Muge N Kuyumcu-Martinez


Primary Appointment

Professor, Molecular Physiology and Biological Physics

Research Disciplines

Molecular Physiology and Biological Physics

Research Interests

RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease

Selected Publications


Verma, S. K., & Kuyumcu-Martinez, M. N. (2024). RNA binding proteins in cardiovascular development and disease.. Current topics in developmental biology, 156, 51-119. doi:10.1016/bs.ctdb.2024.01.007


Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling. COMMUNICATIONS CHEMISTRY, 6(1). doi:10.1038/s42004-023-00873-x

Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). A large-scale LC-MS dataset of murine liver proteome from time course of heavy water metabolic labeling. SCIENTIFIC DATA, 10(1). doi:10.1038/s41597-023-02537-w

Mehlferber, M. M., Kuyumcu-Martinez, M., Miller, C. L., & Sheynkman, G. M. (2023). Transcription Factors and Splice Factors-Interconnected Regulators of Stem Cell Differentiation. CURRENT STEM CELL REPORTS, 9(2), 31-41. doi:10.1007/s40778-023-00227-2

Cao, J., & Kuyumcu-Martinez, M. N. (2023). Alternative polyadenylation regulation in cardiac development and cardiovascular disease. CARDIOVASCULAR RESEARCH, 119(6), 1324-1335. doi:10.1093/cvr/cvad014


Sotcheff, S. L., Chen, J. Y. -C., Elrod, N., Cao, J., Jaworski, E., Kuyumcu-Martinez, M. N., . . . Routh, A. L. (2022). Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells. PATHOGENS, 11(8). doi:10.3390/pathogens11080936

Verma, S. K., Deshmukh, V., Thatcher, K., Belanger, K. K., Rhyner, A. M., Meng, S., . . . Kuyumcu-Martinez, M. N. (2022). RBFOX2 is required for establishing RNA regulatory networks essential for heart development. NUCLEIC ACIDS RESEARCH, 50(4), 2270-2286. doi:10.1093/nar/gkac055

Cooper, A. M., Nutter, C. A., Kuyumcu-Martinez, M. N., & Wright, C. W. (2022). Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. MOLECULAR AND CELLULAR BIOLOGY, 42(5). doi:10.1128/mcb.00503-21


Cao, J., Routh, A. L., & Kuyumcu-Martinez, M. N. (2021). Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA-binding proteins during rat heart development. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 25(17), 8352-8362. doi:10.1111/jcmm.16795

Cao, J., Verma, S. K., Jaworski, E., Mohan, S., Nagasawa, C. K., Rayavara, K., . . . Kuyumcu-Martinez, M. N. (2021). RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts. CELL REPORTS, 37(5). doi:10.1016/j.celrep.2021.109910


Wan, X., Belanger, K., Widen, S. G., Kuyumcu-Martinez, M. N., & Garg, N. J. (2020). Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2.. Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165620. doi:10.1016/j.bbadis.2019.165620


Belanger, K., Nutter, C. A., Li, J., Yu, P., & Kuyumcu-Martinez, M. N. (2019). A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 509(2), 384-389. doi:10.1016/j.bbrc.2018.12.150

Nutter, C. A., & KuyumcuâMartinez, M. N. (2018). Cover Image, Volume 9, Issue 2. WIREs RNA, 9(2). doi:10.1002/wrna.1472

Belanger, K., Nutter, C. A., Li, J., Tasnim, S., Liu, P., Yu, P., & Kuyumcu-Martinez, M. N. (2018). CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(4), 3205-3211. doi:10.1016/j.bbrc.2018.08.126


Nutter, C. A., & Kuyumcu-Martinez, M. N. (2018). Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications. WILEY INTERDISCIPLINARY REVIEWS-RNA, 9(2). doi:10.1002/wrna.1459

Nutter, C. A., Jaworski, E., Verma, S. K., Perez-Carrasco, Y., & Kuyumcu-Martinez, M. N. (2017). DEVELOPMENTALLY REGULATED ALTERNATIVE SPLICING IS PERTURBED IN TYPE 1 DIABETIC SKELETAL MUSCLE. MUSCLE & NERVE, 56(4), 744-749. doi:10.1002/mus.25599


Chattopadhyay, A., Pinkaew, D., Doan, H. Q., Jacob, R. B., Verma, S. K., Friedman, H., . . . Fujise, K. (2016). Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. SCIENTIFIC REPORTS, 6. doi:10.1038/srep18701

Nutter, C. A., Jaworski, E. A., Verma, S. K., Deshmukh, V., Wang, Q., Botvinnik, O. B., . . . Kuyumcu-Martinez, M. N. (2016). Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. CELL REPORTS, 15(10), 2200-2213. doi:10.1016/j.celrep.2016.05.002

Verma, S. K., Deshmukh, V., Nutter, C. A., Jaworski, E., Jin, W., Wadhwa, L., . . . Kuyumcu-Martinez, M. N. (2016). Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts. SCIENTIFIC REPORTS, 6. doi:10.1038/srep30896

Koo, S. -J., Spratt, H. M., Soman, K. V., Stafford, S., Gupta, S., Petersen, J. R., . . . Garg, N. J. (2016). S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.. International journal of proteomics, 2016, 1384523. doi:10.1155/2016/1384523

Kuyumcu-Martinez, M. N., & Bressan, M. C. (2016). Rebuilding a broken heart: lessons from developmental and regenerative biology. DEVELOPMENT, 143(21), 3866-3870. doi:10.1242/dev.143842


Verma, S. K., Deshmukh, V., Liu, P., Nutter, C. A., Espejo, R., Hung, M. -L., . . . Kuyumcu-Martinez, M. N. (2013). Reactivation of Fetal Splicing Programs in Diabetic Hearts Is Mediated by Protein Kinase C Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(49), 35372-35386. doi:10.1074/jbc.M113.507426