Zequan I. Yang

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Primary Appointment

Assistant Professor of Research, Biomedical Engineering

Research Interests

Role of Inflammatory Mediators During the Genesis of Ischemia/ Reperfusion Injury

Research Description

We seek to elucidate the role of inflammatory mediators during the genesis of ischemia/ reperfusion injury. An interdisciplinary approach is used to integrate advanced surgical techniques with cardiovascular physiology and pharmacology. Recently knockout mice were used to evaluate the effects of endogenous IL-10 and poly (ADP-ribose) synthetase on myocardial infarction. Transgenic and knockout mice can help define the various inflammatory pathways that contribute to the myocardial injury induced by ischemia and reperfusion. We are currently extending our research focus from myocardial infarction to encompass the post-infarction state of heart failure. Reliable models of heart failure have been established in mice and rats. These animal models are currently being validated using cardiac MRI. The longterm goal of this research is to test innovative new therapies for the prevention of heart failure. We are also working in collaboration with other faculty to optimize methods for delivering genes directly to the intact myocardium of rats and mice. The ultimate aim of these efforts is to maintain cardiac function after myocardial infarction by using gene therapy to inhibit the inflammatory responses that exacerbate heart failure.

Personal Statement

We seek to elucidate the role of inflammatory mediators during the genesis of ischemia/ reperfusion injury. An interdisciplinary approach is used to integrate advanced surgical techniques with cardiovascular physiology and pharmacology. Recently knockout mice were used to evaluate the effects of endogenous IL-10 and poly (ADP-ribose) synthetase on myocardial infarction. Transgenic and knockout mice can help define the various inflammatory pathways that contribute to the myocardial injury induced by ischemia and reperfusion. We are currently extending our research focus from myocardial infarction to encompass the post-infarction state of heart failure. Reliable models of heart failure have been established in mice and rats. These animal models are currently being validated using cardiac MRI. The longterm goal of this research is to test innovative new therapies for the prevention of heart failure. We are also working in collaboration with other faculty to optimize methods for delivering genes directly to the intact myocardium of rats and mice. The ultimate aim of these efforts is to maintain cardiac function after myocardial infarction by using gene therapy to inhibit the inflammatory responses that exacerbate heart failure.

Selected Publications

Tian Y, Marshall M, French BA, Linden J, Yang Z, The infarct-sparing effect of IB-MECA against myocardial ischemia/reperfusion injury in mice is mediated by sequential activation of adenosine A3 and A 2A receptors., 2015; Basic research in cardiology. 110(2) 16. PMID: 25711314

Tian Y, Linden J, French BA, Yang Z, Atorvastatin at reperfusion reduces myocardial infarct size in mice by activating eNOS in bone marrow-derived cells., 2014; PloS one. 9(12) e114375. PMID: 25470018 | PMCID: PMC4254980

Yang Z, Tian Y, Liu Y, Hennessy S, Kron IL, French BA, Acute hyperglycemia abolishes ischemic preconditioning by inhibiting Akt phosphorylation: normalizing blood glucose before ischemia restores ischemic preconditioning., 2013; Oxidative medicine and cellular longevity. 2013() 329183. PMID: 24371503 | PMCID: PMC3858874

Xiao L, Zhang Y, Yang Z, Xu Y, Kundu B, Chordia MD, Pan D, Synthesis of PECAM-1-specific 64Cu PET imaging agent: evaluation of myocardial infarction caused by ischemia-reperfusion injury in mouse., 2012; Bioorganic & medicinal chemistry letters. 22(12) 4144-7. PMID: 22578454

Rosenberger LH, Hu Y, Yang Z, Sawyer RG, Gastropexy using the Carter-Thomason device in lieu of T-fasteners in a critically ill, severely obese patient: an innovative technique., 2012; Surgical laparoscopy, endoscopy & percutaneous techniques. 22(5) e316-8. PMID: 23047417 | PMCID: PMC3816147

Mirza MA, Lane S, Yang Z, Karaoli T, Akosah K, Hossack J, McDuffie M, Wang J, Zhang XQ, Song J, Cheung JY, Tucker AL, Phospholemman deficiency in postinfarct hearts: enhanced contractility but increased mortality., 2012; Clinical and translational science. 5(3) 235-42. PMID: 22686200 | PMCID: PMC3891564

Alexander MR, Moehle CW, Johnson JL, Yang Z, Lee JK, Jackson CL, Owens GK, Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice., 2011; The Journal of clinical investigation. 122(1) 70-9. PMID: 22201681 | PMCID: PMC3248279

Prasad KM, Xu Y, Yang Z, Acton ST, French BA, Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution., 2010; Gene therapy. 18(1) 43-52. PMID: 20703310 | PMCID: PMC2988989

Ailawadi G, Moehle CW, Pei H, Walton SP, Yang Z, Kron IL, Lau CL, Owens GK, Smooth muscle phenotypic modulation is an early event in aortic aneurysms., 2009; The Journal of thoracic and cardiovascular surgery. 138(6) 1392-9. PMID: 19931668 | PMCID: PMC2956879