Andrew Dudley

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Primary Appointment

Professor, Microbiology, Immunology, and Cancer Biology

Education

  • PhD, University of Melbourne
  • Postdoc, Boston Children's Hospital, Harvard Medical School

Research Disciplines

Cancer Biology, Cardiovascular Biology, Neuroscience

Research Interests

Tumor microenvironment and mechanisms of tumor neovascularization

Research Description

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.
SELECTED PUBLICATIONS

Personal Statement

The Dudley is focused on the tumor microenvironment and mechanisms of tumor neovascularization.
We use transgenic tumor models, in vivo lineage tracing strategies, and freshly isolated tumor-specific endothelial cells to explore differentiation and specialization of the tumor vasculature.
We are also focused on how other cell types in the tumor microenvironment, including adipocytes and inflammatory cells, contribute to the growth and formation of new tumor blood vessels.
Our goals are to
i) understand how different types of cells in the tumor microenvironment coalesce to form new tumor vasculature
ii) determine how abnormalities in the tumor vasculature contribute to tumor progression, responses to therapy, and metastasis
iii) develop new tumor microenvironment-targeted therapies that are based on a systematic understanding of tumor vascular biology.

Training

  • Cancer Research Training in Molecular Biology

Selected Publications

2024

Whately, K. M., Sengottuvel, N., Edatt, L., Srivastava, S., Woods, A. T., Tsai, Y. S., . . . Pecot, C. V. (2024). Spon1*inflammatory monocytes promote collagen remodeling and lung cancer metastasis through lipoprotein receptor 8 signaling. JCI INSIGHT, 9(9). doi:10.1172/jci.insight.168792

2023

Wang, S., Riedstra, C. P., Zhang, Y., Anandh, S., & Dudley, A. C. (2024). PTEN-restoration abrogates brain colonisation and perivascular niche invasion by melanoma cells. BRITISH JOURNAL OF CANCER, 130(4), 555-567. doi:10.1038/s41416-023-02530-5

Dudley, A. C., & Griffioen, A. W. (2023). The modes of angiogenesis: an updated perspective. ANGIOGENESIS, 26(4), 477-480. doi:10.1007/s10456-023-09895-4

Peche, V. S., Pietka, T. A., Jacome-Sosa, M., Samovski, D., Palacios, H., Chatterjee-Basu, G., . . . Abumrad, N. A. (2023). Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-39752-3

Null, J. L., Kim, D. J., McCann, V. J., Pramoonjago, P., Fox, J. W., Zeng, J., . . . Dudley, A. C. (2023). Periostin thorn Stromal Cells Guide Lymphovascular Invasion by Cancer Cells. CANCER RESEARCH, 83(13), 2105-2122. doi:10.1158/0008-5472.CAN-22-2412

Dudley, A. C., & Griffioen, A. W. (2023). Nectins and Nectin-like molecules drive vascular development and barrier function (vol 26, pg 349, 2023). ANGIOGENESIS, 26(3), 313-347. doi:10.1007/s10456-023-09876-7

Kim, D. J., Anandh, S., Null, J. L., Przanowski, P., Bhatnagar, S., Kumar, P., . . . Dudley, A. C. (2023). Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-37807-z

2022

Griffioen, A. W., & Dudley, A. C. (2022). The rising impact of angiogenesis research. ANGIOGENESIS, 25(4), 435-437. doi:10.1007/s10456-022-09849-2

2021

Griffioen, A. W., & Dudley, A. C. (2021). Angiogenesis: a year in review. ANGIOGENESIS, 24(2), 195-196. doi:10.1007/s10456-021-09798-2

Melero-Martin, J. M., Dudley, A. C., & Griffioen, A. W. (2021). Adieu to parting Editor in Chief and pioneering scientist Dr. Joyce Bischoff. ANGIOGENESIS, 24(2), 191-193. doi:10.1007/s10456-021-09786-6

2020

McCann, J. V., Bischoff, S. R., Zhang, Y., Cowley, D. O., Sanchez-Gonzalez, V., Daaboul, G. D., & Dudley, A. C. (2020). Reporter mice for isolating and auditing cell type-specific extracellular vesicles in vivo. GENESIS, 58(7). doi:10.1002/dvg.23369

2019

Dudley, A. C. (2020). Introduction to special issue: vascular co-option in cancer. ANGIOGENESIS, 23(1), 1-2. doi:10.1007/s10456-019-09699-5

McCann, J. V., Liu, A., Musante, L., Erdbrugger, U., Lannigan, J., & Dudley, A. C. (2019). A miRNA signature in endothelial cell-derived extracellular vesicles in tumor-bearing mice. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-52466-1

Zhang, Y., Wang, S., & Dudley, A. C. (2020). Models and molecular mechanisms of blood vessel co-option by cancer cells. ANGIOGENESIS, 23(1), 17-25. doi:10.1007/s10456-019-09684-y

Azam, S. H., Porrello, A., Harrison, E. B., Leslie, P. L., Liu, X., Waugh, T. A., . . . Pecot, C. V. (2019). Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis. ONCOGENE, 38(26), 5191-5210. doi:10.1038/s41388-019-0786-6

McCann, J. V., Xiao, L., Kim, D. J., Khan, O. F., Kowalski, P. S., Anderson, D. G., . . . Dudley, A. C. (2019). Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine 1. JOURNAL OF CLINICAL INVESTIGATION, 129(4), 1654-1670. doi:10.1172/JCI123106

2018

McCann, J. V., Null, J. L., & Dudley, A. C. (2018). Deadly DAaRTS destroy cancer cells via a tumor microenvironment-mediated trigger. JOURNAL OF CLINICAL INVESTIGATION, 128(7), 2750-2753. doi:10.1172/JCI121527

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., . . . Griffioen, A. W. (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. ANGIOGENESIS, 21(3), 425-532. doi:10.1007/s10456-018-9613-x

Kim, D. J., Dunleavey, J. M., Xiao, L., Ollila, D. W., Troester, M. A., Otey, C. A., . . . Dudley, A. C. (2018). Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo) fibroblasts via HDAC inhibition. BRITISH JOURNAL OF CANCER, 118(10), 1359-1368. doi:10.1038/s41416-018-0072-3

2016

Xiao, L., & Dudley, A. C. (2017). Fine-tuning vascular fate during endothelial-mesenchymal transition. JOURNAL OF PATHOLOGY, 241(1), 25-35. doi:10.1002/path.4814

Lucitti, J. L., Sealock, R., Buckley, B. K., Zhang, H., Xiao, L., Dudley, A. C., & Faber, J. E. (2016). Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke.. Stroke, 47(12), 3022-3031. doi:10.1161/strokeaha.116.014160

2015

Xiao, L., McCann, J. V., & Dudley, A. C. (2015). Isolation and Culture Expansion of Tumor-specific Endothelial Cells. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (104). doi:10.3791/53072

Thoppil, R. J., Adapala, R. K., Cappelli, H. C., Kondeti, V., Dudley, A. C., Meszaros, J. G., . . . Thodeti, C. K. (2015). TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation. SCIENTIFIC REPORTS, 5. doi:10.1038/srep14257

Adapala, R. K., Thoppil, R. J., Ghosh, K., Cappelli, H. C., Dudley, A. C., Paruchuri, S., . . . Thodeti, C. K. (2016). Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. ONCOGENE, 35(3), 314-322. doi:10.1038/onc.2015.83

Dudley, A. C., & Bautch, V. L. (2015). Feeding cancer's sweet tooth: specialized tumour vasculature shuttles glucose in pancreatic ductal adenocarcinoma. JOURNAL OF PATHOLOGY, 236(2), 133-135. doi:10.1002/path.4526

Xiao, L., Kim, D. J., Davis, C. L., McCann, J. V., Dunleavey, J. M., Vanderlinden, A. K., . . . Dudley, A. C. (2015). Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. CANCER RESEARCH, 75(7), 1244-1254. doi:10.1158/0008-5472.CAN-14-1616

2014

Dunleavey, J. M., Xiao, L., Thompson, J., Kim, M. M., Shields, J. M., Shelton, S. E., . . . Dudley, A. C. (2014). Vascular channels formed by subpopulations of PECAM1+ melanoma cells. NATURE COMMUNICATIONS, 5. doi:10.1038/ncomms6200

Song, G., Darr, D. B., Santos, C. M., Ross, M., Valdivia, A., Jordan, J. L., . . . Zamboni, W. C. (2014). Effects of Tumor Microenvironment Heterogeneity on Nanoparticle Disposition and Efficacy in Breast Cancer Tumor Models. CLINICAL CANCER RESEARCH, 20(23), 6083-6095. doi:10.1158/1078-0432.CCR-14-0493

Kushner, E. J., Ferro, L. S., Liu, J. -Y., Durrant, J. R., Rogers, S. L., Dudley, A. C., & Bautch, V. L. (2014). Excess centrosomes disrupt endothelial cell migration via centrosome scattering. JOURNAL OF CELL BIOLOGY, 206(2), 257-272. doi:10.1083/jcb.201311013

2013

Xiao, L., Harrell, J. C., Perou, C. M., & Dudley, A. C. (2014). Identification of a stable molecular signature in mammary tumor endothelial cells that persists in vitro. ANGIOGENESIS, 17(3), 511-518. doi:10.1007/s10456-013-9409-y

Harrell, J. C., Pfefferle, A. D., Zalles, N., Prat, A., Fan, C., Khramtsov, A., . . . Perou, C. M. (2014). Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis. CLINICAL & EXPERIMENTAL METASTASIS, 31(1), 33-45. doi:10.1007/s10585-013-9607-4

Wagner, M., Bjerkvig, R., Wiig, H., & Dudley, A. C. (2013). Loss of adipocyte specification and necrosis augment tumor-associated inflammation.. Adipocyte, 2(3), 176-183. doi:10.4161/adip.24472

Wagner, M., & Dudley, A. C. (2013). A three-party alliance in solid tumors: Adipocytes, macrophages and vascular endothelial cells.. Adipocyte, 2(2), 67-73. doi:10.4161/adip.23016

2012

Di Vizio, D., Morello, M., Dudley, A. C., Schow, P. W., Adam, R. M., Morley, S., . . . Freeman, M. R. (2012). Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease. AMERICAN JOURNAL OF PATHOLOGY, 181(5), 1573-1584. doi:10.1016/j.ajpath.2012.07.030

Dunleavey, J. M., & Dudley, A. C. (2012). Vascular Mimicry: Concepts and Implications for Anti-Angiogenic Therapy.. Current angiogenesis, 1(2), 133-138. doi:10.2174/2211552811201020133

Wagner, M., Bjerkvig, R., Wiig, H., Melero-Martin, J. M., Lin, R. -Z., Klagsbrun, M., & Dudley, A. C. (2012). Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. ANGIOGENESIS, 15(3), 481-495. doi:10.1007/s10456-012-9276-y

2011

Panigrahy, D., Edin, M. L., Lee, C. R., Huang, S., Bielenberg, D. R., Butterfield, C. E., . . . Zeldin, D. C. (2012). Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. JOURNAL OF CLINICAL INVESTIGATION, 122(1), 178-191. doi:10.1172/JCI58128

Dudley, A. C. (2012). Tumor Endothelial Cells. COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2(3). doi:10.1101/cshperspect.a006536

Lin, R. -Z., Dreyzin, A., Aamodt, K., Li, D., Jaminet, S. -C. S., Dudley, A. C., & Melero-Martin, J. M. (2011). Induction of erythropoiesis using human vascular networks genetically engineered for controlled erythropoietin release. BLOOD, 118(20), 5420-5428. doi:10.1182/blood-2011-08-372946

Melero-Martin, J. M., & Dudley, A. C. (2011). Concise Review: Vascular Stem Cells and Tumor Angiogenesis. STEM CELLS, 29(2), 163-168. doi:10.1002/stem.583

2010

Lin, R. -Z., Dreyzin, A., Aamodt, K., Dudley, A. C., & Melero-Martin, J. M. (2011). Functional Endothelial Progenitor Cells From Cryopreserved Umbilical Cord Blood. CELL TRANSPLANTATION, 20(4), 515-522. doi:10.3727/096368910X532729

Melero-Martin, J. M., De Obaldia, M. E., Allen, P., Dudley, A. C., Klagsbrun, M., & Bischoff, J. (2010). Host Myeloid Cells Are Necessary for Creating Bioengineered Human Vascular Networks In Vivo. TISSUE ENGINEERING PART A, 16(8), 2457-2466. doi:10.1089/ten.tea.2010.0024

Geretti, E., van Meeteren, L. A., Shimizu, A., Dudley, A. C., Claesson-Welsh, L., & Klagsbrun, M. (2010). A Mutated Soluble Neuropilin-2 B Domain Antagonizes Vascular Endothelial Growth Factor Bioactivity and Inhibits Tumor Progression. MOLECULAR CANCER RESEARCH, 8(8), 1063-1073. doi:10.1158/1541-7786.MCR-10-0157

Dudley, A. C., Udagawa, T., Melero-Martin, J. M., Shih, S. -C., Curatolo, A., Moses, M. A., & Klagsbrun, M. (2010). Bone marrow is a reservoir for proangiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors. BLOOD, 116(17), 3367-3371. doi:10.1182/blood-2010-02-271122