Grady W. Miller

Primary Appointment

Associate Professor, Radiology and Medical Imaging

Education

  • BS, University of Maryland
  • PhD, Princeton University

Selected Publications

2023

Garrison, W. J., Qing, K., He, M., Zhao, L., Tustison, N. J., Patrie, J. T., . . . Miller, G. W. (2023). Lung Volume Dependence and Repeatability of Hyperpolarized 129Xe MRI Gas Uptake Metrics in Healthy Volunteers and Participants with COPD. RADIOLOGY-CARDIOTHORACIC IMAGING, 5(3). doi:10.1148/ryct.220096

Garrison, W. J., Iii, J. P. M., Mata, J. F., Nunoo-Asare, R. N., Shim, Y. M., & Miller, G. W. (2023). Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (201). doi:10.3791/65982

Fisher, D. G., Sharifi, K. A., Ulutas, E. Z., Kumar, J. S., Kalani, M. Y. S., Miller, G. W., . . . Tvrdik, P. (2023). Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 43(6), 958-970. doi:10.1161/ATVBAHA.122.318938

Garrison, W. J. J., Qing, K., Tafti, S., Mugler, J. P. P., Shim, Y. M., Mata, J. F. F., . . . Miller, G. W. (2023). Highly accelerated dynamic acquisition of 3D grid-tagged hyperpolarized-gas lung images using compressed sensing. MAGNETIC RESONANCE IN MEDICINE, 89(6), 2255-2263. doi:10.1002/mrm.29595

2022

Leung, S. A., Moore, D., Gilbo, Y., Snell, J., Webb, T. D., Meyer, C. H., . . . Pauly, K. B. (2022). Comparison between MR and CT imaging used to correct for skull-induced phase aberrations during transcranial focused ultrasound. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-17319-4

Sheybani, N. D., Witter, A. R., Garrison, W. J., Miller, G. W., Price, R. J., & Bullock, T. N. J. (2022). Profiling of the immune landscape in murine glioblastoma following blood brain/tumor barrier disruption with MR image-guided focused ultrasound. JOURNAL OF NEURO-ONCOLOGY, 156(1), 109-122. doi:10.1007/s11060-021-03887-4

2021

Niedbalski, P. J., Hall, C. S., Castro, M., Eddy, R. L., Rayment, J. H., Svenningsen, S., . . . Woods, J. C. (2021). Protocols for multi-site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium. MAGNETIC RESONANCE IN MEDICINE, 86(6), 2966-2986. doi:10.1002/mrm.28985

He, M., Qing, K., Tustison, N. J., Beaulac, Z., King, T. W., Huff, T. B., . . . Shim, Y. M. (2021). Characterizing Gas Exchange Physiology in Healthy Young Electronic-Cigarette Users with Hyperpolarized 129Xe MRI: A Pilot Study. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 16, 3183-3187. doi:10.2147/COPD.S324388

Huang, B., Xiao, H., Liu, W., Zhang, Y., Wu, H., Wang, W., . . . Cai, J. (2021). MRI super-resolution via realistic downsampling with adversarial learning. PHYSICS IN MEDICINE AND BIOLOGY, 66(20). doi:10.1088/1361-6560/ac232e

Tustison, N. J., Altes, T. A., Qing, K., He, M., Miller, G. W., Avants, B. B., . . . Mata, J. F. (2021). Image- versus histogram-based considerations in semantic segmentation of pulmonary hyperpolarized gas images. MAGNETIC RESONANCE IN MEDICINE, 86(5), 2822-2836. doi:10.1002/mrm.28908

Sheybani, N. D., Breza, V. R., Paul, S., McCauley, K. S., Berr, S. S., Miller, G. W., . . . Price, R. J. (2021). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. JOURNAL OF CONTROLLED RELEASE, 331, 19-29. doi:10.1016/j.jconrel.2021.01.023

Myc, L., Qing, K., He, M., Tustison, N., Lin, Z., Manichaikul, A. W., . . . Shim, Y. M. (2021). Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI. THORAX, 76(2), 178-181. doi:10.1136/thoraxjnl-2020-214924

2020

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2021). Transcriptomic response of brain tissue to focused ultrasound-mediated blood-brain barrier disruption depends strongly on anesthesia. BIOENGINEERING & TRANSLATIONAL MEDICINE, 6(2). doi:10.1002/btm2.10198

Tafti, S., Garrison, W. J., Mugler, J. P., Shim, Y. M., Altes, T. A., Mata, J. F., . . . Miller, G. W. (2020). Emphysema Index Based on Hyperpolarized 3He or 129Xe Diffusion MRI: Performance and Comparison with Quantitative CT and Pulmonary Function Tests. RADIOLOGY, 297(1), 201-210. doi:10.1148/radiol.2020192804

Curley, C. T., Mead, B. P., Negron, K., Kim, N., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Augmentation of brain tumor interstitial flow via focused ultrasound promotes brain-penetrating nanoparticle dispersion and transfection. SCIENCE ADVANCES, 6(18). doi:10.1126/sciadv.aay1344

Mathew, A. S., Gorick, C. M., Thim, E. A., Garrison, W. J., Klibanov, A. L., Miller, G. W., . . . Price, R. J. (2020). Transcriptomic Response of Brain Tissue to Focused Ultrasound-Mediated Blood-Brain Barrier Disruption Depends Strongly on Anesthesia. doi:10.1101/2020.07.24.211136

Sheybani, N., Paul, S., McCauley, K., Breza, V., Berr, S., Miller, W., . . . Price, R. (2020). ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma. doi:10.1101/2020.07.27.223206

Curley, C. T., Stevens, A. D., Mathew, A. S., Stasiak, K., Garrison, W. J., Miller, G. W., . . . Price, R. J. (2020). Immunomodulation of intracranial melanoma in response to blood-tumor barrier opening with focused ultrasound. THERANOSTICS, 10(19), 8821-8833. doi:10.7150/thno.47983

Gorick, C. M., Mathew, A. S., Garrison, W. J., Thim, E. A., Fisher, D. G., Copeland, C. A., . . . Price, R. J. (2020). Sonoselective transfection of cerebral vasculature without blood-brain barrier disruption. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(11), 5644-5654. doi:10.1073/pnas.1914595117

2019

Mead, B. P., Curley, C. T., Kim, N., Negron, K., Garrison, W. J., Song, J., . . . Price, R. J. (2019). Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System. SMALL, 15(49). doi:10.1002/smll.201903460

Hu, L., Huang, Q., Cui, T., Duarte, I., Miller, G. W., Mugler, J. P. I. I. I., . . . Cai, J. (2019). A hybrid proton and hyperpolarized gas tagging MRI technique for lung respiratory motion imaging: a feasibility study. PHYSICS IN MEDICINE AND BIOLOGY, 64(10). doi:10.1088/1361-6560/ab160c

2018

Cui, T., Miller, G. W., Mugler, J. P. I. I. I., Cates, G. D. J., Mata, J. F., de Lange, E. E., . . . Cai, J. (2018). An initial investigation of hyperpolarized gas tagging magnetic resonance imaging in evaluating deformable image registration-based lung ventilation. MEDICAL PHYSICS, 45(12), 5535-5542. doi:10.1002/mp.13223

2017

Fielden, S. W., Feng, X., Zhao, L., Miller, G. W., Geeslin, M., Dallapiazza, R. F., . . . Meyer, C. H. (2018). A spiral-based volumetric acquisition for MR temperature imaging. MAGNETIC RESONANCE IN MEDICINE, 79(6), 3122-3127. doi:10.1002/mrm.26981

Zheng, Y., Marx, M., Miller, G. W., & Pauly, K. B. (2018). High sensitivity MR acoustic radiation force imaging using transition band balanced steady-state free precession. MAGNETIC RESONANCE IN MEDICINE, 79(3), 1532-1537. doi:10.1002/mrm.26793

Mead, B. P., Kim, N., Miller, G. W., Hodges, D., Mastorakos, P., Klibanov, A. L., . . . Price, R. J. (2017). Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson's Disease Model. NANO LETTERS, 17(6), 3533-3542. doi:10.1021/acs.nanolett.7b00616

Dallapiazza, R. F., Timbie, K. F., Holmberg, S., Gatesman, J., Lopes, M. B., Price, R. J., . . . Elias, W. J. (2018). Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound. JOURNAL OF NEUROSURGERY, 128(3), 875-884. doi:10.3171/2016.11.JNS16976

Choi, W. -G., Miller, G., Wallace, I., Harper, J., Mittler, R., & Gilroy, S. (2017). Orchestrating rapid long-distance signaling in plants with Ca2+, ROS and electrical signals. PLANT JOURNAL, 90(4), 698-707. doi:10.1111/tpj.13492

Timbie, K. F., Afzal, U., Date, A., Zhang, C., Song, J., Miller, G. W., . . . Price, R. J. (2017). MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 263, 120-131. doi:10.1016/j.jconrel.2017.03.017

Shaver, A., Moon, J. D., Savacool, D., Zhang, W., Narang, G., Miller, G., . . . McGrath, J. E. (2017). Poly(2,6-dimethyl-1,4-phenylene oxide) blends with a poly(arylene ether ketone) for gas separation membranes. POLYMER, 114, 135-143. doi:10.1016/j.polymer.2017.02.041

Nacey, N. C., Geeslin, M. G., Miller, G. W., & Pierce, J. L. (2017). Magnetic Resonance Imaging of the Knee: An Overview and Update of Conventional and State of the Art Imaging. JOURNAL OF MAGNETIC RESONANCE IMAGING, 45(5), 1257-1275. doi:10.1002/jmri.25620

2016

Handsfield, G. G., Inouye, J. M., Slane, L. C., Thelen, D. G., Miller, G. W., & Blemker, S. S. (2017). A 3D model of the Achilles tendon to determine the mechanisms underlying nonuniform tendon displacements. JOURNAL OF BIOMECHANICS, 51, 17-25. doi:10.1016/j.jbiomech.2016.11.062

Komlosi, P., Altes, T. A., Qing, K., Mooney, K. E., Miller, G. W., Mata, J. F., . . . Mugler, J. P. I. I. I. (2017). Signal-to-noise ratio, T2, and T2* for hyperpolarized helium-3 MRI of the human lung at three magnetic field strengths. MAGNETIC RESONANCE IN MEDICINE, 78(4), 1458-1463. doi:10.1002/mrm.26516

Flors, L., Mugler, J. P. I. I. I., de Lange, E. E., Miller, G. W., Mata, J. F., Tustison, N., . . . Altes, T. A. (2016). Hyperpolarized Gas Magnetic Resonance Lung Imaging in Children and Young Adults. JOURNAL OF THORACIC IMAGING, 31(5), 285-295. doi:10.1097/RTI.0000000000000218

Menon, R., Miller, G. W., Jeudy, J., Rajagopalan, S., & Shin, T. (2017). Free Breathing Three-Dimensional Late Gadolinium Enhancement Cardiovascular Magnetic Resonance Using Outer Volume Suppressed Projection Navigators. MAGNETIC RESONANCE IN MEDICINE, 77(4), 1533-1543. doi:10.1002/mrm.26234

Johnson, C., Miller, G. R., Baker, B. A., Hollander, M., Kashon, M. L., Waugh, S., & Krajnak, K. (2016). Changes in the expression of calcitonin gene-related peptide after exposure to injurious stretch-shortening contractions. EXPERIMENTAL GERONTOLOGY, 79, 1-7. doi:10.1016/j.exger.2016.03.006

Zheng, Y., Miller, G. W., Tobias, W. A., & Cates, G. D. (2016). A method for imaging and spectroscopy using γ-rays and magnetic resonance. NATURE, 537(7622), 652-+. doi:10.1038/nature19775

2015

Flors, L., Altes, T. A., Mugler, J. P., de Lange, E. E., Miller, G. W., Mata, J. F., . . . Hersman, F. W. (2015). New insights into lung diseases using hyperpolarized gas MRI. Radiología (English Edition), 57(4), 303-313. doi:10.1016/j.rxeng.2014.12.003

Moyer, L. C., Timbie, K. F., Sheeran, P. S., Price, R. J., Miller, G. W., & Dayton, P. A. (2015). High-intensity focused ultrasound ablation enhancement in vivo via phase-shift nanodroplets compared to microbubbles. JOURNAL OF THERAPEUTIC ULTRASOUND, 3. doi:10.1186/s40349-015-0029-4

Komlosi, P., Altes, T. A., Qing, K., Mooney, K. E., Miller, G. W., Mata, J. F., . . . Mugler, J. P. I. I. I. (2015). Regional Anisotropy of Airspace Orientation in the Lung as Assessed With Hyperpolarized Helium-3 Diffusion MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 42(6), 1777-1782. doi:10.1002/jmri.24950

Miller, G. W., Eames, M., Snell, J., & Aubry, J. -F. (2015). Ultrashort echo-time MRI versus CT for skull aberration correction in MR-guided transcranial focused ultrasound: In vitro comparison on human calvaria. MEDICAL PHYSICS, 42(5), 2223-2233. doi:10.1118/1.4916656

Flors, L., Altes, T. A., Mugler, J. P. I. I. I., de Lange, E. E., Miller, G. W., Mata, J. F., . . . Hersman, F. W. (2015). New insights into lung diseases using hyperpolarized gas MRI. RADIOLOGIA, 57(4), 303-313. doi:10.1016/j.rx.2014.12.011

Zhang, Y., Aubry, J. -F., Zhang, J., Wang, Y., Roy, J., Mata, J. F., . . . Wintermark, M. (2015). DEFINING THE OPTIMAL AGE FOR FOCAL LESIONING IN A RAT MODEL OF TRANSCRANIAL HIFU. ULTRASOUND IN MEDICINE AND BIOLOGY, 41(2), 449-455. doi:10.1016/j.ultrasmedbio.2014.09.029

2014

Qing, K., Altes, T. A., Tustison, N. J., Feng, X., Chen, X., Mata, J. F., . . . Mugler, J. P. I. I. I. (2015). Rapid Acquisition of Helium-3 and Proton Three-Dimensional Image Sets of the Human Lung in a Single Breath-Hold Using Compressed Sensing. MAGNETIC RESONANCE IN MEDICINE, 74(4), 1110-1115. doi:10.1002/mrm.25499

Qing, K., Mugler, J. P. I. I. I., Altes, T. A., Jiang, Y., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2014). Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI. NMR IN BIOMEDICINE, 27(12), 1490-1501. doi:10.1002/nbm.3179

Miller, G. W., Mugler, J. P. I. I. I., Sa, R. C., Altes, T. A., Prisk, G. K., & Hopkins, S. R. (2014). Advances in functional and structural imaging of the human lung using proton MRI. NMR IN BIOMEDICINE, 27(12), 1542-1556. doi:10.1002/nbm.3156

Nance, E., Timbie, K., Miller, G. W., Song, J., Louttit, C., Klibanov, A. L., . . . Price, R. J. (2014). Non-invasive delivery of stealth, brain-penetrating nanoparticles across the blood - brain barrier using MRI-guided focused ultrasound. JOURNAL OF CONTROLLED RELEASE, 189, 123-132. doi:10.1016/j.jconrel.2014.06.031

Timbie, K., Nance, E., Zhang, C., Miller, W., Song, J., Hanes, J., & Price, R. (2014). Ultrasound-mediated nanoparticle delivery across the blood-brain barrier. FASEB JOURNAL, 28(1).

Zheng, Y., Cates, G. D., Tobias, W. A., Mugler, J. P. I. I. I., & Miller, G. W. (2014). Very-low-field MRI of laser polarized xenon-129. JOURNAL OF MAGNETIC RESONANCE, 249, 108-117. doi:10.1016/j.jmr.2014.09.024

2013

Phillips, L. C., Puett, C., Sheeran, P. S., Dayton, P. A., Miller, G. W., & Matsunaga, T. O. (2013). Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating. JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 134(2), 1473-1482. doi:10.1121/1.4812866

Qing, K., Ruppert, K., Jiang, Y., Mata, J. F., Miller, W., Shim, Y. M., . . . Mugler, J. P. I. I. I. (2014). Regional Mapping of Gas Uptake by Blood and Tissue in the Human Lung Using Hyperpolarized Xenon-129 MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 39(2), 346-359. doi:10.1002/jmri.24181

Scirica, B. M., Bhatt, D. L., Braunwald, E., Steg, P. G., Davidson, J., Hirshberg, B., . . . Simmons, D. (2013). Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus. NEW ENGLAND JOURNAL OF MEDICINE, 369(14), 1317-1326. doi:10.1056/NEJMoa1307684

Phillips, L. C., Puett, C., Sheeran, P. S., Dayton, P. A., Miller, G. W., & Matsunaga, T. O. (2013). Phase-shift perfluorocarbon agents enhance high intensity focused ultrasound thermal delivery with reduced near-field heating (vol 134, pg 1473, 2013). JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 134(6), 4575. doi:10.1121/1.4828830

2012

Fonvieille, H., Laveissiere, G., Degrande, N., Jaminion, S., Jutier, C., Todor, L., . . . Zhou, Z. -L. (2012). Virtual Compton scattering and the generalized polarizabilities of the proton at Q2=0.92 and 1.76 GeV2. PHYSICAL REVIEW C, 86(1). doi:10.1103/PhysRevC.86.015210

Hamedani, H., Kadlecek, S. J., Emami, K., Kuzma, N. N., Xu, Y., Xin, Y., . . . Rizi, R. R. (2012). A multislice single breath-hold scheme for imaging alveolar oxygen tension in humans. MAGNETIC RESONANCE IN MEDICINE, 67(5), 1332-1345. doi:10.1002/mrm.23125

2011

Dregely, I., Ruset, I. C., Mata, J. F., Ketel, J., Ketel, S., Distelbrink, J., . . . Ruppert, K. (2012). Multiple-Exchange-Time Xenon Polarization Transfer Contrast (MXTC) MRI: Initial Results in Animals and Healthy Volunteers. MAGNETIC RESONANCE IN MEDICINE, 67(4), 943-953. doi:10.1002/mrm.23066

Altes, T., Johnson, M. A., Miller, G. W., Mugler, J. P., Flors, L., Mata, J., . . . Botfield, M. C. (2011). HYPERPOLARIZED HELIUM-3 MAGNETIC RESONANCE IMAGING OF CFTR POTENTIATOR THERAPY IN SUBJECTS WITH CYSTIC FIBROSIS AND THE G551D MUTATION. PEDIATRIC PULMONOLOGY, 284.

Dregely, I., Mugler, J. P. I. I. I., Ruset, I. C., Altes, T. A., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2011). Hyperpolarized Xenon-129 Gas-Exchange Imaging of Lung Microstructure: First Case Studies in Subjects With Obstructive Lung Disease. JOURNAL OF MAGNETIC RESONANCE IMAGING, 33(5), 1052-1062. doi:10.1002/jmri.22533

2010

Mata, J. F., Bozlar, U., Mugler, J. P. I. I. I., Miller, G. W., Berr, S. S., & Hagspiel, K. D. (2010). Time-resolved and high-resolution MRA in a rabbit model of pulmonary embolism at 7 T: preliminary results. MAGNETIC RESONANCE IMAGING, 28(1), 139-145. doi:10.1016/j.mri.2009.06.005

Mugler, J. P. I. I. I., Altes, T. A., Ruset, I. C., Dregely, I. M., Mata, J. F., Miller, G. W., . . . Ruppert, K. (2010). Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(50), 21707-21712. doi:10.1073/pnas.1011912107

Miller, G. W., Mugler, J. P. I. I. I., Altes, T. A., Cai, J., Mata, J. F., de lange, E. E., . . . Brookeman, J. R. (2010). A Short-Breath-Hold Technique for Lung pO2 Mapping With 3He MRI. MAGNETIC RESONANCE IN MEDICINE, 63(1), 127-136. doi:10.1002/mrm.22181

Tustison, N. J., Awate, S. P., Cai, J., Altes, T. A., Miller, G. W., de lange, E. E., . . . Gee, J. C. (2010). Pulmonary Kinematics From Tagged Hyperpolarized Helium-3 MRI. JOURNAL OF MAGNETIC RESONANCE IMAGING, 31(5), 1236-1241. doi:10.1002/jmri.22137