Lian-Wang Guo


Primary Appointment

Tenured Professor, Surgery


  • PhD, Plant Physiology, Chinese Academy of Sciences

Research Disciplines

Biophysics, Molecular Biology, Retinal Neuroscience, Vascular Epigentics

Research Interests

Vascular wall remodeling, intimal hyperplasia, stenosis, aneurysm, retinal degeneration.

Research Description

The Guo lab studies vascular wall remodeling and retinal degeneration, with a focus on the role of histone-code readers and writers in driving cell phenotypic transitions. We aim to uncover new therapeutic targets for intervention to avert pathogenic cell states. Our research follows a trajectory from mechanistic investigation to therapeutic translation. For example, we delve into basic research on epigenetic dysregulations underlying post-surgery vascular wall thickening and stenosis. Concurrently, we are pioneering precision delivery strategies for chromatin-modulating "epi-drugs" in collaboration with surgeons and engineers. One innovative approach involves developing bio-adhesive nanoparticles suitable for painting on vein grafts to maintain graft patency. Another strategy is tailored for suppressing post-angioplasty restenosis by crafting injectable biomembrane-camouflaged delivery systems that home onto lesion sites. These initiatives have led to approved and pending patents. Our overarching goal is to tackle challenging medical issues by targeting dysregulated epigenetic mechanisms through seamless transitions from bench discoveries to translational innovations.

Selected Publications


Li, J., Shen, H., & Guo, L. -W. (2024). Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression. CELLULAR SIGNALLING, 116. doi:10.1016/j.cellsig.2024.111069


Shirasu, T., Yodsanit, N., Li, J., Huang, Y., Xie, X., Tang, R., . . . Guo, L. -W. (2023). Neointima abating and endothelium preserving-An adventitia-localized nanoformulation to inhibit the epigenetic writer DOT1L. BIOMATERIALS, 301. doi:10.1016/j.biomaterials.2023.122245

Zhang, M., Li, J., Wang, Q., Urabe, G., Tang, R., Huang, Y., . . . Guo, L. -W. (2023). Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation. MOLECULAR THERAPY-NUCLEIC ACIDS, 31. doi:10.1016/j.omtn.2023.02.024

Yodsanit, N., Shirasu, T., Huang, Y., Yin, L., Islam, Z. H., Gregg, A. C., . . . Wang, B. (2023). Targeted PERK inhibition with biomimetic nanoclusters confers preventative and interventional benefits to elastase-induced abdominal aortic aneurysms. BIOACTIVE MATERIALS, 26, 52-63. doi:10.1016/j.bioactmat.2023.02.009

Li, J., Satyshur, K. A., Guo, L. -W., & Ruoho, A. E. (2023). Sphingoid Bases Regulate the Sigma-1 Receptor-Sphingosine and N,N'-Dimethylsphingosine Are Endogenous Agonists. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4). doi:10.3390/ijms24043103

Xie, X., Shirasu, T., Li, J., Guo, L. -W., & Kent, K. C. (2023). miR579-3p is an inhibitory modulator of neointimal hyperplasia and transcription factors c-MYB and KLF4. CELL DEATH DISCOVERY, 9(1). doi:10.1038/s41420-023-01364-7


Mavlyutov, T. A. A., Li, J., Liu, X., Shen, H., Yang, H., McCurdy, C. R. R., . . . Guo, L. -W. (2022). Retinal Photoreceptor Protection in an AMD-Related Mouse Model by Selective Sigma-1 or Sigma-2 Receptor Modulation. GENES, 13(12). doi:10.3390/genes13122386

Li, J., Felix-Soriano, E., Wright, K. R., Shen, H., Baer, L. A., Stanford, K. I., & Guo, L. -W. (2022). Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18). doi:10.3390/ijms231810846

Xie, X., Guo, L. -W., & Kent, C. K. (2022). miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction (Oct, 10.1038/s41420-022-01178-z, 2021). CELL DEATH DISCOVERY, 8(1). doi:10.1038/s41420-022-01178-z

Li, J., Shen, H., Owens, G. K., & Guo, L. -W. (2022). SREBP1 regulates Lgals3 activation in response to cholesterol loading. MOLECULAR THERAPY-NUCLEIC ACIDS, 28, 892-909. doi:10.1016/j.omtn.2022.05.028

Zhang, M., Urabe, G., Ozer, H. G., Xie, X., Webb, A., Shirasu, T., . . . Guo, L. -W. (2022). Angioplasty induces epigenomic remodeling in injured arteries. LIFE SCIENCE ALLIANCE, 5(5). doi:10.26508/lsa.202101114


Wang, Q., Ozer, H. G., Wang, B., Zhang, M., Urabe, G., Huang, Y., . . . Guo, L. -W. (2021). A hierarchical and collaborative BRD4/CEBPD partnership governs vascular smooth muscle cell inflammation. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 21, 54-66. doi:10.1016/j.omtm.2021.02.021

Zhao, Y., Xie, R., Yodsanit, N., Ye, M., Wang, Y., Wang, B., . . . Gong, S. (2021). Hydrogen peroxide-responsive platelet membrane-coated nanoparticles for thrombus therapy. BIOMATERIALS SCIENCE, 9(7), 2696-2708. doi:10.1039/d0bm02125c

Xie, X., Shirasu, T., Guo, L. -W., & Kent, K. C. (2021). Smad2 inhibition of MET transcription potentiates human vascular smooth muscle cell apoptosis. ATHEROSCLEROSIS PLUS, 44, 31-42. doi:10.1016/j.athplu.2021.08.005

Kumar, S., Javed, R., Mudd, M., Pallikkuth, S., Lidke, K. A., Jain, A., . . . Deretic, V. (2021). Mammalian hybrid pre-autophagosomal structure HyPAS generates autophagosomes. CELL, 184(24), 5950-+. doi:10.1016/j.cell.2021.10.017

Xie, X., Guo, L. -W., & Kent, K. C. (2021). miR548ai antagonism attenuates exosome-induced endothelial cell dysfunction. CELL DEATH DISCOVERY, 7(1). doi:10.1038/s41420-021-00720-9

Schmitt, H. M., Fehrman, R. L., Maes, M. E., Yang, H., Guo, L. -W., Schlamp, C. L., . . . Nickells, R. W. (2021). Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 62(10). doi:10.1167/iovs.62.10.14

Zhao, Y., Shirasu, T., Yodsanit, N., Kent, E., Ye, M., Wang, Y., . . . Wang, B. (2021). Biomimetic, ROS-detonable nanoclusters-A multimodal nanoplatform for anti-restenotic therapy. JOURNAL OF CONTROLLED RELEASE, 338, 295-306. doi:10.1016/j.jconrel.2021.08.025

Shen, H., Li, J., Heisler-Taylor, T., Makin, R., Yang, H., Mavlyutov, T. A., . . . Guo, L. -W. (2021). TMEM97 ablation aggravates oxidant-induced retinal degeneration. CELLULAR SIGNALLING, 86. doi:10.1016/j.cellsig.2021.110078

Shirasu, T., Yodsanit, N., Xie, X., Zhao, Y., Wang, Y., Xie, R., . . . Kent, K. C. (2021). An adventitial painting modality of local drug delivery to abate intimal hyperplasia. BIOMATERIALS, 275. doi:10.1016/j.biomaterials.2021.120968

Li, J., Urabe, G., Huang, Y., Zhang, M., Wang, B., Marcho, L., . . . Guo, L. -W. (2021). A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition. JACC-BASIC TO TRANSLATIONAL SCIENCE, 6(3), 257-283. doi:10.1016/j.jacbts.2020.12.015

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., . . . Tong, C. -K. (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). AUTOPHAGY, 17(1), 1-382. doi:10.1080/15548627.2020.1797280

Shen, H., Li, J., Xie, X., Yang, H., Zhang, M., Wang, B., . . . Guo, L. -W. (2021). BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. LIFE SCIENCE ALLIANCE, 4(1). doi:10.26508/lsa.201900540

Yodsanit, N., Wang, B., Zhao, Y., Guo, L. -W., Kent, K. C., & Gong, S. (2021). Recent progress on nanoparticles for targeted aneurysm treatment and imaging. BIOMATERIALS, 265. doi:10.1016/j.biomaterials.2020.120406


Wang, B., Zhang, M., Urabe, G., Shirasu, T., Guo, L. -W., & Kent, K. C. (2021). PERK Inhibition Promotes Post-angioplasty Re-endothelialization via Modulating SMC Phenotype Changes.. The Journal of surgical research, 257, 294-305. doi:10.1016/j.jss.2020.05.070

Yang, H., Shen, H., Li, J., Stanford, K. I., & Guo, L. -W. (2020). Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts. CELLULAR SIGNALLING, 75. doi:10.1016/j.cellsig.2020.109732

Borck, P. C., Guo, L. -W., & Plutzky, J. (2020). BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. CIRCULATION RESEARCH, 126(9), 1190-1208. doi:10.1161/CIRCRESAHA.120.315929

Huang, Y., Urabe, G., Zhang, M., Li, J., Ozer, H. G., Wang, B., . . . Guo, L. -W. (2020). Nullifying epigenetic writer DOT1L attenuates neointimal hyperplasia. ATHEROSCLEROSIS, 308, 22-31. doi:10.1016/j.atherosclerosis.2020.06.002

Xie, X., Urabe, G., Marcho, L., Williams, C., Guo, L. -W., & Kent, K. C. (2020). Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5â² Untranslated Region. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 9(8). doi:10.1161/JAHA.119.015487

Wang, B., Zhang, M., Urabe, G., Huang, Y., Chen, G., Wheeler, D., . . . Kent, K. C. (2020). PERK Inhibition Mitigates Restenosis and Thrombosis A Potential Low-Thrombogenic Antirestenotic Paradigm. JACC-BASIC TO TRANSLATIONAL SCIENCE, 5(3), 245-263. doi:10.1016/j.jacbts.2019.12.005


Zhang, J., McIntosh, B. E., Wang, B., Brown, M. E., Probasco, M. D., Webster, S., . . . Thomson, J. A. (2019). A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia. STEM CELL REPORTS, 12(6), 1269-1281. doi:10.1016/j.stemcr.2019.04.013

Yang, H., Shen, H., Li, J., & Guo, L. -W. (2019). SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance. AUTOPHAGY, 15(9), 1539-1557. doi:10.1080/15548627.2019.1586248

Shi, Y., Johnson, J., Wang, B., Chen, B., Fisher, G. L., Urabe, G., . . . Li, L. (2019). Mass Spectrometric Imaging Reveals Temporal and Spatial Dynamics of Bioactive Lipids in Arteries Undergoing Restenosis. JOURNAL OF PROTEOME RESEARCH, 18(4), 1669-1678. doi:10.1021/acs.jproteome.8b00941

Xie, X., Urabe, G., Marcho, L., Stratton, M., Guo, L. -W., & Kent, C. K. (2019). ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation. ISCIENCE, 19, 872-+. doi:10.1016/j.isci.2019.08.044

Zhang, M., Wang, B., Urabe, G., Huang, Y., Plutzky, J., Kent, K. C., & Guo, L. -W. (2019). The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation. CELLULAR SIGNALLING, 61, 20-29. doi:10.1016/j.cellsig.2019.05.005


Wang, B., Chen, G., Urabe, G., Xie, R., Wang, Y., Shi, X., . . . Kent, K. C. (2018). A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters. BIOMATERIALS, 178, 293-301. doi:10.1016/j.biomaterials.2018.06.025

Mavylutov, T., Chen, X., Guo, L., & Yang, J. (2018). APEX2-tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus. PROTEIN & CELL, 9(8), 733-737. doi:10.1007/s13238-017-0468-5

Zent, J., & Guo, L. -W. (2018). Signaling Mechanisms of Myofibroblastic Activation: Outside-in and Inside-Out. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 49(3), 848-868. doi:10.1159/000493217

Zhang, M., Urabe, G., Little, C., Wang, B., Kent, A. M., Huang, Y., . . . Guo, L. -W. (2018). HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity. JACC-BASIC TO TRANSLATIONAL SCIENCE, 3(6), 782-795. doi:10.1016/j.jacbts.2018.08.010

Pan, X., Wang, B., Yuan, T., Zhang, M., Kent, K. C., & Guo, L. -W. (2018). Analysis of Combined Transcriptomes Identifies Gene Modules that Differentially Respond to Pathogenic Stimulation of Vascular Smooth Muscle and Endothelial Cells. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-017-18675-2


Yu, Q., Wang, B., Chen, Z., Urabe, G., Glover, M. S., Shi, X., . . . Li, L. (2017). Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)-Enabled Intact Glycopeptide/Glycoproteome Characterization. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 28(9), 1751-1764. doi:10.1007/s13361-017-1701-4

Chen, G., Shi, X., Wang, B., Xie, R., Guo, L. -W., Gong, S., & Kent, K. C. (2017). Unimolecular Micelle-Based Hybrid System for Perivascular Drug Delivery Produces Long-Term Efficacy for Neointima Attenuation in Rats. BIOMACROMOLECULES, 18(7), 2205-2213. doi:10.1021/acs.biomac.7b00617

Kumar, A., D'Souza, S. S., Moskvin, O. V., Toh, H., Wang, B., Zhang, J., . . . Slukvin, I. I. (2017). Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts. CELL REPORTS, 19(9), 1902-1916. doi:10.1016/j.celrep.2017.05.019

Zhao, L., Chen, G., Li, J., Fu, Y., Mavlyutov, T. A., Yao, A., . . . Guo, L. -W. (2017). An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration. JOURNAL OF CONTROLLED RELEASE, 247, 153-166. doi:10.1016/j.jconrel.2016.12.038

Mavlyutov, T. A., & Guo, L. -W. (2017). Peeking into Sigma-1 Receptor Functions Through the Retina. SIGMA RECEPTORS: THEIR ROLE IN DISEASE AND AS THERAPEUTIC TARGETS, 964, 285-297. doi:10.1007/978-3-319-50174-1_19

Zhao, L., Li, J., Fu, Y., Zhang, M., Wang, B., Ouellette, J., . . . Guo, L. -W. (2017). Photoreceptor protection via blockade of BET epigenetic readers in a murine model of inherited retinal degeneration. JOURNAL OF NEUROINFLAMMATION, 14. doi:10.1186/s12974-016-0775-4

Li, J., Zhao, L., Urabe, G., Fu, Y., & Guo, L. -W. (2017). Epigenetic intervention with a BET inhibitor ameliorates acute retinal ganglion cell death in mice. MOLECULAR VISION, 23, 149-159.

Liu, X., Fu, Y., Yang, H., Mavlyutov, T., Li, J., McCurdy, C. R., . . . Pattnaik, B. R. (2017). Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel. ONCOTARGET, 8(35), 59345-59358. doi:10.18632/oncotarget.19581

Yang, H., Fu, Y., Liu, X., Shahi, P. K., Mavlyutov, T. A., Li, J., . . . Guo, L. -W. (2017). Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa. MOLECULAR NEURODEGENERATION, 12. doi:10.1186/s13024-017-0202-z

Mavlyutov, T. A., Yang, H., Epstein, M. L., Ruoho, A. E., Yang, J., & Guo, L. -W. (2017). APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum. ONCOTARGET, 8(31), 51317-51330. doi:10.18632/oncotarget.17906

Zhu, Y., Takayama, T., Wang, B., Kent, A., Zhang, M., Binder, B. Y. K., . . . Guo, L. -W. (2017). Restenosis Inhibition and Re-differentiation of TGFβ/Smad3-activated Smooth Muscle Cells by Resveratrol. SCIENTIFIC REPORTS, 7. doi:10.1038/srep41916


Chaudhary, M. A., Guo, L. -W., Shi, X., Chen, G., Gong, S., Liu, B., & Kent, K. C. (2016). Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery. JOURNAL OF CONTROLLED RELEASE, 233, 174-180. doi:10.1016/j.jconrel.2016.05.002

DiRenzo, D. M., Chaudhary, M. A., Shi, X., Franco, S. R., Zent, J., Wang, K., . . . Kent, K. C. (2016). A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation. CELLULAR SIGNALLING, 28(5), 498-505. doi:10.1016/j.cellsig.2016.02.011

Shi, X., Guo, L. -W., Seedial, S., Takayama, T., Wang, B., Zhang, M., . . . Kent, K. C. (2016). Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia. STEM CELLS, 34(11), 2744-2757. doi:10.1002/stem.2442


Abate, C., Riganti, C., Pati, M. L., Ghigo, D., Berardi, F., Mavlyutov, T., . . . Ruoho, A. (2016). Development of sigma-1 (Ï1) receptor fluorescent ligands as versatile tools to study Ï1 receptors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 108, 577-585. doi:10.1016/j.ejmech.2015.12.014

Mavlyutov, T. A., Epstein, M., & Guo, L. -W. (2015). Subcellular Localization of the Sigma-1 Receptor in Retinal Neurons - an Electron Microscopy Study. SCIENTIFIC REPORTS, 5. doi:10.1038/srep10689

Tsai, T. -L., Wang, B., Squire, M. W., Guo, L. -W., & Li, W. -J. (2015). Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. STEM CELL RESEARCH & THERAPY, 6. doi:10.1186/s13287-015-0065-6

Takayama, T., Shi, X., Wang, B., Franco, S., Zhou, Y., DiRenzo, D., . . . Guo, L. -W. (2015). A Murine Model of Arterial Restenosis: Technical Aspects of Femoral Wire Injury. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (97). doi:10.3791/52561

Mavlyutov, T. A., Guo, L. -W., Epstein, M. L., & Ruoho, A. E. (2015). Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS). JOURNAL OF PHARMACOLOGICAL SCIENCES, 127(1), 10-16. doi:10.1016/j.jphs.2014.12.013

Chu, U. B., Mavlyutov, T. A., Chu, M. -L., Yang, H., Schulman, A., Mesangeau, C., . . . Ruoho, A. E. (2015). The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. EBIOMEDICINE, 2(11), 1806-1813. doi:10.1016/j.ebiom.2015.10.017

Wang, B., Zhang, M., Takayama, T., Shi, X., Roenneburg, D. A., Kent, K. C., & Guo, L. -W. (2015). BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries. EBIOMEDICINE, 2(11), 1650-1661. doi:10.1016/j.ebiom.2015.09.045


Yu, X., Takayama, T., Goel, S. A., Shi, X., Zhou, Y., Kent, K. C., . . . Guo, L. -W. (2014). A rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia. JOURNAL OF CONTROLLED RELEASE, 191, 47-53. doi:10.1016/j.jconrel.2014.05.017

Shi, X., Guo, L. -W., Seedial, S. M., Si, Y., Wang, B., Takayama, T., . . . Kent, K. C. (2014). TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A. CELL DEATH & DISEASE, 5. doi:10.1038/cddis.2014.282

Shi, X., DiRenzo, D., Guo, L. -W., Franco, S. R., Wang, B., Seedial, S., & Kent, K. C. (2014). TGF-β/Smad3 Stimulates Stem Cell/Developmental Gene Expression and Vascular Smooth Muscle Cell De-Differentiation. PLOS ONE, 9(4). doi:10.1371/journal.pone.0093995

Goel, S. A., Guo, L. -W., Wang, B., Guo, S., Roenneburg, D., Ananiev, G. E., . . . Kent, K. C. (2014). High-Throughput Screening Identifies Idarubicin as a Preferential Inhibitor of Smooth Muscle versus Endothelial Cell Proliferation. PLOS ONE, 9(2). doi:10.1371/journal.pone.0089349

Shi, X., Chen, G., Guo, L. -W., Si, Y., Zhu, M., Pilla, S., . . . Kent, K. C. (2014). Periadventitial Application of Rapamycin-Loaded Nanoparticles Produces Sustained Inhibition of Vascular Restenosis. PLOS ONE, 9(2). doi:10.1371/journal.pone.0089227

Guo, L. -W., Wang, B., Goel, S. A., Little, C., Takayama, T., Shi, X. D., . . . Kent, K. C. (2014). Halofuginone Stimulates Adaptive Remodeling and Preserves Re-Endothelialization in Balloon-Injured Rat Carotid Arteries. CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 7(4), 594-+. doi:10.1161/CIRCINTERVENTIONS.113.001181


Goel, S. A., Guo, L. -W., Shi, X. -D., Kundi, R., Sovinski, G., Seedial, S., . . . Kent, K. C. (2013). Preferential secretion of collagen type 3 versus type 1 from adventitial fibroblasts stimulated by TGF-β/Smad3-treated medial smooth muscle cells. CELLULAR SIGNALLING, 25(4), 955-960. doi:10.1016/j.cellsig.2012.12.021

Guo, L. -W., Hajipour, A. R., Karaoglu, K., Mavlyutov, T. A., & Ruoho, A. E. (2012). Development of Benzophenone-Alkyne Bifunctional Sigma Receptor Ligands. CHEMBIOCHEM, 13(15), 2277-2289. doi:10.1002/cbic.201200427

Goel, S. A., Guo, L. -W., Liu, B., & Kent, K. C. (2012). Mechanisms of post-intervention arterial remodelling. CARDIOVASCULAR RESEARCH, 96(3), 363-371. doi:10.1093/cvr/cvs276


Hajipour, A. R., Guo, L. -W., Pal, A., Mavlyutov, T., & Ruoho, A. E. (2011). Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand. BIOORGANIC & MEDICINAL CHEMISTRY, 19(24), 7435-7440. doi:10.1016/j.bmc.2011.10.046

Mavlyutov, T. A., Nickells, R. W., & Guo, L. -W. (2011). Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor. MOLECULAR VISION, 17(116), 1034-1043.

Guo, L. -W., & Ruoho, A. E. (2011). N-terminal Half of the cGMP Phosphodiesterase γ-Subunit Contributes to Stabilization of the GTPase-accelerating Protein Complex. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(17), 15260-15267. doi:10.1074/jbc.M110.210567


Chu, U. B., Song, J., Mavlyutov, T. A., & Guo, L. -W. (2010). In vitro interaction of tubulin with the photoreceptor cGMP phosphodiesterase γ-subunit. NEUROSCIENCE LETTERS, 482(3), 225-229. doi:10.1016/j.neulet.2010.07.044

Guo, L. -W., Hajipour, A. R., & Ruoho, A. E. (2010). Complementary Interactions of the Rod PDE6 Inhibitory Subunit with the Catalytic Subunits and Transducin. JOURNAL OF BIOLOGICAL CHEMISTRY, 285(20), 15209-15219. doi:10.1074/jbc.M109.086116