Clint L. Miller

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Primary Appointment

Associate Professor of Public Health Sciences, Public Health Sciences

Education

  • PhD, Pharmacology, University of Rochester
  • Postdoc, Human Genetics, Stanford University

Research Disciplines

Biochemistry, Bioinformatics and Genomics, Cardiovascular Biology, Computational Biology, Epigenetics, Experimental Pathology, Genetics, Molecular Biology, Molecular Pharmacology, Physiology

Research Interests

Genetic variation, Complex diseases, Coronary artery disease, Genomics, Epigenomics, Regulatory mechanisms, Vascular biology, Pharmacology and Physiology

Research Description

My laboratory's research focus involves the application of modern genomics and bioinformatics approaches to unravel complex and rare cardiovascular diseases. By integrating large-scale human genetic association and whole genome sequencing data with multi-omic profiles and clinically-relevant models, our work seeks to better understand causal disease mechanisms. We are dissecting the role of genetic and drug perturbations on vascular wall processes during atherosclerosis progression. We are also studying gene-gene and gene-environment interactions at the molecular level to further inform translational targeting of multiple risk loci.

Training

  • Basic Cardiovascular Research Training Grant

Selected Publications

2024

Lu, H., Lary, C. W., Hodonsky, C. J., Peyser, P. A., Bos, D., van der Laan, S. W., . . . Medina-Gomez, C. (2024). Association between bone mineral density and coronary artery calcification: an observational and Mendelian randomization study.. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, zjae022. doi:10.1093/jbmr/zjae022

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2024). Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci. CELL GENOMICS, 4(1). doi:10.1016/j.xgen.2023.100465

2023

Mosquera, J. V., Auguste, G., Wong, D., Turner, A. W., Hodonsky, C. J., Alvarez-Yela, A. C., . . . Miller, C. L. (2023). Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. CELL REPORTS, 42(11). doi:10.1016/j.celrep.2023.113380

Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N. A., . . . Finn, A. V. (2024). Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 44(1), 300-313. doi:10.1161/ATVBAHA.123.319818

Kavousi, M., Bos, M. M., Barnes, H. J., Cardenas, C. L. L., Wong, D., Lu, H., . . . Miller, C. L. (2023). Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification. NATURE GENETICS, 55(10), 1651-+. doi:10.1038/s41588-023-01518-4

Cornelissen, A., Gadhoke, N. V., Ryan, K., Hodonsky, C. J., Mitchell, R., Bihlmeyer, N., . . . Finn, A. V. (2023). Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy.. bioRxiv. doi:10.1101/2023.07.05.547891

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., . . . Miller, C. L. (2023). Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.. medRxiv. doi:10.1101/2023.02.09.23285622

Aherrahrou, R., Lue, D., Perry, R. N., Aberra, Y. T., Khan, M. D., Soh, J. Y., . . . Civelek, M. (2023). Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes. CIRCULATION RESEARCH, 132(3), 323-338. doi:10.1161/CIRCRESAHA.122.321586

de Vries, P. S., Conomos, M. P., Singh, K., Nicholson, C. J., Jain, D., Hasbani, N. R., . . . Malhotra, R. (2023). Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification. NATURE CARDIOVASCULAR RESEARCH, 2(12), 1159-+. doi:10.1038/s44161-023-00375-y

Mekke, J. M., Sakkers, T. R., Verwer, M. C., van den Dungen, N. A. M., Song, Y., Miller, C. L., . . . van der Laan, S. W. (2023). The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-43369-3

Zhang, W., Zhao, J., Deng, L., Ishimwe, N., Pauli, J., Wu, W., . . . Long, X. (2023). INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. CIRCULATION, 148(1), 47-67. doi:10.1161/CIRCULATIONAHA.123.063760

Zheng, J., Wheeler, E., Pietzner, M., Andlauer, T. F. M., Yau, M. S., Hartley, A. E., . . . Tobias, J. H. (2023). Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization. ARTHRITIS & RHEUMATOLOGY, 75(10), 1781-1792. doi:10.1002/art.42538

Wong, D., Auguste, G., Lino Cardenas, C. L., Turner, A. W., Chen, Y., Song, Y., . . . Miller, C. L. (2023). FHL5 Controls Vascular Disease-Associated Gene Programs in Smooth Muscle Cells. CIRCULATION RESEARCH, 132(9), 1144-1161. doi:10.1161/CIRCRESAHA.122.321692

Song, Y., Cisternino, F., Mekke, J. M. M., de Borst, G. J. J., de Kleijn, D. P. V., Pasterkamp, G., . . . Miller, C. L. L. (2023). An automatic entropy method to efficiently mask histology whole-slide images. SCIENTIFIC REPORTS, 13(1). doi:10.1038/s41598-023-29638-1

Zhang, M., Li, J., Wang, Q., Urabe, G., Tang, R., Huang, Y., . . . Guo, L. -W. (2023). Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation. MOLECULAR THERAPY-NUCLEIC ACIDS, 31. doi:10.1016/j.omtn.2023.02.024

Sakamoto, A., Kawakami, R., Mori, M., Guo, L., Paek, K. H., Mosquera, J. V., . . . Finn, A. V. (2023). CD163+macrophages restrain vascular calcification, promoting the development of high-risk plaque. JCI INSIGHT, 8(5). doi:10.1172/jci.insight.154922

Safabakhsh, S., Ma, W. F., Miller, C. L. L., & Laksman, Z. (2023). Cardiovascular utility of single cell RNA-Seq. CURRENT OPINION IN CARDIOLOGY, 38(3), 193-200. doi:10.1097/HCO.0000000000001014

2022

Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. NATURE GENETICS, 54(6), 804-+. doi:10.1038/s41588-022-01069-0

Mokry, M., Boltjes, A., Slenders, L., Bel-Bordes, G., Cui, K., Brouwer, E., . . . Pasterkamp, G. (2022). Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. NATURE CARDIOVASCULAR RESEARCH, 1(12), 1140-+. doi:10.1038/s44161-022-00171-0

Ma, W. F., Turner, A. W., Gancayco, C., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics. FRONTIERS IN CARDIOVASCULAR MEDICINE, 9. doi:10.3389/fcvm.2022.969421

Turner, A. W., Hu, S. S., Mosquera, J. V., Ma, W. F., Hodonsky, C. J., Wong, D., . . . Miller, C. L. (2022). Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk (vol 54, pg 804, 2022). NATURE GENETICS, 54(8), 1259. doi:10.1038/s41588-022-01142-8

Ma, L., Bryce, N. S., Turner, A. W., Di Narzo, A. F., Rahman, K., Xu, Y., . . . Kovacic, J. C. (2022). The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. PLOS GENETICS, 18(6). doi:10.1371/journal.pgen.1010261

Reddy, M. S., Serbulea, V., Shamsuzzaman, S., Salamon, A., Tripathi, R., Miller, C., . . . Owens, G. (2022). A Transcriptional Regulation Bioinformatics Pipeline to Predict Co-Regulated Genes in Vascular Smooth Muscle Cell Phenotypic Transitions During Atherosclerosis. FASEB JOURNAL, 36. doi:10.1096/fasebj.2022.36.S1.L7569

Slenders, L., Landsmeer, L. P. L., Cui, K., Depuydt, M. A. C., Verwer, M., Mekke, J., . . . Mokry, M. (2022). Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis.. European heart journal open, 2(1), oeab043. doi:10.1093/ehjopen/oeab043

Wang, Y., Gao, H., Wang, F., Ye, Z., Mokry, M., Turner, A. W., . . . Leeper, N. J. (2022). Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells. CARDIOVASCULAR RESEARCH, 118(13), 2792-2804. doi:10.1093/cvr/cvab347

2021

Hao, K., Ermel, R., Sukhavasi, K., Cheng, H., Ma, L., Li, L., . . . Kovacic, J. C. (2022). Integrative Prioritization of Causal Genes for Coronary Artery Disease. CIRCULATION-GENOMIC AND PRECISION MEDICINE, 15(1). doi:10.1161/CIRCGEN.121.003365

Ma, W. F., Hodonsky, C. J., Turner, A. W., Wong, D., Song, Y., Mosquera, J. V., . . . Miller, C. L. (2022). Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. ATHEROSCLEROSIS, 340, 12-22. doi:10.1016/j.atherosclerosis.2021.11.025

Aguilar-Pineda, J. A., Vera-Lopez, K. J., Shrivastava, P., Chavez-Fumagalli, M. A., Nieto-Montesinos, R., Alvarez-Fernandez, K. L., . . . Lino Cardenas, C. L. (2021). Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. ISCIENCE, 24(9). doi:10.1016/j.isci.2021.102993

Hartiala, J. A., Han, Y., Jia, Q., Hilser, J. R., Huang, P., Gukasyan, J., . . . Allayee, H. (2021). Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. EUROPEAN HEART JOURNAL, 42(9), 919-933. doi:10.1093/eurheartj/ehaa1040

Drake, J. C., Wilson, R. J., Laker, R. C., Guan, Y., Spaulding, H. R., Nichenko, A. S., . . . Yan, Z. (2021). Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(37). doi:10.1073/pnas.2025932118

Miller, C. L., Kontorovich, A. R., Hao, K., Ma, L., Iyegbe, C., Bjorkegren, J. L. M., & Kovacic, J. C. (2021). Precision Medicine Approaches to Vascular Disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 77(20), 2531-2550. doi:10.1016/j.jacc.2021.04.001

Cornelissen, A., Fuller, D. T., Fernandez, R., Zhao, X., Kutys, R., Binns-Roemer, E., . . . Finn, A. V. (2021). APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 41(7), 2201-2214. doi:10.1161/ATVBAHA.120.315788

2020

Wang, Y., Nanda, V., Direnzo, D., Ye, J., Xiao, S., Kojima, Y., . . . Leeper, N. J. (2020). Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(27), 15818-15826. doi:10.1073/pnas.2006348117

Aherrahrou, R., Guo, L., Nagraj, V. P., Aguhob, A., Hinkle, J., Chen, L., . . . Civelek, M. (2020). Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. CIRCULATION RESEARCH, 127(12), 1552-1565. doi:10.1161/CIRCRESAHA.120.317415

2019

Wirka, R. C., Wagh, D., Paik, D. T., Pjanic, M., Trieu, N., Miller, C. L., . . . Quertermous, T. (2019). Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. NATURE MEDICINE, 25(8), 1280-+. doi:10.1038/s41591-019-0512-5

Xu, S., Xu, Y., Liu, P., Zhang, S., Liu, H., Slavin, S., . . . Jin, Z. G. (2019). The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. EUROPEAN HEART JOURNAL, 40(29), 2398-+. doi:10.1093/eurheartj/ehz303

Zhao, Q., Wirka, R., Trieu, N., Nagao, M., Cheng, P., Miller, C. L., . . . Quertermous, T. (2019). TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression. GENOME MEDICINE, 11. doi:10.1186/s13073-019-0635-9

Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2019). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis (vol 124, pg 1083, 2014). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2164. doi:10.1172/JCI129277

Jaffre, F., Miller, C. L., Schaenzer, A., Evans, T., Roberts, A. E., Hahn, A., & Kontaridis, M. I. (2019). Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. CIRCULATION, 140(3), 207-224. doi:10.1161/CIRCULATIONAHA.118.037227

Wong, D., Turner, A. W., & Miller, C. L. (2019). Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 39(6), 1006-1017. doi:10.1161/ATVBAHA.119.312141

Turner, A. W., Wong, D., Khan, M. D., Dreisbach, C. N., Palmore, M., & Miller, C. L. (2019). Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis. FRONTIERS IN CARDIOVASCULAR MEDICINE, 6. doi:10.3389/fcvm.2019.00009

2018

Nanda, V., Wang, T., Pjanic, M., Liu, B., Trieu, N., Matic, L. P., . . . Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLOS GENETICS, 14(11). doi:10.1371/journal.pgen.1007755

Iyer, D., Zhao, Q., Wirka, R., Naravane, A., Trieu, N., Liu, B., . . . Quertermous, T. (2018). Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. PLOS GENETICS, 14(10). doi:10.1371/journal.pgen.1007681

Liu, B., Pjanic, M., Wang, T., Nguyen, T., Gloudemans, M., Rao, A., . . . Quertermous, T. (2018). Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci. AMERICAN JOURNAL OF HUMAN GENETICS, 103(3), 377-388. doi:10.1016/j.ajhg.2018.08.001

Turner, A. W., Wong, D., Dreisbach, C. N., & Miller, C. L. (2018). GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease. FRONTIERS IN CARDIOVASCULAR MEDICINE, 5. doi:10.3389/fcvm.2018.00072

Wang, Z., Civelek, M., Miller, C. L., Sheffield, N. C., Guertin, M. J., & Zang, C. (2018). BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. BIOINFORMATICS, 34(16), 2867-2869. doi:10.1093/bioinformatics/bty194

2017

Kim, J. B., Pjanic, M., Trieu, N., Miller, C. L., Iyer, D., Liu, B., . . . Quertermous, T. (2017). TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells. PLOS GENETICS, 13(5). doi:10.1371/journal.pgen.1006750

2016

Miller, C. L., & Leeper, N. J. (2016). Genome-Wide Association Studies Candidate Gene to Dual Modifier of Nonalcoholic Steatohepatitis and Atherosclerosis.. JACC. Basic to translational science, 1(7), 680-683. doi:10.1016/j.jacbts.2016.09.006

Pjanic, M., Miller, C. L., Wirka, R., Kim, J. B., DiRenzo, D. M., & Quertermous, T. (2016). Genetics and Genomics of Coronary Artery Disease. CURRENT CARDIOLOGY REPORTS, 18(10). doi:10.1007/s11886-016-0777-y

Kojima, Y., Volkmer, J. -P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., . . . Leeper, N. J. (2016). CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. NATURE, 536(7614), 86-+. doi:10.1038/nature18935

Miller, C. L., Pjanic, M., Wang, T., Nguyen, T., Cohain, A., Lee, J. D., . . . Quertermous, T. (2016). Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. NATURE COMMUNICATIONS, 7. doi:10.1038/ncomms12092

Matic, L. P., Rykaczewska, U., Razuvaev, A., Sabater-Lleal, M., Lengquist, M., Miller, C. L., . . . Hedin, U. (2016). Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 36(9), 1947-1961. doi:10.1161/ATVBAHA.116.307893

Knight, W. E., Chen, S., Zhang, Y., Oikawa, M., Wu, M., Zhou, Q., . . . Yan, C. (2016). PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(45), E7116-E7125. doi:10.1073/pnas.1607728113

2015

Sazonova, O., Zhao, Y., Nuernberg, S., Miller, C., Pjanic, M., Castano, V. G., . . . Quertermous, T. (2015). Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005202

Dewey, F. E., Grove, M. E., Priest, J. R., Waggott, D., Batra, P., Miller, C. L., . . . Ashley, E. A. (2015). Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. PLOS GENETICS, 11(10). doi:10.1371/journal.pgen.1005496

Miller, C. L., Pjanic, M., & Quertermous, T. (2015). From Locus Association to Mechanism of Gene Causality The Devil Is in the Details. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 35(10), 2079-2080. doi:10.1161/ATVBAHA.115.306366

Perez, M. V., Pavlovic, A., Shang, C., Wheeler, M. T., Miller, C. L., Liu, J., . . . Ashley, E. A. (2015). Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 66(22), 2522-2533. doi:10.1016/j.jacc.2015.09.061

Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary artery disease associated transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap. GENOMICS DATA, 5, 36-37. doi:10.1016/j.gdata.2015.05.007

Nurnberg, S. T., Cheng, K., Raiesdana, A., Kundu, R., Miller, C. L., Kim, J. B., . . . Quertermous, T. (2015). Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLOS GENETICS, 11(5). doi:10.1371/journal.pgen.1005155

2014

Miller, C. L., Assimes, T. L., Montgomery, S. B., & Quertermous, T. (2014). Dissecting the Causal Genetic Mechanisms of Coronary Heart Disease. CURRENT ATHEROSCLEROSIS REPORTS, 16(5). doi:10.1007/s11883-014-0406-4

Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., . . . Leeper, N. J. (2014). Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis. JOURNAL OF CLINICAL INVESTIGATION, 124(3), 1083-1097. doi:10.1172/JCI70391

Miller, C. L., Haas, U., Diaz, R., Leeper, N. J., Kundu, R. K., Patlolla, B., . . . Sczakiel, G. (2014). Coronary Heart Disease-Associated Variation in TCF21 Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation. PLOS GENETICS, 10(3). doi:10.1371/journal.pgen.1004263

2013

Oikawa, M., Wu, M., Lim, S., Knight, W. E., Miller, C. L., Cai, Y., . . . Yan, C. (2013). Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 64, 11-19. doi:10.1016/j.yjmcc.2013.08.003

Miller, C. L., Anderson, D. R., Kundu, R. K., Raiesdana, A., Nuernberg, S. T., Diaz, R., . . . Quertermous, T. (2013). Disease-Related Growth Factor and Embryonic Signaling Pathways Modulate an Enhancer of TCF21 Expression at the 6q23.2 Coronary Heart Disease Locus. PLOS GENETICS, 9(7). doi:10.1371/journal.pgen.1003652

Leeper, N. J., Raiesdana, A., Kojima, Y., Kundu, R. K., Cheng, H., Maegdefessel, L., . . . Quertermous, T. (2013). Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 33(1), E1-+. doi:10.1161/ATVBAHA.112.300399

2011

Miller, C. L., Cai, Y., Oikawa, M., Thomas, T., Dostmann, W. R., Zaccolo, M., . . . Yan, C. (2011). Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. BASIC RESEARCH IN CARDIOLOGY, 106(6), 1023-1039. doi:10.1007/s00395-011-0228-2

Cai, Y., Miller, C. L., Nagel, D. J., Jeon, K. -I., Lim, S., Gao, P., . . . Yan, C. (2011). Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 31(3), 616-623. doi:10.1161/ATVBAHA.110.212621

2010

Miller, C. L., & Yan, C. (2010). Targeting Cyclic Nucleotide Phosphodiesterase in the Heart: Therapeutic Implications. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 3(5), 507-515. doi:10.1007/s12265-010-9203-9

Jeon, K. -I., Jono, H., Miller, C. L., Cai, Y., Lim, S., Liu, X., . . . Yan, C. (2010). Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS JOURNAL, 277(24), 5026-5039. doi:10.1111/j.1742-4658.2010.07908.x