Ukpong Bassey Eyo

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Primary Appointment

Assistant Professor, Neuroscience

Education

  • BS, Biology: Pre-Professional Zoology, Northwest Missouri State
  • PhD, Biology: Neuroscience, University of Iowa
  • Postdoc, Microglia-Neuron Interactions, Rutgers University, NJ
  • Postdoc, Microglia-Neuron Interactions, Mayo Clinic, Rochester, MN

Research Disciplines

Neuroimmunology, Neuroscience

Research Interests

Neuroscience

Research Description

Microglia in neurodevelopment and neurodevelopment disorders

Personal Statement

I am broadly interested in microglial behaviors in the healthy and diseased mammalian brain especially during development. During my graduate training, I developed a keen interest in microglial biology. There, I focused on understanding and elucidating microglial dynamics during early postnatal development in the mammalian hippocampus both under normal conditions and during simulated ischemia in acute brain slices using confocal microscopy. For my postdoctoral training, I turned my attention to microglial interactions with neurons in living tissues to elucidate some of the interesting bi-directional communication that occurs between these two brain cell types in the healthy brain. As an independent investigator I will combine my graduate and postgraduate training to study microglial roles in and interactions with the nervous system elements during development and developmental disorders such as seizures. I am confident that my studies will help provide significant insights into the function of microglial cells in the mammalian brain.

Training

  • Basic Cardiovascular Research Training Grant
  • Predoctoral Training in Neuroscience
  • Training in Cell and Molecular Biology

Selected Publications

Mo M, Eyo UB, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P, Wu LJ, Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections., 2019; The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(47) 9453-9464. PMID: 31597724 | PMCID: PMC6867812

Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z, Liu XG, Wu LJ, Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain., 2019; Cell reports. 27(13) 3844-3859.e6. PMID: 31242418

Uweru JO, Eyo UB, A decade of diverse microglial-neuronal physical interactions in the brain (2008-2018)., 2019; Neuroscience letters. 698() 33-38. PMID: 30625349 | PMCID: PMC6435396

Eyo UB, Wu LJ, Microglia: Lifelong patrolling immune cells of the brain., 2019; Progress in neurobiology. 179() 101614. PMID: 31075285 | PMCID: PMC6599472

Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ, Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling., 2019; Nature neuroscience. 22(11) 1771-1781. PMID: 31636449 | PMCID: PMC6858573

Zhao X, Eyo UB, Murugan M, Wu LJ, Microglial interactions with the neurovascular system in physiology and pathology., 2018; Developmental neurobiology. 78(6) 604-617. PMID: 29318762 | PMCID: PMC5980686

Eyo UB, Bispo A, Liu J, Sabu S, Wu R, DiBona VL, Zheng J, Murugan M, Zhang H, Tang Y, Wu LJ, The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions., 2018; Scientific reports. 8(1) 828. PMID: 29339791 | PMCID: PMC5770428

Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis DJ, Xu P, Wu LJ, P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape., 2018; Cell reports. 23(4) 959-966. PMID: 29694903 | PMCID: PMC5965271

Bosco DB, Zheng J, Xu Z, Peng J, Eyo UB, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson JR, Wang H, Wu LJ, RNAseq analysis of hippocampal microglia after kainic acid-induced seizures., 2018; Molecular brain. 11(1) 34. PMID: 29925434 | PMCID: PMC6011524

Tian DS, Peng J, Murugan M, Feng LJ, Liu JL, Eyo UB, Zhou LJ, Mogilevsky R, Wang W, Wu LJ, Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1β Production after Status Epilepticus., 2017; The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(33) 7878-7892. PMID: 28716963 | PMCID: PMC5559763

Eyo UB, Peng J, Murugan M, Mo M, Lalani A, Xie P, Xu P, Margolis DJ, Wu LJ, Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus., 2017; eNeuro. 3(6) . PMID: 28101527 | PMCID: PMC5237828

Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ, Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury., 2016; Neuroscience. 318() 22-33. PMID: 26791526 | PMCID: PMC4753827

Eyo UB, Murugan M, Wu LJ, Microglia-Neuron Communication in Epilepsy., 2016; Glia. 65(1) 5-18. PMID: 27189853 | PMCID: PMC5116010

Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ, Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury., 2016; Cell reports. 16(3) 605-14. PMID: 27373153 | PMCID: PMC4956495

Eyo UB, Gu N, De S, Dong H, Richardson JR, Wu LJ, Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium., 2015; The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(6) 2417-22. PMID: 25673836 | PMCID: PMC4323526

Liu J, Tian D, Murugan M, Eyo UB, Dreyfus CF, Wang W, Wu LJ, Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage., 2015; Journal of neurochemistry. 135(2) 347-56. PMID: 26173779 | PMCID: PMC4721248

Eyo UB, Miner SA, Weiner JA, Dailey ME, Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus., 2015; Brain, behavior, and immunity. 55() 49-59. PMID: 26576723 | PMCID: PMC4864211

Gu N, Eyo UB, Murugan M, Peng J, Matta S, Dong H, Wu LJ, Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain., 2015; Brain, behavior, and immunity. 55() 82-92. PMID: 26576724 | PMCID: PMC4864135

Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ, Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus., 2014; The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(32) 10528-40. PMID: 25100587 | PMCID: PMC4200107

Dailey ME, Eyo U, Fuller L, Hass J, Kurpius D, Imaging microglia in brain slices and slice cultures., 2013; Cold Spring Harbor protocols. 2013(12) 1142-8. PMID: 24298036

Eyo UB, Dailey ME, Microglia: key elements in neural development, plasticity, and pathology., 2013; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 8(3) 494-509. PMID: 23354784 | PMCID: PMC3657325

Eyo UB, Miner SA, Ahlers KE, Wu LJ, Dailey ME, P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation., 2013; Neuropharmacology. 73() 311-9. PMID: 23770338 | PMCID: PMC3786777

Eyo UB, Wu LJ, Bidirectional microglia-neuron communication in the healthy brain., 2013; Neural plasticity. 2013() 456857. PMID: 24078884 | PMCID: PMC3775394

Eyo U, Dailey ME, Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues., 2012; Glia. 60(11) 1747-60. PMID: 22847985 | PMCID: PMC3786781