Urszula Derewenda
- Email: ud3a@Virginia.EDU
- Phone: 434-982-4267
Primary Appointment
Assistant Professor of Research, Molecular Physiology and Biological Physics
Research Interests
Our primary interest is in the mechanisms by which protein molecules accomplish their diverse biological tasks.
Research Description
Personal Statement
Selected Publications
2020
Derewenda, Z. S., Hawro, I., & Derewenda, U. (2020). C&x2500;HMIDLINE HORIZONTAL ELLIPSISO hydrogen bonds in kinase-inhibitor interfaces. IUBMB LIFE, 72(6), 1233-1242. doi:10.1002/iub.2282
2018
Radwanska, M. J., Jaskolowski, M., Davydova, E., Derewenda, U., Miyake, T., Engel, D. A., . . . Derewenda, Z. S. (2018). The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 681-689. doi:10.1107/S2059798318007878
Artamonov, M. V., Sonkusare, S. K., Good, M. E., Momotani, K., Eto, M., Isakson, B. E., . . . Somlyo, A. V. (2018). RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. SCIENCE SIGNALING, 11(554). doi:10.1126/scisignal.aar3924
2017
Bukrejewska, M., Derewenda, U., Radwanska, M., Engel, D. A., & Derewenda, Z. S. (2017). Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 73, 767-774. doi:10.1107/S2059798317010737
2016
Utepbergenov, D., Hennig, P. M., Derewenda, U., Artamonov, M. V., Somlyo, A. V., & Derewenda, Z. S. (2016). Bacterial Expression, Purification and In Vitro Phosphorylation of Full-Length Ribosomal S6 Kinase 2 (RSK2). PLOS ONE, 11(10). doi:10.1371/journal.pone.0164343
Amin, E., Jaiswal, M., Derewenda, U., Reis, K., Nouri, K., Koessmeier, K. T., . . . Ahmadian, M. R. (2016). Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(39), 20353-20371. doi:10.1074/jbc.M116.736967
Baker, L. E., Ellena, J. F., Handing, K. B., Derewenda, U., Utepbergenov, D., Engel, D. A., & Derewenda, Z. S. (2016). Molecular architecture of the nucleoprotein C-terminal domain from the Ebola and Marburg viruses. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 72, 49-58. doi:10.1107/S2059798315021439
2014
Derewenda, Z., Dziubanska, P., Derewenda, U., Ellena, J., Haley, K., & Engel, D. (2014). The crystal structure of the C-terminal domain of the Ebola virus nucleoprotein. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 70, C1594. doi:10.1107/S2053273314084058
Dziubanska, P. J., Derewenda, U., Ellena, J. F., Engel, D. A., & Derewenda, Z. S. (2014). The structure of the C-terminal domain of the Zaire ebolavirus nucleoprotein. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 70, 2420-2429. doi:10.1107/S1399004714014710
2013
Artamonov, M. V., Momotani, K., Stevenson, A., Trentham, D. R., Derewenda, U., Derewenda, Z. S., . . . Somlyo, A. V. (2013). Agonist-induced Ca2+ Sensitization in Smooth Muscle REDUNDANCY OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS (RhoGEFs) AND RESPONSE KINETICS, A CAGED COMPOUND STUDY. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(47), 34030-34040. doi:10.1074/jbc.M113.514596
Yeh, T. -Y., Kowalska, A. K., Scipioni, B. R., Cheong, F. K. Y., Zheng, M., Derewenda, U., . . . Schroer, T. A. (2013). Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. EMBO JOURNAL, 32(7), 1023-1035. doi:10.1038/emboj.2013.30
Derewenda, U., Artamonov, M., Szukalska, G., Utepbergenov, D., Olekhnovich, N., Parikh, H. I., . . . Derewenda, Z. S. (2013). Identification of quercitrin as an inhibitor of the p90 S6 ribosomal kinase (RSK): structure of its complex with the N-terminal domain of RSK2 at 1.8 Ã resolution. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 69, 266-275. doi:10.1107/S0907444912045520
2012
Utepbergenov, D., Derewenda, U., Olekhnovich, N., Szukalska, G., Banerjee, B., Hilinski, M. K., . . . Derewenda, Z. S. (2012). Insights into the Inhibition of the p90 Ribosomal 56 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 Ã Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor. BIOCHEMISTRY, 51(33), 6499-6510. doi:10.1021/bi300620c
2011
Momotani, K., Artamonov, M. V., Utepbergenov, D., Derewenda, U., Derewenda, Z. S., & Somlyo, A. V. (2011). p63RhoGEF Couples Gαq/11-Mediated Signaling to Ca2+ Sensitization of Vascular Smooth Muscle Contractility. CIRCULATION RESEARCH, 109(9), 993-U42. doi:10.1161/CIRCRESAHA.111.248898
Zheng, M., Cierpicki, T., Burdette, A. J., Utepbergenov, D., Janczyk, P. L., Derewenda, U., . . . Derewenda, Z. S. (2011). Structural Features and Chaperone Activity of the NudC Protein Family. JOURNAL OF MOLECULAR BIOLOGY, 409(5), 722-741. doi:10.1016/j.jmb.2011.04.018
Kowalska, A. K., Zheng, M., Derewenda, U., & Derewenda, Z. S. (2011). The crystal structure of the p27 component of human dynactin. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 67, C222. doi:10.1107/S0108767311094463
Bielnicki, J. A., Shkumatov, A. V., Derewenda, U., Somlyo, A. V., Svergun, D. I., & Derewenda, Z. S. (2011). Insights into the Molecular Activation Mechanism of the RhoA-specific Guanine Nucleotide Exchange Factor, PDZRhoGEF. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(40), 35163-35175. doi:10.1074/jbc.M111.270918
Zylkiewicz, E., Kijanska, M., Choi, W. -C., Derewenda, U., Derewenda, Z. S., & Stukenberg, P. T. (2011). The N-terminal coiled-coil of Ndell is a regulated scaffold that recruits LIS1 to dynein. JOURNAL OF CELL BIOLOGY, 192(3), 433-445. doi:10.1083/jcb.201011142