Clint L. Miller
- Email: clintm@virginia.edu
- Phone: 434-982-0502
- Fax: 434-982-1815
- Website: http://millerlab.org
Primary Appointment
Associate Professor of Public Health Sciences, Public Health Sciences
Education
- PhD, Pharmacology, University of Rochester
- Postdoc, Human Genetics, Stanford University
Research Disciplines
Biochemistry, Bioinformatics and Genomics, Cardiovascular Biology, Computational Biology, Epigenetics, Experimental Pathology, Genetics, Molecular Biology, Molecular Pharmacology, Physiology
Research Interests
Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology
Research Description
Training
- Basic Cardiovascular Research Training Grant
Selected Publications
2024
Lu, H., Lary, C. W., Hodonsky, C. J., Peyser, P. A., Bos, D., van der Laan, S. W., . . . Medina-Gomez, C. (2024). Association between bone mineral density and coronary artery calcification: an observational and Mendelian randomization study.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, zjae022. doi:10.1093/jbmr/zjae022
Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2024). Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci. CELL GENOMICS, 4(1). doi:10.1016/j.xgen.2023.100465
2023
Mosquera, J. V., Auguste, G., Wong, D., Turner, A. W., Hodonsky, C. J., Alvarez-Yela, A. C., . . . Miller, C. L. (2023). Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. CELL REPORTS, 42(11). doi:10.1016/j.celrep.2023.113380
Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N. A., . . . Finn, A. V. (2024). Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 44(1), 300-313. doi:10.1161/ATVBAHA.123.319818
Kavousi, M., Bos, M. M., Barnes, H. J., Cardenas, C. L. L., Wong, D., Lu, H., . . . Miller, C. L. (2023). Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. NATURE GENETICS, 55(10), 1651-+. doi:10.1038/s41588-023-01518-4
Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N., . . . Finn, A. V. (2023). Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy.. bioRxiv. doi:10.1101/2023.07.05.547891
Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2023). Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.. medRxiv. doi:10.1101/2023.02.09.23285622
de Vries, P. S., Conomos, M. P., Singh, K., Nicholson, C. J., Jain, D., Hasbani, N. R., . . . Malhotra, R. (2023). Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. NATURE CARDIOVASCULAR RESEARCH, 2(12), 1159-+. doi:10.1038/s44161-023-00375-y
Mekke, J. M., Sakkers, T. R., Verwer, M. C., van den Dungen, N. A. M., Song, Y., Miller, C. L., . . . van der Laan, S. W. (2023). The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-43369-3
Zhang, W., Zhao, J., Deng, L., Ishimwe, N., Pauli, J., Wu, W., . . . Long, X. (2023). INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. CIRCULATION, 148(1), 47-67. doi:10.1161/CIRCULATIONAHA.123.063760
Zheng, J., Wheeler, E., Pietzner, M., Andlauer, T. F. M., Yau, M. S., Hartley, A. E., . . . Tobias, J. H. (2023). Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization. ARTHRITIS & RHEUMATOLOGY, 75(10), 1781-1792. doi:10.1002/art.42538
Wong, D., Auguste, G., Lino Cardenas, C. L., Turner, A. W., Chen, Y., Song, Y., . . . Miller, C. L. (2023). FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. CIRCULATION RESEARCH, 132(9), 1144-1161. doi:10.1161/CIRCRESAHA.122.321692
Song, Y., Cisternino, F., Mekke, J. M. M., de Borst, G. J. J., de Kleijn, D. P. V., Pasterkamp, G., . . . Miller, C. L. L. (2023). An automatic entropy method to efficiently mask histology whole-slide images. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-29638-1
Zhang, M., Li, J., Wang, Q., Urabe, G., Tang, R., Huang, Y., . . . Guo, L. -W. (2023). Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation. MOLECULAR THERAPY-NUCLEIC ACIDS, 31. doi:10.1016/j.omtn.2023.02.024
Sakamoto, A., Kawakami, R., Mori, M., Guo, L., Paek, K. H., Mosquera, J. V., . . . Finn, A. V. (2023). CD163+macrophages restrain vascular calcification, promoting the development of high-risk plaque. JCI INSIGHT, 8(5). doi:10.1172/jci.insight.154922
Safabakhsh, S., Ma, W. F., Miller, C. L. L., & Laksman, Z. (2023). Cardiovascular utility of single cell RNA-Seq. CURRENT OPINION IN CARDIOLOGY, 38(3), 193-200. doi:10.1097/HCO.0000000000001014
Aherrahrou, R., Lue, D., Perry, R. N., Aberra, Y. T., Khan, M. D., Soh, J. Y., . . . Civelek, M. (2023). Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes. CIRCULATION RESEARCH, 132(3), 323-338. doi:10.1161/CIRCRESAHA.122.321586
2022
Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. NATURE GENETICS, 54(6), 804-+. doi:10.1038/s41588-022-01069-0
Mokry, M., Boltjes, A., Slenders, L., Bel-Bordes, G., Cui, K., Brouwer, E., . . . Pasterkamp, G. (2022). Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. NATURE CARDIOVASCULAR RESEARCH, 1(12), 1140-+. doi:10.1038/s44161-022-00171-0
Ma, W. F., Turner, A. W., Gancayco, C., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.969421
Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk (vol 54, pg 804, 2022). NATURE GENETICS, 54(8), 1259. doi:10.1038/s41588-022-01142-8
Ma, L., Bryce, N. S., Turner, A. W., Di Narzo, A. F., Rahman, K., Xu, Y., . . . Kovacic, J. C. (2022). The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. PLOS GENETICS, 18(6). doi:10.1371/journal.pgen.1010261
Reddy, M. S., Serbulea, V., Shamsuzzaman, S., Salamon, A., Tripathi, R., Miller, C., . . . Owens, G. (2022). A Transcriptional Regulation Bioinformatics Pipeline to Predict Co-Regulated Genes in Vascular Smooth Muscle Cell Phenotypic Transitions During Atherosclerosis. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.L7569
Slenders, L., Landsmeer, L. P. L., Cui, K., Depuydt, M. A. C., Verwer, M., Mekke, J., . . . Mokry, M. (2022). Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.. European heart journal open, 2(1), oeab043. doi:10.1093/ehjopen/oeab043
Hao, K., Ermel, R., Sukhavasi, K., Cheng, H., Ma, L., Li, L., . . . Kovacic, J. C. (2022). Integrative Prioritization of Causal Genes for Coronary Artery Disease. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 15(1). doi:10.1161/CIRCGEN.121.003365
Wang, Y., Gao, H., Wang, F., Ye, Z., Mokry, M., Turner, A. W., . . . Leeper, N. J. (2022). Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells. CARDIOVASCULAR RESEARCH, 118(13), 2792-2804. doi:10.1093/cvr/cvab347
Ma, W. F., Hodonsky, C. J., Turner, A. W., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. ATHEROSCLEROSIS, 340, 12-22. doi:10.1016/j.atherosclerosis.2021.11.025
2021
Aguilar-Pineda, J. A., Vera-Lopez, K. J., Shrivastava, P., Chavez-Fumagalli, M. A., Nieto-Montesinos, R., Alvarez-Fernandez, K. L., . . . Lino Cardenas, C. L. (2021). Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. ISCIENCE, 24(9). doi:10.1016/j.isci.2021.102993
Hartiala, J. A., Han, Y., Jia, Q., Hilser, J. R., Huang, P., Gukasyan, J., . . . Allayee, H. (2021). Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. EUROPEAN HEART JOURNAL, 42(9), 919-933. doi:10.1093/eurheartj/ehaa1040
Drake, J. C., Wilson, R. J., Laker, R. C., Guan, Y., Spaulding, H. R., Nichenko, A. S., . . . Yan, Z. (2021). Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(37). doi:10.1073/pnas.2025932118
Miller, C. L., Kontorovich, A. R., Hao, K., Ma, L., Iyegbe, C., Bjorkegren, J. L. M., & Kovacic, J. C. (2021). Precision Medicine Approaches to Vascular Disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 77(20), 2531-2550. doi:10.1016/j.jacc.2021.04.001
Cornelissen, A., Fuller, D. T., Fernandez, R., Zhao, X., Kutys, R., Binns-Roemer, E., . . . Finn, A. V. (2021). APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(7), 2201-2214. doi:10.1161/ATVBAHA.120.315788
2020
Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., . . . Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(27), 15818-15826. doi:10.1073/pnas.2006348117
Aherrahrou, R., Guo, L., Nagraj, V. P., Aguhob, A., Hinkle, J., Chen, L., . . . Civelek, M. (2020). Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. CIRCULATION RESEARCH, 127(12), 1552-1565. doi:10.1161/CIRCRESAHA.120.317415
2019
Wirka, R. C., Wagh, D., Paik, D. T., Pjanic, M., Trieu, N., Miller, C. L., . . . Quertermous, T. (2019). Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. NATURE MEDICINE, 25(8), 1280-+. doi:10.1038/s41591-019-0512-5
Zhao, Q., Wirka, R., Trieu, N., Nagao, M., Cheng, P., Miller, C. L., . . . Quertermous, T. (2019). TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression. GENOME MEDICINE, 11. doi:10.1186/s13073-019-0635-9
Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2019). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (vol 124, pg 1083, 2014). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2164. doi:10.1172/JCI129277
Xu, S., Xu, Y., Liu, P., Zhang, S., Liu, H., Slavin, S., . . . Jin, Z. G. (2019). The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. EUROPEAN HEART JOURNAL, 40(29), 2398-+. doi:10.1093/eurheartj/ehz303
Jaffre, F., Miller, C. L., Schaenzer, A., Evans, T., Roberts, A. E., Hahn, A., & Kontaridis, M. I. (2019). Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. CIRCULATION, 140(3), 207-224. doi:10.1161/CIRCULATIONAHA.118.037227
Wong, D., Turner, A. W., & Miller, C. L. (2019). Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(6), 1006-1017. doi:10.1161/ATVBAHA.119.312141
Turner, A. W., Wong, D., Khan, M. D., Dreisbach, C. N., Palmore, M., & Miller, C. L. (2019). Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis. FRONTIERS IN CARDIOVASCULAR MEDICINE, 6. doi:10.3389/fcvm.2019.00009
2018
Nanda, V., Wang, T., Pjanic, M., Liu, B., Trieu, N., Matic, L. P., . . . Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLOS GENETICS, 14(11). doi:10.1371/journal.pgen.1007755
Iyer, D., Zhao, Q., Wirka, R., Naravane, A., Trieu, N., Liu, B., . . . Quertermous, T. (2018). Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. PLOS GENETICS, 14(10). doi:10.1371/journal.pgen.1007681
Liu, B., Pjanic, M., Wang, T., Nguyen, T., Gloudemans, M., Rao, A., . . . Quertermous, T. (2018). Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci. AMERICAN JOURNAL OF HUMAN GENETICS, 103(3), 377-388. doi:10.1016/j.ajhg.2018.08.001
Turner, A. W., Wong, D., Dreisbach, C. N., & Miller, C. L. (2018). GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 5. doi:10.3389/fcvm.2018.00072
Wang, Z., Civelek, M., Miller, C. L., Sheffield, N. C., Guertin, M. J., & Zang, C. (2018). BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. BIOINFORMATICS, 34(16), 2867-2869. doi:10.1093/bioinformatics/bty194
2017
Kim, J. B., Pjanic, M., Trieu, N., Miller, C. L., Iyer, D., Liu, B., . . . Quertermous, T. (2017). TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells. PLOS GENETICS, 13(5). doi:10.1371/journal.pgen.1006750
2016
Miller, C. L., & Leeper, N. J. (2016). Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis.. JACC. Basic to translational science, 1(7), 680-683. doi:10.1016/j.jacbts.2016.09.006
Pjanic, M., Miller, C. L., Wirka, R., Kim, J. B., DiRenzo, D. M., & Quertermous, T. (2016). Genetics and Genomics of Coronary Artery Disease. CURRENT CARDIOLOGY REPORTS, 18(10). doi:10.1007/s11886-016-0777-y
Kojima, Y., Volkmer, J. -P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., . . . Leeper, N. J. (2016). CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. NATURE, 536(7614), 86-+. doi:10.1038/nature18935
Miller, C. L., Pjanic, M., Wang, T., Nguyen, T., Cohain, A., Lee, J. D., . . . Quertermous, T. (2016). Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12092
Matic, L. P., Rykaczewska, U., Razuvaev, A., Sabater-Lleal, M., Lengquist, M., Miller, C. L., . . . Hedin, U. (2016). Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(9), 1947-1961. doi:10.1161/ATVBAHA.116.307893
Knight, W. E., Chen, S., Zhang, Y., Oikawa, M., Wu, M., Zhou, Q., . . . Yan, C. (2016). PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(45), E7116-E7125. doi:10.1073/pnas.1607728113
2015
Sazonova, O., Zhao, Y., Nuernberg, S., Miller, C., Pjanic, M., Castano, V. G., . . . Quertermous, T. (2015). Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005202
Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., . . . Ashley, E. A. (2015). Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLOS GENETICS, 11(10). doi:10.1371/journal.pgen.1005496
Miller, C. L., Pjanic, M., & Quertermous, T. (2015). From Locus Association to Mechanism of Gene Causality The Devil Is in the Details. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(10), 2079-2080. doi:10.1161/ATVBAHA.115.306366
Perez, M. V., Pavlovic, A., Shang, C., Wheeler, M. T., Miller, C. L., Liu, J., . . . Ashley, E. A. (2015). Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(22), 2522-2533. doi:10.1016/j.jacc.2015.09.061
Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap. GENOMICS DATA, 5, 36-37. doi:10.1016/j.gdata.2015.05.007
Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005155
2014
Miller, C. L., Assimes, T. L., Montgomery, S. B., & Quertermous, T. (2014). Dissecting the Causal Genetic Mechanisms of Coronary Heart Disease. CURRENT ATHEROSCLEROSIS REPORTS, 16(5). doi:10.1007/s11883-014-0406-4
Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2014). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 124(3), 1083-1097. doi:10.1172/JCI70391
Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., . . . Sczakiel, G. (2014). Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004263
2013
Oikawa, M., Wu, M., Lim, S., Knight, W. E., Miller, C. L., Cai, Y., . . . Yan, C. (2013). Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 64, 11-19. doi:10.1016/j.yjmcc.2013.08.003
Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., Diaz, R., . . . Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7). doi:10.1371/journal.pgen.1003652
Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., Maegdefessel, L., . . . Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-+. doi:10.1161/ATVBAHA.112.300399
2011
Miller, C. L., Cai, Y., Oikawa, M., Thomas, T., Dostmann, W. R., Zaccolo, M., . . . Yan, C. (2011). Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. BASIC RESEARCH IN CARDIOLOGY, 106(6), 1023-1039. doi:10.1007/s00395-011-0228-2
Cai, Y., Miller, C. L., Nagel, D. J., Jeon, K. -I., Lim, S., Gao, P., . . . Yan, C. (2011). Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(3), 616-623. doi:10.1161/ATVBAHA.110.212621
2010
Miller, C. L., & Yan, C. (2010). Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 3(5), 507-515. doi:10.1007/s12265-010-9203-9
Jeon, K. -I., Jono, H., Miller, C. L., Cai, Y., Lim, S., Liu, X., . . . Yan, C. (2010). Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS JOURNAL, 277(24), 5026-5039. doi:10.1111/j.1742-4658.2010.07908.x