Nick Dimitrios Tsihlis
- Phone: 434-297-9431
- Website: https://med.virginia.edu/kibbe-tsihlis-lab/
Primary Appointment
Professor, Surgery
Education
- B.A., Biochemistry and Cell Biology, Rice University
- Ph.D., Biochemistry, Louisiana State University
Research Disciplines
Biochemistry, Cardiovascular Biology, Cell and Developmental Biology, Experimental Pathology, Molecular and Cellular Physiology, Molecular Biology, Physiology
Research Interests
Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery
Research Description
Selected Publications
2023
Ledford, B. T., Wyatt, T. G., Vang, J., Weiss, J., Tsihlis, N. D., & Kibbe, M. R. (2023). Effects of Particle Size, Charge, Shape, Animal Disease State, and Sex on the Biodistribution of Intravenously Administered Nanoparticles. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 40(7). doi:10.1002/ppsc.202300001
2022
Ledford, B. T., Akerman, A. W., Sun, K., Gillis, D. C., Weiss, J. M., Vang, J., . . . Kibbe, M. R. (2022). Peptide Amphiphile Supramolecular Nanofibers Designed to Target Abdominal Aortic Aneurysms. ACS NANO, 16(5), 7309-7322. doi:10.1021/acsnano.1c06258
2021
Peters, E. B., Karver, M. R., Sun, K., Gillis, D. C., Biswas, S., Clemons, T. D., . . . Kibbe, M. R. (2021). Self-Assembled Peptide Amphiphile Nanofibers for Controlled Therapeutic Delivery to the Atherosclerotic Niche. ADVANCED THERAPEUTICS, 4(9). doi:10.1002/adtp.202100103
Marulanda, K., Mercel, A., Gillis, D. C., Sun, K., Gambarian, M., Roark, J., . . . Kibbe, M. R. (2021). Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice. ADVANCED HEALTHCARE MATERIALS, 10(13). doi:10.1002/adhm.202100302
Mercel, A. I., Marulanda, K., Gillis, D. C., Sun, K., Clemons, T. D., Willcox, S., . . . Kibbe, M. R. (2021). Development of novel nanofibers targeted to smoke-injured lungs. BIOMATERIALS, 274. doi:10.1016/j.biomaterials.2021.120862
Yu, L., Newton, E. R., Gillis, D. C., Sun, K., Cooley, B. C., Keith, A. N., . . . Kibbe, M. R. (2021). Coating small-diameter ePTFE vascular grafts with tunable poly(diol-co-citrate-co-ascorbate) elastomers to reduce neointimal hyperplasia. BIOMATERIALS SCIENCE, 9(15), 5160-+. doi:10.1039/d1bm00101a
Newton, E. R., Gillis, D. C., Sun, K., Dandurand, B. R., Siletzky, R., Biswas, S., . . . Kibbe, M. R. (2021). Evaluation of a Targeted Drug-Eluting Intravascular Nanotherapy to Prevent Neointimal Hyperplasia in an Atherosclerotic Rat Model. ADVANCED NANOBIOMED RESEARCH, 1(7). doi:10.1002/anbr.202000093
2020
Kassam, H. A., Bahnson, E. M., Cartaya, A., Jiang, W., Avram, M. J., Tsihlis, N. D., . . . Kibbe, M. R. (2020). Pharmacokinetics and biodistribution of a collagen-targeted peptide amphiphile for cardiovascular applications. PHARMACOLOGY RESEARCH & PERSPECTIVES, 8(6). doi:10.1002/prp2.672
Marulanda, K., Tsihlis, N. D., McLean, S. E., & Kibbe, M. R. (2021). Emerging antenatal therapies for congenital diaphragmatic hernia-induced pulmonary hypertension in preclinical models. PEDIATRIC RESEARCH, 89(7), 1641-1649. doi:10.1038/s41390-020-01191-x
Mercel, A. I., Gillis, D. C., Sun, K., Dandurand, B. R., Weiss, J. M., Tsihlis, N. D., . . . Kibbe, M. R. (2020). A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 319(3), L471-L480. doi:10.1152/ajplung.00241.2020
Klein, M. K., Kassam, H. A., Lee, R. H., Bergmeier, W., Peters, E. B., Gillis, D. C., . . . Kibbe, M. R. (2020). Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage. ACS NANO, 14(6), 6649-6662. doi:10.1021/acsnano.9b09243
Mercel, A., Tsihlis, N. D., Maile, R., & Kibbe, M. R. (2020). Emerging therapies for smoke inhalation injury: a review. JOURNAL OF TRANSLATIONAL MEDICINE, 18(1). doi:10.1186/s12967-020-02300-4
Yu, L., He, W., Peters, E. B., Ledford, B. T., Tsihlis, N. D., & Kibbe, M. R. (2020). Development of Poly(1,8-octanediol-co-citrate-co-ascorbate) Elastomers with Enhanced Ascorbate Performance for Use as a Graft Coating to Prevent Neointimal Hyperplasia. ACS APPLIED BIO MATERIALS, 3(4), 2150-2159. doi:10.1021/acsabm.0c00019
Kassam, H. A., Gillis, D. C., Dandurand, B. R., Karver, M. R., Tsihlis, N. D., Stupp, S. I., & Kibbe, M. R. (2020). Development of Fractalkine-Targeted Nanofibers that Localize to Sites of Arterial Injury. NANOMATERIALS, 10(3). doi:10.3390/nano10030420
2019
Klein, M. K., Tsihlis, N. D., Pritts, T. A., & Kibbe, M. R. (2020). Emerging Therapies for Prehospital Control of Hemorrhage. JOURNAL OF SURGICAL RESEARCH, 248, 182-190. doi:10.1016/j.jss.2019.09.070
Mansukhani, N. A., Peters, E. B., So, M. M., Albaghdadi, M. S., Wang, Z., Karver, M. R., . . . Kibbe, M. R. (2019). Peptide Amphiphile Supramolecular Nanostructures as a Targeted Therapy for Atherosclerosis. MACROMOLECULAR BIOSCIENCE, 19(6). doi:10.1002/mabi.201900066
Peters, E. B., Tsihlis, N. D., Karver, M. R., Chin, S. M., Musetti, B., Ledford, B. T., . . . Kibbe, M. R. (2019). Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery. ADVANCED HEALTHCARE MATERIALS, 8(3). doi:10.1002/adhm.201801545
2018
Morgan, C. E., Dombrowski, A. W., Perez, C. M. R., Bahnson, E. S. M., Tsihlis, N. D., Jiang, W., . . . Kibbe, M. R. (2018). Tissue-Factor Targeted Peptide Amphiphile Nanofibers as an Injectable Therapy To Control Hemorrhage (vol 10, pg 899, 2016). ACS NANO, 12(11), 11711. doi:10.1021/acsnano.8b07028
2016
Tsihlis, N. D., Rodriguez, M. P., Jiang, Q., Schwartz, A., Flynn, M. E., Vercammen, J. M., & Kibbe, M. R. (2016). Nitric oxide differentially affects proteasome activator 28 after arterial injury in type 1 and type 2 diabetic rats. JOURNAL OF SURGICAL RESEARCH, 202(2), 413-421. doi:10.1016/j.jss.2016.01.030
2015
Morgan, C. E., Dombrowski, A. W., Perez, C. M. R., Bahnson, E. S. M., Tsihlis, N. D., Jiang, W., . . . Kibbe, M. R. (2016). Tissue-Factor Targeted Peptide Amphiphile Nanofibers as an Injectable Therapy To Control Hemorrhage. ACS NANO, 10(1), 899-909. doi:10.1021/acsnano.5b06025
Rodriguez, M. P., Tsihlis, N. D., Emond, Z. M., Wang, Z., Varu, V. N., Jiang, Q., . . . Kibbe, M. R. (2015). Nitric oxide affects UbcH10 levels differently in type 1 and type 2 diabetic rats. JOURNAL OF SURGICAL RESEARCH, 196(1), 180-189. doi:10.1016/j.jss.2015.02.012
2013
Tsihlis, N. D., Vavra, A. K., Martinez, J., Lee, V. R., & Kibbe, M. R. (2013). Nitric oxide is less effective at inhibiting neointimal hyperplasia in spontaneously hypertensive rats. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 35, 165-174. doi:10.1016/j.niox.2013.10.005
Tsihlis, N. D., Kapadia, M. R., Vavra, A. K., Flannery, W. D., Oustwani, C. S., Jiang, Q., & Kibbe, M. R. (2013). Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature. JOURNAL OF VASCULAR SURGERY, 58(1), 179-186. doi:10.1016/j.jvs.2012.10.066
Havelka, G. E., Moreira, E. S., Rodriguez, M. P., Tsihlis, N. D., Wang, Z., Martinez, J., . . . Kibbe, M. R. (2013). Nitric Oxide Delivery via a Permeable Balloon Catheter Inhibits Neointimal Growth after Arterial Injury (vol 180, pg 35, 2013). JOURNAL OF SURGICAL RESEARCH, 183(2), 984. doi:10.1016/j.jss.2013.03.056
2012
Havelka, G. E., Moreira, E. S., Rodriguez, M. P., Tsihlis, N. D., Wang, Z., Martinez, J., . . . Kibbe, M. R. (2013). Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury. JOURNAL OF SURGICAL RESEARCH, 180(1), 35-42. doi:10.1016/j.jss.2012.10.048
Tsihlis, N. D., Kapadia, M. R., Vavra, A. K., Jiang, Q., Fu, B., Martinez, J., & Kibbe, M. R. (2012). Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 27(1), 50-58. doi:10.1016/j.niox.2012.04.006
2010
Tsihlis, N. D., Murar, J., Kapadia, M. R., Ahanchi, S. S., Oustwani, C. S., Saavedra, J. E., . . . Kibbe, M. R. (2010). Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury. JOURNAL OF VASCULAR SURGERY, 51(5), 1248-1259. doi:10.1016/j.jvs.2009.12.028