DIABETES AND LYMPHOPOENIA. DIABETOLOGIA, 30(10), 774-781. Retrieved from https://www.webofscience.com/

GRAY, L. S., GNARRA, J. R., RUSSELL, J. H., & ENGELHARD, V. H. (1987). THE ROLE OF K+ IN THE REGULATION OF THE INCREASE IN INTRACELLULAR CA-2+ MEDIATED BY THE LYMPHOCYTE-T ANTIGEN RECEPTOR. CELL, 50(1), 119-127. doi:10.1016/0092-8674(87)90668-4

SCOTT, J., ENGELHARD, V. H., SCOTT, C. A., HERR, J. C., & BENJAMIN, D. C. (1987). NEONATAL TRANSPLANTATION OF MHC-COMPATIBLE THYMUSES INTO DIABETES-PRONE BB RATS. In DIABETOLOGIA Vol. 30 (pp. A580). Retrieved from https://www.webofscience.com/

HOGAN, K. T., HOLTERMAN, M. J., WALK, S. F., LE, A. T., & ENGELHARD, V. H. (1987). DETERMINATION OF HLA-A2 STRUCTURE-FUNCTION-RELATIONSHIPS BY SITE DIRECTED MUTAGENESIS. In FEDERATION PROCEEDINGS Vol. 46 (pp. 1496). Retrieved from https://www.webofscience.com/

BERNHARD, E., LE, A. T., YANNELLI, J., HOLTERMAN, M., PARHAM, P., & ENGELHARD, V. (1987). THE ABILITY OF CYTOTOXIC T-CELLS TO RECOGNIZE HLA-A2.1 OR HLA-B7 ANTIGENS EXPRESSED ON MURINE TARGETS CORRELATES WITH RECOGNITION OF PARTICULAR EPITOPES. In FEDERATION PROCEEDINGS Vol. 46 (pp. 1049). Retrieved from https://www.webofscience.com/

GRAY, L. S., GNARRA, J. R., & ENGELHARD, V. H. (1987). DEMONSTRATION OF A CALCIUM INFLUX IN CYTOLYTIC LYMPHOCYTES-T IN RESPONSE TO TARGET-CELL BINDING. JOURNAL OF IMMUNOLOGY, 138(1), 63-69. Retrieved from https://www.webofscience.com/

1986

HOLTERMAN, M. J., & ENGELHARD, V. H. (1986). HLA ANTIGENS EXPRESSED ON MURINE CELLS ARE PREFERENTIALLY RECOGNIZED BY MURINE CYTOTOXIC-T CELLS IN THE CONTEXT OF THE H-2 MAJOR HISTOCOMPATIBILITY COMPLEX. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 83(24), 9699-9703. doi:10.1073/pnas.83.24.9699

GNARRA, J. R., & ENGELHARD, V. H. (1986). DERIVATION OF CYTOTOXIC T-CELL LINES THAT EXPRESS T-CELL RECEPTOR BUT EXHIBIT REVERSIBLE LOSS OF STABLE ANTIGEN-BINDING. JOURNAL OF IMMUNOLOGY, 137(10), 3057-3064. Retrieved from https://www.webofscience.com/

SCOTT, J., ENGELHARD, V. H., CURNOW, R. T., & BENJAMIN, D. C. (1986). PREVENTION OF DIABETES IN BB RATS .1. EVIDENCE SUGGESTING A REQUIREMENT FOR MATURE T-CELLS IN BONE-MARROW INOCULUM OF NEONATALLY INJECTED RATS. DIABETES, 35(9), 1034-1040. doi:10.2337/diabetes.35.9.1034

YANNELLI, J., TEWKSBURY, S., THURMAN, G., OLDHAM, R., ENGELHARD, V., SULLIVAN, J., & MANDELL, G. (1986). MORPHOLOGICAL ANALYSIS OF CYTOTOXIC LYMPHOCYTE-TARGET CELL-INTERACTIONS. In PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH Vol. 27 (pp. 360). Retrieved from https://www.webofscience.com/

GNARRA, J. R., & ENGELHARD, V. H. (1986). NONCYTOTOXIC CELL-LINES DERIVED FROM CTL CLONES CONTINUE TO EXPRESS THE ANTIGEN RECEPTOR. In FEDERATION PROCEEDINGS Vol. 45 (pp. 384). Retrieved from https://www.webofscience.com/

YANNELLI, J. R., SULLIVAN, J. A., MANDELL, G. L., & ENGELHARD, V. H. (1986). REORIENTATION AND FUSION OF CYTOTOXIC LYMPHOCYTE-T GRANULES AFTER INTERACTION WITH TARGET-CELLS AS DETERMINED BY HIGH-RESOLUTION CINEMICROGRAPHY. JOURNAL OF IMMUNOLOGY, 136(2), 377-382. Retrieved from https://www.webofscience.com/

YANNELLI, J. R., TEWKSBURY, S. G., THURMAN, G. B., OLDHAM, R. K., ENGELHARD, V. H., SULLIVAN, J. A., & MANDELL, G. L. (1986). MORPHOLOGICAL ANALYSIS OF CYTOTOXIC LYMPHOCYTE-TARGET CELL-INTERACTIONS. In JOURNAL OF CELLULAR BIOCHEMISTRY (pp. 95). Retrieved from https://www.webofscience.com/

1985

YANNELLI, J. R., MOORE, L. C., & ENGELHARD, V. H. (1985). MULTIPLE EPITOPES ON HUMAN AND MURINE CELLS EXPRESSING HLA-B7 AS DEFINED BY SPECIFIC MURINE CYTO-TOXIC T-CELL CLONES. JOURNAL OF IMMUNOLOGY, 135(2), 900-905. Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., YANNELLI, J. R., EVANS, G. A., WALK, S. F., & HOLTERMAN, M. J. (1985). CONSTRUCTION OF NOVEL CLASS-I HISTOCOMPATIBILITY ANTIGENS BY INTERSPECIES EXON SHUFFLING. JOURNAL OF IMMUNOLOGY, 134(6), 4218-4225. Retrieved from https://www.webofscience.com/

1984

ENGELHARD, V. H., POWERS, G. A., MOORE, L. C., HOLTERMAN, M. J., & CORREAFREIRE, M. C. (1984). CYTO-TOXIC LYMPHOCYTE-T RECOGNITION OF HLA-A/B ANTIGENS INTRODUCED INTO EL4-CELLS BY CELL-LIPOSOME FUSION. JOURNAL OF IMMUNOLOGY, 132(1), 76-80. Retrieved from https://www.webofscience.com/

CORREAFREIRE, M. C., POWERS, G. A., & ENGELHARD, V. H. (1984). INTRODUCTION OF HLA-A/B ANTIGENS INTO LYMPHOID-CELL MEMBRANES BY CELL-LIPOSOME FUSION. JOURNAL OF IMMUNOLOGY, 132(1), 69-75. Retrieved from https://www.webofscience.com/

1983

HERMAN, A., WEISSMAN, S., PARHAM, P., & ENGELHARD, V. H. (1983). HLA-SPECIFIC MONOCLONAL MURINE CTL RECOGNIZE L-CELLS EXPRESSING HLA-B7 AFTER DNA-MEDIATED GENE-TRANSFER. In FEDERATION PROCEEDINGS Vol. 42 (pp. 1372). Retrieved from https://www.webofscience.com/

YANNELLI, J. R., BENJAMIN, C., PARHAM, P., & ENGELHARD, V. H. (1983). XENOGENEIC ANTI-HLA-A2 CTL CLONES RECOGNIZE DIFFERENT ANTIGENIC DETERMINANTS ON THE A2 MOLECULE. In FEDERATION PROCEEDINGS Vol. 42 (pp. 1373). Retrieved from https://www.webofscience.com/

HERMAN, A., PARHAM, P., WEISSMAN, S. M., & ENGELHARD, V. H. (1983). RECOGNITION BY XENOGENEIC CYTO-TOXIC LYMPHOCYTES-T OF CELLS EXPRESSING HLA-A2 OR HLA-B7 AFTER DNA-MEDIATED GENE-TRANSFER. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 80(16), 5056-5060. doi:10.1073/pnas.80.16.5056

ENGELHARD, V. H., & BENJAMIN, C. (1983). XENOGENEIC CYTO-TOXIC T-CELL CLONES RECOGNIZE ALLOANTIGENIC DETERMINANTS ON HLA-A2. IMMUNOGENETICS, 18(5), 461-473. doi:10.1007/BF00364388

1982

ENGELHARD, V. H., & BENJAMIN, C. (1982). ISOLATION AND CHARACTERIZATION OF MONOCLONAL MOUSE CYTO-TOXIC LYMPHOCYTE-T WITH SPECIFICITY FOR HLA-A,B OR HLA-DR ALLOANTIGENS. JOURNAL OF IMMUNOLOGY, 129(6), 2621-2629. Retrieved from https://www.webofscience.com/

CORREAFRIERE, M. C., & ENGELHARD, V. H. (1982). INTRODUCTION OF HUMAN HISTOCOMPATIBILITY ANTIGENS INTO MOUSE LYMPHOID-CELL MEMBRANES BY CELL-LIPOSOME FUSION. In BIOPHYSICAL JOURNAL Vol. 37 (pp. A28). Retrieved from https://www.webofscience.com/

CORREAFRIERE, M. C., & ENGELHARD, V. H. (1982). INTRODUCTION OF HLA-A, B-ANTIGENS INTO LYMPHOBLASTOID CELL-MEMBRANES BY CELL-LIPOSOME FUSION - RECOGNITION BY ANTIBODY AND CYTO-TOXIC T-CELLS. In FEDERATION PROCEEDINGS Vol. 41 (pp. 604). Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., & BENJAMIN, C. (1982). MONOCLONAL MOUSE CTL SPECIFIC FOR HLA-A, HLA-B AND HLA-DR ANTIGENS. In FEDERATION PROCEEDINGS Vol. 41 (pp. 431). Retrieved from https://www.webofscience.com/

1981

Strominger, J. L., Engelhard, V. H., Guild, B. C., Kostyk, T. G., Lancet, D., Lopez de Castro, J. A., . . . Pober, J. S. (1981). Complete Primary Structure of Human Histocompatibility Antigen HLA-B7. In Current Trends in Histocompatibility (pp. 479-493). Springer US. doi:10.1007/978-1-4684-3758-4_20

1980

Reiss, C. S., Hemler, M. E., Englehard, V. H., Mier, J. W., Strominger, J. L., & Burakoff, S. J. (1980). Development and characterization of allospecific long-term human cytolytic T-cell lines.. Proceedings of the National Academy of Sciences of the United States of America, 77(9), 5432-5436. doi:10.1073/pnas.77.9.5432

Strominger, J. L., Engelhard, V. H., Guild, B. C., Kostyk, T. G., Lancet, D., Lopez de Castro, J. A., . . . Pober, J. S. (1980). Complete primary structure of human histocompatibility antigen HLA-B7: evolutionary and functional implications.. Current topics in developmental biology, 14(Pt 2), 97-113. doi:10.1016/s0070-2153(08)60190-8

ENGELHARD, V. H., KAUFMAN, J. F., STROMINGER, J. L., & BURAKOFF, S. J. (1980). SPECIFICITY OF MOUSE CYTO-TOXIC LYMPHOCYTE-T STIMULATED WITH EITHER HLA-A AND HLA-B OR HLA-DR ANTIGENS RECONSTITUTED INTO PHOSPHOLIPID-VESICLES. JOURNAL OF EXPERIMENTAL MEDICINE, 152(2), S54-S64. Retrieved from https://www.webofscience.com/

BURAKOFF, S. J., ENGELHARD, V. H., KAUFMAN, J., & STROMINGER, J. L. (1980). INDUCTION OF SECONDARY CYTO-TOXIC LYMPHOCYTES-T BY LIPOSOMES CONTAINING HLA-DR ANTIGENS. NATURE, 283(5746), 495-497. doi:10.1038/283495a0

1979

ENGELHARD, V. H., BURAKOFF, S., & STROMINGER, J. L. (1979). STIMULATION OF SECONDARY MOUSE CYTOTOXIC T-CELLS WITH HLA-A AND HLA-B ANTIGENS IN PHOSPHOLIPID-VESICLES. In JOURNAL OF SUPRAMOLECULAR STRUCTURE (pp. 260). Retrieved from https://www.webofscience.com/

WESTCOTT, K. R., ENGELHARD, V. H., & STORM, D. R. (1979). PRODUCTION OF CYCLIC-AMP FROM EXTRACELLULAR ATP BY INTACT LM-CELLS. BIOCHIMICA ET BIOPHYSICA ACTA, 583(1), 47-54. doi:10.1016/0304-4165(79)90308-8

1978

ENGELHARD, V. H., STROMINGER, J. L., MESCHER, M., & BURAKOFF, S. (1978). INDUCTION OF SECONDARY CYTOTOXIC LYMPHOCYTES-T BY PURIFIED HLA-A AND HLA-B ANTIGENS RECONSTITUTED INTO PHOSPHOLIPID VESICLES. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(11), 5688-5691. doi:10.1073/pnas.75.11.5688

ENGELHARD, V. H., STORM, D. R., & GLASER, M. (1978). NEGATIVE COOPERATIVITY EXHIBITED BY PROSTAGLANDIN-E1 STIMULATED ADENYLATE-CYCLASE IN LM-CELLS. BIOCHEMISTRY, 17(24), 5304-5308. doi:10.1021/bi00617a034

ENGELHARD, V. H., GUILD, B. C., HELENIUS, A., TERHORST, C., & STROMINGER, J. L. (1978). RECONSTITUTION OF PURIFIED DETERGENT-SOLUBLE HLA-A AND HLA-B ANTIGENS INTO PHOSPHOLIPID VESICLES. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 75(7), 3230-3234. doi:10.1073/pnas.75.7.3230

ENGELHARD, V. H. (1978). RECONSTITUTION OF PURIFIED HUMAN HISTOCOMPATIBILITY ANTIGENS INTO MODEL MEMBRANES. In FEDERATION PROCEEDINGS Vol. 37 (pp. 1468). Retrieved from https://www.webofscience.com/

ENGELHARD, V. H., GLASER, M., & STORM, D. R. (1978). EFFECT OF MEMBRANE PHOSPHOLIPID COMPOSITIONAL CHANGES ON ADENYLATE-CYCLASE IN LM CELLS. BIOCHEMISTRY, 17(16), 3191-3200. doi:10.1021/bi00609a004

1976

ENGELHARD, V. H., PLUT, D. A., & STORM, D. R. (1976). SUBCELLULAR LOCATION OF ADENYLATE-CYCLASE IN RAT CARDIAC-MUSCLE. BIOCHIMICA ET BIOPHYSICA ACTA, 451(1), 48-61. doi:10.1016/0304-4165(76)90256-7

ENGELHARD, V. H., ESKO, J. D., STORM, D. R., & GLASER, M. (1976). MODIFICATION OF ADENYLATE-CYCLASE ACTIVITY IN LM CELLS BY MANIPULATION OF MEMBRANE PHOSPHOLIPID COMPOSITION INVIVO. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 73(12), 4482-4486. doi:10.1073/pnas.73.12.4482

ENGELHARD, V. H., ESKO, J. D., STORM, D. R., & GLASER, M. (1976). EFFECT OF CHANGES IN MEMBRANE LIPID-COMPOSITION ON ADENYLATE-CYCLASE OF MOUSE LM CELLS. In FEDERATION PROCEEDINGS Vol. 35 (pp. 1532). Retrieved from https://www.webofscience.com/