Muge N Kuyumcu-Martinez

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Primary Appointment

Professor, Molecular Physiology and Biological Physics

Education

  • Ph.D., Molecular Viology and RNA biology, Baylor College of Medicine
  • Postdoc, RNA biology/ heart disease and development, Baylor College of Medicine

Research Disciplines

Development, Stem Cells & Regeneration, Molecular Biology, Molecular Physiology and Biological Physics

Research Interests

RNA regulatory networks and RNA binding proteins during cardiovascular development and in cardiovascular disease

Selected Publications

2024

Verma, S. K., & Kuyumcu-Martinez, M. N. (2024). RNA binding proteins in cardiovascular development and disease.. Current topics in developmental biology, 156, 51-119. doi:10.1016/bs.ctdb.2024.01.007

2023

Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). A large-scale LC-MS dataset of murine liver proteome from time course of heavy water metabolic labeling. SCIENTIFIC DATA, 10(1). doi:10.1038/s41597-023-02537-w

Mehlferber, M. M., Kuyumcu-Martinez, M., Miller, C. L., & Sheynkman, G. M. (2023). Transcription Factors and Splice Factors-Interconnected Regulators of Stem Cell Differentiation. CURRENT STEM CELL REPORTS, 9(2), 31-41. doi:10.1007/s40778-023-00227-2

Deberneh, H. M., Abdelrahman, D. R., Verma, S. K., Linares, J. J., Murton, A. J., Russell, W. K., . . . Sadygov, R. G. (2023). Quantifying label enrichment from two mass isotopomers increases proteome coverage for in vivo protein turnover using heavy water metabolic labeling. COMMUNICATIONS CHEMISTRY, 6(1). doi:10.1038/s42004-023-00873-x

Cao, J., & Kuyumcu-Martinez, M. N. (2023). Alternative polyadenylation regulation in cardiac development and cardiovascular disease. CARDIOVASCULAR RESEARCH, 119(6), 1324-1335. doi:10.1093/cvr/cvad014

2022

Sotcheff, S. L., Chen, J. Y. -C., Elrod, N., Cao, J., Jaworski, E., Kuyumcu-Martinez, M. N., . . . Routh, A. L. (2022). Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells. PATHOGENS, 11(8). doi:10.3390/pathogens11080936

Cooper, A. M., Nutter, C. A., Kuyumcu-Martinez, M. N., & Wright, C. W. (2022). Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies. MOLECULAR AND CELLULAR BIOLOGY, 42(5). doi:10.1128/mcb.00503-21

Verma, S. K., Deshmukh, V., Thatcher, K., Belanger, K. K., Rhyner, A. M., Meng, S., . . . Kuyumcu-Martinez, M. N. (2022). RBFOX2 is required for establishing RNA regulatory networks essential for heart development. NUCLEIC ACIDS RESEARCH, 50(4), 2270-2286. doi:10.1093/nar/gkac055

2021

Cao, J., Verma, S. K., Jaworski, E., Mohan, S., Nagasawa, C. K., Rayavara, K., . . . Kuyumcu-Martinez, M. N. (2021). RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts. CELL REPORTS, 37(5). doi:10.1016/j.celrep.2021.109910

Cao, J., Routh, A. L., & Kuyumcu-Martinez, M. N. (2021). Nanopore sequencing reveals full-length Tropomyosin 1 isoforms and their regulation by RNA-binding proteins during rat heart development. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 25(17), 8352-8362. doi:10.1111/jcmm.16795

2020

Wan, X., Belanger, K., Widen, S. G., Kuyumcu-Martinez, M. N., & Garg, N. J. (2020). Genes of the cGMP-PKG-Ca2+ signaling pathway are alternatively spliced in cardiomyopathy: Role of RBFOX2.. Biochimica et biophysica acta. Molecular basis of disease, 1866(3), 165620. doi:10.1016/j.bbadis.2019.165620

2018

Belanger, K., Nutter, C. A., Li, J., Yu, P., & Kuyumcu-Martinez, M. N. (2019). A developmentally regulated spliced variant of PTBP1 is upregulated in type 1 diabetic hearts. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 509(2), 384-389. doi:10.1016/j.bbrc.2018.12.150

Belanger, K., Nutter, C. A., Li, J., Tasnim, S., Liu, P., Yu, P., & Kuyumcu-Martinez, M. N. (2018). CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 503(4), 3205-3211. doi:10.1016/j.bbrc.2018.08.126

Nutter, C. A., & KuyumcuâMartinez, M. N. (2018). Cover Image, Volume 9, Issue 2. WIREs RNA, 9(2). doi:10.1002/wrna.1472

2017

Nutter, C. A., & Kuyumcu-Martinez, M. N. (2018). Emerging roles of RNA-binding proteins in diabetes and their therapeutic potential in diabetic complications. WILEY INTERDISCIPLINARY REVIEWS-RNA, 9(2). doi:10.1002/wrna.1459

Nutter, C. A., Jaworski, E., Verma, S. K., Perez-Carrasco, Y., & Kuyumcu-Martinez, M. N. (2017). DEVELOPMENTALLY REGULATED ALTERNATIVE SPLICING IS PERTURBED IN TYPE 1 DIABETIC SKELETAL MUSCLE. MUSCLE & NERVE, 56(4), 744-749. doi:10.1002/mus.25599

2016

Kuyumcu-Martinez, M. N., & Bressan, M. C. (2016). Rebuilding a broken heart: lessons from developmental and regenerative biology. DEVELOPMENT, 143(21), 3866-3870. doi:10.1242/dev.143842

Verma, S. K., Deshmukh, V., Nutter, C. A., Jaworski, E., Jin, W., Wadhwa, L., . . . Kuyumcu-Martinez, M. N. (2016). Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts. SCIENTIFIC REPORTS, 6. doi:10.1038/srep30896

Nutter, C. A., Jaworski, E. A., Verma, S. K., Deshmukh, V., Wang, Q., Botvinnik, O. B., . . . Kuyumcu-Martinez, M. N. (2016). Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. CELL REPORTS, 15(10), 2200-2213. doi:10.1016/j.celrep.2016.05.002

Chattopadhyay, A., Pinkaew, D., Doan, H. Q., Jacob, R. B., Verma, S. K., Friedman, H., . . . Fujise, K. (2016). Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice. SCIENTIFIC REPORTS, 6. doi:10.1038/srep18701

Koo, S. -J., Spratt, H. M., Soman, K. V., Stafford, S., Gupta, S., Petersen, J. R., . . . Garg, N. J. (2016). S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure.. International journal of proteomics, 2016, 1384523. doi:10.1155/2016/1384523

2013

Verma, S. K., Deshmukh, V., Liu, P., Nutter, C. A., Espejo, R., Hung, M. -L., . . . Kuyumcu-Martinez, M. N. (2013). Reactivation of Fetal Splicing Programs in Diabetic Hearts Is Mediated by Protein Kinase C Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(49), 35372-35386. doi:10.1074/jbc.M113.507426