Nick Tsihlis

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Primary Appointment

Professor, Surgery

Research Disciplines

Biochemistry, Cardiovascular Biology, Cell and Developmental Biology, Experimental Pathology, Molecular and Cellular Physiology, Molecular Biology, Physiology

Research Interests

Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery

Research Description

Vascular Biology, Nanotechnology, Biomaterials, Drug Delivery

Selected Publications

2023

Ledford, B. T., Wyatt, T. G., Vang, J., Weiss, J., Tsihlis, N. D., & Kibbe, M. R. (2023). Effects of Particle Size, Charge, Shape, Animal Disease State, and Sex on the Biodistribution of Intravenously Administered Nanoparticles. PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 40(7). doi:10.1002/ppsc.202300001

2022

Ledford, B. T., Akerman, A. W., Sun, K., Gillis, D. C., Weiss, J. M., Vang, J., . . . Kibbe, M. R. (2022). Peptide Amphiphile Supramolecular Nanofibers Designed to Target Abdominal Aortic Aneurysms. ACS NANO, 16(5), 7309-7322. doi:10.1021/acsnano.1c06258

2021

Marulanda, K., Mercel, A., Gillis, D. C., Sun, K., Gambarian, M., Roark, J., . . . Kibbe, M. R. (2021). Intravenous Delivery of Lung-Targeted Nanofibers for Pulmonary Hypertension in Mice. ADVANCED HEALTHCARE MATERIALS, 10(13). doi:10.1002/adhm.202100302

Newton, E. R., Gillis, D. C., Sun, K., Dandurand, B. R., Siletzky, R., Biswas, S., . . . Kibbe, M. R. (2021). Evaluation of a Targeted Drug-Eluting Intravascular Nanotherapy to Prevent Neointimal Hyperplasia in an Atherosclerotic Rat Model. ADVANCED NANOBIOMED RESEARCH, 1(7). doi:10.1002/anbr.202000093

Yu, L., Newton, E. R., Gillis, D. C., Sun, K., Cooley, B. C., Keith, A. N., . . . Kibbe, M. R. (2021). Coating small-diameter ePTFE vascular grafts with tunable poly(diol-co-citrate-co-ascorbate) elastomers to reduce neointimal hyperplasia. BIOMATERIALS SCIENCE, 9(15), 5160-+. doi:10.1039/d1bm00101a

Marulanda, K., Tsihlis, N. D., McLean, S. E., & Kibbe, M. R. (2021). Emerging antenatal therapies for congenital diaphragmatic hernia-induced pulmonary hypertension in preclinical models. PEDIATRIC RESEARCH, 89(7), 1641-1649. doi:10.1038/s41390-020-01191-x

Mercel, A. I., Marulanda, K., Gillis, D. C., Sun, K., Clemons, T. D., Willcox, S., . . . Kibbe, M. R. (2021). Development of novel nanofibers targeted to smoke-injured lungs. BIOMATERIALS, 274. doi:10.1016/j.biomaterials.2021.120862

Peters, E. B., Karver, M. R., Sun, K., Gillis, D. C., Biswas, S., Clemons, T. D., . . . Kibbe, M. R. (2021). Self-Assembled Peptide Amphiphile Nanofibers for Controlled Therapeutic Delivery to the Atherosclerotic Niche. ADVANCED THERAPEUTICS, 4(9). doi:10.1002/adtp.202100103

2020

Kassam, H. A., Bahnson, E. M., Cartaya, A., Jiang, W., Avram, M. J., Tsihlis, N. D., . . . Kibbe, M. R. (2020). Pharmacokinetics and biodistribution of a collagen-targeted peptide amphiphile for cardiovascular applications. PHARMACOLOGY RESEARCH & PERSPECTIVES, 8(6). doi:10.1002/prp2.672

Klein, M. K., Kassam, H. A., Lee, R. H., Bergmeier, W., Peters, E. B., Gillis, D. C., . . . Kibbe, M. R. (2020). Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage. ACS NANO, 14(6), 6649-6662. doi:10.1021/acsnano.9b09243

Kassam, H. A., Gillis, D. C., Dandurand, B. R., Karver, M. R., Tsihlis, N. D., Stupp, S. I., & Kibbe, M. R. (2020). Development of Fractalkine-Targeted Nanofibers that Localize to Sites of Arterial Injury. NANOMATERIALS, 10(3). doi:10.3390/nano10030420

Klein, M. K., Tsihlis, N. D., Pritts, T. A., & Kibbe, M. R. (2020). Emerging Therapies for Prehospital Control of Hemorrhage. JOURNAL OF SURGICAL RESEARCH, 248, 182-190. doi:10.1016/j.jss.2019.09.070

Mercel, A., Tsihlis, N. D., Maile, R., & Kibbe, M. R. (2020). Emerging therapies for smoke inhalation injury: a review. JOURNAL OF TRANSLATIONAL MEDICINE, 18(1). doi:10.1186/s12967-020-02300-4

Yu, L., He, W., Peters, E. B., Ledford, B. T., Tsihlis, N. D., & Kibbe, M. R. (2020). Development of Poly(1,8-octanediol-co-citrate-co-ascorbate) Elastomers with Enhanced Ascorbate Performance for Use as a Graft Coating to Prevent Neointimal Hyperplasia. ACS APPLIED BIO MATERIALS, 3(4), 2150-2159. doi:10.1021/acsabm.0c00019

Mercel, A. I., Gillis, D. C., Sun, K., Dandurand, B. R., Weiss, J. M., Tsihlis, N. D., . . . Kibbe, M. R. (2020). A comparative study of a preclinical survival model of smoke inhalation injury in mice and rats. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 319(3), L471-L480. doi:10.1152/ajplung.00241.2020

2019

Mansukhani, N. A., Peters, E. B., So, M. M., Albaghdadi, M. S., Wang, Z., Karver, M. R., . . . Kibbe, M. R. (2019). Peptide Amphiphile Supramolecular Nanostructures as a Targeted Therapy for Atherosclerosis. MACROMOLECULAR BIOSCIENCE, 19(6). doi:10.1002/mabi.201900066

Peters, E. B., Tsihlis, N. D., Karver, M. R., Chin, S. M., Musetti, B., Ledford, B. T., . . . Kibbe, M. R. (2019). Atheroma Niche-Responsive Nanocarriers for Immunotherapeutic Delivery. ADVANCED HEALTHCARE MATERIALS, 8(3). doi:10.1002/adhm.201801545

2018

Morgan, C. E., Dombrowski, A. W., Perez, C. M. R., Bahnson, E. S. M., Tsihlis, N. D., Jiang, W., . . . Kibbe, M. R. (2018). Tissue-Factor Targeted Peptide Amphiphile Nanofibers as an Injectable Therapy To Control Hemorrhage (vol 10, pg 899, 2016). ACS NANO, 12(11), 11711. doi:10.1021/acsnano.8b07028

2016

Tsihlis, N. D., Rodriguez, M. P., Jiang, Q., Schwartz, A., Flynn, M. E., Vercammen, J. M., & Kibbe, M. R. (2016). Nitric oxide differentially affects proteasome activator 28 after arterial injury in type 1 and type 2 diabetic rats. JOURNAL OF SURGICAL RESEARCH, 202(2), 413-421. doi:10.1016/j.jss.2016.01.030

Morgan, C. E., Dombrowski, A. W., Perez, C. M. R., Bahnson, E. S. M., Tsihlis, N. D., Jiang, W., . . . Kibbe, M. R. (2016). Tissue-Factor Targeted Peptide Amphiphile Nanofibers as an Injectable Therapy To Control Hemorrhage. ACS NANO, 10(1), 899-909. doi:10.1021/acsnano.5b06025

2015

Rodriguez, M. P., Tsihlis, N. D., Emond, Z. M., Wang, Z., Varu, V. N., Jiang, Q., . . . Kibbe, M. R. (2015). Nitric oxide affects UbcH10 levels differently in type 1 and type 2 diabetic rats. JOURNAL OF SURGICAL RESEARCH, 196(1), 180-189. doi:10.1016/j.jss.2015.02.012

2013

Tsihlis, N. D., Vavra, A. K., Martinez, J., Lee, V. R., & Kibbe, M. R. (2013). Nitric oxide is less effective at inhibiting neointimal hyperplasia in spontaneously hypertensive rats. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 35, 165-174. doi:10.1016/j.niox.2013.10.005

Havelka, G. E., Moreira, E. S., Rodriguez, M. P., Tsihlis, N. D., Wang, Z., Martinez, J., . . . Kibbe, M. R. (2013). Nitric Oxide Delivery via a Permeable Balloon Catheter Inhibits Neointimal Growth after Arterial Injury (vol 180, pg 35, 2013). JOURNAL OF SURGICAL RESEARCH, 183(2), 984. doi:10.1016/j.jss.2013.03.056

Tsihlis, N. D., Kapadia, M. R., Vavra, A. K., Flannery, W. D., Oustwani, C. S., Jiang, Q., & Kibbe, M. R. (2013). Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature. JOURNAL OF VASCULAR SURGERY, 58(1), 179-186. doi:10.1016/j.jvs.2012.10.066

2012

Havelka, G. E., Moreira, E. S., Rodriguez, M. P., Tsihlis, N. D., Wang, Z., Martinez, J., . . . Kibbe, M. R. (2013). Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury. JOURNAL OF SURGICAL RESEARCH, 180(1), 35-42. doi:10.1016/j.jss.2012.10.048

Tsihlis, N. D., Kapadia, M. R., Vavra, A. K., Jiang, Q., Fu, B., Martinez, J., & Kibbe, M. R. (2012). Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 27(1), 50-58. doi:10.1016/j.niox.2012.04.006

2010

Tsihlis, N. D., Murar, J., Kapadia, M. R., Ahanchi, S. S., Oustwani, C. S., Saavedra, J. E., . . . Kibbe, M. R. (2010). Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury. JOURNAL OF VASCULAR SURGERY, 51(5), 1248-1259. doi:10.1016/j.jvs.2009.12.028