Zygmunt S. Derewenda

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Primary Appointment

Professor, Molecular Physiology and Biological Physics

Education

  • MSc, Biophysics, University of Lodz, Poland
  • PhD, Chemistry, University of Lodz, Poland
  • Postdoc, Protein Crystallography, University of York, United Kingdom

Research Disciplines

Biochemistry, Biophysics, Biotechnology, Molecular Biology, Physiology, Structural Biology

Research Interests

Structure-function relationships in proteins

Research Description

Current funded projects in the laboratory:
(1) Elucidation of molecular mechanisms controlling smooth muscle contractility;
(2) Development of drugs against the influenza and Ebola viruses;
(3) Studies of the mechanism of protein crystallization and development of new methods in this field.
List of Publications in Pubmed

Training

  • Training in Molecular Biophysics

Selected Publications

Goldschmidt L, Eisenberg D, Derewenda ZS, Salvage or recovery of failed targets by mutagenesis to reduce surface entropy., 2014; Methods in molecular biology (Clifton, N.J.). 1140() 201-9. PMID: 24590720

DziubaÅska PJ, Derewenda U, Ellena JF, Engel DA, Derewenda ZS, The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein., 2014; Acta crystallographica. Section D, Biological crystallography. 70(0) 2420-9. PMID: 25195755 | PMCID: PMC4157450

Derewenda ZS, Protein crystallization in drug design: towards a rational approach., 2013; Expert opinion on drug discovery. 2(10) 1329-40. PMID: 23484529

Derewenda U, Artamonov M, Szukalska G, Utepbergenov D, Olekhnovich N, Parikh HI, Kellogg GE, Somlyo AV, Derewenda ZS, Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Ã resolution., 2013; Acta crystallographica. Section D, Biological crystallography. 69(0) 266-75. PMID: 23385462 | PMCID: PMC3565440

Yeh TY, Kowalska AK, Scipioni BR, Cheong FK, Zheng M, Derewenda U, Derewenda ZS, Schroer TA, Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit., 2013; The EMBO journal. 32(7) 1023-35. PMID: 23455152 | PMCID: PMC3616283

Utepbergenov D, Derewenda ZS, The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides., 2013; Biochimica et biophysica acta. 1834(7) 1285-91. PMID: 23541530 | PMCID: PMC3683371

Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind JS, Somlyo AV, Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study., 2013; The Journal of biological chemistry. 288(47) 34030-40. PMID: 24106280 | PMCID: PMC3837142

Artamonov M, Momotani K, Utepbergenov D, Franke A, Khromov A, Derewenda ZS, Somlyo AV, The p90 ribosomal S6 kinase (RSK) is a mediator of smooth muscle contractility., 2013; PloS one. 8(3) e58703. PMID: 23516539 | PMCID: PMC3596281

CieÅlik M, Derewenda ZS, Mura C, Abstractions, algorithms and data structures for structural bioinformatics in PyCogent., 2012; Journal of applied crystallography. 44(0) 424-428. PMID: 22479120 | PMCID: PMC3253748

Utepbergenov D, Derewenda U, Olekhnovich N, Szukalska G, Banerjee B, Hilinski MK, Lannigan DA, Stukenberg PT, Derewenda ZS, Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Ã crystal structure of the N-terminal domain of RSK2 with bound inhibitor., 2012; Biochemistry. 51(33) 6499-510. PMID: 22846040 | PMCID: PMC3462495

Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS, Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF., 2011; The Journal of biological chemistry. 286(40) 35163-75. PMID: 21816819 | PMCID: PMC3186380

Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PÅ, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS, Structural features and chaperone activity of the NudC protein family., 2011; Journal of molecular biology. 409(5) 722-41. PMID: 21530541 | PMCID: PMC3159028

Momotani K, Artamonov MV, Utepbergenov D, Derewenda U, Derewenda ZS, Somlyo AV, p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility., 2011; Circulation research. 109(9) 993-1002. PMID: 21885830 | PMCID: PMC3211138

ZyÅkiewicz E, KijaÅska M, Choi WC, Derewenda U, Derewenda ZS, Stukenberg PT, The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein., 2011; The Journal of cell biology. 192(3) 433-45. PMID: 21282465 | PMCID: PMC3101096

Derewenda ZS, It's all in the crystalsâ¦., 2011; Acta crystallographica. Section D, Biological crystallography. 67(0) 243-8. PMID: 21460442 | PMCID: PMC3069739

Cooper DR, Grelewska K, Kim CY, Joachimiak A, Derewenda ZS, The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily., 2010; Acta crystallographica. Section F, Structural biology and crystallization communications. 66(0) 219-24. PMID: 20208147 | PMCID: PMC2833023

Derewenda ZS, Application of protein engineering to enhance crystallizability and improve crystal properties., 2010; Acta crystallographica. Section D, Biological crystallography. 66(0) 604-15. PMID: 20445236 | PMCID: PMC3089013

CieÅlik M, Derewenda ZS, The role of entropy and polarity in intermolecular contacts in protein crystals., 2009; Acta crystallographica. Section D, Biological crystallography. 65(0) 500-9. PMID: 19390155 | PMCID: PMC2672819

Zheng M, Cooper DR, Grossoehme NE, Yu M, Hung LW, Cieslik M, Derewenda U, Lesley SA, Wilson IA, Giedroc DP, Derewenda ZS, Structure of Thermotoga maritima TM0439: implications for the mechanism of bacterial GntR transcription regulators with Zn2+-binding FCD domains., 2009; Acta crystallographica. Section D, Biological crystallography. 65(0) 356-65. PMID: 19307717 | PMCID: PMC2659884

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS, On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF., 2009; BMC structural biology. 9() 36. PMID: 19460155 | PMCID: PMC2695464

Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, Joachimiak A, Raines RT, Derewenda ZS, Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif ., 2009; Biochemistry. 48(36) 8664-71. PMID: 19653655 | PMCID: PMC2739605

Cierpicki T, Bielnicki J, Zheng M, Gruszczyk J, Kasterka M, Petoukhov M, Zhang A, Fernandez EJ, Svergun DI, Derewenda U, Bushweller JH, Derewenda ZS, The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA., 2009; Protein science : a publication of the Protein Society. 18(10) 2067-79. PMID: 19670212 | PMCID: PMC2786971

Smietana K, Kasztura M, Paduch M, Derewenda U, Derewenda ZS, Otlewski J, Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG., 2008; Acta biochimica Polonica. 55(2) 269-80. PMID: 18542831

Jelen F, Lachowicz P, Apostoluk W, Mateja A, Derewenda ZS, Otlewski J, Dissecting the thermodynamics of GAP-RhoA interactions., 2008; Journal of structural biology. 165(1) 10-8. PMID: 18929667 | PMCID: PMC2656442

Cooper DR, Boczek T, Grelewska K, Pinkowska M, Sikorska M, Zawadzki M, Derewenda Z, Protein crystallization by surface entropy reduction: optimization of the SER strategy., 2007; Acta crystallographica. Section D, Biological crystallography. 63(0) 636-45. PMID: 17452789

Derewenda Z, Advances in Protein Crystallography - fourth annual meeting., 2007; IDrugs : the investigational drugs journal. 10(4) 256-8. PMID: 17390248

Derewenda U, Tarricone C, Choi WC, Cooper DR, Lukasik S, Perrina F, Tripathy A, Kim MH, Cafiso DS, Musacchio A, Derewenda ZS, The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly., 2007; Structure (London, England : 1993). 15(11) 1467-81. PMID: 17997972

Cooper DR, Surendranath Y, Devedjiev Y, Bielnicki J, Derewenda ZS, Structure of the Bacillus subtilis OhrB hydroperoxide-resistance protein in a fully oxidized state., 2007; Acta crystallographica. Section D, Biological crystallography. 63(0) 1269-73. PMID: 18084074

Derewenda ZS, On wine, chirality and crystallography., 2007; Acta crystallographica. Section A, Foundations of crystallography. 64(0) 246-58. PMID: 18156689

Paduch M, Biernat M, Stefanowicz P, Derewenda ZS, Szewczuk Z, Otlewski J, Bivalent peptides as models for multimeric targets of PDZ domains., 2007; Chembiochem : a European journal of chemical biology. 8(4) 443-52. PMID: 17279591

Goldschmidt L, Cooper DR, Derewenda ZS, Eisenberg D, Toward rational protein crystallization: A Web server for the design of crystallizable protein variants., 2007; Protein science : a publication of the Protein Society. 16(8) 1569-76. PMID: 17656576 | PMCID: PMC2203352

Mateja A, Cierpicki T, Paduch M, Derewenda ZS, Otlewski J, The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif., 2006; Journal of molecular biology. 357(2) 621-31. PMID: 16445939

Cierpicki T, Kim MH, Cooper DR, Derewenda U, Bushweller JH, Derewenda ZS, The DC-module of doublecortin: dynamics, domain boundaries, and functional implications., 2006; Proteins. 64(4) 874-82. PMID: 16835924

Oleksy A, OpaliÅski Å, Derewenda U, Derewenda ZS, Otlewski J, The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF., 2006; The Journal of biological chemistry. 281(43) 32891-7. PMID: 16954208

Grembecka J, Cierpicki T, Devedjiev Y, Derewenda U, Kang BS, Bushweller JH, Derewenda ZS, The binding of the PDZ tandem of syntenin to target proteins., 2006; Biochemistry. 45(11) 3674-83. PMID: 16533050

Kim MH, Choi WC, Kang HO, Lee JS, Kang BS, Kim KJ, Derewenda ZS, Oh TK, Lee CH, Lee JK, The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase., 2005; Proceedings of the National Academy of Sciences of the United States of America. 102(49) 17606-11. PMID: 16314577 | PMCID: PMC1295591

Derewenda ZS, Vekilov PG, Entropy and surface engineering in protein crystallization., 2005; Acta crystallographica. Section D, Biological crystallography. 62(0) 116-24. PMID: 16369101

Cierpicki T, Bushweller JH, Derewenda ZS, Probing the supramodular architecture of a multidomain protein: the structure of syntenin in solution., 2005; Structure (London, England : 1993). 13(2) 319-27. PMID: 15698575

Bielnicki J, Devedjiev Y, Derewenda U, Dauter Z, Joachimiak A, Derewenda ZS, B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes., 2005; Proteins. 62(1) 144-51. PMID: 16287140 | PMCID: PMC2792008

Tarricone C, Perrina F, Monzani S, Massimiliano L, Kim MH, Derewenda ZS, Knapp S, Tsai LH, Musacchio A, Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase., 2004; Neuron. 44(5) 809-21. PMID: 15572112

Derewenda U, Oleksy A, Stevenson AS, Korczynska J, Dauter Z, Somlyo AP, Otlewski J, Somlyo AV, Derewenda ZS, The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle., 2004; Structure (London, England : 1993). 12(11) 1955-65. PMID: 15530360

Janda I, Devedjiev Y, Derewenda U, Dauter Z, Bielnicki J, Cooper DR, Graf PC, Joachimiak A, Jakob U, Derewenda ZS, The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism., 2004; Structure (London, England : 1993). 12(10) 1901-7. PMID: 15458638 | PMCID: PMC3691021

Devedjiev Y, Surendranath Y, Derewenda U, Gabrys A, Cooper DR, Zhang RG, Lezondra L, Joachimiak A, Derewenda ZS, The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins., 2004; Journal of molecular biology. 343(2) 395-406. PMID: 15451668 | PMCID: PMC2792028

Derewenda ZS, The use of recombinant methods and molecular engineering in protein crystallization., 2004; Methods (San Diego, Calif.). 34(3) 354-63. PMID: 15325653

Kim MH, Cooper DR, Oleksy A, Devedjiev Y, Derewenda U, Reiner O, Otlewski J, Derewenda ZS, The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications., 2004; Structure (London, England : 1993). 12(6) 987-98. PMID: 15274919

Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys A, Minor W, Joachimiak A, Derewenda ZS, Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution., 2004; Acta crystallographica. Section D, Biological crystallography. 60(0) 1101-7. PMID: 15159570 | PMCID: PMC2792027

Kang BS, Devedjiev Y, Derewenda U, Derewenda ZS, The PDZ2 domain of syntenin at ultra-high resolution: bridging the gap between macromolecular and small molecule crystallography., 2004; Journal of molecular biology. 338(3) 483-93. PMID: 15081807

Derewenda ZS, Rational protein crystallization by mutational surface engineering., 2004; Structure (London, England : 1993). 12(4) 529-35. PMID: 15062076

Oleksy A, Barton H, Devedjiev Y, Purdy M, Derewenda U, Otlewski J, Derewenda ZS, Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF., 2004; Acta crystallographica. Section D, Biological crystallography. 60(0) 740-2. PMID: 15039571

Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS, The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague., 2004; Structure (London, England : 1993). 12(2) 301-6. PMID: 14962390

Czepas J, Devedjiev Y, Krowarsch D, Derewenda U, Otlewski J, Derewenda ZS, The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI., 2004; Acta crystallographica. Section D, Biological crystallography. 60(0) 275-80. PMID: 14747703

Cierpicki T, Kim MH, Otlewski J, Derewenda ZS, Bushweller JH, Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin., 2003; Journal of biomolecular NMR. 25(1) 81-2. PMID: 12567003

Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS, Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm., 2003; Structure (London, England : 1993). 11(7) 845-53. PMID: 12842047

Longenecker K, Read P, Lin SK, Somlyo AP, Nakamoto RK, Derewenda ZS, Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution., 2003; Acta crystallographica. Section D, Biological crystallography. 59(0) 876-80. PMID: 12777804 | PMCID: 12777804

Kim MH, Cierpicki T, Derewenda U, Krowarsch D, Feng Y, Devedjiev Y, Dauter Z, Walsh CA, Otlewski J, Bushweller JH, Derewenda ZS, The DCX-domain tandems of doublecortin and doublecortin-like kinase., 2003; Nature structural biology. 10(5) 324-33. PMID: 12692530

Kang BS, Cooper DR, Jelen F, Devedjiev Y, Derewenda U, Dauter Z, Otlewski J, Derewenda ZS, PDZ tandem of human syntenin: crystal structure and functional properties., 2003; Structure (London, England : 1993). 11(4) 459-68. PMID: 12679023

Kim MH, Derewenda U, Devedjiev Y, Dauter Z, Derewenda ZS, Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase., 2003; Acta crystallographica. Section D, Biological crystallography. 59(0) 502-5. PMID: 12595708

Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS, The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product., 2002; Acta crystallographica. Section D, Biological crystallography. 58(0) 381-91. PMID: 11856822

Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC, The crystal structure of a major dust mite allergen Der p 2, and its biological implications., 2002; Journal of molecular biology. 318(1) 189-97. PMID: 12054778

Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U, Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein., 2002; Structure (London, England : 1993). 10(7) 933-42. PMID: 12121648

Mateja A, Devedjiev Y, Krowarsch D, Longenecker K, Dauter Z, Otlewski J, Derewenda ZS, The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution., 2002; Acta crystallographica. Section D, Biological crystallography. 58(0) 1983-91. PMID: 12454455

Garrard SM, Longenecker KL, Lewis ME, Sheffield PJ, Derewenda ZS, Expression, purification, and crystallization of the RGS-like domain from the Rho nucleotide exchange factor, PDZ-RhoGEF, using the surface entropy reduction approach., 2001; Protein expression and purification. 21(3) 412-6. PMID: 11281715

McMullen TW, Li J, Sheffield PJ, Aoki J, Martin TW, Arai H, Inoue K, Derewenda ZS, The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib)., 2001; Protein engineering. 13(12) 865-71. PMID: 11239086

Longenecker KL, Garrard SM, Sheffield PJ, Derewenda ZS, Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI., 2001; Acta crystallographica. Section D, Biological crystallography. 57(0) 679-88. PMID: 11320308

Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS, Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases., 2001; Structure (London, England : 1993). 9(7) 559-69. PMID: 11470431

Sheffield PJ, McMullen TW, Li J, Ho YS, Garrard SM, Derewenda U, Derewenda ZS, Preparation and crystal structure of the recombinant alpha(1)/alpha(2) catalytic heterodimer of bovine brain platelet-activating factor acetylhydrolase Ib., 2001; Protein engineering. 14(7) 513-9. PMID: 11522926

Sheffield PJ, Garrard S, Caspi M, Aoki J, Arai H, Derewenda U, Inoue K, Suter B, Reiner O, Derewenda ZS, Homologs of the alpha- and beta-subunits of mammalian brain platelet-activating factor acetylhydrolase Ib in the Drosophila melanogaster genome., 2000; Proteins. 39(1) 1-8. PMID: 10737922

Li J, Derewenda U, Dauter Z, Smith S, Derewenda ZS, Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme., 2000; Nature structural biology. 7(7) 555-9. PMID: 10876240

Ducros V, Charnock SJ, Derewenda U, Derewenda ZS, Dauter Z, Dupont C, Shareck F, Morosoli R, Kluepfel D, Davies GJ, Substrate specificity in glycoside hydrolase family 10. Structural and kinetic analysis of the Streptomyces lividans xylanase 10A., 2000; The Journal of biological chemistry. 275(30) 23020-6. PMID: 10930426

Longenecker KL, Zhang B, Derewenda U, Sheffield PJ, Dauter Z, Parsons JT, Zheng Y, Derewenda ZS, Structure of the BH domain from graf and its implications for Rho GTPase recognition., 2000; The Journal of biological chemistry. 275(49) 38605-10. PMID: 10982819

Devedjiev Y, Dauter Z, Kuznetsov SR, Jones TL, Derewenda ZS, Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A., 2000; Structure (London, England : 1993). 8(11) 1137-46. PMID: 11080636

Derewenda ZS, Ho YS, PAF-acetylhydrolases., 1999; Biochimica et biophysica acta. 1441(2) 229-36. PMID: 10570251

Sheffield P, Garrard S, Derewenda Z, Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors., 1999; Protein expression and purification. 15(1) 34-9. PMID: 10024467

Wei Y, Contreras JA, Sheffield P, Osterlund T, Derewenda U, Kneusel RE, Matern U, Holm C, Derewenda ZS, Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase., 1999; Nature structural biology. 6(4) 340-5. PMID: 10201402

Sheffield PJ, Derewenda U, Taylor J, Parsons TJ, Derewenda ZS, Expression, purification and crystallization of a BH domain from the GTPase regulatory protein associated with focal adhesion kinase., 1999; Acta crystallographica. Section D, Biological crystallography. 55(0) 356-9. PMID: 10232922

Osterlund T, Beussman DJ, Julenius K, Poon PH, Linse S, Shabanowitz J, Hunt DF, Schotz MC, Derewenda ZS, Holm C, Domain identification of hormone-sensitive lipase by circular dichroism and fluorescence spectroscopy, limited proteolysis, and mass spectrometry., 1999; The Journal of biological chemistry. 274(22) 15382-8. PMID: 10336425

Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, Walker L, Somlyo AV, Nakamoto RK, Somlyo AP, Derewenda ZS, How RhoGDI binds Rho., 1999; Acta crystallographica. Section D, Biological crystallography. 55(0) 1503-15. PMID: 10489445

Ho YS, Sheffield PJ, Masuyama J, Arai H, Li J, Aoki J, Inoue K, Derewenda U, Derewenda ZS, Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase., 1999; Protein engineering. 12(8) 693-700. PMID: 10469831

Martin TW, Derewenda ZS, The name is bond--H bond., 1999; Nature structural biology. 6(5) 403-6. PMID: 10331860

Derewenda ZS, Martin TW, Structure of the gangrene alpha-toxin: the beauty in the beast., 1998; Nature structural biology. 5(8) 659-62. PMID: 9699620

Wei Y, Swenson L, Castro C, Derewenda U, Minor W, Arai H, Aoki J, Inoue K, Servin-Gonzalez L, Derewenda ZS, Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution., 1998; Structure (London, England : 1993). 6(4) 511-9. PMID: 9562561

Derewenda ZS, Derewenda U, The structure and function of platelet-activating factor acetylhydrolases., 1998; Cellular and molecular life sciences : CMLS. 54(5) 446-55. PMID: 9645224

Ho YS, Swenson L, Derewenda U, Serre L, Wei Y, Dauter Z, Hattori M, Adachi T, Aoki J, Arai H, Inoue K, Derewenda ZS, Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer., 1997; Nature. 385(6611) 89-93. PMID: 8985254

Wei Y, Zhang Y, Derewenda U, Liu X, Minor W, Nakamoto RK, Somlyo AV, Somlyo AP, Derewenda ZS, Crystal structure of RhoA-GDP and its functional implications., 1997; Nature structural biology. 4(9) 699-703. PMID: 9302995

Li J, Szittner R, Derewenda ZS, Meighen EA, Conversion of serine-114 to cysteine-114 and the role of the active site nucleophile in acyl transfer by myristoyl-ACP thioesterase from Vibrio harveyi., 1996; Biochemistry. 35(31) 9967-73. PMID: 8756458

Yamaguchi S, Takeuchi K, Mase T, Oikawa K, McMullen T, Derewenda U, McElhaney RN, Kay CM, Derewenda ZS, The consequences of engineering an extra disulfide bond in the Penicillium camembertii mono- and diglyceride specific lipase., 1996; Protein engineering. 9(9) 789-95. PMID: 8888145

Wei Y, Swenson L, Kneusel RE, Matern U, Derewenda ZS, Crystallization of a novel esterase which inactivates the macrolide toxin brefeldin A., 1996; Acta crystallographica. Section D, Biological crystallography. 52(0) 1194-5. PMID: 15299584

Wei Y, Schottel JL, Derewenda U, Swenson L, Patkar S, Derewenda ZS, A novel variant of the catalytic triad in the Streptomyces scabies esterase., 1995; Nature structural biology. 2(3) 218-23. PMID: 7773790

Serre L, Verbree EC, Dauter Z, Stuitje AR, Derewenda ZS, The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component., 1995; The Journal of biological chemistry. 270(22) 12961-4. PMID: 7768883

Derewenda ZS, Lee L, Derewenda U, The occurrence of C-H...O hydrogen bonds in proteins., 1995; Journal of molecular biology. 252(2) 248-62. PMID: 7674305

Derewenda ZS, A twist in the tale of lipolytic enzymes., 1995; Nature structural biology. 2(5) 347-9. PMID: 7664087

Serre L, Swenson L, Green R, Wei Y, Verwoert II, Verbree EC, Stuitje AR, Derewenda ZS, Crystallization of the malonyl coenzyme A-acyl carrier protein transacylase from Escherichia coli., 1994; Journal of molecular biology. 242(1) 99-102. PMID: 8078074

Swenson L, Green R, Joerger R, Haas M, Scott K, Wei Y, Derewenda U, Lawson DM, Derewenda ZS, Crystallization and preliminary crystallographic studies of the precursor and mature forms of a neutral lipase from the fungus Rhizopus delemar., 1994; Proteins. 18(3) 301-6. PMID: 8202471

Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, An unusual buried polar cluster in a family of fungal lipases., 1994; Nature structural biology. 1(1) 36-47. PMID: 7656005

Derewenda ZS, Structure and function of lipases., 1994; Advances in protein chemistry. 45() 1-52. PMID: 8154368

Lawson DM, Derewenda U, Serre L, Ferri S, Szittner R, Wei Y, Meighen EA, Derewenda ZS, Structure of a myristoyl-ACP-specific thioesterase from Vibrio harveyi., 1994; Biochemistry. 33(32) 9382-8. PMID: 8068614

Derewenda U, Swenson L, Green R, Wei Y, Morosoli R, Shareck F, Kluepfel D, Derewenda ZS, Crystal structure, at 2.6-A resolution, of the Streptomyces lividans xylanase A, a member of the F family of beta-1,4-D-glycanases., 1994; The Journal of biological chemistry. 269(33) 20811-4. PMID: 8063693

Derewenda U, Swenson L, Wei Y, Green R, Kobos PM, Joerger R, Haas MJ, Derewenda ZS, Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar., 1994; Journal of lipid research. 35(3) 524-34. PMID: 8014587

Derewenda ZS, Derewenda U, Kobos PM, (His)C epsilon-H...O=C PMID: 8051710

Hayakawa K, Swenson L, Baksh S, Wei Y, Michalak M, Derewenda ZS, Crystallization of canine cardiac calsequestrin., 1994; Journal of molecular biology. 235(1) 357-60. PMID: 8289256

Swenson L, Green R, Smith S, Derewenda ZS, Crystallization of thioesterase II from Escherichia coli., 1994; Journal of molecular biology. 236(2) 660-2. PMID: 8107148

Derewenda U, Swenson L, Green R, Wei Y, Yamaguchi S, Joerger R, Haas MJ, Derewenda ZS, Current progress in crystallographic studies of new lipases from filamentous fungi., 1994; Protein engineering. 7(4) 551-7. PMID: 8029211

Derewenda ZS, Sharp AM, News from the interface: the molecular structures of triacylglyceride lipases., 1993; Trends in biochemical sciences. 18(1) 20-5. PMID: 8438232

Derewenda U, Brzozowski AM, Lawson DM, Derewenda ZS, Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase., 1992; Biochemistry. 31(5) 1532-41. PMID: 1737010

Green R, Schottel JL, Swenson L, Wei Y, Derewenda ZS, Crystallization and preliminary crystallographic data of a Streptomyces scabies extracellular esterase., 1992; Journal of molecular biology. 227(2) 569-71. PMID: 1404370

Swenson L, Ferri SR, Green R, Sharp AM, Meighen EA, Derewenda ZS, Expression, purification and crystallization of the Vibrio harveyi acyltransferase., 1992; Journal of molecular biology. 227(2) 572-4. PMID: 1404371

Derewenda ZS, Derewenda U, Dodson GG, The crystal and molecular structure of the Rhizomucor miehei triacylglyceride lipase at 1.9 A resolution., 1992; Journal of molecular biology. 227(3) 818-39. PMID: 1404390

Liddington R, Derewenda Z, Dodson E, Hubbard R, Dodson G, High resolution crystal structures and comparisons of T-state deoxyhaemoglobin and two liganded T-state haemoglobins: T(alpha-oxy)haemoglobin and T(met)haemoglobin., 1992; Journal of molecular biology. 228(2) 551-79. PMID: 1453464

Bentley GA, Brange J, Derewenda Z, Dodson EJ, Dodson GG, Markussen J, Wilkinson AJ, Wollmer A, Xiao B, Role of B13 Glu in insulin assembly. The hexamer structure of recombinant mutant (B13 Glu-->Gln) insulin., 1992; Journal of molecular biology. 228(4) 1163-76. PMID: 1361949

Swift HJ, Brady L, Derewenda ZS, Dodson EJ, Dodson GG, Turkenburg JP, Wilkinson AJ, Structure and molecular model refinement of Aspergillus oryzae (TAKA) alpha-amylase: an application of the simulated-annealing method., 1991; Acta crystallographica. Section B, Structural science. 47() 535-44. PMID: 1930835

Derewenda ZS, Cambillau C, Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pancreatic triglyceride lipase., 1991; The Journal of biological chemistry. 266(34) 23112-9. PMID: 1744109

Derewenda ZS, Derewenda U, Relationships among serine hydrolases: evidence for a common structural motif in triacylglyceride lipases and esterases., 1991; Biochemistry and cell biology = Biochimie et biologie cellulaire. 69(12) 842-51. PMID: 1818588

Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Bing X, Markussen J, X-ray analysis of the single chain B29-A1 peptide-linked insulin molecule. A completely inactive analogue., 1991; Journal of molecular biology. 220(2) 425-33. PMID: 1856866

Brady RL, Brzozowski AM, Derewenda ZS, Dodson EJ, Dodson GG, Solution of the structure of Aspergillus niger acid alpha-amylase by combined molecular replacement and multiple isomorphous replacement methods., 1991; Acta crystallographica. Section B, Structural science. 47() 527-35. PMID: 1930834

Brzozowski AM, Derewenda U, Derewenda ZS, Dodson GG, Lawson DM, Turkenburg JP, Bjorkling F, Huge-Jensen B, Patkar SA, Thim L, A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex., 1991; Nature. 351(6326) 491-4. PMID: 2046751

Derewenda Z, Dodson G, Emsley P, Harris D, Nagai K, Perutz M, Renaud JP, Reynaud JP, Stereochemistry of carbon monoxide binding to normal human adult and Cowtown haemoglobins., 1990; Journal of molecular biology. 211(3) 515-9. PMID: 2308164

Boel E, Brady L, Brzozowski AM, Derewenda Z, Dodson GG, Jensen VJ, Petersen SB, Swift H, Thim L, Woldike HF, Calcium binding in alpha-amylases: an X-ray diffraction study at 2.1-A resolution of two enzymes from Aspergillus., 1990; Biochemistry. 29(26) 6244-9. PMID: 2207069

Brady L, Brzozowski AM, Derewenda ZS, Dodson E, Dodson G, Tolley S, Turkenburg JP, Christiansen L, Huge-Jensen B, Norskov L, A serine protease triad forms the catalytic centre of a triacylglycerol lipase., 1990; Nature. 343(6260) 767-70. PMID: 2304552

Hunter WN, Smith K, Derewenda Z, Harrop SJ, Habash J, Islam MS, Helliwell JR, Fairlamb AH, Initiating a crystallographic study of trypanothione reductase., 1990; Journal of molecular biology. 216(2) 235-7. PMID: 2254926

Derewenda U, Derewenda Z, Dodson GG, Hubbard RE, Korber F, Molecular structure of insulin: the insulin monomer and its assembly., 1989; British medical bulletin. 45(1) 4-18. PMID: 2676073

Hough E, Hansen LK, Birknes B, Jynge K, Hansen S, Hordvik A, Little C, Dodson E, Derewenda Z, High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus., 1989; Nature. 338(6213) 357-60. PMID: 2493587

Derewenda U, Derewenda Z, Dodson EJ, Dodson GG, Reynolds CD, Smith GD, Sparks C, Swenson D, Phenol stabilizes more helix in a new symmetrical zinc insulin hexamer., 1989; Nature. 338(6216) 594-6. PMID: 2648161

Derewenda Z, Yariv J, Helliwell JR, Kalb AJ, Dodson EJ, Papiz MZ, Wan T, Campbell J, The structure of the saccharide-binding site of concanavalin A., 1989; The EMBO journal. 8(8) 2189-93. PMID: 2792084 | PMCID: PMC401146

Tolley SP, Derewenda Z, Hyde SC, Higgins CF, Wilkinson AJ, Crystallization of the periplasmic oligopeptide-binding protein of Salmonella typhimurium., 1988; Journal of molecular biology. 204(2) 493-4. PMID: 3065513

Liddington R, Derewenda Z, Dodson G, Harris D, Structure of the liganded T state of haemoglobin identifies the origin of cooperative oxygen binding., 1988; Nature. 331(6158) 725-8. PMID: 3344047

Brzozowski A, Derewenda Z, Dodson E, Dodson G, Grabowski M, Liddington R, SkarzyÅski T, Vallely D, Bonding of molecular oxygen to T state human haemoglobin., 1984; Nature. 307(5946) 74-6. PMID: 6690986

Grabowski MJ, Brzozowski AM, Derewenda ZS, SkarźnÅski T, Cygler M, StepieÅ A, Derewenda AE, Crystallization of human oxyhaemoglobin from poly(ethylene glycol) solutions., 1978; The Biochemical journal. 171(1) 277-9. PMID: 646822 | PMCID: PMC1184159